Treatment of Murine Lupus with CTLA4Ig

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

A new member of the immunoglobulin superfamily—CTLA-4

1987 • 1,214 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation

1993 • 911 citations

B70 antigen is a second ligand for CTLA-4 and CD28

1993 • 907 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

The Role of the T3/Antigen Receptor Complex in T-Cell Activation

1986 • 627 citations

T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.

1992 • 558 citations

Identification of an Alternative CTLA-4 Ligand Costimulatory for T Cell Activation

1993 • 517 citations

Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1.

1993 • 494 citations

Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4.

1985 • 466 citations

B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2.

1991 • 445 citations

CD28 ligation in T-cell activation: evidence for two signal transduction pathways

1990 • 173 citations

Monoclonal antibody to L3T4 blocks the function of T cells specific for class 2 major histocompatibility complex antigens.

1984 • 140 citations

B cell function in mice transgenic for mCTLA4-H gamma 1: lack of germinal centers correlated with poor affinity maturation and class switching despite normal priming of CD4+ T cells.

1994 • 136 citations

Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4+ T cells and defective antibody production in vivo.

1994 • 132 citations

The CD28 ligand, B7, enhances IL-2 production by providing a costimulatory signal to T cells.

1992 • 125 citations

CTLA4Ig TREATMENT AMELIORATES THE LETHALITY OF MURINE GRAFT-VERSUS-HOST DISEASE ACROSS MAJOR HISTOCOMPATIBILITY COMPLEX BARRIERS

1994 • 123 citations

Treatment of refractory rheumatoid arthritis with a chimeric ANTI‐CD4 monoclonal antibody

1994 • 118 citations

Systemic Lupus Erythematosus

1991 • 113 citations

The antiglobulin response to therapeutic antibodies.

1990 • 58 citations

Chimeric L6 anti-tumor antibody. Genomic construction, expression, and characterization of the antigen binding site.

1992 • 45 citations

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