Human Cathepsin G Lacking Functional Glycosylation Site Is Proteolytically Processed and Targeted for Storage in Granules after Transfection to the Rat Basophilic/Mast Cell Line RBL or the Murine Myeloid Cell Line 32D

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

Biological roles of oligosaccharides: all of the theories are correct

1993 • 5,121 citations

The Biogenesis of Lysosomes

1989 • 1,583 citations

The Receptor with High Affinity for Immunoglobulin E

1986 • 540 citations

Trafficking of lysosomal enzymes ¹

1987 • 497 citations

Inflammation: Basic Principles and Clinical Correlates

1993 • 473 citations

Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line.

1987 • 369 citations

Human neutrophil granules and secretory vesicles

1993 • 306 citations

Molecular cloning of human cathepsin G: structural similarity to mast cell and cytotoxic T lymphocyte proteinases

1987 • 218 citations

Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I.

1993 • 205 citations

Antimicrobial polypeptides of human neutrophils

1990 • 188 citations

Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils.

1990 • 171 citations

Theearly andlate processing of lysosomal enzymes: Proteolysis and compartmentation

1992 • 160 citations

Mannose 6-phosphate-independent membrane association of cathepsin D, glucocerebrosidase, and sphingolipid-activating protein in HepG2 cells.

1991 • 156 citations

Antimicrobial polypeptides of human neutrophils

1990 • 152 citations

Detergent Influence on Rat‐Liver Galactosyltransferase Activities towards Different Acceptors

1977 • 150 citations

Antibiotic peptides and serine protease homologs in human polymorphonuclear leukocytes: defensins and azurocidin

1993 • 140 citations

Mannose 6-phosphate-independent targeting of cathepsin D to lysosomes in HepG2 cells.

1991 • 106 citations

Molecular recognition and targeting of lysosomal proteins

1991 • 105 citations

A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene

1991 • 104 citations

Secretion of functional papain precursor from insect cells. Requirement for N-glycosylation of the pro-region.

1990 • 101 citations

Covalent structure of two novel neutrophile leucocyte‐derived proteins of porcine and human origin

1991 • 100 citations

An unusual specificity in the activation of neutrophil serine proteinase zymogens

1990 • 92 citations

The pro region of human neutrophil defensin contains a motif that is essential for normal subcellular sorting

1995 • 87 citations

Procathepsins L and D are membrane-bound in acidic microsomal vesicles

1991 • 87 citations

Carboxyl-terminal Prodomain-deleted Human Leukocyte Elastase and Cathepsin G Are Efficiently Targeted to Granules and Enzymatically Activated in the Rat Basophilic/Mast Cell Line RBL

1995 • 82 citations

Activation of recombinant murine cytotoxic cell proteinase-1 requires deletion of an amino-terminal dipeptide.

1993 • 81 citations

Serine Proteinases of Mast Cell and Leukocyte Granules: A League of Their Own

1994 • 78 citations

Roles for mannose-6-phosphate receptors in lysosomal enzyme sorting, IGF-II binding and clathrin-coat assembly

1995 • 77 citations

The pH-dependent membrane association of procathepsin L is mediated by a 9-residue sequence within the propeptide.

1994 • 74 citations

Amino acid sequence of CAP37, a human neutrophil granule‐derived antibacterial and monocyte‐specific chemotactic glycoprotein structurally similar to neutrophil elastase

1990 • 74 citations

The role of N-linked oligosaccharides in glycoprotein function

1991 • 73 citations

Proteases and lymphocyte cytotoxic killing mechanisms

1993 • 72 citations

Dipeptidyl peptidase I is enriched in granules of in vitro- and in vivo-activated cytotoxic T lymphocytes.

1993 • 59 citations

Induction of the granulocyte-macrophage colony-stimulating factor (CSF) receptor by granulocyte CSF increases the differentiative options of a murine hematopoietic progenitor cell.

1990 • 55 citations

The lysosomal proenzyme receptor that binds procathepsin L to microsomal membranes at pH 5 is a 43-kDa integral membrane protein.

1993 • 49 citations

Human acid β-glucosidase: Glycosylation is required for catalytic activity

1990 • 44 citations

Biosynthesis and processing of cathepsin G and neutrophil elastase in the leukemic myeloid cell line U-937

1990 • 43 citations

Processing of human cathepsin G after transfection to the rat basophilic/mast cell tumor line RBL.

1994 • 42 citations

Dipeptide processing activates recombinant human prochymase.

1993 • 41 citations

Molecular forms and activities of glycosidases in cultures of amniotic-fluid cells

1976 • 36 citations

A chymotrypsin-type serine protease in rat basophilic leukemia cells: evidence for its immunologic identity with atypical mast cell protease.

1986 • 34 citations

The Isoforms of Human Neutrophil Elastase and Cathepsin G Differ in their Carbohydrate Side Chain Structures

1993 • 32 citations

Human cathepsin D precursor is associated with a 60 kDa glycosylated polypeptide

1992 • 22 citations

Transient membrane association of the precursors of cathepsin C during their transfer into lysosomes

1991 • 15 citations