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Blockade of T Lymphocyte Costimulation with Cytotoxic T Lymphocyte–Associated Antigen 4–Immunoglobulin (Ctla4ig) Reverses the Cellular Pathology of Psoriatic Plaques, Including the Activation of Keratinocytes, Dendritic Cells, and Endothelial Cells

Data up to Jan 2025

Published2000
Citations322
References66

Total Citations Per Year

Abstract

References (66)

Dendritic cells and the control of immunity

1998 • 14,345 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

1986 • 2,490 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Endothelial Leukocyte Adhesion Molecule 1: an Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins

1989 • 2,045 citations

Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation

1999 • 1,912 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

Activation of human dendritic cells through CD40 cross-linking.

1994 • 1,351 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

ELAM-1 is an adhesion molecule for skin-homing T cells

1991 • 843 citations

Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily.

1995 • 756 citations

P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues

1997 • 735 citations

Migration and maturation of Langerhans cells in skin transplants and explants.

1990 • 663 citations

Recognition of an endothelial determinant for CD 18-dependent human neutrophil adherence and transendothelial migration.

1988 • 626 citations

CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris

1999 • 607 citations

The Role of T-Cell Costimulatory Activation Pathways in Transplant Rejection

1998 • 585 citations

The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies.

1990 • 561 citations

Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1.

1995 • 472 citations

Dermal injection of immunocytes induces psoriasis.

1996 • 441 citations

Cyclosporine for Plaque-Type Psoriasis

1991 • 427 citations

A Novel Lysosome-Associated Membrane Glycoprotein, DC-LAMP, Induced upon DC Maturation, Is Transiently Expressed in MHC Class II Compartment

1998 • 402 citations

Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells.

1994 • 379 citations

Cultured Human Langerhans Cells Resemble Lymphoid Dendritic Cells in Phenotype and Function

1989 • 376 citations

Characterization of factor XIIIa positive dermal dendritic cells in normal and inflamed skin

1989 • 351 citations

B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells.

1994 • 347 citations

Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells

1988 • 343 citations

Dendritic Cells Are Recruited into the Airway Epithelium during the Inflammatory Response to a Broad Spectrum of Stimuli

1996 • 331 citations

Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokines.

1994 • 299 citations

The pathogenesis of psoriasis: immunological facts and speculations

1999 • 286 citations

Interleukin 4 or oncostatin M induces a prolonged increase in P-selectin mRNA and protein in human endothelial cells.

1996 • 248 citations

CD8+ T cells in psoriatic lesions preferentially use T-cell receptor V beta 3 and/or V beta 13.1 genes.

1994 • 233 citations

A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels

1998 • 232 citations

HLA-DR expression on keratinocytes is a common feature of diseased skin

1986 • 199 citations

Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice.

1994 • 188 citations

The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen

1994 • 181 citations

Interaction of Dendritic Cells with Skin Endothelium: A New Perspective on Immunosurveillance

1999 • 178 citations

PUVA bath therapy strongly suppresses immunological and epidermal activation in psoriasis: a possible cellular basis for remittive therapy.

1994 • 177 citations

A Skin Homing Molecule Defines the Langerhans Cell Progenitor in Human Peripheral Blood

1997 • 173 citations

α6 Integrins Are Required for Langerhans Cell Migration from the Epidermis

1997 • 170 citations

Epidermal Keratiocytes Express the Adhesion Molecule Intercellular Adhesion Molecule-1 in Inflammatory Dermatoses.

1989 • 170 citations

Expression and function of B7 on human epidermal Langerhans cells.

1993 • 166 citations

Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness.

1994 • 163 citations

Expression of a tumor necrosis factor alpha transgene in murine pancreatic beta cells results in severe and permanent insulitis without evolution towards diabetes.

1992 • 151 citations

Major histocompatibility complex class II-expressing endothelial cells induce allospecific nonresponsiveness in naive T cells.

1996 • 127 citations

Maturation and Migration of Cutaneous Dendritic Cells

1995 • 114 citations

Human Cutaneous Dendritic Cells Migrate Through Dermal Lymphatic Vessels in a Skin Organ Culture Model

1996 • 114 citations

CD40 is functionally expressed on human keratinocytes

1996 • 111 citations

UM4D4+ (CDw60) T Cells Are Compartmentalized into Psoriatic Skin and Release Lymphokines That Induce a Keratinocyte Phenotype Expressed in Psoriatic Lesions

1990 • 95 citations

Both Dendritic Cells and Memory T Lymphocytes Emigrate From Organ Cultures of Human Skin and Form Distinctive Dendritic-T-Cell Conjugates

1995 • 95 citations

Maturation and Migration of Cutaneous Dendritic Cells.

1995 • 93 citations

Kaposi's sarcoma cells express the macrophage-associated antigen mannose receptor and develop in peripheral blood cultures of Kaposi's sarcoma patients.

1997 • 91 citations

The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen

1994 • 83 citations

Epidermal keratinocytes express the adhesion molecule intercellular adhesion molecule-1 in inflammatory dermatoses

1989 • 75 citations

The development of manifest psoriatic lesions is linked with the invasion of CD8+ T cells and CD11c+ macrophages into the epidermis

1992 • 73 citations

T-cell receptor V beta expression in normal human skin.

1993 • 73 citations

Expression of the Co-stimulator Molecule B7–1 in Pancreatic β-Cells Accelerates Diabetes in the NOD Mouse

1995 • 67 citations

Human epidermal keratinocytes are induced to secrete interleukin‐6 and co‐stimulate T lymphocyte proliferation by a CD40‐dependent mechanism

1996 • 65 citations

Systemic tacrolimus (FK506) is effective for the treatment of psoriasis in a double-blind, placebo-controlled study

1995 • 62 citations

Effects of contact allergens on human Langerhans cells in skin organ culture: migration, modulation of cell surface molecules, and early expression of interleukin-1 beta protein.

1996 • 60 citations

CD8+ T‐Cells in Psoriatic Lesions Preferentially Use T‐Cell Receptors Vβ3 and/or Vβ13.1 Genes

1995 • 56 citations

T lymphocytes in skin lesions of psoriasis and mycosis fungoides express B7-1: a ligand for CD28

1994 • 55 citations

T-Lymphocyte—Activating Properties of Epidermal Antigen-Presenting Cells from Normal and Psoriatic Skin: Evidence that Psoriatic Epidermal Antigen-Presenting Cells Resemble Cultured Normal Langerhans Cells

1991 • 52 citations

The BB1 Monoclonal Antibody Recognizes Both Cell Surface CD74 (MHC Class II-Associated Invariant Chain) as Well as B7-1 (CD80), Resolving the Question Regarding a Third CD28/CTLA-4 Counterreceptor

1998 • 45 citations

Functional CD86 (B7-2/B70) on Cultured Human Langerhans Cells

1996 • 41 citations

Systemic tacrolimus (FK 506) is effective for the treatment of psoriasis in a double-blind, placebo-controlled study. The European FK 506 Multicentre Psoriasis Study Group

1996 • 37 citations

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Blockade of T Lymphocyte Costimulation with Cytotoxic T Lymphocyte–Associated Antigen… (2000) – The Journal of Experimental Medicine | Metascience Observatory Explorer