Transporter Associated with Antigen Processing**This article was accepted for publication on 1 October 1996.

A simple method for displaying the hydropathic character of a protein

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ABC Transporters: From Microorganisms to Man

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The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides

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Association of class I major histocompatibility heavy and light chains induced by viral peptides

1989 • 995 citations

Enhanced immunological surveillance in mice heterozygous at the H-2 gene complex

1975 • 751 citations

Herpes simplex virus turns off the TAP to evade host immunity

1995 • 736 citations

Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism.

1985 • 734 citations

TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4−8+ T cells

1992 • 726 citations

Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters

1990 • 717 citations

Roles for Calreticulin and a Novel Glycoprotein, Tapasin, in the Interaction of MHC Class I Molecules with TAP

1996 • 697 citations

Cytotoxic T cells recognize fragments of the influenza nucleoprotein

1985 • 669 citations

A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway

1990 • 644 citations

Identification of human cancers deficient in antigen processing.

1993 • 625 citations

H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D;.

1975 • 623 citations

A viral inhibitor of peptide transporters for antigen presentation

1995 • 599 citations

Predicting the orientation of eukaryotic membrane-spanning proteins.

1989 • 596 citations

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

1987 • 576 citations

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

1992 • 567 citations

Selective and ATP-Dependent Translocation of Peptides by the MHC-Encoded Transporter

1993 • 556 citations

A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes

1994 • 553 citations

Calnexin: a membrane-bound chaperone of the endoplasmic reticulum

1994 • 533 citations

A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.

1988 • 489 citations

Transport Protein Genes in the Murine MHC: Possible Implications for Antigen Processing

1990 • 438 citations

Impaired assembly and transport of HLA-A and -B antigens in a mutant TxB cell hybrid.

1986 • 437 citations

GENERATION, TRANSLOCATION, AND PRESENTATION OF MHC CLASS I-RESTRICTED PEPTIDES

1995 • 428 citations

MHC class II region encoding proteins related to the muKidrug resistance family of transmembrane transporters

1990 • 426 citations

Guilt by association: HLA-B27 and ankylosing spondylitis

1990 • 418 citations

Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter

1991 • 413 citations

Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex

1992 • 407 citations

Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies.

1990 • 386 citations

An investigation of the role of transmembrane domains in Golgi protein retention.

1995 • 384 citations

Presentation of viral antigen controlled by a gene in the major histocompatibility complex

1990 • 381 citations

H-2 compatibility is required for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus.

1975 • 366 citations

TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective

1993 • 365 citations

Participation of the endoplasmic reticulum chaperone calnexin (p88, IP90) in the biogenesis of the cystic fibrosis transmembrane conductance regulator.

1994 • 359 citations

MHC class l/β2-microglobulin complexes associate with TAP transporters before peptide binding

1994 • 356 citations

Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47.

1996 • 350 citations

Homozygous Human TAP Peptide Transporter Mutation in HLA Class I Deficiency

1994 • 348 citations

Selectivity of MHC-encoded peptide transporters from human, mouse and rat

1994 • 339 citations

Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas.

1994 • 333 citations

Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporter

1991 • 329 citations

Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

1992 • 328 citations

Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer

1992 • 322 citations

Cytotoxic T cell recognition of the influenza nucleoprotein and hemagglutinin expressed in transfected mouse L cells

1984 • 318 citations

The carboxy-terminal segment of the yeast α-factor receptor is a regulatory domain

1988 • 317 citations

Participation of a novel 88-kD protein in the biogenesis of murine class I histocompatibility molecules.

1991 • 312 citations

Structural and serological similarity of MHC-linked LMP and proteasome (multicatalytic proteinase) complexes

1991 • 310 citations

Interaction of MHC Class I Molecules with the Transporter Associated with Antigen Processing

1994 • 300 citations

A sequential model for peptide binding and transport by the transporters associated with antigen processing

1994 • 290 citations

Ham-2 corrects the class I antigen-processing defect in RMA-S cells

1992 • 289 citations

Generation of both cross-reactive and virus-specific T-cell populations after immunization with serologically distinct influenza A viruses.

1977 • 285 citations

Predicting the topology of eukaryotic membrane proteins

1993 • 272 citations

Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP.

1996 • 271 citations

Evidence that transporters associated with antigen processing translocate a major histocompatibility complex class I-binding peptide into the endoplasmic reticulum in an ATP-dependent manner.

1993 • 266 citations

Homology of proteasome subunits to a major histocompatibility complex-linked LMP gene

1991 • 256 citations

Membrane Topology of a Cysteine-less Mutant of Human P-glycoprotein

1995 • 252 citations

Retention of Unassembled Components of Integral Membrane Proteins by Calnexin

1994 • 243 citations

Cytotoxic T lymphocytes recognize influenza haemagglutinin that lacks a signal sequence

1986 • 242 citations

Coordinate regulation of the human TAP1 and LMP2 genes from a shared bidirectional promoter.

1995 • 241 citations

Molecular Characterization of Defective Antigen Processing in Human Prostate Cancer

1995 • 240 citations

Topology and functional domains of Sec63p, an endoplasmic reticulum membrane protein required for secretory protein translocation.

1992 • 239 citations

Allelic variants of the human putative peptide transporter involved in antigen processing.

1992 • 235 citations

Cytotoxic T cells kill influenza virus infected cells but do not distinguish between serologically distinct type A viruses

1977 • 229 citations

The Structural Basis of Sequence-Independent Peptide Binding by OppA Protein

1994 • 226 citations

On the nature of peptides involved in T cell alloreactivity.

1991 • 220 citations

Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2

1993 • 217 citations

Genes required for cytotoxicity against virus-infected target cells in K and D regions of H-2 complex

1975 • 217 citations

Endogenously synthesized peptide with an endoplasmic reticulum signal sequence sensitizes antigen processing mutant cells to class I-restricted cell-mediated lysis.

1991 • 215 citations

Beta 2-microglobulin is not required for cell surface expression of the murine class I histocompatibility antigen H-2Db or of a truncated H-2Db.

1986 • 212 citations

Peptide size selection by the major histocompatibility complex-encoded peptide transporter.

1994 • 212 citations

Linkage of Faulty Major Histocompatibility Complex Class I to Autoimmune Diabetes

1991 • 212 citations

Location of MHC-encoded transporters in the endoplasmic reticulum and cis-Golgi

1992 • 208 citations

Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator.

1994 • 207 citations

Expression of influenza A virus internal antigens on the surface of infected P815 cells.

1981 • 206 citations

Functional expression and purification of the ABC transporter complex associated with antigen processing (TAP) in insect cells

1994 • 201 citations

Primary structural requirements for the enzymatic formation of the N-glycosidic bond in glycoproteins. Studies with natural and synthetic peptides.

1979 • 197 citations

A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer

1996 • 196 citations

Major photoaffinity drug labeling sites for iodoaryl azidoprazosin in P-glycoprotein are within, or immediately C-terminal to, transmembrane domains 6 and 12

1993 • 194 citations

Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex.

1992 • 190 citations

Dependence of Peptide Binding by MHC Class I Molecules on Their Interaction with TAP

1995 • 189 citations

Peptide Translocation by Variants of the Transporter Associated with Antigen Processing

1993 • 188 citations

Homozygous deletions that simultaneously eliminate expressions of class I and class II antigens of EBV-transformed B-lymphoblastoid cells. I. Reduced proliferative responses of autologous and allogeneic T cells to mutant cells that have decreased expression of class II antigens

1984 • 187 citations

Loss of antigen-presenting molecules (MHC class I and TAP-1) in lung cancer

1996 • 186 citations

Bovine opsin has more than one signal sequence

1985 • 186 citations

Efficient dissociation of the p88 chaperone from major histocompatibility complex class I molecules requires both beta 2-microglobulin and peptide.

1992 • 184 citations

Human transporters associated with antigen processing possess a promiscuous peptide-binding site

1994 • 178 citations

Net N-C charge imbalance may be important for signal sequence function in bacteria

1986 • 176 citations

Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing.

1996 • 174 citations

Reconstitution of drug-stimulated ATPase activity following co-expression of each half of human P-glycoprotein as separate polypeptides.

1994 • 174 citations

Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region.

1991 • 173 citations

Frequency of down-regulation of individual HLA-A and -B alleles in cervical carcinomas in relation to TAP-1 expression

1995 • 172 citations

Sorting of membrane proteins in the secretory pathway

1993 • 171 citations

Trimming of antigenic peptides in an early secretory compartment.

1994 • 169 citations

Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum.

1995 • 163 citations

Topological ?frustration? in multispanning E. coli inner membrane proteins

1994 • 162 citations

DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing

1992 • 161 citations

Species-specific differences in chaperone interaction of human and mouse major histocompatibility complex class I molecules.

1995 • 157 citations

Cytotoxic T cells to type A influenza virus; viral hemagglutinin induces A‐strain specificity while infected cells confer cross‐reactive cytotoxicity

1977 • 150 citations

Characteristics of peptide and major histocompatibility complex class I/beta 2-microglobulin binding to the transporters associated with antigen processing (TAP1 and TAP2).

1994 • 150 citations

Translocation of long peptides by transporters associated with antigen processing (TAP)

1996 • 149 citations

Modular structural units, exons, and function in chicken lysozyme.

1983 • 147 citations

A family of closely related ATP‐binding subunits from prokaryotic and eukaryotic cells

1988 • 146 citations

A Point Mutation in HLA-A*0201 Results in Failure to Bind the TAP Complex and to Present Virus-Derived Peptides to CTL

1996 • 139 citations

Differences in MHC and TAP-1 expression in cervical cancer lymph node metastases as compared with the primary tumours

1994 • 138 citations

Loss of transporter in antigen processing 1 transport protein and major histocompatibility complex class I molecules in metastatic versus primary breast cancer.

1995 • 137 citations

Novel allele-specific, post-translational reduction in HLA class I surface expression in a mutant human B cell line.

1994 • 136 citations

Cytoplasmic Orientation and Two-domain Structure of the Multidrug Transporter, P-glycoprotein, Demonstrated with Sequence-specific Antibodies

1989 • 135 citations

RMA/S cells present endogenously synthesized cytosolic proteins to class I-restricted cytotoxic T lymphocytes.

1992 • 132 citations

Study of membrane orientation and glycosylated extracellular loops of mouse P-glycoprotein by in vitro translation.

1991 • 132 citations

Point mutations in the α2 domain of HLA-A2.1 define a functionally relevant interaction with TAP

1996 • 130 citations

Genes encoded in the major histocompatibility complex affecting the generation of peptides for TAP transport

1995 • 129 citations

P-glycoprotein

1995 • 125 citations

Immunologic recognition of influenza virus-infected cells. II. Expression of influenza A matrix protein on the infected cell surface and its role in recognition by cross-reactive cytotoxic T cells

1977 • 118 citations

The Rat cim Effect: TAP Allele-Dependent Changes in a Class I MHC Anchor Motif and Evidence Against C-Terminal Trimming of Peptides in the ER

1996 • 117 citations

TAP associates with a unique class I conformation, whereas calnexin associates with multiple class I forms in mouse and man.

1995 • 116 citations

Molecular analysis of H-2-deficient lymphoma lines. Distinct defects in biosynthesis and association of MHC class I heavy chains and beta 2-microglobulin observed in cells with increased sensitivity to NK cell lysis.

1989 • 115 citations

Cytokines increase transporter in antigen processing-1 expression more rapidly than HLA class I expression in endothelial cells.

1992 • 115 citations

Major histocompatibility complex (MHC)-encoded HAM2 is necessary for antigenic peptide loading onto class I MHC molecules.

1992 • 111 citations

Requirements for Peptide Binding to the Human Transporter Associated with Antigen Processing Revealed by Peptide Scans and Complex Peptide Libraries

1995 • 110 citations

MHC class I molecules form ternary complexes with calnexin and TAP and undergo peptide-regulated interaction with TAP via their extracellular domains.

1996 • 102 citations

Analysis of the fine specificity of rat, mouse and human TAP peptide transporters

1995 • 102 citations

Loss of major histocompatibility complex-encoded transporter associated with antigen presentation (TAP) in colorectal cancer.

1994 • 100 citations

Functional Evidence That Transmembrane 12 and the Loop between Transmembrane 11 and 12 Form Part of the Drug-binding Domain in P-glycoprotein Encoded by MDR1

1995 • 100 citations

Substrate specificity of allelic variants of the TAP peptide transporter

1994 • 95 citations

TAP polymorphism does not influence transport of peptide variants in mice and humans

1995 • 94 citations

A trans-acting major histocompatibility complex-linked gene whose alleles determine gain and loss changes in the antigenic structure of a classical class I molecule.

1989 • 94 citations

ATP is required for in vitro assembly of MHC class I antigens but not to transfer of peptides acrosss the ER membrane

1991 • 92 citations

Early presence of ribonucleoprotein antigen on surface of influenza virus-infected cells

1977 • 91 citations

Comparison of cell lines deficient in antigen presentation reveals a functional role for TAP-1 alone in antigen processing.

1994 • 89 citations

The KKXX signal mediates retrieval of membrane proteins from the Golgi to the ER in yeast.

1994 • 89 citations

Assembly, Intracellular Localization, and Nucleotide Binding Properties of the Human Peptide Transporters TAP1 and TAP2 Expressed by Recombinant Vaccinia Viruses

1995 • 88 citations

A point mutation in the human transporter associated with antigen processing (TAP2) alters the peptide transport specificity

1996 • 78 citations

Residues in TAP2 peptide transporters controlling substrate specificity.

1996 • 77 citations

Evolutionary Dynamics of Non-coding Sequences Within the Class II Region of the Human MHC

1996 • 77 citations

Protection from insulin‐dependent diabetes mellitus is linked to a peptide transporter gene

1993 • 76 citations

Identification of a contact region for peptide on the TAP1 chain of the transporter associated with antigen processing.

1996 • 75 citations

Antibody to influenza virus matrix protein detects a common antigen on the surface of cells infected with type A influenza viruses.

1977 • 75 citations

Colinearity of novel genes in the class II regions of the MHC in mouse and human

1991 • 74 citations

Influenza A specific cytotoxic T-cell clones that do not recognize viral glycoproteins

1982 • 74 citations

Peptide selection by class I molecules of the major histocompatibility complex

1993 • 74 citations

Folding and assembly of major histocompatibility complex class I heterodimers in the endoplasmic reticulum of intact cells precedes the binding of peptide.

1993 • 73 citations

Mutations that alter the transmembrane signalling pathway in an ATP binding cassette (ABC) transporter.

1994 • 72 citations

MHC class II deletion mutant expresses normal levels of transgene encoded class II molecules that have abnormal conformation and impaired antigen presentation ability.

1992 • 72 citations

Induction of assembly of MHC class I heavy chains with beta 2microglobulin by interferon-gamma.

1989 • 72 citations

Substrate recognition by oligosaccharyl transferase. Inhibition of co-translational glycosylation by acceptor peptides.

1983 • 71 citations

Nucleotide binding to the hydrophilic C-terminal domain of the transporter associated with antigen processing (TAP).

1994 • 70 citations

Different types of allospecific CTL clones identified by their ability to recognize peptide loading‐defective target cells

1991 • 69 citations

TAP1 alleles in insulin-dependent diabetes mellitus: a newly defined centromeric boundary of disease susceptibility.

1993 • 68 citations

MHC antigens and cancer: implications for T-cell surveillance

1992 • 68 citations

Polymorphism of antigen processing (TAP, LMP) and HLA class II genes in celiac disease

1994 • 68 citations

Tumorigenicity conferred to lymphoma mutant by major histocompatibility complex-encoded transporter gene.

1993 • 65 citations

Characteristics of peptide and class I/b2m binding to the transporters associated with antigen processing (TAP. 1 and TAP. 2)

1994 • 59 citations

PROFILEGRAPH: an interactive graphical tool for protein sequence analysis

1992 • 59 citations

Sorting of peroxisomal membrane protein PMP47 from Candida boidinii into peroxisomal membranes of Saccharomyces cerevisiae

1990 • 57 citations

Analysis of the MHC class II encoded components of the HLA class I antigen processing pathway in ankylosing spondylitis.

1994 • 56 citations

MHC class I surface expression in embryo-derived cell lines inducible with peptide or interferon

1991 • 54 citations

Major Histocompatibility Complex–Encoded Antigen Processing Gene Polymorphism in IDDM

1994 • 52 citations

The distribution of Tap2 alleles among laboratory rat RT1 haplotypes

1994 • 51 citations

Nomenclature for factors of theHLA system, 1991

1992 • 50 citations

The major histocompatibility complex class II-linked cim locus controls the kinetics of intracellular transport of a classical class I molecule.

1991 • 50 citations

Susceptibility to reiter's syndrome is associated with alleles of tap genes

1995 • 47 citations

P-glycoprotein and cell volume-activated chloride channels

1995 • 47 citations

Structural requirements for the peptide‐induced conformational change of free major histocompatibility complex class I heavy chains

1992 • 45 citations

Immune response genes controlling responsiveness to major transplantation antigens. Specific major histocompatibility complex-linked defect for antibody responses to class I alloantigens.

1982 • 45 citations

Evolution of the ATP-binding-cassette transmembrane transporters of vertebrates.

1994 • 45 citations

Resistance to natural killer cell lysis conferred by TAP1/2 genes in human antigen-processing mutant cells.

1994 • 45 citations

Antigen processing gene polymorphisms in HLA‐DR2 multiple sclerosis

1993 • 45 citations

TAP2‐defective RMA‐S cells present Sendai virus antigen to cytotoxic T lymphocytes

1993 • 44 citations

In vivo topological analysis of Ste2, a yeast plasma membrane protein, by using beta-lactamase gene fusions.

1991 • 44 citations

Cim: an MHC class II-linked allelism affecting the antigenicity of a classical class I molecule for T lymphocytes

1991 • 42 citations

Lack of primary association between transporter associated with antigen processing genes and atopic dermatitis

1995 • 37 citations

Characterization of the hemolysin transporter, HlyB, using an epitope insertion.

1992 • 34 citations

Insulin‐dependent diabetes mellitus and the major histocompatibility complex peptide transporters TAP1 and TAP2: no association in a population with a high disease incidence

1994 • 34 citations

Polymorphisms of transporter associated with antigen processing genes in atopic dermatitis

1994 • 32 citations

Polymorphism of human major histocompatibility complex-encoded transporter associated with antigen processing (TAP) genes and susceptibility to juvenile rheumatoid arthritis

1994 • 32 citations

Evidence for peptide transport across microsomal membranes.

1992 • 31 citations

TAP2 Association with Insulin-Dependent Diabetes Mellitus Is Secondary to HLA-DQB1

1995 • 30 citations

TAP polymorphism in patients with Behcet's disease.

1995 • 28 citations

Expression of TAP1 by human trophoblast

1995 • 28 citations

Analysis of H LA-class-li-encoded antigen-processing genes TAP1 and TAP2 in primary biliary cirrhosis

1994 • 27 citations

Abnormal class I assembly and peptide presentation in the nonobese diabetic mouse.

1994 • 27 citations

New allelic polymorphisms in TAP genes

1994 • 25 citations

Expression of HLA class II-associated peptide transporter and proteasome genes in human placentas and trophoblast cell lines.

1994 • 22 citations

Absence of association of TAP and LMP genes with type 1 (insulin-dependent) diabetes mellitus

1994 • 22 citations

Characteristics of ATP-dependent peptide transport in isolated microsomes.

1995 • 21 citations

Exons and the evolution of proteins

1983 • 20 citations

EFFECTS OF MHC-ENCODED TAP1 AND TAP2 GENE POLYMORPHISM AND MATCHING ON KIDNEY GRAFT REJECTION

1995 • 19 citations

A defect in the presentation of intracellular viral antigens is restored by interferon‐γ in cell lines with impaired major histocompatibility complex class I assembly

1992 • 19 citations

PEPTIDE TRANSPORTER GENES (TAP) POLYMORPHISMS AND GENETIC SUSCEPTIBILITY TO RHEUMATOID ARTHRITIS

1995 • 18 citations

Analysis of TAP2 and HLA-DP gene polymorphism in Psoriasis

1994 • 17 citations

The Measurement of Haemagglutinin and Matrix Protein Present on the Surface of Influenza Virus Infected P815 Mastocytoma Cells

1979 • 17 citations

Enhanced expression of HLA-A,B,C and inducibility of TAP-1, TAP-2, and HLA-A,B,C by interferon-gamma in a multidrug-resistant small cell lung cancer line.

1994 • 16 citations

Expression of the transporter for antigen processing-1 (Tap-1) gene in subpopulations of human trophoblast cells

1996 • 15 citations

The relationship of TAP1 and TAP2 dimorphisms to multiple sclerosis susceptibility

1995 • 13 citations

HLA DQA1-DQB1-TAP2 haplotypes in IDDM families: no evidence for an additional contribution to disease risk by the TAP2 locus

1995 • 13 citations

HLA and TAP associations in Chinese systemic lupus erythematosus patients

1995 • 13 citations

Expression of Intra-MHC Transporter ( Ham ) Genes and Class I Antigens in Diabetes-Susceptible NOD Mice

1992 • 11 citations

Lack of association of the transporter associated with antigen processing with Japanese insulin-dependent diabetes mellitus

1994 • 11 citations

Characterization of defectiveness in endogenous antigen presentation of novel murine cells established from methylcholanthrene-induced fibrosarcomas.

1995 • 10 citations

Recombinant expression of vaccinia virus‐encoded TAP1 and TAP2 promotes MHC class I‐restricted antigen presentation in a Syrian hamster cell line

1995 • 9 citations

The first hydrophobic segment of the ABC‐transporter, Ste6, functions as a signal sequence

1994 • 9 citations

Nomenclature for factors of the HLA system, 1991

1992 • 8 citations

Levels of Tap-1 and Tap-2 mRNA and Expression of Kd and Db on Splenic Lymphocytes Are Normal in NOD Mice

1995 • 8 citations

[Polymorphism of the TAP genes Japanese healthy control and type I diabetes mellitus].

1994 • 1 citations