A theoretical approach towards the identification of cleavage-determining amino acid motifs of the 20s proteasome 1 1Edited by R. Huber

On the size of the active site in proteases. I. Papain

1967 • 5,150 citations

Structure of 20S proteasome from yeast at 2.4Å resolution

1997 • 2,211 citations

Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution

1995 • 1,513 citations

Ubiquitin, proteasomes, and the regulation of intracellular protein degradation

1995 • 862 citations

A protein catalytic framework with an N-terminal nucleophile is capable of self-activation

1995 • 609 citations

Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids

1993 • 323 citations

Identification of the yeast 20S proteasome catalytic centers and subunit interactions required for active-site formation

1997 • 295 citations

PRE2, highly homologous to the human major histocompatibility complex-linked RING10 gene, codes for a yeast proteasome subunit necessary for chrymotryptic activity and degradation of ubiquitinated proteins.

1993 • 260 citations

Selective protein degradation: A journey's end within the proteasome

1995 • 259 citations

Autocatalytic processing of the 20S proteasome

1996 • 226 citations

Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules

1995 • 225 citations

Modeling studies of the change in conformation required for cleavage of limited proteolytic sites

1994 • 204 citations

Molecular Basis for the Binding Promiscuity of an Anti-p24 (HIV-1) Monoclonal Antibody

1997 • 197 citations

A Single Residue Exchange Within a Viral CTL Epitope Alters Proteasome-Mediated Degradation Resulting in Lack of Antigen Presentation

1996 • 181 citations

Existence of a molecular ruler in proteasomes suggested by analysis of degradation products

1994 • 179 citations

Incorporation of major histocompatibility complex – encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products independent of interferon‐γ

1995 • 167 citations

Processing and delivery of peptides presented by MHC class I molecules

1996 • 161 citations

Pituitary multicatalytic proteinase complex. Specificity of components and aspects of proteolytic activity

1989 • 139 citations

The Sequence Alteration Associated with a Mutational Hotspot in p53 Protects Cells From Lysis by Cytotoxic T Lymphocytes Specific for a Flanking Peptide Epitope

1998 • 124 citations

The cleavage preference of the proteasome governs the yield of antigenic peptides.

1995 • 117 citations

The proteolytic fragments generated by vertebrate proteasomes: structural relationships to major histocompatibility complex class I binding peptides.

1996 • 108 citations

Effects of Major‐Histocompatibility‐Complex‐Encoded Subunits on the Peptidase and Proteolytic Activities of Human 20S Proteasomes

1996 • 95 citations

PRE3, highly homologous to the human major histocompatibility complex‐linked LMP2 (RING12) gene, codes for a yeast proteasome subunit necessary for the peptidylglutamyl‐peptide hydrolyzing activity

1994 • 80 citations

The apolar surface area of amino acids and its empirical correlation with hydrophobic free energy

1984 • 77 citations

Double‐cleavage production of the CTL epitope by proteasomes and PA28: role of the flanking region

1997 • 59 citations

Functions of the Proteasome in Antigen Presentation

1995 • 56 citations

Van der Waals volume fragmental constants

1985 • 45 citations

Use of serine‐protease inhibitors as probes for the different proteolytic activities of the rat liver multicatalytic proteinase complex

1992 • 44 citations

Analysis of Cleavage-Site Patterns in Protein Precursor Sequences with a Perceptron-Type Neural Network

1993 • 22 citations