Early Signals in the Mitogenic Response

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

1983 • 1,657 citations

Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor

1983 • 1,550 citations

Induction of c-fos gene and protein by growth factors precedes activation of c-myc

1984 • 1,463 citations

Autocrine growth factors and cancer

1985 • 1,462 citations

Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer

1985 • 1,360 citations

Molecular cloning of gene sequences regulated by platelet-derived growth factor

1983 • 989 citations

Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

1984 • 949 citations

Dual control of cell growth by somatomedins and platelet-derived growth factor.

1979 • 926 citations

Growth factors: Mechanism of action and relation to oncogenes

1984 • 885 citations

Characterization of a gastrin releasing peptide from porcine non-antral gastric tissue

1979 • 871 citations

Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation

1984 • 785 citations

Animal Cell Cycle

1978 • 723 citations

Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts

1983 • 721 citations

C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity.

1984 • 715 citations

The Action of Oncogenes in the Cytoplasm and Nucleus

1985 • 708 citations

Induction of DNA synthesis in BALB/c 3T3 cells by serum components: Reevaluation of the commitment process

1977 • 695 citations

Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

1984 • 656 citations

The platelet-derived growth factor

1978 • 649 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

Viral oncogenes

1985 • 605 citations

Functional role for c-myc in mitogenic response to platelet-derived growth factor

1984 • 578 citations

A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH.

1984 • 544 citations

Viral and cellular fos proteins: A comparative analysis

1984 • 523 citations

Inositol trisphosphate formation and calcium mobilization in Swiss 3T3 cells in response to platelet-derived growth factor

1984 • 520 citations

Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors

1979 • 517 citations

Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells.

1983 • 470 citations

A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells

1985 • 456 citations

Phorbol ester and diacylglycerol mimic growth factors in raising cytoplasmic pH

1984 • 447 citations

Expression of the c- fos Gene and of an fos -Related Gene Is Stimulated by Platelet-Derived Growth Factor

1984 • 445 citations

Specific receptors for platelet-derived growth factor on cells derived from connective tissue and glia.

1981 • 427 citations

A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains

1986 • 418 citations

Growth factors immediately raise cytoplasmic free Ca2+ in human fibroblasts.

1984 • 394 citations

Molecular aspects of cellular regulation

1980 • 394 citations

POLYPEPTIDE GROWTH FACTORS

1984 • 381 citations

Phorbol esters, phospholipase C, and growth factors rapidly stimulate the phosphorylation of a Mr 80,000 protein in intact quiescent 3T3 cells.

1983 • 377 citations

Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins

1982 • 366 citations

Platelet-derived growth factor. II. Specific binding to cultured cells.

1982 • 366 citations

Growth factor action and intracellular pH regulation in fibroblasts. Evidence for a major role of the Na+/H+ antiport.

1984 • 354 citations

Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor

1983 • 352 citations

Phorbol esters and vasopressin stimulate DNA synthesis by a common mechanism

1980 • 334 citations

c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF

1985 • 331 citations

Serum rapidly stimulates ouabain-sensitive 86-RB+ influx in quiescent 3T3 cells.

1975 • 329 citations

Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms

1986 • 325 citations

Serum stimulates the Na+,K+ pump in quiescent fibroblasts by increasing Na+ entry.

1978 • 319 citations

Epidermal growth factor (EGF) and somatomedin C regulate G1 progression in competent BALB/c-3T3 cells

1982 • 318 citations

Blockade of the Na+/H+ antiport abolishes growth factor-induced DNA synthesis in fibroblasts. Structure-activity relationships in the amiloride series.

1984 • 305 citations

Platelet-derived growth factor stimulates tyrosine-specific protein kinase activity in Swiss mouse 3T3 cell membranes.

1982 • 293 citations

Nuclear Localization and DNA Binding Properties of a Protein Expressed by Human c- myc Oncogene

1984 • 288 citations

Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity.

1985 • 284 citations

Na+/H+ antiport in Swiss 3T3 cells: mitogenic stimulation leads to cytoplasmic alkalinization.

1982 • 282 citations

Transforming protein of simian sarcoma virus stimulates autocrine growth of SSV-transformed cells through PDGF cell-surface receptors

1984 • 277 citations

Protein kinase C-stimulated phosphorylation in vitro of a Mr 80,000 protein phosphorylated in response to phorbol esters and growth factors in intact fibroblasts. Distinction from protein kinase C and prominence in brain.

1986 • 277 citations

Diacylglycerol stimulates DNA synthesis and cell division in mouse 3T3 cells: role of Ca2+-sensitive phospholipid-dependent protein kinase.

1984 • 266 citations

The molecular biology of platelet-derived growth factor

1983 • 252 citations

Nuclear location of the putative transforming protein of avian myelocytomatosis virus

1982 • 245 citations

Possible involvement of protein kinase C and calcium ion in growth factor-induced expression of c-myc oncogene in Swiss 3T3 fibroblasts.

1986 • 241 citations

Identification of nuclear proteins encoded by viral and cellular myc oncogenes

1983 • 235 citations

Production of platelet-derived growth factor-like molecules and reduced expression of platelet-derived growth factor receptors accompany transformation by a wide spectrum of agents.

1984 • 233 citations

Platelet-derived growth factor

1985 • 226 citations

Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. I. Activation of protein kinase C and inhibition of epidermal growth factor binding.

1986 • 225 citations

Neuromedin C: A bombesin-like peptide identified in porcine spinal cord

1984 • 223 citations

Vasopressin stimulation of mouse 3T3 cell growth.

1979 • 210 citations

Platelet-derived growth factor receptors form a high affinity state in membrane preparations. Kinetics and affinity cross-linking studies.

1984 • 207 citations

Stimulation of DNA synthesis by tumour promoter and pure mitogenic factors

1978 • 207 citations

Inhibition of epidermal growth factor binding to surface receptors by tumor promotors

1979 • 206 citations

High-affinity receptors for peptides of the bombesin family in Swiss 3T3 cells.

1985 • 202 citations

Reduction of epidermal growth factor receptor affinity by heterologous ligands: Evidence for a mechanism involving the breakdown of phosphoinositides and the activation of protein kinase C

1984 • 197 citations

Platelet-derived growth factor elicits cyclic AMP accumulation in swiss 3T3 cells: Role of prostaglandin production

1983 • 189 citations

Chemical and biological properties of a growth factor from human‐cultured osteosarcoma cells: Resemblance with platelet‐derived growth factor

1980 • 188 citations

Platelet-dependent stimulation of prostacyclin synthesis by platelet-derived growth factor

1980 • 185 citations

Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange.

1984 • 185 citations

Tumor-promoting phorbol diesters mediate phosphorylation of the epidermal growth factor receptor.

1984 • 180 citations

Serum, platelet-derived growth factor, vasopressin and phorbol esters increase intracellular pH in Swiss 3T3 cells

1983 • 170 citations

Interactions between the receptors for platelet-derived growth factor and epidermal growth factor.

1983 • 168 citations

Binding of phorbol esters to high‐affinity sites on murine fibroblastic cells elicits a mitogenic response

1982 • 167 citations

Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. II. Changes in Na+ and Ca2+ fluxes, Na+/K+ pump activity, and intracellular pH.

1986 • 164 citations

Platelet-derived growth factor. Specific binding to target cells.

1982 • 163 citations

A glioma-derived analog to platelet-derived growth factor: demonstration of receptor competing activity and immunological crossreactivity.

1984 • 160 citations

Homologous and heterologous mitogenic desensitization of Swiss 3T3 cells to phorbol esters and vasopressin: Role of receptor and postreceptor steps

1984 • 154 citations

Mechanism of tumor promoter inhibition of cellular binding of epidermal growth factor

1979 • 154 citations

Cyclic AMP: a mitogenic signal for Swiss 3T3 cells.

1981 • 150 citations

Characterization of platelet-derived growth factor-stimulated phosphorylation in cell membranes.

1983 • 147 citations

Phosphorylation of an acidic mol. wt. 80 000 cellular protein in a cell-free system and intact Swiss 3T3 cells: a specific marker of protein kinase C activity.

1986 • 147 citations

Bombesin-like peptides in rat brain: Quantitation and biochemical characterization

1979 • 145 citations

Platelet-derived growth factor stimulates Na+/H+ exchange and induces cytoplasmic alkalinization in NR6 cells.

1983 • 145 citations

Simian Sarcoma Virus—Transformed Cells Secrete a Mitogen Identical to Platelet-Derived Growth Factor

1984 • 137 citations

Platelet-derived growth factor. III. Identification of a platelet-derived growth factor receptor by affinity labeling.

1982 • 137 citations

Regulatory Peptides in the Mammalian Respiratory Tract*

1982 • 131 citations

Vasopressin inhibition of epidermal growth factor binding to cultured mouse cells.

1981 • 130 citations

Platelet-derived growth factor treatment decreases the affinity of the epidermal growth factor receptors of Swiss 3T3 cells.

1983 • 129 citations

Stimulation of Na influx, Na-K pump activity and DNA synthesis in quiescent cultured cells

1981 • 126 citations

Phorbol esters rapidly stimulate amiloride-sensitive Na+/H+ exchange in a human leukemic cell line.

1984 • 121 citations

A transient rise in cytosolic calcium follows stimulation of quiescent cells with growth factors and is inhibitable with phorbol myristate acetate.

1985 • 121 citations

Production of PDGF‐like growth factor by breast cancer cell lines

1985 • 120 citations

Na entry and Na‐K pump activity in murine, hamster, and human cells ‐ effect of monensin, serum, platelet extract, and viral transformation

1980 • 119 citations

Extracellular Na+ and initiation of DNA synthesis: role of intracellular pH and K+.

1984 • 117 citations

Stimulation of DNA Synthesis in Quiescent Cultured Cells: Exogenous Agents, Internal Signals, and Early Events

1980 • 113 citations

Stimulation of Na+H+ antiport activity by epidermal growth factor and insulin occurs without activation of protein kinase C

1985 • 112 citations

Serum, like phorbol esters, rapidly activates protein kinase C in intact quiescent fibroblasts.

1985 • 110 citations

Antitubulin agents enhance the stimulation of DNA synthesis by polypeptide growth factors in 3T3 mouse fibroblasts.

1979 • 108 citations

Phorbol ester stimulation of Na influx and Na-K pump activity in swiss 3T3 cells

1981 • 106 citations

Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654.

1985 • 101 citations

An 18,000 molecular weight polypeptide induces early events and stimulates DNA synthesis in cultured cells.

1976 • 93 citations

Lithium transport by fibroblastic mouse cells: Characterization and stimulation by serum and growth factors in quiescent cultures

1978 • 93 citations

Bradykinin and angiotensin II activation of arachidonic acid deacylation and prostaglandin E2 formation in rabbit kidney. Hormone-sensitive versus hormone-insensitive lipid pools of arachidonic acid.

1981 • 92 citations

Intracellular K+ and the mitogenic response of 3T3 cells to peptide factors in serum-free medium.

1982 • 92 citations

Role of stimulation of arachidonic acid release in the proliferative response of 3T3 mouse fibroblasts to platelet‐derived growth factor

1982 • 91 citations

Ionic responses rapidly elicited by activation of protein kinase C in quiescent Swiss 3T3 cells.

1985 • 91 citations

Inhibition of epidermal growth factor binding to mouse cultured cells by fibroblast-derived growth factor. Evidence for an indirect mechanism.

1982 • 90 citations

Similarities between fibroblast-derived growth factor and platelet-derived growth factor

1981 • 90 citations

Stimulation of DNA synthesis by transient exposure of cell cultures to TPA or polypeptide mitogens: Induction of competence or incomplete removal?

1981 • 86 citations

Serum rapidly stimulates ouabainsensitive ^86Rb^+ influx in quiescent 3T3 cells

1975 • 83 citations

Synergistic stimulation of DNA synthesis by cyclic AMP derivatives and growth factors in mouse 3T3 cells

1982 • 78 citations

Adenosine receptor activation in quiescent Swiss 3T3 cells

1982 • 71 citations

Mitogenic effect of prostaglandin E₁ in Swiss 3T3 cells: Role of cyclic AMP

1983 • 70 citations

Modulation of the epidermal growth factor receptor by mitogenic ligands: effects of bombesin and role of protein kinase C.

1985 • 69 citations

Efflux of ⁴⁵CA²⁺ from human fibroblasts in response to serum or growth factors

1983 • 67 citations

Inhibition of epidermal growth factor binding to mouse embryonal carcinoma cells by phorbol esters mediated by specific phorbol ester receptors.

1981 • 65 citations

Vasopressin induces selective desensitization of its mitogenic response in Swiss 3T3 cells.

1983 • 56 citations

Serum rapidly mobilizes calcium from an intracellular pool in quiescent fibroblastic cells

1983 • 54 citations

Diacylglycerol treatment rapidly decreases the affinity of the epidermal growth factor receptors of Swiss 3T3 cells

1985 • 49 citations

Ionic responses rapidly elicited by porcine platelet-derived growth factor in Swiss 3T3 cells.

1984 • 46 citations

Stimulation of DNA synthesis in murine fibroblasts by the tumour promoter teleocidin: Relationship to phorbol esters and vasopressin

1982 • 46 citations

A substance P antagonist also inhibits specific binding and mitogenic effects of vasopressin and bombesin-related peptides in Swiss 3T3 cells

1986 • 43 citations

Molecular aspects of growth factor action: Receptors and intracellular signals

1983 • 41 citations

Phorbol esters and diacylglycerol inhibit vasopressin-induced increases in cytoplasmic-free Ca2+ and 45Ca2+ efflux in Swiss 3T3 cells

1986 • 39 citations

Enhancement of DNA synthesis by colchicine in 3T3 mouse fibroblasts stimulated with growth factors

1980 • 38 citations

Cell cycle-dependent changes in arachidonic acid and glycerol metabolism in Swiss 3T3 cells stimulated by platelet-derived growth factor.

1985 • 37 citations

Interplay of cyclic AMP and microtubules in modulating the initiation of DNA synthesis in 3T3 cells.

1983 • 32 citations

Cyclic AMP: a growth-promoting signal for mouse 3T3 cells.

1981 • 31 citations

Vasopressin rapidly stimulates Ca2+ efflux from intracellular pool in quiescent Swiss 3T3 cells

1984 • 30 citations

Highly purified fibroblast-derived growth factor, an SV40-transformed fibroblast-secreted mitogen, is closely related to platelet-derived growth factor.

1985 • 30 citations

Signalling Mitogenesis in 3T3 Cells: Role of Ca ²⁺ ‐Sensitive, Phospholipid‐Dependent Protein Kinase

1985 • 16 citations

Ciba Foundation Symposium 114 ‐ Fibrosis

1985 • 9 citations

Proteins in and out of membranes

1975 • 1 citations