Peripheral tolerance in T cell receptor‐transgenic mice: Evidence for T cell anergy

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Negative selection of lymphocytes

1994 • 810 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

Separation of IL-4 Production from Th Cell Proliferation by an Altered T Cell Receptor Ligand

1991 • 565 citations

High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

1994 • 544 citations

T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

1994 • 530 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells

1988 • 343 citations

Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid.

1983 • 293 citations

Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S).

1989 • 289 citations

Peripheral T-cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Fel d I.

1993 • 280 citations

Tolerance of class I histocompatibility antigens expressed extrathymically

1989 • 251 citations

Autoimmune diabetes as a consequence of locally produced interleukin-2

1992 • 242 citations

Response of naive antigen-specific CD4+ T cells in vitro: characteristics and antigen-presenting cell requirements.

1992 • 239 citations

Levels of Peripheral T Cell Tolerance Induced by Different Doses of Tolerogen

1994 • 229 citations

Peptide therapy for diabetes in NOD mice

1994 • 205 citations

Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen.

1993 • 184 citations

On the cellular basis of immunological T cell memory

1995 • 159 citations

Expression of two alpha chains on the surface of T cells in T cell receptor transgenic mice.

1993 • 136 citations

"Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype.

1994 • 134 citations

Requirement for CD8⁺Cells in T Cell Receptor Peptide-Induced Clonal Unresponsiveness

1993 • 122 citations

T cells with two functional antigen-specific receptors.

1995 • 119 citations

Anti-CD3 antibody induces unresponsiveness to IL-2 in Th1 clones but not in Th2 clones.

1990 • 109 citations

Failure of clonal deletion in neonatally thymectomized mice: tolerance is preserved through clonal anergy.

1990 • 102 citations

Peripheral tolerance to allogeneic class II histocompatibility antigens expressed in transgenic mice: evidence against a clonal-deletion mechanism.

1989 • 91 citations

Peripheral deletion of mature CD8+ antigen-specific T cells after in vivo exposure to male antigen.

1992 • 84 citations

Induction and reversal of long-lived specific unresponsiveness to a T-dependent antigen following CTLA4Ig treatment.

1995 • 70 citations

T cell deletion follows chronic antigen specific T cell activation in vivo

1993 • 68 citations

Pertussis toxin prevents the induction of peripheral T cell anergy and enhances the T cell response to an encephalitogenic peptide of myelin basic protein.

1991 • 65 citations

Clonal anergy blocks the response to IL-4, as well as the production of IL-2, in dual-producing T helper cell clones.

1991 • 64 citations

T-cell tolerance and autoimmunity in transgenic models of central and peripheral tolerance

1994 • 64 citations

A simple screening method for transgenic mice using the polymerase chain reaction.

1990 • 58 citations

Long life span of tolerant T cells and the role of antigen in maintenance of peripheral tolerance

1995 • 54 citations

Specific T-cell tolerance may reflect selective activation of lymphokine synthesis.

1995 • 29 citations

High‐Dose Soluble Antigen: Peripheral T‐Cell Proliferation or Apoptosis

1994 • 28 citations

Induction of T cell tolerance by pretreatment with anti-ICAM-1 and anti-lymphocyte function-associated antigen-1 antibodies prevents antigen-induced eosinophil recruitment into the mouse airways.

1994 • 27 citations

In vivo tolerance induction and associated cytokine production by subsets of murine CD4+ T cells.

1995 • 19 citations

T cell unresponsiveness correlates with quantitative TCR levels in a transgenic model

1993 • 17 citations

Role of the thymus in natural tolerance to an autologous protein antigen.

1989 • 12 citations