Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability.

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

1980 • 2,099 citations

Stereological Methods. Practical methods for biological morphometry

1979 • 2,038 citations

Rapid microassays for the measurement of superoxide and hydrogen peroxide production by macrophages in culture using an automatic enzyme immunoassay reader

1981 • 1,143 citations

A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration

1980 • 915 citations

The biologically active leukotrienes. Biosynthesis, metabolism, receptors, functions, and pharmacology.

1984 • 664 citations

A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration

1980 • 589 citations

Local Effects of Synthetic Leukotrienes (LTC4, LTD4, and LTB4) in Human Skin

1983 • 585 citations

Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds.

1979 • 556 citations

Purification and identification of formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli.

1984 • 520 citations

Lung neutrophils in the adult respiratory distress syndrome. Clinical and pathophysiologic significance

1987 • 452 citations

Molecular and Cellular Mechanisms of Leukocyte Chemotaxis

1981 • 415 citations

Leukotriene B4 is a potent and stereospecific stimulator of neutrophil chemotaxis and adherence

1981 • 396 citations

Studies on the Pathogenesis of the Adult Respiratory Distress Syndrome

1982 • 359 citations

Increased surface expression of CD11b/CD18 (Mac-1) is not required for stimulated neutrophil adherence to cultured endothelium.

1988 • 333 citations

Definition of a common leukocyte cell-surface antigen (Lp95-150) associated with diverse cell-mediated immune functions.

1983 • 305 citations

Secretory Responses of Human Neutrophils: Exocytosis of Specific (Secondary) Granules by Human Neutrophils during Adherence in vitro and during Exudation in vivo

1979 • 286 citations

Human alveolar macrophages produce leukotriene B4.

1982 • 278 citations

Granulocytes mediate acute edematous lung injury in rabbits and in isolated rabbit lungs perfused with phorbol myristate acetate: role of oxygen radicals.

1982 • 257 citations

Subcellular localization of the large subunit of Mo1 (Mo1 alpha; formerly gp 110), a surface glycoprotein associated with neutrophil adhesion.

1984 • 249 citations

Increase in vascular permeability induced by leukotriene b4 and the role of polymorphonuclear leukocytes

1982 • 238 citations

Protein permeability in the adult respiratory distress syndrome. Loss of size selectivity of the alveolar epithelium.

1986 • 232 citations

Leukocyte adhesion receptors are stored in peroxidase-negative granules of human neutrophils.

1987 • 229 citations

Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidative metabolism by various agonists. Differential effects of a novel protein kinase inhibitor.

1986 • 215 citations

Novel structural determinants of the human neutrophil chemotactic activity of leukotriene B.

1981 • 189 citations

Leukotriene B4 production by the human alveolar macrophage: a potential mechanism for amplifying inflammation in the lung.

1984 • 188 citations

The lung at high altitude: bronchoalveolar lavage in acute mountain sickness and pulmonary edema

1988 • 188 citations

The effects of chronic bronchitis and chronic air-flow obstruction on lung cell populations recovered by bronchoalveolar lavage.

1985 • 184 citations

Monoclonal antibody-defined functional epitopes on the adhesion- promoting glycoprotein complex (CDw18) of human neutrophils

1986 • 173 citations

Separation and characterization of human neutrophil granules.

1974 • 163 citations

Exudation primes human and guinea pig neutrophils for subsequent responsiveness to the chemotactic peptide N-formylmethionylleucylphenylalanine and increases complement component C3bi receptor expression.

1986 • 142 citations

Eicosanoids and lung inflammation.

1987 • 136 citations

Long-term clearance of liquid and protein from the lungs of unanesthetized sheep

1985 • 134 citations

Relative contribution of leukotriene B4 to the neutrophil chemotactic activity produced by the resident human alveolar macrophage.

1987 • 128 citations

Leukotriene production and inactivation by normal, chronic granulomatous disease and myeloperoxidase-deficient neutrophils.

1983 • 128 citations

Phagocytic Function of Polymorphonuclear Leukocytes in Rheumatic Diseases

1973 • 114 citations

Leukotriene B4 Induces In Vitro Fibroblast Chemotaxis

1984 • 109 citations

Deactivation of human neutrophil chemotaxis by chemoattractants: effect on receptors for the chemotactic factor f-Met-Leu-Phe.

1981 • 97 citations

Arachidonic acid induced degranulation of rabbit peritoneal neutrophils

1979 • 97 citations

Studies of leukotriene B4-specific binding and function in rat polymorphonuclear leukocytes: absence of a chemotactic response.

1985 • 92 citations

Association between gelatinase release and increased plasma membrane expression of the Mo1 glycoprotein.

1987 • 86 citations

Receptor-mediated Modulation of Human Monocyte, Neutrophil, Lymphocyte, and Platelet Function by Phorbol Diesters

1982 • 80 citations

A functional comparison of blood and gingival inflammatory polymorphonuclear leucocytes in man.

1977 • 70 citations

Diapedesis and the permeability of venous microvessels to protein macromolecules: The impact of leukotriene B4 (LTB4)

1988 • 67 citations

Production of Arachidonic Acid Metabolites by Macrophages Exposed in vitro to Asbestos, Carbonyl Iron Particles, or Calcium Ionophore

1985 • 66 citations

Phorbol myristate acetate and the calcium ionophore A23187 synergistically induce release of LTB4 by human neutrophils: involvement of protein kinase C activation in regulation of the 5-lipoxygenase pathway.

1987 • 63 citations

Inhibition by methylprednisolone of zymosan-induced leukotriene synthesis in alveolar macrophages.

1987 • 63 citations

Ultrastructural characterization and morphometric analysis of human eosinophil degranulation

1985 • 60 citations

Effects of Leukotriene B₄Inhalation: Airway Sensitization and Lung Granulocyte Infiltration in the Guinea Pig

1987 • 53 citations

Isolation and characterization of the receptor on human neutrophils that mediates cellular adherence.

1987 • 53 citations

Synthetic leukotriene B4 is a potent chemotaxin but a weak secretagogue from human PMN

1983 • 41 citations

An in vitro study of neutrophils obtained from the normal gingival sulcus

1982 • 40 citations

Phospholipase A2-induced rat mast cell secretion. Role of arachidonic acid metabolites.

1982 • 39 citations

Granulocyte-dependent injury of pulmonary endothelium: A case of miscommunication?

1984 • 38 citations

Bronchoalveolar Lavage in Patients with the Adult Respiratory Distress Syndrome

1985 • 37 citations

Effect of neutrophil migration induced by leukotriene B4 on protein permeability in sheep lung.

1985 • 33 citations

Mechanism of action of leukotriene B₄: Intracellular calcium redistribution in rabbit neutrophils

1984 • 33 citations

Leukotriene B4 is a potent and stereospecific stimulator of neutrophil chemotaxis and adherence

1981 • 25 citations

Comparison of locomotion, chemotaxis and adhesiveness of rabbit neutrophils from blood and peritoneal exudates.

1984 • 16 citations

A rapid, flexibel method for biochemical assays using a microtiter plate reader and a microcomputer. Application for assays of protein, Na,K-Atpase and K-p-Nitrophenylphosphatase

1986 • 9 citations

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