An acute myeloid leukemia gene, AML1, regulates hemopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms.

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

GAL4-VP16 is an unusually potent transcriptional activator

1988 • 1,379 citations

SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1988 • 1,351 citations

A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the sam mRNA

1991 • 1,019 citations

Current Protocols in Molecular Biology

1989 • 1,007 citations

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

1991 • 897 citations

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

1991 • 861 citations

Fusion Between Transcription Factor CBFβ/PEBP2β and a Myosin Heavy Chain in Acute Myeloid Leukemia

1993 • 760 citations

CREM gene: Use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription

1991 • 655 citations

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene.

1993 • 621 citations

Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

1992 • 582 citations

The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript.

1993 • 523 citations

Molecular Cloning and Characterization of PEBP2β, the Heterodimeric Partner of a Novel Drosophila runt-Related DNA Binding Protein PEBP2α

1993 • 504 citations

Developmental switch of CREM function during spermatogenesis: from antagonist to activator

1992 • 495 citations

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions.

1993 • 484 citations

Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing

1989 • 437 citations

A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity

1991 • 436 citations

Cloning and Characterization of Subunits of the T-Cell Receptor and Murine Leukemia Virus Enhancer Core-Binding Factor

1993 • 425 citations

Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia.

1994 • 335 citations

Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.

1991 • 316 citations

The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system.

1990 • 299 citations

Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor

1993 • 283 citations

Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations.

1994 • 272 citations

Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia.

1992 • 234 citations

Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1.

1993 • 229 citations

Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer

1990 • 218 citations

PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials.

1994 • 204 citations

Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers.

1992 • 194 citations

Two different factors bind to the alpha-domain of the polyoma virus enhancer, one of which also interacts with the SV40 and c-fos enhancers.

1987 • 179 citations

The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1.

1993 • 179 citations

An alternative spliced form of FosB is a negative regulator of transcriptional activation and transformation by Fos proteins.

1991 • 150 citations

Alternative splicing of fosB transcripts results in differentially expressed mRNAs encoding functionally antagonistic proteins.

1991 • 145 citations

3. Teratocarcinomas and Embryonic Stem Cells

2016 • 141 citations

Isolation of the Drosophila segmentation gene runt and analysis of its expression during embryogenesis.

1988 • 135 citations

A Dominant Negative form of Transcription Activator mTFE3 Created by Differential Splicing

1991 • 129 citations

Blasticidin S-resistance gene (bsr): A novel selectable marker for mammalian cells

1991 • 122 citations

Identification of the SL3-3 virus enhancer core as a T-lymphoma cell-specific element

1989 • 119 citations

Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis

1993 • 116 citations

Mutations of the p53 gene in lymphoid leukemia

1991 • 104 citations

Indistinguishable nuclear factor binding to functional core sites of the T-cell receptor delta and murine leukemia virus enhancers.

1992 • 102 citations

Evi-1 raises AP-1 activity and stimulates c-fos promoter transactivation with dependence on the second zinc finger domain.

1994 • 99 citations

Both products of the fosB gene, FosB and its short form, FosB/SF, are transcriptional activators in fibroblasts.

1991 • 98 citations

The murine myeloperoxidase promoter contains several functional elements, one of which binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNF1).

1993 • 98 citations

Selection of lineage-restricted cell lines immortalized at different stages of hematopoietic differentiation from the murine cell line 32D.

1989 • 96 citations

Identification of AML-1 and the (8;21) Translocation Protein (AML-1/ETO) as Sequence-Specific DNA-Binding Proteins: theruntHomology Domain is Required for DNA Binding and Protein-Protein Interactions

1993 • 90 citations

Effect of Abelson murine leukemia virus on granulocytic differentiation and interleukin-3 dependence of a murine progenitor cell line.

1987 • 88 citations

Murine and Human T-Lymphocyte GATA-3 Factors Mediate Transcription through a cis-Regulatory Element within the Human T-Cell Receptor δ Gene Enhancer

1991 • 75 citations

Negative and Positive Transcriptional Regulation by Thyroid Hormone Receptor Isoforms

1990 • 74 citations

Purification of Core-Binding Factor, a Protein That Binds the Conserved Core Site in Murine Leukemia Virus Enhancers

1992 • 65 citations

PEBP2αB/Mouse AML1 Consists of Multiple Isoforms That Possess Differential Transactivation Potentials

1994 • 52 citations

Differential Expression of Subspecies of Polyomavirus and Murine Leukemia Virus Enhancer Core Binding Protein, PEBP2, in Various Hematopoietic Cells

1992 • 46 citations

A ubiquitous repressor interacting with an F9 cell-specific silencer and its functional suppression by differentiated cell-specific positive factors.

1990 • 44 citations

Transcriptional regulation of two myeloid-specific genes, myeloperoxidase and lactoferrin, during differentiation of the murine cell line 32D C13

1991 • 41 citations

Molecular cloning of bovine actin-like protein, actin2

1992 • 32 citations

Alteration of growth and differentiation factors response by Kirsten and Harvey sarcoma viruses in the IL-3-dependent murine hematopoietic cell line 32D C13(G).

1989 • 29 citations

The Murine Myeloperoxidase Promoter Contains Several Functional Elements, One of Which Binds a Cell Type-Restricted Transcription Factor, Myeloid Nuclear Factor 1 (MyNF1)

1993 • 27 citations

Indistinguishable Nuclear Factor Binding to Functional Core Sites of the T-Cell Receptor δ and Murine Leukemia Virus Enhancers

1992 • 24 citations