Allergen-specific Th1 cells fail to counterbalance Th2 cell–induced airway hyperreactivity but cause severe airway inflammation

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Asthma and Wheezing in the First Six Years of Life

1995 • 3,773 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Lymphokine Production by Human T Cells in Disease States

1994 • 1,351 citations

The Inverse Association Between Tuberculin Responses and Atopic Disorder

1997 • 1,305 citations

Noninvasive Measurement of Airway Responsiveness in Allergic Mice Using Barometric Plethysmography

1997 • 1,294 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation

1988 • 764 citations

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

1996 • 734 citations

Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: Comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness

1991 • 681 citations

Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo

1995 • 672 citations

Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice.

1995 • 626 citations

IL-13, IL-4Rα, and Stat6 Are Required for the Expulsion of the Gastrointestinal Nematode Parasite Nippostrongylus brasiliensis

1998 • 582 citations

Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals.

1993 • 549 citations

Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures.

1995 • 533 citations

Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization.

1996 • 524 citations

Bronchoalveolar Cell Profiles of Asthmatic and Nonasthmatic Subjects

1987 • 480 citations

Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses.

1993 • 479 citations

Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production

1997 • 464 citations

Expression of Interleukin 9 in the Lungs of Transgenic Mice Causes Airway Inflammation, Mast Cell Hyperplasia, and Bronchial Hyperresponsiveness

1998 • 448 citations

Reversibility of T helper 1 and 2 populations is lost after long-term stimulation.

1996 • 437 citations

Reduced interferon-γ secretion in neonates and subsequent atopy

1994 • 434 citations

Myelin Basic Protein–specific T Helper 2 (Th2) Cells Cause Experimental Autoimmune Encephalomyelitis in Immunodeficient Hosts Rather than Protect Them from the Disease

1997 • 433 citations

Changing Patterns of Asthma Hospitalization Among Children: 1979 to 1987

1990 • 398 citations

The Major Histocompatibility Complex-Restricted Antigen Receptor on T Cells

1984 • 368 citations

Selective Expression and Functions of Interleukin 18 Receptor on T Helper (Th) Type 1 but not Th2 Cells

1998 • 356 citations

Late Complications of Immune Deviation Therapy in a Nonhuman Primate

1996 • 319 citations

The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (MHC) class I-restricted CD8+ T cell-mediated but MHC class II-restricted CD4+ T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production.

1993 • 317 citations

Generation of Antigen-Specific Suppressor Cells during Allergy Desensitization

1980 • 307 citations

Immunoprophylaxis of allergen–induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization

1996 • 293 citations

A Novel T Cell-Regulated Mechanism Modulating Allergen-Induced Airways Hyperreactivity in BALB/c Mice Independently of IL-4 and IL-5

1998 • 291 citations

Human atopen-specific types 1 and 2 T helper cell clones.

1991 • 273 citations

T1 and T2 CD4+ cells in human allergic diseases

1997 • 269 citations

Requirement for γδ T Cells in Allergic Airway Inflammation

1998 • 268 citations

Elevated Release of Tumor Necrosis Factor-alpha and Interferon-gamma by Bronchoalveolar Leukocytes from Patients with Bronchial Asthma

1993 • 262 citations

Costimulation through B7-2 (CD86) Is Required for the Induction of a Lung Mucosal T Helper Cell 2 (TH2) Immune Response and Altered Airway Responsiveness

1997 • 251 citations

T Helper 2 (Th2) T Cells Induce Acute Pancreatitis and Diabetes in Immune-compromised Nonobese Diabetic (NOD) Mice

1997 • 223 citations

Development of airway hyperresponsiveness is dependent on interferon-gamma and independent of eosinophil infiltration.

1997 • 191 citations

The major histocompatibility complex-restricted antigen receptor on T cells. IV. An antiidiotypic antibody predicts both antigen and I-specificity.

1983 • 181 citations

An ovalbumin-IL-12 fusion protein is more effective than ovalbumin plus free recombinant IL-12 in inducing a T helper cell type 1-dominated immune response and inhibiting antigen-specific IgE production.

1997 • 178 citations

Allergic airway sensitization induces T cell activation but not airway hyperresponsiveness in B cell-deficient mice

1997 • 133 citations

Heat-KilledListeria monocytogenesas an Adjuvant Converts Established Murine Th2-Dominated Immune Responses into Th1-Dominated Responses

1998 • 125 citations

The effects of nebulized recombinant interferon-γ in asthmatic airways

1995 • 120 citations

Induction of Pulmonary Allergic Responses by Antigen-Specific Th2 Cells

1998 • 91 citations

Regulation of disease susceptibility: Decreased prevalence of IgE-mediated allergic disease in patients with multiple sclerosis

1996 • 89 citations

Antigen-Primed T Cells from B Cell-Deficient JHD Mice Fail to Provide B Cell Help

1998 • 83 citations

Th1 CD4+Cells Adoptively Transfer Experimental Hypersensitivity Pneumonitis

1997 • 75 citations

Regulation of the interaction between Th1 and Th2 T cell clones to provide help for antibody production in vivo

1995 • 56 citations

Pathology of graft vascular disease after heart and heart-lung transplantation and its relationship to obliterative bronchiolitis.

1995 • 33 citations

Pathology of lung transplantation.

1992 • 29 citations