Low molecular weight GTP-binding proteins in human neutrophil granule membranes.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Isolation of mononuclear cells and granulocytes from human blood.

1968 • 9,672 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

ras GENES

1987 • 3,818 citations

Silver staining of proteins in polyacrylamide gels

1981 • 3,565 citations

Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum.

1982 • 1,765 citations

Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments

1990 • 1,150 citations

Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation.

1983 • 938 citations

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

1989 • 881 citations

Rapid Charcoal Assay for Intrinsic Factor (IF), Gastric Juice Unsaturated B12 Binding Capacity, Antibody to IF, and Serum Unsaturated B12 Binding Capacity

1965 • 743 citations

The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery

1988 • 699 citations

Metalloenzymes and myocardial infarction. II. Malic and lactic dehydrogenase activities and zinc concentrations in serum.

1956 • 669 citations

A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeast

1988 • 592 citations

rac, a novel ras-related family of proteins that are botulinum toxin substrates

1989 • 585 citations

The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding.

1982 • 542 citations

Do GTPases direct membrane traffic in secretion?

1988 • 540 citations

rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles.

1990 • 486 citations

Purification of a novel class of coated vesicles mediating biosynthetic protein transport through the Golgi stack

1989 • 432 citations

Fluoroaluminates activate transducin‐GDP by mimicking the γ‐phosphate of GTP in its binding site

1985 • 420 citations

The Human Rab Genes Encode a Family of GTP-binding Proteins Related to Yeast YPT1 and SEC4 Products Involved in Secretion

1989 • 387 citations

MECHANISMS OF LYSOSOMAL ENZYME RELEASE FROM HUMAN LEUKOCYTES

1973 • 346 citations

Two roles for guanine nucleotides in the stimulus-secretion sequence of neutrophils

1986 • 339 citations

Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region.

1988 • 334 citations

Evidence for distinct intracellular pools of receptors for C3b and C3bi in human neutrophils.

1985 • 291 citations

SEQUENTIAL DEGRANULATION OF THE TWO TYPES OF POLYMORPHONUCLEAR LEUKOCYTE GRANULES DURING PHAGOCYTOSIS OF MICROORGANISMS

1973 • 272 citations

GE: A GTP-Binding Protein Mediating Exocytosis

1990 • 256 citations

Association of a Ras-related protein with cytochrome b of human neutrophils

1989 • 248 citations

Yeast and mammalian ras proteins have conserved biochemical properties

1985 • 195 citations

Regulation of neutrophil NADPH oxidase activation in a cell-free system by guanine nucleotides and fluoride. Evidence for participation of a pertussis and cholera toxin-insensitive G protein.

1987 • 188 citations

Detection of 23-27 kDa GTP-binding proteins in platelets and other cells

1987 • 166 citations

A modified procedure for the determination of loukocyte alkaline phosphatase

1970 • 165 citations

Separation and characterization of human neutrophil granules.

1974 • 163 citations

Expression of p21ras in normal and malignant human tissues: lack of association with proliferation and malignancy.

1987 • 159 citations

Adhesomes: specific granules containing receptors for laminin, C3bi/fibrinogen, fibronectin, and vitronectin in human polymorphonuclear leukocytes and monocytes.

1989 • 157 citations

GTPase activity of the stimulatory GTP-binding regulatory protein of adenylate cyclase, Gs. Accumulation and turnover of enzyme-nucleotide intermediates.

1985 • 143 citations

[52] Photoaffinity labeling of nucleotide binding sites with 8-azidopurine analogs: Techniques and applications

1983 • 138 citations

ADP-ribosylation of the bovine brain rho protein by botulinum toxin type C1.

1988 • 126 citations

Human neutrophils contain an intracellular pool of putative receptors for the chemoattractant N-formyl-methionyl-leucyl-phenylalanine

1983 • 118 citations

Loss of the normal N-ras allele in a mouse thymic lymphoma induced by a chemical carcinogen.

1985 • 103 citations

Identification of the ral and rac1 Gene Products, Low Molecular Mass GTP-binding Proteins from Human Platelets

1989 • 100 citations

Inflammation: basic principles and clinical correlates

1988 • 98 citations

Inhibition of exocytosis in bovine adrenal medullary cells by botulinum toxin type D

1985 • 96 citations

Subcellular localization and quantitation of the major neutrophil pertussis toxin substrate, Gn.

1988 • 94 citations

AN IMPROVED METHOD FOR ISOLATING ALPHA GRANULES AND MITOCHONDRIA FROM HUMAN PLATELETS

1974 • 87 citations

Subcellular localization of Gi alpha in human neutrophils.

1988 • 85 citations

Purification and properties of the cytosolic substrate for botulinum ADP-ribosyltransferase. Identification as an Mr 22,000 guanine nucleotide-binding protein.

1988 • 84 citations

Human neutrophil plasminogen activator is localized in specific granules and is translocated to the cell surface by exocytosis.

1986 • 74 citations

Stimuli which provoke secretion of azurophil enzymes from human neutrophils induce increments in adenosine cyclic 3′-5′-monophosphate

1981 • 73 citations

Purification and characterization of the 22,000-dalton GTP-binding protein substrate for ADP-ribosylation by botulinum toxin, G22K.

1988 • 72 citations

Chemoattractant-stimulated GTPase activity is decreased on membranes from polymorphonuclear leukocytes incubated in chemoattractant

1989 • 69 citations

Identification of novel GTP-binding proteins in the human neutrophil

1988 • 59 citations

Botulinum ADP‐ribosyltransferase C3 but not botulinum neurotoxins C1 and D ADP‐ribosylates low molecular mass GTP‐binding proteins

1987 • 57 citations

Guanine nucleotide binding properties of rap1 purified from human neutrophils

1990 • 53 citations

The distribution of the CR3 receptor on human cells and tissue as revealed by a monoclonal antibody

1984 • 52 citations

Botulinum toxin‐induced ADP‐ribosylation and inhibition of exocytosis are unrelated events

1988 • 45 citations

Identification of rho as a substrate for botulinum toxin C₃‐catalyzed ADP‐ribosylation

1989 • 41 citations

Stimulation of exocytotic degranulation by microinjection of the ras oncogene protein into rat mast cells.

1988 • 31 citations

Subcellular distribution and membrane association of human neutrophil substrates for ADP-ribosylation by pertussis toxin and cholera toxin.

1989 • 29 citations

Chapter 4 Signal Transduction by GTP Binding Proteins during Leukocyte Activation: Phagocytic Cells

1990 • 26 citations

A Cytochrome P450 Immunochemically Related to P450_c,d(P450I) Localized to the Smooth Microsomes and Inner Zone of the Guinea Pig Adrenal*

1989 • 21 citations

The neutrophil glycoprotein Mo1 is an integral membrane protein of plasma membranes and specific granules.

1987 • 17 citations

Platelet cytosolic 44-kDa protein is a substrate of cholera toxin-induced ADP-ribosylation and is not recognized by antisera against the alpha subunit of the stimulatory guanine nucleotide-binding regulatory protein.

1988 • 13 citations

Effect of botulinum D toxin on neutrophils

1988 • 9 citations