Molecular Mimicry and Autoimmunity

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

A Clinical Trial of Immunosuppressive Therapy for Myocarditis

1995 • 1,222 citations

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1992 • 1,200 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Dominance and Crypticity of T Cell Antigenic Determinants

1993 • 838 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

T Cell-Dependent B Cell Activation

1993 • 727 citations

Vaccination against Lyme Disease with RecombinantBorrelia burgdorferiOuter-Surface Lipoprotein A with Adjuvant

1998 • 715 citations

Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry

1998 • 669 citations

Autoantibodies to GABA-ergic Neurons and Pancreatic Beta Cells in Stiff-Man Syndrome

1990 • 618 citations

Theiler's virus infection in mice: an unusual biphasic disease process leading to demyelination

1975 • 615 citations

Identification of LFA-1 as a Candidate Autoantigen in Treatment-Resistant Lyme Arthritis

1998 • 514 citations

Molecular Mimicry by Herpes Simplex Virus-Type 1: Autoimmune Disease After Viral Infection

1998 • 505 citations

Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus.

1992 • 494 citations

Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes.

1994 • 452 citations

Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires.

1996 • 451 citations

Chlamydia Infections and Heart Disease Linked Through Antigenic Mimicry

1999 • 419 citations

Molecular Mimicry: Antigen Sharing by Parasite and Host and Its Consequences

1964 • 415 citations

A Vaccine Consisting of RecombinantBorrelia burgdorferiOuter-Surface Protein A to Prevent Lyme Disease

1998 • 382 citations

Essential flexibility in the T-cell recognition of antigen

1996 • 330 citations

Identification of High Potency Microbial and Self Ligands for a Human Autoreactive Class II–restricted T Cell Clone

1997 • 320 citations

Autoantibodies to HLA B27 in the sera of HLA B27 patients with ankylosing spondylitis and Reiter's syndrome. Molecular mimicry with Klebsiella pneumoniae as potential mechanism of autoimmune disease.

1987 • 317 citations

AN IMMUNOLOGICAL RELATIONSHIP BETWEEN THE GROUP A STREPTOCOCCUS AND MAMMALIAN MUSCLE

1966 • 275 citations

Viral infections trigger multiple sclerosis relapses: a prospective seroepidemiological study

1993 • 264 citations

Immunity causing blindness: five different paths to herpes stromal keratitis

1997 • 235 citations

Epitopes of streptococcal M proteins shared with cardiac myosin.

1985 • 222 citations

Positive selection in autoimmunity: Abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis

1995 • 180 citations

Coexpression of B7-1 and viral (“self”) transgenes in pancreatic β cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes

1995 • 177 citations

Lack of Immune Responsiveness to Bovine Serum Albumin in Insulin-Dependent Diabetes

1993 • 163 citations

T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele.

1994 • 162 citations

Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology.

1998 • 156 citations

T lymphocyte clones illuminate pathogenesis and affect therapy of experimental arthritis

1985 • 155 citations

Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients.

1997 • 148 citations

Viral Infection of Transgenic Mice Expressing a Viral Protein in Oligodendrocytes Leads to Chronic Central Nervous System Autoimmune Disease

1996 • 140 citations

Cutting Edge: Predictable TCR Antigen Recognition Based on Peptide Scans Leads to the Identification of Agonist Ligands with No Sequence Homology

1998 • 118 citations

Streptococcal M protein peptide with similarity to myosin induces CD4+ T cell-dependent myocarditis in MRL/++ mice and induces partial tolerance against coxsakieviral myocarditis.

1996 • 102 citations

A hypothesis for the HLA-B27 immune dysregulation in spondyloarthropathy: contributions from enteric organisms, B27 structure, peptides bound by B27, and convergent evolution.

1993 • 93 citations

Mechanisms of autoimmune disease induction

1995 • 91 citations

Thymocyte selection: not by TCR alone

1998 • 88 citations

IMMUNOLOGIC STUDIES OF HEART TISSUE

1961 • 80 citations

Sequence homology of the diabetes-associated autoantigen glutamate decarboxylase with coxsackie B4-2C protein and heat shock protein 60 mediates no molecular mimicry of autoantibodies.

1994 • 75 citations

Reactive arthritis after Salmonella among medical doctors--study of an outbreak.

1993 • 74 citations

Molecular Analysis of Polyreactive Monoclonal Antibodies from Rheumatic Carditis: Human Anti-N-Acetylglucosamine/Anti-Myosin Antibody V Region Genes

1998 • 68 citations

Molecular mimicry reflected through database screening: serendipity or survival strategy?

1996 • 53 citations

T cell selection and autoimmunity: flexibility and tuning

1996 • 52 citations

Activation of autoreactive T cells by peptides from human pathogens

1997 • 50 citations

Poststreptococcal reactive arthritis in children: a potential predecessor of rheumatic heart disease.

1995 • 48 citations

Immunization of mice with Yersinia enterocolitica leads to the induction of antithyrotropin receptor antibodies.

1993 • 41 citations

Purification and characterization of Yersinia enterocolitica envelope proteins which induce antibodies that react with human thyrotropin receptor.

1994 • 37 citations

The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells

1998 • 31 citations

Studies of humoral and cell-mediated immunity to peptides shared by HLA-27.1 and Klebsiella pneumoniae nitrogenase in ankylosing spondylitis.

1989 • 31 citations

Naturally Occurring Low Affinity Peptide/MHC Class I Ligands Can Mediate Negative Selection and T Cell Activation

1998 • 13 citations

A monoclonal anti-HLA-B27 antibody which is reactive with a linear sequence of the HLA-B27 protein is useful for the study of molecular mimicry.

1989 • 12 citations

Tolerance to the HLA-B27 and Klebsiella pneumoniae crossreactive epitope in mice transgenic for HLA-B2705 and human beta 2-microglobulin.

1994 • 7 citations