cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

A simple and very efficient method for generating cDNA libraries

1983 • 4,606 citations

Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs

1984 • 3,334 citations

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

1983 • 1,657 citations

Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor

1983 • 1,550 citations

New Human Tumor Cell Lines

1975 • 974 citations

Human Tumor Cells in Vitro

1975 • 753 citations

How signal sequences maintain cleavage specificity

1984 • 725 citations

A significant part of macrophage-derived growth factor consists of at least two forms of PDGF

1985 • 719 citations

A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA

1985 • 668 citations

Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells

1982 • 507 citations

Specific receptors for platelet-derived growth factor on cells derived from connective tissue and glia.

1981 • 427 citations

A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains

1986 • 418 citations

Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity

1986 • 380 citations

The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor.

1984 • 376 citations

Human platelet-derived growth factor. Purification and resolution into two active protein fractions.

1981 • 353 citations

Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor

1983 • 352 citations

Two established in vitro cell lines from human mesenchymal tumours

1967 • 331 citations

Coexpression of the sis and myc proto-oncogenes in developing human placenta suggests autocrine control of trophoblast growth

1985 • 328 citations

Cultivation in vitro of cells derived from a human rhabdomyosarcoma

1969 • 324 citations

Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis

1985 • 286 citations

Transforming protein of simian sarcoma virus stimulates autocrine growth of SSV-transformed cells through PDGF cell-surface receptors

1984 • 277 citations

Platelet-derived growth factor: Identification of constituent polypeptide chains

1982 • 275 citations

Purification and properties of porcine platelet-derived growth factor.

1984 • 260 citations

Expression of a Platelet-Derived Growth Factor-Like Protein in Simian Sarcoma Virus Transformed Cells

1983 • 246 citations

Coexpression of a PDGF-like growth factor and PDGF receptors in a human osteosarcoma cell line: Implications for autocrine receptor activation

1984 • 238 citations

Production of platelet-derived growth factor-like molecules and reduced expression of platelet-derived growth factor receptors accompany transformation by a wide spectrum of agents.

1984 • 233 citations

Arterial smooth muscle cells in primary culture produce a platelet-derived growth factor-like protein.

1985 • 231 citations

Platelet-derived growth factor

1985 • 226 citations

Antibodies against platelet-derived growth factor inhibit acute transformation by simian sarcoma virus

1985 • 205 citations

Human-Proto-Oncogene Nucleotide Sequences Corresponding to the Transforming Region of Simian Sarcoma Virus

1984 • 203 citations

Specific covalent binding of platelet-derived growth factor to human plasma alpha 2-macroglobulin.

1984 • 186 citations

Chromosomal mapping of the simian sarcoma virus onc gene analogue in human cells.

1982 • 181 citations

Platelet-derived growth factor. Specific binding to target cells.

1982 • 163 citations

Blockade of autocrine stimulation in simian sarcoma virus-transformed cells reverses down-regulation of platelet-derived growth factor receptors.

1984 • 163 citations

A glioma-derived analog to platelet-derived growth factor: demonstration of receptor competing activity and immunological crossreactivity.

1984 • 160 citations

Interleukin 2 (IL2) is assigned to human chromosome 4

1984 • 143 citations

The v-sis/PDGF-2 transforming gene product localizes to cell membranes but is not a secretory protein.

1985 • 143 citations

Growth factors adherent to cell substrate are mitogenically active in situ

1982 • 141 citations

Simian Sarcoma Virus—Transformed Cells Secrete a Mitogen Identical to Platelet-Derived Growth Factor

1984 • 137 citations

Detection of c- sis Transcripts and Synthesis of PDGF-Like Proteins by Human Osteosarcoma Cells

1984 • 134 citations

Synthesis and secretion of proteins resembling platelet-derived growth factor by human glioblastoma and fibrosarcoma cells in culture.

1985 • 125 citations

Production of PDGF‐like growth factor by breast cancer cell lines

1985 • 120 citations

Synthesis of a PDGF-like growth factor in human glioma and sarcoma cells suggests the expression of the cellular homologue to the transforming protein of simian sarcoma virus

1983 • 116 citations

Demonstration of an antibody against platelet-derived growth factor

1981 • 97 citations

Growth factor‐induced proliferation of human fibroblasts in serum‐free culture depends on cell density and extracellular calcium concentration

1984 • 95 citations

Platelet-derived growth factor agonist activity of a secreted form of the v-sis oncogene product.

1985 • 72 citations

In vitro mutagenesis of the v-sis transforming gene defines functional domains of its growth factor-related product.

1985 • 54 citations

Construction and Evaluation of an Instrument for the Automated Synthesis of Oligodeoxyribonucleotides

1984 • 39 citations

Coronavirus 229E susceptibility in man-mouse hybrids is located on human chromosome 15

1982 • 24 citations

Human neoplastic cells in tissue culture: two established cell lines derived from giant cell tumor and fibrosarcoma.

1976 • 20 citations