In Autoimmune Diabetes the Transition from Benign to Pernicious Insulitis Requires an Islet Cell Response to Tumor Necrosis Factor α

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

The Fas Death Factor

1995 • 4,070 citations

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas

1967 • 2,783 citations

ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

1996 • 2,527 citations

Tumor Necrosis Factor (TNF)

1985 • 1,932 citations

Inducible Gene Targeting in Mice

1995 • 1,897 citations

Determination of lymphocyte division by flow cytometry

1994 • 1,712 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1995 • 1,454 citations

Cytokines and endothelial cell biology

1990 • 1,275 citations

Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

1993 • 1,267 citations

Insulin-Dependent Diabetes Mellitus

1996 • 1,171 citations

The Pathogenesis of Insulin-Dependent Diabetes Mellitus

1994 • 1,077 citations

Insulin-Dependent Diabetes Mellitus as an Autoimmune Disease

1994 • 818 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

Following a diabetogenic T cell from genesis through pathogenesis

1993 • 708 citations

Death Receptor 5, a New Member of the TNFR Family, and DR4 Induce FADD-Dependent Apoptosis and Activate the NF-κB Pathway

1997 • 685 citations

Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes.

1988 • 639 citations

Constitutive class I-restricted exogenous presentation of self antigens in vivo.

1996 • 637 citations

Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice

1994 • 607 citations

The Role of Fas in Autoimmune Diabetes

1997 • 503 citations

Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha.

1996 • 467 citations

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.

1988 • 455 citations

HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxin

1987 • 451 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

Acceleration of Diabetes in Young Nod Mice with a CD4 ⁺ Islet-specific T Cell Clone

1990 • 385 citations

Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.

1990 • 356 citations

Markers of mouse macrophage development detected by monoclonal antibodies

1994 • 345 citations

Checkpoints in the progression of autoimmune disease: lessons from diabetes models.

1996 • 340 citations

β cell apoptosis in T cell-mediated autoimmune diabetes

1997 • 330 citations

Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process.

1994 • 300 citations

Chronic Tumor Necrosis Factor Alters T Cell Responses by Attenuating T Cell Receptor Signaling

1997 • 287 citations

Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide.

1992 • 283 citations

Cytokines and Nitric Oxide in Islet Inflammation and Diabetes

1996 • 252 citations

Pancreatic islet-specific T-cell clones from nonobese diabetic mice.

1989 • 246 citations

Genetic Absence of γ-Interferon Delays but Does Not Prevent Diabetes in NOD Mice

1996 • 244 citations

Nitric Oxide Primes Pancreatic β Cells for Fas-mediated Destruction in Insulin-dependent Diabetes Mellitus

1997 • 242 citations

Requirement of Fas for the Development of Autoimmune Diabetes in Nonobese Diabetic Mice

1997 • 238 citations

T Helper 2 (Th2) T Cells Induce Acute Pancreatitis and Diabetes in Immune-compromised Nonobese Diabetic (NOD) Mice

1997 • 223 citations

Interferon-γ Is Essential for Destruction of β Cells and Development of Insulin-dependent Diabetes Mellitus

1997 • 220 citations

Apoptosis Is the Mode of β-Cell Death Responsible for the Development of IDDM in the Nonobese Diabetic (NOD) Mouse

1997 • 203 citations

Interferon-γ impacts at multiple points during the progression of autoimmune diabetes

1997 • 201 citations

Local Expression of TNFα in Neonatal NOD Mice Promotes Diabetes by Enhancing Presentation of Islet Antigens

1998 • 195 citations

Interleukin-1β-Induced Nitric Oxide Production Activates Apoptosis in Pancreatic RINm5F Cells

1994 • 194 citations

T-Lymphocyte Clone Specific for Pancreatic Islet Antigen

1988 • 188 citations

BETA-CELL APOPTOSIS IS RESPONSIBLE FOR THE DEVELOPMENT OF IDDM IN THE MULTIPLE LOW-DOSE STREPTOZOTOCIN MODEL

1996 • 181 citations

Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice.

1989 • 180 citations

Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice.

1993 • 169 citations

Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells.

1996 • 162 citations

Administration of Silica Particles or Anti-Lyt2 Antibody Prevents β-Cell Destruction in NOD Mice Given Cyclophosphamide

1988 • 156 citations

Expression of a tumor necrosis factor alpha transgene in murine pancreatic beta cells results in severe and permanent insulitis without evolution towards diabetes.

1992 • 151 citations

Insulitis in transgenic mice expressing tumor necrosis factor beta (lymphotoxin) in the pancreas.

1992 • 128 citations

Viruses, cytokines, antigens, and autoimmunity.

1996 • 102 citations

Correlation between the Vß4+CD8+ T-cell population and theH-2 d haplotype

1990 • 89 citations

Treatment With Neutralizing Antibodies Specific for IL-1β Prevents Cyclophosphamide-Induced Diabetes in Nonobese Diabetic Mice

1997 • 53 citations

Monoclonal anti-tumor necrosis factor antibody renders non-obese diabetic mice hypersensitive to irradiation and enhances insulitis development

1992 • 42 citations

EFFECT OF LOW-TEMPERATURE CULTURE AND SITE OF TRANSPLANTATION ON HAMSTER ISLET XENOGRAFT SURVIVAL (HAMSTER TO MOUSE)

1987 • 33 citations