Two Genetic Loci Regulate T Cell–Dependent Islet Inflammation and Drive Autoimmune Diabetes Pathogenesis

MAPMAKER: An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations

1987 • 6,762 citations

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

1995 • 5,291 citations

HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

1987 • 2,045 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

A genome-wide search for human type 1 diabetes susceptibility genes

1994 • 1,294 citations

Breeding of a Non-Obese, Diabetic Strain of Mice

1980 • 1,255 citations

Properties of Monoclonal Antibodies to Mouse Ig Allotypes, H-2, and Ia Antigens

1979 • 993 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus

1995 • 749 citations

Genetic Analysis of Autoimmune Disease

1996 • 739 citations

Type-I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat

1990 • 650 citations

Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice.

1994 • 640 citations

Genetic Control of Autoimmune Diabetes in the Nod Mouse

1995 • 586 citations

Genetic analysis of autoimmune type 1 diabetes mellitus in mice

1991 • 494 citations

The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families.

1996 • 468 citations

RecA Protein: Structure, Function, and Role in Recombinational DNA Repair

1997 • 433 citations

The NOD Mouse: Recessive Diabetogenic Gene in the Major Histocompatibility Complex

1986 • 424 citations

CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice.

1997 • 414 citations

The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.

1987 • 402 citations

Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients.

1993 • 347 citations

A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus

1998 • 340 citations

NOD mouse colonies around the world- recent facts and figures

1993 • 339 citations

Immunohistochemical Characterization of Monocytes-Macrophages and Dendritic Cells Involved in the Initiation of the Insulitis and β-Cell Destruction in NOD Mice

1994 • 331 citations

A search for type 1 diabetes susceptibility genes in families from the United Kingdom

1998 • 329 citations

Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat

1996 • 300 citations

Polygenic control of autoimmune diabetes in nonobese diabetic mice

1993 • 298 citations

HUMAN TYPE 1 DIABETES AND THE INSULIN GENE: Principles of Mapping Polygenes

1996 • 291 citations

A diabetes-susceptible HLA haplotype is best defined by a combination of HLA-DR and -DQ alleles.

1989 • 260 citations

Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat

1996 • 253 citations

Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus.

1992 • 243 citations

Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity.

1997 • 234 citations

Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse.

1987 • 222 citations

Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31–q33

1995 • 211 citations

Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes.

1992 • 178 citations

A locus on chromosome 15q26 (IDDM3) produces susceptibility to insulin-dependent diabetes mellitus

1994 • 175 citations

Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/lty/Bcg genes on chromosome 1

1991 • 171 citations

Macrophage NRAMP1 and its role in resistance to microbial infections

1998 • 164 citations

Administration of Silica Particles or Anti-Lyt2 Antibody Prevents β-Cell Destruction in NOD Mice Given Cyclophosphamide

1988 • 156 citations

Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex.

1981 • 155 citations

NOR/Lt Mice: MHC-Matched Diabetes-Resistant Control Strain for NOD Mice

1992 • 151 citations

Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene.

1994 • 147 citations

The natural history of lymphocyte subsets infiltrating the pancreas of NOD mice

1989 • 146 citations

Crosses of NOD Mice With the Related NON Strain: A Polygenic Model for IDDM

1995 • 140 citations

Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1.

1997 • 129 citations

Identification and mapping to chromosome 1 of a susceptibility locus for periinsulitis in non-obese diabetic mice

1991 • 129 citations

IL-4 expression at the onset of islet inflammation predicts nondestructive insulitis in nonobese diabetic mice.

1997 • 123 citations

Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse Chromosome 3

1998 • 116 citations

Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to theIdd5diabetes susceptibility region

1997 • 115 citations

Markers on Distal Chromosome 2q Linked to Insulin-Dependent Diabetes Mellitus

1996 • 111 citations

Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin.

1998 • 104 citations

The HLA class II locus DPB1 can influence susceptibility to type 1 diabetes.

2000 • 104 citations

Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping.

1995 • 98 citations

Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: An approach for the genetic dissection of complex traits

1996 • 97 citations

Multifactorial inheritance in type 1 diabetes

1995 • 95 citations

Chromosomal Localization of Muscle Nicotinic Acetylcholine Receptor Genes in the Mouse

1986 • 95 citations

Tyro 3 Receptor Tyrosine Kinase and its Ligand, Gas6, Stimulate the Function of Osteoclasts

1998 • 93 citations

Evidence by allelic association-dependent methods for a type 1 diabetes polygene (IDDM6) on chromosome 18q21

1997 • 93 citations

Genetic analysis of immune dysfunction in non‐obese diabetic (NOD) mice: Mapping of a susceptibility locus close to the Bcl‐2 gene correlates with increased resistance of NOD T cells to apoptosis induction

1994 • 92 citations

Anti‐α/β T cell receptor monoclonal antibody provides an efficient therapy for autoimmune diabetes in nonobese diabetic (NOD) mice

1991 • 89 citations

Association of LMP2 and LMP7 genes within the major histocompatibility complex with insulin-dependent diabetes mellitus: population and family studies.

1995 • 89 citations

Subcongenic Analysis of theIdd13Locus in NOD/Lt Mice: Evidence for Several Susceptibility Genes Including a Possible Diabetogenic Role for β2-Microglobulin

1998 • 79 citations

Backcross analysis of genes linked to autoantibody production in New Zealand White mice.

1996 • 77 citations

The HOXD8 Locus (2q31) is Linked to Type I Diabetes: Interaction with Chromosome 6 and 11 Disease Susceptibility Genes

1995 • 76 citations

Independent genetic regulation of T-cell and antigen-presenting cell participation in autoimmune islet inflammation.

1998 • 69 citations

Mapping of Col3a1 and Col6a3 to proximal murine chromosome 1 identifies conserved linkage of structural protein genes between murine chromosome 1 and human chromosome 2q

1990 • 68 citations

Genetic analysis of chromosome 2 in type 1 diabetes: analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster. IMDIAB Group.

1998 • 66 citations

Genomic analysis of the C57BL/Ks mouse strain

1995 • 66 citations

Cutting Edge: Homologous Recombination of the MHC Class I K Region Defines New MHC-Linked Diabetogenic Susceptibility Gene(s) in Nonobese Diabetic Mice

1999 • 64 citations

Association of HLA-DPB1*0301 With IDDM in Mexican-Americans

1996 • 63 citations

Flow cytometric enumeration of mononuclear cell populations infiltrating the islets of Langerhans in prediabetic NOD mice: development of a model of autoimmune insulitis for type I diabetes.

1990 • 62 citations

Mouse chromosome 2

1997 • 60 citations

Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat.

1999 • 50 citations

Mouse chromosome 1

1997 • 50 citations

Programmed Cell Death in the Pathogenesis of Murine IDDM: Resistance to Apoptosis Induced in Lymphocytes by Cyclophosphamide

1996 • 48 citations

Transmission of haplotypes of microsatellite markers rather than single marker alleles in the mapping of a putative type 1 diabetes susceptibility gene (IDDM6)

1998 • 47 citations

Genetics of beta-2 microglobulin in the mouse

1983 • 47 citations

Multiple TCR Vβ Usage by Infiltrates of Young NOD Mouse Islets of Langerhans: A Polymerase Chain Reaction Analysis

1992 • 45 citations

β-Cell Function Relative to Islet Volume and Hormone Content in the Isolated Perfused Mouse Pancreas*

1983 • 40 citations

Family study of linkage disequilibrium between TAP2 transporter and HLA class II genes absence of TAP2 contribution to association with insulin-dependent diabetes mellitus

1995 • 40 citations

Antigen presenting cells and the immunogenetics of autoimmune diabetes in NOD mice.

1992 • 37 citations

Histological study of pancreatic beta-cell loss in relation to the insulitis process in the non-obese diabetic mouse

1994 • 34 citations

Contribution of T cells to the development of autoimmune diabetes in the NOD mouse model

1998 • 32 citations

Linkage of type I diabetes to 15q26 (IDDM3) in the Danish population

1996 • 30 citations

Chromosome Mapping of the Human (RECA) and Mouse (Reca) Homologs of the Yeast RAD51 and Escherichia coli recA Genes to Human (15q15.1) and Mouse (2F1) Chromosomes by Direct R-banding Fluorescence in Situ Hybridization

1994 • 29 citations

The gene for retinal S-antigen (48-kDa protein) maps to the centromeric portion of mouse chromosome 1 near idh-1

1989 • 27 citations

Localization of the acetylcholine receptor γ subunit gene to human chromosome 2q32→qter

1989 • 17 citations

Localization of the Gene for High-Density Lipoprotein Binding Protein (HDLBP) to Human Chromosome 2q37

1993 • 15 citations

Mapping multiple linked quantitative trait loci in non-obese diabetic mice using a stepwise regression strategy

1998 • 14 citations

Genotypic and phenotypic characterization of six new recombinant congenic strains derived from NOD/Shi and CBA/J genomes

1999 • 10 citations

DPB1*5901a: a novel HLA‐DPB1 allele from a Caucasian family with insulin‐dependent diabetes mellitus

1996 • 10 citations

Continued mapping of chromosome 2 genes

1994 • 7 citations

A Lymphocyte-specific Ltk Tyrosine Kinase Isoform Is Retained in the Endoplasmic Reticulum in Association with Calnexin

1997 • 7 citations

Mapping of the Gene for High-Density Lipoprotein Binding Protein (Hdlbp) to Proximal Mouse Chromosome 1

1994 • 6 citations

RECONSTITUTION OF (BALB/c × B6)F1 NORMAL MICE WITH STEM CELLS AND THYMUS FROM NONOBESE DIABETIC MICE RESULTS IN AUTOIMMUNE INSULITIS OF THE NORMAL HOSTS' PANCREASES

1992 • 4 citations

Receptor tyrosine kinase gene Tyro3 maps to mouse Chromosome 2, closely linked to Ltk

1996 • 3 citations

Encyclopedia of the mouse genome V. Mouse chromosome 1.

1996 • 2 citations

Encyclopedia of the mouse genome V. Mouse chromosome 2.

1996 • 2 citations

Deleted Work

1955 • 0 citations