Mechanisms of Growth Control in Normal and Malignant Breast Epithelium

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Angiogenic Factors

1987 • 3,702 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

1986 • 2,341 citations

Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal

1962 • 2,192 citations

Growth Factors and Cancer

1991 • 2,044 citations

The biology of platelet-derived growth factor

1986 • 2,036 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

Cloning of Human Mineralocorticoid Receptor Complementary DNA: Structural and Functional Kinship with the Glucocorticoid Receptor

1987 • 1,920 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

The Molecular Genetics of Cancer

1987 • 1,729 citations

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

1985 • 1,687 citations

The c-erb-A gene encodes a thyroid hormone receptor

1986 • 1,505 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture.

1986 • 1,408 citations

Autocrine Secretion and Malignant Transformation of Cells

1980 • 1,370 citations

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

1987 • 1,353 citations

The c-erb-A protein is a high-affinity receptor for thyroid hormone

1986 • 1,340 citations

Sequence and Expression of Human Estrogen Receptor Complementary DNA

1986 • 1,321 citations

Some recent advances in the chemistry and biology of transforming growth factor-beta.

1987 • 1,308 citations

Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture.

1986 • 1,282 citations

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

1986 • 1,244 citations

Type beta transforming growth factor: a bifunctional regulator of cellular growth.

1985 • 1,107 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

1987 • 999 citations

Evidence that transforming growth factor-β is a hormonally regulated negative growth factor in human breast cancer cells

1987 • 998 citations

Isolation of the bovine and human genes for müllerian inhibiting substance and expression of the human gene in animal cells

1986 • 997 citations

Tenascin: an extracellular matrix protein involved in tissue interactions during fetal development and oncogenesis

1986 • 989 citations

Functional domains of the human glucocorticoid receptor

1986 • 933 citations

Dual control of cell growth by somatomedins and platelet-derived growth factor.

1979 • 926 citations

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

1984 • 906 citations

Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

1987 • 895 citations

Human transforming growth factor-α: Precursor structure and expression in E. coli

1984 • 888 citations

Growth factors: Mechanism of action and relation to oncogenes

1984 • 885 citations

EPIDERMAL-GROWTH-FACTOR RECEPTOR STATUS AS PREDICTOR OF EARLY RECURRENCE OF AND DEATH FROM BREAST CANCER

1987 • 881 citations

Insulin-like growth factor II receptor as a multifunctional binding protein

1987 • 858 citations

Identification of a new class of steroid hormone receptors

1988 • 845 citations

Expression of Cellular Oncogenes in Human Malignancies

1984 • 840 citations

Peptide growth factors are multifunctional

1988 • 835 citations

The Biology of Cancer Invasion and Metastasis

1978 • 819 citations

Cellular tumorigenicity in nude mice: Correlation with cell growth in semi-solid medium

1974 • 814 citations

Estrogen control of progesterone receptor in human breast cancer. Correlation with nuclear processing of estrogen receptor.

1978 • 797 citations

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo

1987 • 796 citations

Chapter 1: Interferons (IFNs)

1986 • 793 citations

Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.

1986 • 791 citations

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

1986 • 786 citations

Growth Inhibitor from BSC-1 Cells Closely Related to Platelet Type β Transforming Growth Factor

1984 • 779 citations

A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-β family

1987 • 756 citations

The pathology of invasive breast cancerA Syllabus Derived from Findings of the National Surgical Adjuvant Breast Project (Protocol No. 4)

1975 • 755 citations

Cloning of the human estrogen receptor cDNA.

1985 • 720 citations

Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF.

1985 • 710 citations

The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors

1987 • 710 citations

Estrogens as a cause of human cancer: the Richard and Hinda Rosenthal Foundation award lecture.

1988 • 703 citations

BIOCHEMICAL INTERACTIONS OF TUMOR CELLS WITH THE BASEMENT MEMBRANE

1986 • 693 citations

After Insulin Binds

1987 • 687 citations

An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I.

1987 • 682 citations

A fixed site of DNA replication in eucaryotic cells

1980 • 669 citations

Cellular Localization of Somatomedin (Insulin-Like Growth Factor) Messenger RNA in the Human Fetus

1987 • 663 citations

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

1987 • 657 citations

The biochemistry of glycoproteins and proteoglycans

1980 • 651 citations

Estrogen Receptors in Human Breast Cancer

1976 • 621 citations

Mechanisms of Tumor Progression

2010 • 608 citations

Human basic fibroblast growth factor: nucleotide sequence and genomic organization.

1986 • 604 citations

Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus

1982 • 599 citations

Functional role for c-myc in mitogenic response to platelet-derived growth factor

1984 • 578 citations

Estrogenic Regulation of Growth and Polypeptide Growth Factor Secretion in Human Breast Carcinoma

1987 • 576 citations

Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading.

1988 • 570 citations

Type beta transforming growth factor is an inhibitor of myogenic differentiation.

1986 • 559 citations

WOODPECKERS' TONGUES

1976 • 553 citations

Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor beta: a proposed model for indirect mitogenesis involving autocrine activity.

1986 • 541 citations

Tumor cell autocrine motility factor.

1986 • 539 citations

Localisation of the oestradiol-binding and putative DNA-binding domains of the human oestrogen receptor.

1986 • 533 citations

An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family

1987 • 525 citations

Molecular Cloning of Complementary DNA Encoding the Avian Receptor for Vitamin D

1987 • 516 citations

Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression.

1987 • 508 citations

Overproduction of protein kinase C causesdisordered growth control in rat fibroblasts

1988 • 492 citations

A secreted glycoprotein induced by estrogen in human breast cancer cell lines

1980 • 481 citations

Inhibition of protein kinase C by tamoxifen.

1985 • 464 citations

Structure of a Mouse Submaxillary Messenger RNA Encoding Epidermal Growth Factor and Seven Related Proteins

1983 • 448 citations

Epidermal-Growth-Factor-Dependent Transformation by a Human EGF Receptor Proto-Oncogene

1987 • 448 citations

Expression of Transforming Growth Factor α and its Messenger Ribonucleic Acid in Human Breast Cancer: Its Regulation by Estrogen and its Possible Functional Significance

1988 • 440 citations

Immunochemical studies of estrogen receptors

1984 • 439 citations

Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract.

1984 • 435 citations

Evidence that somatomedin is synthesized by multiple tissues in the fetus

1980 • 434 citations

Identification of a Novel Thyroid Hormone Receptor Expressed in the Mammalian Central Nervous System

1987 • 429 citations

Biochemical pharmacology of antiestrogen action.

1984 • 417 citations

Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene.

1985 • 416 citations

Estrogen Receptor in a Human Cell Line (MCF-7) from Breast Carcinoma

1973 • 415 citations

Proliferation, hormonal responsiveness, and estrogen receptor content of MCF-7 human breast cancer cells grown in the short-term and long-term absence of estrogens.

1987 • 413 citations

OVEREXPRESSION OF THE c-erbB-2 ONCOPROTEIN IN HUMAN BREAST CARCINOMAS: IMMUNOHISTOLOGICAL ASSESSMENT CORRELATES WITH GENE AMPLIFICATION

1987 • 409 citations

Reversible Inhibition of Mammary Gland Growth by Transforming Growth Factor-β

1987 • 408 citations

Regulation of myogenic differentiation by type beta transforming growth factor.

1986 • 408 citations

Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cells

1987 • 407 citations

Sequence of cDNA encoding human insulin-like growth factor I precursor

1983 • 401 citations

Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice.

1985 • 396 citations

The Mammary gland : development, regulation, and function

1987 • 396 citations

Suramin inhibition of growth factor receptor binding and mitogenicity in AKR‐2B cells

1987 • 387 citations

Cellular transformation by coordinated action of three peptide growth factors from human platelets

1984 • 383 citations

Allosteric regulation of the epidermal growth factor receptor kinase.

1986 • 381 citations

Basic fibroblast growth factor fused to a signal peptide transforms cells

1988 • 379 citations

Autocrine saturation of pro-urokinase receptors on human A431 cells

1986 • 361 citations

Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis.

1987 • 360 citations

The ovalbumin gene is associated with the nuclear matrix of chicken oviduct cells

1982 • 356 citations

Expression of insulin-like growth factor-II transcripts in Wilms' tumour

1985 • 352 citations

QUANTITATIVE STUDIES OF PROSTATIC SECRETION

1940 • 347 citations

Expression in rat fibroblasts of a human transforming growth factor-α cDNA results in transformation

1986 • 346 citations

Human breast carcinoma cells in continuous culture: a review.

1978 • 345 citations

Biological and molecular bases of mammary carcinogenesis.

1987 • 341 citations

Morphological evaluation of cell turnover in relation to the menstrual cycle in the “resting” human breast

1981 • 341 citations

T cell suppressor factor from human glioblastoma cells is a 12.5-kd protein closely related to transforming growth factor-beta.

1987 • 337 citations

Normal embryo fibroblasts release transforming growth factors in a latent form

1984 • 336 citations

Phosphoinositides in mitogenesis: Neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation

1985 • 332 citations

Role of epidermal growth factor in carcinogenesis.

1986 • 330 citations

Differential responsiveness of human breast cancer cell lines MCF-7 and T47D to growth factors and 17 beta-estradiol.

1988 • 330 citations

Characterization of estrogen responsive transforming activity in human breast cancer cell lines.

1986 • 330 citations

Reduction to Homozygosity of Genes on Chromosome 11 in Human Breast Neoplasia

1987 • 329 citations

Molecular Biology of the Human T-Lymphotropic Retroviruses

1986 • 324 citations

Epidermal Growth Factor Is a Major Growth-Promoting Agent in Human Milk

1980 • 315 citations

STEROIDAL PURE ANTIOESTROGENS

1987 • 313 citations

Secretion of an insulin-like growth factor-I-related protein by human breast cancer cells.

1986 • 310 citations

A 90,000-dalton binding protein common to both steroid receptors and the Rous sarcoma virus transforming protein, pp60v-src.

1985 • 304 citations

Sequence of the pS2 mRNA induced by estrogen in the human breast cancer cell line MCF-7

1984 • 304 citations

The specific binding of estrogens and androgens to the nuclear matrix of sex hormone responsive tissues.

1980 • 304 citations

Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats.

1986 • 301 citations

Two Syngeneic Cell Lines from Human Breast Tissue: The Aneuploid Mammary Epithelial (Hs578T) and the Diploid Myoepithelial (Hs578Bst) Cell Lines 2

1977 • 299 citations

Isolation of amplified and overexpressed DNA sequences from adriamycin-resistant human breast cancer cells.

1987 • 296 citations

Induction of Epidermal Growth Factor-Related Polypeptides by 17β-Estradiol in MCF-7 Human Breast Cancer Cells

1986 • 296 citations

Pure brain-derived acidic fibroblast growth factor is a potent angiogenic vascular endothelial cell mitogen with sequence homology to interleukin 1.

1985 • 294 citations

Enhanced levels of insulin-like growth factor messenger RNA in human colon carcinomas and liposarcomas.

1986 • 293 citations

Cell proliferation kinetics of MCF-7 human mammary carcinoma cells in culture and effects of tamoxifen on exponentially growing and plateau-phase cells.

1983 • 288 citations

Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-I cDNA

1988 • 285 citations

Stimulation of c-myc oncogene expression associated with estrogen-induced proliferation of human breast cancer cells.

1987 • 282 citations

Participation of c- myc Protein in DNA Synthesis of Human Cells

1986 • 282 citations

A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma

1987 • 282 citations

Transforming protein of simian sarcoma virus stimulates autocrine growth of SSV-transformed cells through PDGF cell-surface receptors

1984 • 277 citations

Effects of tamoxifen on human breast cancer cell cycle kinetics: accumulation of cells in early G1 phase.

1983 • 275 citations

Bioactivities, estrogen receptor interactions, and plasminogen activator-inducing activities of tamoxifen and hydroxy-tamoxifen isomers in MCF-7 human breast cancer cells.

1984 • 274 citations

Epidermal Growth Factor Receptor Gene Expression in Estrogen Receptor-Positive and Negative Human Breast Cancer Cell Lines

1987 • 274 citations

Autocrine Growth Stimulation of the MCF 7 Breast Cancer Cells by the Estrogen-Regulated 52 K Protein*

1986 • 273 citations

Influence of Estrogens on Mouse Uterine Epidermal Growth Factor Precursor Protein and Messenger Ribonucleic Acid

1988 • 273 citations

Estrogen-Induced Factors of Breast Cancer Cells Partially Replace Estrogen to Promote Tumor Growth

1986 • 273 citations

Effect of estradiol on human breast cancer cells in culture.

1983 • 272 citations

Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts.

1986 • 269 citations

Biological differences among MCF-7 human breast cancer cell lines from different laboratories

1987 • 267 citations

Autocrine Stimulation of Intracellular PDGF Receptors in v- sis -Transformed Cells

1988 • 267 citations

Synthesis and secretion of platelet-derived growth factor by human breast cancer cell lines.

1987 • 266 citations

Different transforming growth factor-α species are derived from a glycosylated and palmitoylated transmembrane precursor

1987 • 264 citations

Acidic and basic fibroblast growth factors stimulate tyrosine kinase activity in vivo.

1988 • 261 citations

Two insulin-like growth factor I messenger RNAs are expressed in human liver.

1986 • 260 citations

Evidence for a functional role of endogenously produced somatomedinlike peptides in the regulation of DNA synthesis in cultured human fibroblasts and porcine smooth muscle cells.

1985 • 257 citations

Abnormal oxidative metabolism of estradiol in women with breast cancer.

1982 • 256 citations

Somatomedin-C receptors and growth effects in human breast cells maintained in long-term tissue culture.

1984 • 256 citations

Mitogenic stimulation of human breast cancer cells in a growth factor‐defined medium: Synergistic action of insulin and estrogen

1988 • 245 citations

Phorbol esters induce multidrug resistance in human breast cancer cells.

1988 • 241 citations

An antibody that blocks insulin-like growth factor (IGF) binding to the type II IGF receptor is neither an agonist nor an inhibitor of IGF-stimulated biologic responses in L6 myoblasts.

1987 • 237 citations

A new diploid nontumorigenic human breast epithelial cell line isolated and propagated in chemically defined medium

1987 • 237 citations

Cultured fibroblast monolayers secrete a protein that alters the cellular binding of somatomedin-C/insulinlike growth factor I.

1986 • 231 citations

Frequency and distribution of estrogen receptor-positive cells in normal, nonlactating human breast tissue.

1987 • 230 citations

Presence of epidermal growth factor receptor as an indicator of poor prognosis in patients with breast cancer.

1985 • 230 citations

Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissues.

1986 • 230 citations

Beta-type transforming growth factor specifies organizational behavior in vascular smooth muscle cell cultures.

1987 • 229 citations

Ha-ras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic mice.

1987 • 228 citations

Role of chromosome translocations in human neoplasia

1987 • 226 citations

Differential effects of transforming growth factor-beta on proliferation of normal and malignant rat liver epithelial cells in culture.

1986 • 224 citations

Epidermal growth factor stimulation of human breast cancer cells in culture.

1980 • 223 citations

Presence of transforming growth factors in human breast cancer cells.

1984 • 222 citations

Ligand-Modulated Regulation of Progesterone Receptor Messenger Ribonucleic Acid and Protein in Human Breast Cancer Cell Lines

1988 • 214 citations

Basement Membrane and the Invasive Activity of Metastatic Tumor Cells

1986 • 209 citations

Human transforming growth factor type .beta.2: production by a prostatic adenocarcinoma cell line, purification, and initial characterization

1987 • 204 citations

Cellular distribution of type I and type II receptors for transforming growth factor-beta.

1986 • 203 citations

Breast Cancer Incidence Among Atomic Bomb Survivors, Hiroshima and Nagasaki, 1950–69

1977 • 202 citations

Characterization of epidermal growth factor receptor and action on human breast cancer cells in culture.

1984 • 201 citations

Activation of growth factor secretion in tumorigenic states of breast cancer induced by 17 beta-estradiol or v-Ha-ras oncogene.

1987 • 199 citations

Direct action of 17 beta-estradiol on mouse mammary ducts analyzed by sustained release implants and steroid autoradiography.

1987 • 196 citations

Regulation of Progesterone Receptor Messenger Ribonucleic Acid and Protein Levels in MCF-7 Cells by Estradiol: Analysis of Estrogen’s Effect on Progesterone Receptor Synthesis and Degradation*

1988 • 192 citations

Direct inhibitory effects of somatostatin (analogues) on the growth of human breast cancer cells.

1987 • 191 citations

Estrogen control of prolactin synthesis in vitro.

1978 • 190 citations

Growth Hormone Dependence of Somatomedin-C/lnsulin-Like Growth Factor-I and Insulin-Like Growth Factor-ll Messenger Ribonucleic Acids*

1987 • 186 citations

Transfection of v- ras ^H DNA into MCF-7 Human Breast Cancer Cells Bypasses Dependence on Estrogen for Tumorigenicity

1985 • 185 citations

Induction of cell division in medium lacking serum growth factor by SV40

1971 • 185 citations

Isolation and growth of human mammary epithelial cells

1985 • 185 citations

Breast Cancer: Cellular and Molecular Biology

1988 • 182 citations

Hormonal synergism in mammary growth

1958 • 182 citations

Monoclonal antibodies as probes for estrogen receptor detection and characterization

1982 • 181 citations

Antiglucocorticosteroid effects suggest why steroid hormone is required for receptors to bind DNA in vivo but not in vitro

1987 • 179 citations

Estrogen responsive proliferation of clonal human breast carcinoma cells in athymic mice

1980 • 178 citations

Estrogens Stimulate Cell Proliferation and Induce Secretory Proteins in a Human Breast Cancer Cell Line (T₄₇D)*

1982 • 175 citations

Gonadotropin-Releasing Hormone Binding Sites in Human Breast Carcinoma

1985 • 170 citations

Estrogen Regulation of Epidermal Growth Factor Receptor Messenger Ribonucleic Acid

1988 • 168 citations

Pertussis toxin inhibits thrombin-induced activation of phosphoinositide hydrolysis and Na+/H+ exchange in hamster fibroblasts.

1986 • 165 citations

Lentropin, a protein that controls lens fiber formation, is related functionally and immunologically to the insulin-like growth factors.

1987 • 165 citations

Epidermal growth factor requirement for development of cultured mammary gland

1980 • 165 citations

Oral-Contraceptive Use and the Risk of Breast Cancer

1986 • 165 citations

Expression of Rat Transforming Growth Factor Alpha mRNA during Development Occurs Predominantly in the Maternal Decidua

1987 • 162 citations

Construction of a Novel Oncogene Based on Synthetic Sequences Encoding Epidermal Growth Factor

1987 • 162 citations

Multihormonal Regulation of Insulin-Like Growth Factor-I-Related Protein in MCF-7 Human Breast Cancer Cells

1988 • 161 citations

Resistance to multiple chemotherapeutic agents in human cancer cells

1988 • 161 citations

Tumorigenic and metastatic properties of "normal" and ras-transfected NIH/3T3 cells.

1985 • 159 citations

Cell Proliferation of Estrogen-Sensitive Cells: The Case for Negative Control*

1987 • 157 citations

An antibody to the receptor for insulin-like growth factor I inhibits the growth of MCF-7 cells in tissue culture

1987 • 155 citations

Frequent expression of growth factors for mesenchymal cells in human mammary carcinoma cell lines.

1987 • 151 citations

Transformation of mouse BALB/c 3T3 cells with human basic fibroblast growth factor cDNA.

1988 • 150 citations

A Multidrug-Resistant MCF-7 Human Breast Cancer Cell Line Which Exhibits Cross-Resistance to Antiestrogens and Hormone-Independent Tumor Growthin Vivo

1988 • 149 citations

Antibodies to the epidermal growth factor receptor block the biological activities of sarcoma growth factor.

1983 • 148 citations

Distribution of an estrogen-induced protein with a molecular weight of 24,000 in normal and malignant human tissues and cells.

1983 • 148 citations

Local effects of EGF, α‐TGF, and EGF‐like growth factors on lobuloalveolar development of the mouse mammary gland in vivo

1987 • 147 citations

Phosphorylation, glycosylation, and proteolytic activity of the 52-kD estrogen-induced protein secreted by MCF7 cells.

1987 • 147 citations

The receptor for insulin-like growth factor II mediates an insulin-like response.

1987 • 145 citations

On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors

1987 • 145 citations

Epidermal growth factor stimulates the synthesis of its own receptor in a human breast cancer cell line.

1986 • 145 citations

Proto-oncogene abnormalities in human breast cancer: correlations with anatomic features and clinical course of disease.

1987 • 143 citations

Expression of the 21,000 molecular weight ras protein in a spectrum of benign and malignant human mammary tissues.

1986 • 140 citations

Effects of serum and insulin on the sensitivity of the human breast cancer cell line MCF-7 to estrogen and antiestrogens.

1981 • 138 citations

Stimulation by insulin-like growth factors is required for cellular transformation by type beta transforming growth factor.

1985 • 137 citations

A 22-kd protein (sorcin/V19) encoded by an amplified gene in multidrug-resistant cells, is homologous to the calcium-binding light chain of calpain.

1986 • 137 citations

Induction of plasminogen activator by estrogen in a human breast cancer cell line (MCF-7)

1979 • 137 citations

Effects of epidermal growth factor receptor concentration on tumorigenicity of A431 cells in nude mice.

1986 • 135 citations

Transforming Growth Factor α Production and Epidermal Growth Factor Receptor Expression in Normal and Oncogene Transformed Human Mammary Epithelial Cells

1989 • 135 citations

Calmodulin-stimulated phosphorylation of 17 beta-estradiol receptor on tyrosine.

1984 • 134 citations

Selection and Characterization of a Breast Cancer Cell Line Resistant to the Antiestrogen LY 117018

1985 • 130 citations

Modulation of insulinlike growth factor I binding to human fibroblast monolayer cultures by insulinlike growth factor carrier proteins released to the incubation media.

1986 • 130 citations

The human c-Kirstenrasgene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231

1987 • 130 citations

Variables controlling somatomedin production by cultured human fibroblasts

1983 • 129 citations

Growth factors and transformation.

1986 • 128 citations

Isolation of a Somatomedin-Binding Protein from Preterm Amniotic Fluid. Development of a Radioimmunoassay*

1984 • 127 citations

Characterization of the Estrogen-Induced pS2 Protein Secreted by the Human Breast Cancer Cell Line MCF-7*

1987 • 125 citations

Expression of Transforming Growth Factor α (TGFα) in Differentiated Rat Mammary Tumors: Estrogen Induction of TGFα Production

1987 • 124 citations

A simplified method for passage and long-term growth of human mammary epithelial cells

1986 • 123 citations

Protein kinases in signal transduction

1984 • 123 citations

Biologically active precursor for transforming growth factor type alpha, released by retrovirally transformed cells.

1986 • 121 citations

Expression of rat transforming growth factor alpha mRNA during development occurs predominantly in the maternal decidua.

1987 • 121 citations

Production of PDGF‐like growth factor by breast cancer cell lines

1985 • 120 citations

Role of serum in the prolactin responsiveness of MCF-7 human breast cancer cells in long-term tissue culture.

1987 • 119 citations

Localization of a major receptor-binding domain for epidermal growth factor by affinity labeling.

1988 • 119 citations

Evidence for the involvement of the submandibular gland epidermal growth factor in mouse mammary tumorigenesis.

1985 • 118 citations

Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells

1987 • 118 citations

Membrane binding characteristics of two forms of transforming growth factor-beta.

1987 • 118 citations

Loss of epidermal growth factor requirement and malignant transformation

1979 • 117 citations

Mammary fibroblast influence on normal mouse mammary epithelial cell responses to estrogen in vitro.

1986 • 117 citations

Epidermal growth factor receptor gene-amplified MDA-468 breast cancer cell line and its nonamplified variants.

1987 • 114 citations

Aromatic Hydroxylation of Estrogens

1983 • 114 citations

Immunological detection and quantitation of alpha transforming growth factors in human breast carcinoma cells

1986 • 114 citations

Post-transcriptional control of the onset of DNA synthesis by an insulin-like growth factor.

1984 • 113 citations

17 beta-estradiol regulates and v-Ha-ras transfection constitutively enhances MCF7 breast cancer cell interactions with basement membrane.

1986 • 113 citations

Progestin regulation of epidermal growth factor receptor in human mammary carcinoma cells.

1986 • 111 citations

Proliferation kinetics of a human breast cancer line in vitro following treatment with 17beta-estradiol and 1-beta-D-arabinofuranosylcytosine.

1978 • 110 citations

Demonstration of insulin-like growth factor (IGF-I and -II) receptors and binding protein in human breast cancer cell lines

1988 • 110 citations

Augmentation of the response of normal mammary epithelial cells to estradiol by mammary stroma.

1983 • 110 citations

Processing of the platelet-derived growth factor receptor. Biosynthetic and degradation studies using anti-receptor antibodies.

1987 • 110 citations

Estradiol receptor: phosphorylation on tyrosine in uterus and interaction with anti-phosphotyrosine antibody.

1986 • 109 citations

Establishment and characterization of SV40-transformed human breast epithelial cell lines.

1982 • 108 citations

Regression of mouse mammary gland anlagen in recombinants of Tfm and wild-type tissues: testosterone acts via the mesenchyme

1977 • 105 citations

Progression to steroid insensitivity can occur irrespective of the presence of functional steroid receptors

1987 • 105 citations

Serum regulation of the estrogen responsiveness of the human breast cancer cell line MCF-7.

1983 • 103 citations

Transformation of human mammary epithelial cells by oncogenic retroviruses.

1988 • 103 citations

Estrogen/Antiestrogen Action and Breast Cancer Therapy

1986 • 102 citations

Regulation of transferrin receptor expression at the cell surface by insulin-like growth factors, epidermal growth factor and platelet-derived growth factor.

1986 • 101 citations

Transformation of normal rat kidney (NRK) cells by an infectious retrovirus carrying a synthetic rat type alpha transforming growth factor gene.

1987 • 100 citations

Expression and characterization of transforming growth factor alpha precursor protein in transfected mammalian cells.

1987 • 100 citations

cDNA clones reveal differences between human glial and endothelial cell platelet-derived growth factor A-chains

1987 • 99 citations

Characterization of the Estrogen Receptor and Its Dynamics in MCF-7 Human Breast Cancer Cells Using a Covalently Attaching Antiestrogen*

1984 • 98 citations

Transforming growth factors in solid human malignant neoplasms.

1983 • 98 citations

On the prenatal growth of the mammary gland rudiment in the mouse.

1950 • 97 citations

Epithelial HBL-100 cell line derived from milk of an apparently healthy woman harbours SV40 genetic information

1985 • 96 citations

05. Control of cell growth and proliferation

2005 • 95 citations

In Vitro Growth Promotion of Human Mammary Carcinoma Cells by Steroid Hormones, Tamoxifen, and Prolactin23

1984 • 92 citations

Pharmacology and clinical uses of inhibitors of hormone secretion and action

1987 • 91 citations

TOPOGRAPHY OF DNA SYNTHESIS IN THE MAMMARY GLAND OF THE C3H MOUSE AND ITS CONTROL BY OVARIAN HORMONES: AN AUTORADIOGRAPHIC STUDY

1968 • 91 citations

Radiometric analysis of biological oxidations in man: sex differences in estradiol metabolism.

1980 • 91 citations

In situ c-myc expression and genomic status of the c-myc locus in infiltrating ductal carcinomas of the breast.

1988 • 90 citations

Indirect mechanism of oestradiol stimulation of cell proliferation of human breast cancer cell lines

1986 • 89 citations

Evidence for an increased somatomedin-C/insulin-like growth factor I content in primary human lung tumors

1987 • 89 citations

Demonstration of a Specific Serum Carrier Protein of Nonsuppressible Insulin-like Activity in Vivo*

1977 • 88 citations

Both Type I and II Insulin-Like Growth Factor Receptor Binding Increase during Lactogenesis in Bovine Mammary Tissue*

1988 • 88 citations

Insulin - Like Growth Factors. Somatomedins

1983 • 86 citations

Alpha-transforming growth factor secreted by untransformed bovine anterior pituitary cells in culture. II. Identification using a sequence-specific monoclonal antibody.

1986 • 86 citations

Identification of a signal for nuclear targeting in platelet-derived-growth-factor-related molecules.

1987 • 85 citations

Epithelial tissue-derived growth factor-like polypeptides.

1983 • 85 citations

Partial purification of transforming growth factors from human milk.

1986 • 84 citations

Purification and biologic properties of fibroblast somatomedin.

1986 • 84 citations

Cloning of estrogen-regulated messenger RNA sequences from human breast cancer cells.

1986 • 84 citations

Estrogen- and tamoxifen-induced rearrangement of cytoskeletal and adhesion structures in breast cancer MCF-7 cells.

1986 • 83 citations

Internalization of transforming growth factor‐β and its receptor in BALB/c 3T3 fibroblasts

1986 • 82 citations

Effects of estrogen and antiestrogen on DNA polymerase in human breast cancer.

1980 • 79 citations

Purification of a mammary-derived growth factor from human milk and human mammary tumors.

1985 • 79 citations

Estrogen Responsiveness of Normal Mouse Mammary Cells in Primary Cell Culture: Association of Mammary Fibroblasts with Estrogeiiic Regulation of Progesterone Receptors*

1985 • 78 citations

Molecules involved in proliferation of normal and cancer cells: presidential address.

1987 • 76 citations

Dual effects of the progestin R5020 on proteins released by the T47D human breast cancer cells.

1984 • 75 citations

1,25-dihydroxyvitamin D3 receptor in a cultured human breast cancer cell line (MCF 7 cells)

1980 • 75 citations

Dihydrofolate reductase gene amplification and possible rearrangement in estrogen-responsive methotrexate-resistant human breast cancer cells.

1982 • 75 citations

Effect of estrogens and antiestrogens on growth-regulatory enzymes in human breast cancer cells in tissue culture.

1985 • 75 citations

The human transforming growth factor type alpha coding sequence is not a direct-acting oncogene when overexpressed in NIH 3T3 cells.

1987 • 73 citations

Insulin-Like Growth Factor (IGF)&slash;Somatomedin Receptor Subtypes: Structure, Function, and Relationships to Insulin Receptors and IGF Carrier Proteins

1986 • 72 citations

Transcriptional control of thymidine kinase gene expression by estrogen and antiestrogens in MCF-7 human breast cancer cells.

1986 • 72 citations

Cellular and Molecular Biology of Mammary Cancer

1988 • 72 citations

Molecular cloning of gene sequences that are regulated by insulin-like growth factor I.

1987 • 71 citations

Induction of carcinoembryonic antigen secretion and modulation of protein secretion/expression and fibronectin/laminin expression in human colon carcinoma cells by transforming growth factor-beta.

1988 • 71 citations

Stem cells and the development of mammary cancers in experimental rats and in humans

1987 • 70 citations

Evidence for a direct growth-stimulating effect of estradiol on human MCF-7 cells in vivo.

1984 • 69 citations

Purification and properties of a mammary-uterine-pituitary tumor cell growth factor from pregnant sheep uterus.

1984 • 68 citations

Distinct high-performance liquid chromatography pattern of transforming growth factor activity in urine of cancer patients as compared with that of normal individuals.

1984 • 67 citations

Characterization of estrogen and progesterone receptors and the dissociated regulation of growth and progesterone receptor stimulation by estrogen in MDA-MB-134 human breast cancer cells.

1986 • 66 citations

Identification of a High Affinity Nuclear Acceptor Site for Estrogen Receptor of Calf Uterus

1974 • 66 citations

Epidermal growth factor receptor is increased in multidrug-resistant Chinese hamster and mouse tumor cells.

1986 • 65 citations

Appearance of high affinity receptors for type beta transforming growth factor during differentiation of murine embryonal carcinoma cells.

1987 • 65 citations

Lactate dehydrogenase in estrogen-responsive human breast cancer cells.

1978 • 64 citations

Microsomal binding sites for nonsteroidal anti-estrogens in MCF 7 human mammary carcinoma cells. Demonstration of high affinity and narrow specificity for basic ether derivatives of triphenylethylene.

1984 • 64 citations

Transient protection of cultured human cells against antitumor agents by 12-O-tetradecanoylphorbol-13-acetate.

1987 • 64 citations

Introduction of estrogen-responsiveness into mammalian cell lines

1986 • 64 citations

Histochemical studies with an estrogen receptor-related protein in human breast tumors.

1986 • 63 citations

Ultrastructural localization of a platelet-derived growth factor/v-sis-related protein(s) in cytoplasm and nucleus of simian sarcoma virus-transformed cells.

1987 • 63 citations

Presence of tumor-associated antigens in epidermal growth factor receptors from different human carcinomas.

1987 • 63 citations

Efforts to combine endocrine and chemotherapy in the management of breast cancer: Do two and two equal three?

1983 • 62 citations

Oestradiol 16 alpha-hydroxylase: a risk marker for breast cancer.

1986 • 62 citations

Growth factor requirements of oncogene-transformed NIH 3T3 and BALB/c 3T3 cells cultured in defined media.

1986 • 62 citations

Different growth factors stimulate cell division of rat mammary epithelial, myoepithelial, and stromal cell lines in culture

1984 • 61 citations

Chromosomal proteins regulate steroid binding to chromatin

1976 • 61 citations

Negative regulators of cell growth

1986 • 58 citations

The autoimmune nature of cancer.

1987 • 57 citations

Growth of mouse mammary gland end buds cultured in a collagen gel matrix

1982 • 55 citations

Alterations in Phosphoinositide Metabolism Associated with 17β-Estradiol and Growth Factor Treatment of MCF-7 Breast Cancer Cells

1988 • 55 citations

Growth signal transduction: Rapid activation of covalently bound ornithine decarboxylase during phosphatidylinositol breakdown

1987 • 53 citations

Adriamycin resistance in human tumor cells associated with marked alteration in the regulation of the hexose monophosphate shunt and its response to oxidant stress.

1987 • 52 citations

Use of two MCF-7 cell variants to evaluate the growth regulatory potential of estrogen-induced products.

1986 • 51 citations

Growth of mammary epithelial cells in breast‐cancer biopsies correlates with egf binding

1987 • 49 citations

Hormonal Control of Plasminogen Activator Secretion in ZR-75-1 Human Breast Cancer Cells in Culture

1984 • 48 citations

Hormonal carcinogenesis: Separation of estrogenicity from carcinogenicity

1986 • 47 citations

Two new estrogen-supersensitive variants of the MCF-7 human breast cancer cell line

1983 • 47 citations

Heterologous transmembrane signaling by a human insulin receptor-v-ros hybrid in Chinese hamster ovary cells.

1987 • 46 citations

Activation of transforming potential of the human insulin receptor gene.

1987 • 46 citations

Antiestrogen Stimulation of the Production of a 37,000 Molecular Weight Secreted Protein and Estrogen Stimulation of the Production of a 32,000 Molecular Weight Secreted Protein in MCF-7 Human Breast Cancer Cells*

1987 • 45 citations

Estrogen receptors in mammary gland primordia of fetal mouse

1980 • 45 citations

A New Human Breast Carcinoma Cell Line (PMC42) With Stem Cell Characteristics. III. Hormone Receptor Status and Responsiveness

1984 • 44 citations

Transforming Growth Factor α: Mutation of Aspartic Acid 47 and Leucine 48 Results in Different Biological Activities

1988 • 40 citations

Interplay between Estradiol and Prolactin in the Regulation of Steroid Hormone Receptor Levels, Nature, and Functionality in Normal Mouse Mammary Tissue*

1981 • 40 citations

Demonstration of Insulin-Like Growth Factor I in Human Urine*

1987 • 40 citations

Autocrine stimulation by estradiol-regulated growth factors of rat hormone-responsive mammary cancer: interaction with the polyamine pathway.

1986 • 40 citations

Purification and characterization of a novel transforming growth factor.

1987 • 39 citations

Mesenchyme-mediated effect of testosterone on embryonic mammary epithelium.

1978 • 39 citations

Rapid changes in specific estrogen binding elicited by cGMP or cAMP in cytosol from human endometrial cells.

1983 • 38 citations

Autocrine, paracrine and endocrine mechanisms of growth control.

1985 • 38 citations

Modulation by Estrogen and Growth Factors of Transforming Growth Factor-Alpha and Epidermal Growth Factor Receptor Expression in Normal and Malignant Human Mammary Epithelial Cells

1989 • 38 citations

Activation of the ribosomal DNA promoter in cells exposed to insulinlike growth factor I.

1987 • 37 citations

Response to estrogen by the human mammary carcinoma cell line CAMA-1.

1982 • 36 citations

Effect of v-rasH oncogene transfection on estrogen-independent tumorigenicity of estrogen-dependent human breast cancer cells.

1987 • 36 citations

Transfection with plasmid pSV2gptEJ induces chromosome rearrangements in CHEF cells.

1987 • 36 citations

Hormonal regulation of de novo pyrimidine synthesis and utilization in human breast cancer cells in tissue culture.

1983 • 35 citations

Transferrin receptor is inversely correlated with estrogen receptor in breast cancer

1986 • 35 citations

Oncogenes with potential nuclear function: myc, myb and fos.

1986 • 34 citations

Relationship between the expression of estrogen-regulated genes and estrogen-stimulated proliferation of MCF-7 mammary tumor cells.

1985 • 32 citations

Breast Cancer: Origins, Detection, and Treatment

1986 • 30 citations

Estrogen conjugates and serum factors mediating the estrogenic trophic effect on MCF-7 cell growth.

1987 • 30 citations

Do antiestrogens and antiprogestins act as hormone antagonists or receptor-targeted drugs in breast cancer?

1987 • 29 citations

Isolation and characterization of an estrogen-inhibited variant derived from the MCF-7 breast cancer cell line.

1984 • 29 citations

Estrogen inhibition of a Mr 39,000 glycoprotein secreted by human breast cancer cells.

1987 • 28 citations

Primary culture of mouse mammary tumor epithelial cells embedded in collagen gels

1980 • 27 citations

Cell culture methods for molecular and cell biology. Vol. 1, 2, 3 & 4.

1984 • 25 citations

Human brain tumor-associated urinary high molecular weight transforming growth factor: a high molecular weight form of epidermal growth factor.

1987 • 24 citations

Biochemical mechanisms of oncogene activity: proteins encoded by oncogenes. Introduction.

1986 • 24 citations

Transforming growth factor alpha: mutation of aspartic acid 47 and leucine 48 results in different biological activities.

1988 • 22 citations

Hormonal proteins and peptides, vol. 9

1981 • 22 citations

Relationship between ER-ICA and conventional steroid receptor assays in human breast cancer

1986 • 21 citations

Evaluation of an enzyme immunoassay kit for estrogen receptor measurements.

1986 • 18 citations

Development of Monoclonal Antibodies to the Human Breast Carcinoma Cell Line PMC42<xref ref-type="fn" rid="FN1">2</xref>

1986 • 17 citations

LOCAL RESPONSES OF THE ‘SEXUAL SKIN’ AND MAMMARY GLANDS OF MONKEYS TO CUTANEOUS APPLICATIONS OF ESTROGEN

1941 • 14 citations

High molecular weight forms of insulin-like growth factor II and its binding protein identified by protein immunoblotting

1988 • 13 citations

Receptor-bound estrogens and their metabolites in the nucleus of the isolated rat liver parenchymal cell.

1980 • 13 citations

Role of estrogens in the malignant progression of breast cancer: new perspectives

1986 • 12 citations

A nuclear localization signal in steroid hormone receptors?

1987 • 12 citations

Ketononestrol Aziridine, an Agonistic Estrogen Receptor Affinity Label: Study of Its Bioactivity and Estrogen Receptor Covalent Labeling*

1987 • 11 citations

Combining endocrine and chemotherapy — any true benefits?

1984 • 10 citations

Endocytosis of polypeptides and their receptors

1985 • 9 citations

Growth factors and oncogenes in breast cancer

1988 • 9 citations

Morpho-functional effects of Phenol Red on oestrogen-sensitive breast cancer cells

1987 • 9 citations

Polyoma Virus Transformation of Rat Kidney Fibroblasts Results in Loss of Requirement For Insulin and Retinoic Acid

1983 • 7 citations

Mammalian G proteins: models for ras proteins in transmembrane signalling?

1986 • 6 citations

Clinical comparison of glucose quantitation methods.

1985 • 6 citations

What role for concurrent chemohormonal therapy in breast cancer?

1987 • 5 citations

Receptor- and signal transductionrelated proto-oncogenes in breast cancer

1987 • 3 citations