Transforming Growth Factor α Production and Epidermal Growth Factor Receptor Expression in Normal and Oncogene Transformed Human Mammary Epithelial Cells

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Growth Factors and Cancer

1991 • 2,044 citations

Autocrine growth factors and cancer

1985 • 1,462 citations

Autocrine Secretion and Malignant Transformation of Cells

1980 • 1,370 citations

Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA

1984 • 973 citations

Assay for nanogram quantities of DNA in cellular homogenates

1979 • 923 citations

Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

1987 • 895 citations

EPIDERMAL-GROWTH-FACTOR RECEPTOR STATUS AS PREDICTOR OF EARLY RECURRENCE OF AND DEATH FROM BREAST CANCER

1987 • 881 citations

Production and auto-induction of transforming growth factor-α in human keratinocytes

1987 • 870 citations

Transforming growth factors: isolation of polypeptides from virally and chemically transformed cells by acid/ethanol extraction.

1980 • 461 citations

Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract.

1984 • 435 citations

Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene.

1985 • 416 citations

Amplification and Enhanced Expression of the Epidermal Growth Factor Receptor Gene in A431 Human Carcinoma Cells

1984 • 400 citations

Cellular transformation by coordinated action of three peptide growth factors from human platelets

1984 • 383 citations

Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type alpha and type beta transforming growth factors.

1983 • 381 citations

Transformation by murine and feline sarcoma viruses specifically blocks binding of epidermal growth factor to cells

1976 • 374 citations

GROWTH FACTORS AND CANCER

1985 • 352 citations

Expression in rat fibroblasts of a human transforming growth factor-α cDNA results in transformation

1986 • 346 citations

MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF

1985 • 332 citations

Characterization of estrogen responsive transforming activity in human breast cancer cell lines.

1986 • 330 citations

Epidermal Growth Factor Receptor Gene Expression in Estrogen Receptor-Positive and Negative Human Breast Cancer Cell Lines

1987 • 274 citations

Estrogen-Induced Factors of Breast Cancer Cells Partially Replace Estrogen to Promote Tumor Growth

1986 • 273 citations

Epidermal growth factor-like transforming growth factor. I. Isolation, chemical characterization, and potentiation by other transforming factors from feline sarcoma virus-transformed rat cells.

1983 • 266 citations

Presence of transforming growth factors in human breast cancer cells.

1984 • 222 citations

A position 12-activated H-ras oncogene in all HS578T mammary carcinosarcoma cells but not normal mammary cells of the same patient.

1984 • 207 citations

Activation of growth factor secretion in tumorigenic states of breast cancer induced by 17 beta-estradiol or v-Ha-ras oncogene.

1987 • 199 citations

Growth of Cells in Hormonally Defined Media

1983 • 187 citations

Synthesis, turnover, and down-regulation of epidermal growth factor receptors in human A431 epidermoid carcinoma cells and skin fibroblasts.

1982 • 185 citations

Isolation and growth of human mammary epithelial cells

1985 • 185 citations

Expression of Rat Transforming Growth Factor Alpha mRNA during Development Occurs Predominantly in the Maternal Decidua

1987 • 162 citations

Differential responsiveness of myc- and ras-transfected cells to growth factors: selective stimulation of myc-transfected cells by epidermal growth factor.

1986 • 159 citations

Augmented Mitogenic Responsiveness to Epidermal Growth Factor in Murine Fibroblasts That Overexpress pp60^c-src

1988 • 147 citations

Ligand activation of overexpressed epidermal growth factor receptors transforms NIH 3T3 mouse fibroblasts.

1988 • 139 citations

Effects of epidermal growth factor receptor concentration on tumorigenicity of A431 cells in nude mice.

1986 • 135 citations

The human c-Kirstenrasgene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231

1987 • 130 citations

Expression of Transforming Growth Factor α (TGFα) in Differentiated Rat Mammary Tumors: Estrogen Induction of TGFα Production

1987 • 124 citations

Expression of rat transforming growth factor alpha mRNA during development occurs predominantly in the maternal decidua.

1987 • 121 citations

Immunological detection and quantitation of alpha transforming growth factors in human breast carcinoma cells

1986 • 114 citations

Loss of growth responsiveness to epidermal growth factor and enhanced production of alpha‐transforming growth factors in ras‐transformed mouse mammary epithelial cells

1987 • 108 citations

ras gene alterations and enhanced levels of ras p21 expression in a spectrum of benign and malignant human mammary tissues.

1986 • 104 citations

Transformation of human mammary epithelial cells by oncogenic retroviruses.

1988 • 103 citations

Cellular responsiveness to growth factors correlates with a cell's ability to express the transformed phenotype

1983 • 100 citations

Alpha-transforming growth factor secreted by untransformed bovine anterior pituitary cells in culture. I. Purification from conditioned medium.

1986 • 88 citations

Detection of larger polypeptides structurally and functionally related to type I transforming growth factor.

1985 • 87 citations

Partial purification of transforming growth factors from human milk.

1986 • 84 citations

Human mammary epithelial cells in culture: differentiation and transformation

1988 • 77 citations

Growth of mammary epithelial cells in breast‐cancer biopsies correlates with egf binding

1987 • 49 citations

Heparin-treated, v-myc-transformed chicken heart mesenchymal cells assume a normal morphology but are hypersensitive to epidermal growth factor (EGF) and brain fibroblast growth factor (bFGF); cells transformed by the v-Ha-ras oncogene are refractory to EGF and bFGF but are hypersensitive to insulin-like growth factors.

1985 • 31 citations

Transforming growth factors: sources, properties and possible roles in normal and malignant cell growth control

1984 • 30 citations

Transforming Growth Factors Produced by Viral-Transformed and Human Tumor Cells

1984 • 15 citations

Demonstration of transforming growth factor activity in mammary epithelial tissues.

1985 • 15 citations