Recognition of Misfolding Proteins by PA700, the Regulatory Subcomplex of the 26 S Proteasome

Molecular chaperones in cellular protein folding

1996 • 3,540 citations

The Hsp70 and Hsp60 Chaperone Machines

1998 • 2,793 citations

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

Structure of 20S proteasome from yeast at 2.4Å resolution

1997 • 2,211 citations

Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

1990 • 1,756 citations

The Proteasome: Paradigm of a Self-Compartmentalizing Protease

1998 • 1,483 citations

Degradation of CFTR by the ubiquitin-proteasome pathway

1995 • 1,285 citations

Chaperone-Mediated Protein Folding

1999 • 1,043 citations

Identification of a protein required for disulfide bond formation in vivo

1991 • 967 citations

Thioredoxin catalyzes the reduction of insulin disulfides by dithiothreitol and dihydrolipoamide.

1979 • 907 citations

A Subcomplex of the Proteasome Regulatory Particle Required for Ubiquitin-Conjugate Degradation and Related to the COP9-Signalosome and eIF3

1998 • 901 citations

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

1995 • 885 citations

A 26 S protease subunit that binds ubiquitin conjugates.

1994 • 759 citations

Protein quality control: triage by chaperones and proteases.

1997 • 543 citations

The Proteasome, a Novel Protease Regulated by Multiple Mechanisms

1999 • 540 citations

The ATP hydrolysis-dependent reaction cycle of the Escherichia coli Hsp70 system DnaK, DnaJ, and GrpE.

1994 • 520 citations

The Regulatory Particle of the Saccharomyces cerevisiae Proteasome

1998 • 487 citations

The base of the proteasome regulatory particle exhibits chaperone-like activity

1999 • 485 citations

Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome

1997 • 451 citations

Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain).

1992 • 439 citations

Hip, a novel cochaperone involved in the eukaryotic hsc70/hsp40 reaction cycle

1995 • 436 citations

Global unfolding of a substrate protein by the Hsp100 chaperone ClpA

1999 • 427 citations

THE PROTEASOME

1999 • 418 citations

The Multiubiquitin-Chain-Binding Protein Mcb1 Is a Component of the 26S Proteasome in Saccharomyces cerevisiae and Plays a Nonessential, Substrate-Specific Role in Protein Turnover

1996 • 393 citations

ATP-induced protein Hsp70 complex dissociation requires K+ but not ATP hydrolysis

1993 • 366 citations

Participation of the endoplasmic reticulum chaperone calnexin (p88, IP90) in the biogenesis of the cystic fibrosis transmembrane conductance regulator.

1994 • 359 citations

A molecular chaperone, ClpA, functions like DnaK and DnaJ.

1994 • 358 citations

The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment.

1993 • 335 citations

Interaction of hsp70 with unfolded proteins: effects of temperature and nucleotides on the kinetics of binding.

1991 • 332 citations

Proteasomes: protein degradation machines of the cell

1994 • 320 citations

Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome

1998 • 306 citations

Ubiquitin-dependent Degradation of Certain Protein Substrates in Vitro Requires the Molecular Chaperone Hsc70

1997 • 294 citations

Disassembly of the Mu transposase tetramer by the ClpX chaperone.

1995 • 276 citations

The Escherichia coli DnaK chaperone, the 70-kDa heat shock protein eukaryotic equivalent, changes conformation upon ATP hydrolysis, thus triggering its dissociation from a bound target protein

1991 • 245 citations

Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence

1998 • 244 citations

Nucleotide-induced Conformational Changes in the ATPase and Substrate Binding Domains of the DnaK Chaperone Provide Evidence for Interdomain Communication

1995 • 241 citations

Identification, purification, and characterization of a high molecular weight, ATP-dependent activator (PA700) of the 20 S proteasome.

1994 • 238 citations

Multiple forms of the 20 S multicatalytic and the 26 S ubiquitin/ATP-dependent proteases from rabbit reticulocyte lysate.

1992 • 229 citations

[27] Analysis of chaperone function using citrate synthase as nonnative substrate protein

1998 • 223 citations

The 19S Regulatory Complex of the Proteasome Functions Independently of Proteolysis in Nucleotide Excision Repair

1999 • 203 citations

Conformational constraints in protein degradation by the 20S proteasome

1995 • 202 citations

PA700, an ATP-dependent activator of the 20 S proteasome, is an ATPase containing multiple members of a nucleotide-binding protein family.

1994 • 200 citations

Protein Translocation Channels in the Proteasome and Other Proteases

1997 • 167 citations

Alteration of the Cystic Fibrosis Transmembrane Conductance Regulator Folding Pathway

1996 • 165 citations

The Purification of Citrate-condensing Enzyme

1961 • 157 citations

Identification, Purification, and Characterization of a PA700-dependent Activator of the Proteasome

1996 • 138 citations

The Molecular Chaperone Hsc70 Assists the in VitroFolding of the N-terminal Nucleotide-binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator

1997 • 121 citations

The high molecular weight multicatalytic proteinase, macropain, exists in a latent form in human erythrocytes

1989 • 115 citations

Renaturation of citrate synthase: Influence of denaturant and folding assistants

1992 • 103 citations

Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1.

1997 • 92 citations

Molecular chaperones in protein folding and translocation

1996 • 83 citations

Structural and functional effects of PA700 and modulator protein on proteasomes 1 1Edited by W. Baumeister

1997 • 69 citations

Cystic fibrosis: a disease of altered protein folding.

1997 • 62 citations

Nucleotidase Activities of the 26 S Proteasome and Its Regulatory Complex

1996 • 57 citations

Concurrent Chaperone and Protease Activities of ClpAP and the Requirement for the N-terminal ClpA ATP Binding Site for Chaperone Activity

1999 • 54 citations

Effects of the ?F508 mutation on the structure, function, and folding of the first nucleotide-binding domain of CFTR

1993 • 37 citations

Chapter 23 Assaying Proteins for Molecular Chaperone Activity

1995 • 33 citations