Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease

General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

1985 • 1,650 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

Titins: Giant Proteins in Charge of Muscle Ultrastructure and Elasticity

1995 • 1,195 citations

Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation

1998 • 1,190 citations

A very high level of crossreactivity is an essential feature of the T-cell receptor

1998 • 930 citations

Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.

1992 • 766 citations

Identification of LFA-1 as a Candidate Autoantigen in Treatment-Resistant Lyme Arthritis

1998 • 514 citations

Recommendations for Test Performance and Interpretation From the Second National Conference on Serologic Diagnosis of Lyme Disease

1995 • 458 citations

A new type of transforming growth factor-beta, TGF-beta 3.

1988 • 396 citations

Association of Chronic Lyme Arthritis with HLA-DR4 and HLA-DR2 Alleles

1990 • 359 citations

Direct demonstration of the clonogenic potential of every human peripheral blood T cell. Clonal analysis of HLA-DR expression and cytolytic activity.

1983 • 351 citations

Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries.

1992 • 326 citations

Identification of High Potency Microbial and Self Ligands for a Human Autoreactive Class II–restricted T Cell Clone

1997 • 320 citations

Molecular cloning and analysis of functional envelope genes from human immunodeficiency virus type 1 sequence subtypes A through G. The WHO and NIAID Networks for HIV Isolation and Characterization

1996 • 293 citations

Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis.

1991 • 277 citations

Cloning the interleukin 1 receptor from human T cells.

1989 • 267 citations

T Helper 1 Response Is Dominant and Localized to the Synovial Fluid in Patients with Lyme Arthritis

1998 • 167 citations

Inflammatory brain changes in Lyme borreliosis

1996 • 162 citations

Relationships Among TCR Ligand Potency, Thresholds for Effector Function Elicitation, and the Quality of Early Signaling Events in Human T Cells

1998 • 157 citations

Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology.

1998 • 156 citations

Diversity in fine specificity and T cell receptor usage of the human CD4+ cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106.

1992 • 148 citations

Borrelia burgdorferi P35 and P37 Proteins, Expressed In Vivo, Elicit Protective Immunity

1997 • 146 citations

LYME DISEASE:A Review of Aspects of Its Immunology and Immunopathogenesis

1997 • 145 citations

The Immunoglobulin (IgG) Antibody Response to OspA and OspB Correlates with Severe and Prolonged Lyme Arthritis and the IgG Response to P35 Correlates with Mild and Brief Arthritis

1999 • 138 citations

Probing degeneracy in T-cell recognition using peptide combinatorial libraries

1998 • 137 citations

The T helper cell response in Lyme arthritis: differential recognition of Borrelia burgdorferi outer surface protein A in patients with treatment-resistant or treatment-responsive Lyme arthritis.

1994 • 123 citations

Association of susceptibility to multiple sclerosis in Sweden with HLA class II DRB1 and DQB1 alleles

1994 • 119 citations

Cutting Edge: Predictable TCR Antigen Recognition Based on Peptide Scans Leads to the Identification of Agonist Ligands with No Sequence Homology

1998 • 118 citations

Acquisition of the human adeno-associated virus type-2 rep gene by human herpesvirus type-6

1991 • 118 citations

Oligopeptide permease in Borrelia burgdorferi: putative peptide-binding components encoded by both chromosomal and plasmid loci

1998 • 106 citations

Molecular mimicry and multiple sclerosis: Degenerate T-cell recognition and the induction of autoimmunity

1999 • 105 citations

Mapping the major human T helper epitopes of tetanus toxin. The emerging picture.

1993 • 104 citations

Molecular cloning of the human kidney differentiation antigen gp160: human aminopeptidase A.

1993 • 103 citations

Cloning of Human and Mouse EBI1, a Lymphoid-Specific G-Protein-Coupled Receptor Encoded on Human Chromosome 17q12-q21.2

1994 • 100 citations

Borrelia burgdorferi—specific and autoreactive T‐cell lines from cerebrospinal fluid in lyme radiculomyelitis

1988 • 97 citations

Investigation of antigen-antibody interactions using a soluble, non-support-bound synthetic decapeptide library composed of four trillion (4 × 1012) sequences

1994 • 93 citations

Cloning and expression of myelin-associated oligodendrocytic basic protein. A novel basic protein constituting the central nervous system myelin.

1994 • 84 citations

Molecular characterization and expression of p23 (OspC) from a North American strain of Borrelia burgdorferi

1993 • 83 citations

Dominant recognition of a Borrelia burgdorferi outer surface protein A peptide by T helper cells in patients with treatment-resistant Lyme arthritis

1996 • 67 citations

HLA‐DR‐restricted presentation of purified myelin basic protein is independent of intracellular processing

1997 • 49 citations

Human enteric adenovirus type 41 (Tak) contains a second fiber protein gene

1990 • 47 citations

cDNA Cloning and Expression of Human Glutamyl Aminopeptidase (Aminopeptidase A)

1993 • 47 citations

Immunologic Mechanisms in Lyme Neuroborreliosis: The Potential Role of Autoimmunity and Molecular Mimicry

1997 • 42 citations

T-cell epitope determination

1996 • 40 citations

Borrelia burgdorferi induces chemokines in human monocytes

1997 • 38 citations

Coordinate defects in human histocompatibility leukocyte antigen class II expression and antigen presentation in bare lymphocyte syndrome.

1994 • 36 citations

Establishment and application of a novel T cell clonality analysis using single-strand conformation polymorphism of T cell receptor messenger signals

1996 • 35 citations

Unique genetic arrangement in the dnaA region of theBorrelia burgdorferilinear chromosome: Nucleotide sequence of the dnaA gene

1993 • 33 citations

A chromosomal Borrelia burgdorferi gene encodes a 22-kilodalton lipoprotein, P22, that is serologically recognized in Lyme disease

1994 • 31 citations

Identification of Autoimmune T Cells Among In Vivo Expanded CD25+ T Cells in Multiple Sclerosis

1999 • 27 citations

Mechanisms of Injury in Lyme Neuroborreliosis

1997 • 27 citations

The use of soluble synthetic peptide combinatorial libraries to determine antigen recognition of T cells

1998 • 27 citations

Molecular cloning and characterization of Borrelia burgdorferi rpoB

1997 • 26 citations

Relationship between theBorrelia burgdorferi specific immune response and different stages and syndromes in neuroborreliosis

1997 • 14 citations

A cheA cheW operon in Borrelia burgdorferi, the agent of Lyme disease

1997 • 13 citations

Lyme neuroborreliosis

1998 • 12 citations

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