The receptor for insulin-like growth factor II mediates an insulin-like response.

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Human Hepatocellular Carcinoma Cell Lines Secrete the Major Plasma Proteins and Hepatitis B Surface Antigen

1980 • 2,034 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Actions of Insulin-Like Growth Factors

1985 • 1,141 citations

The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor.

1982 • 709 citations

The Nature and Regulation of the Receptors for Insulin-Like Growth Factors

1985 • 639 citations

The Molecular Mechanism of Insulin Action

1985 • 424 citations

Monoclonal antibodies to receptors for insulin and somatomedin-C.

1983 • 423 citations

Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor.

1983 • 395 citations

Direct demonstration that receptor crosslinking or aggregation is important in insulin action

1978 • 388 citations

Direct Demonstration of Separate Receptors for Growth and Metabolic Activities of Insulin and Multiplication-stimulating Activity (an Insulinlike Growth Factor) Using Antibodies to the Insulin Receptor

1980 • 346 citations

Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts.

1986 • 269 citations

Antibodies to Purified Insulin Receptor Have Insulin-Like Activity

1978 • 222 citations

Growth-Stimulatory Actions of Insulinin Vitroandin Vivo*

1984 • 222 citations

Acute insulin action requires insulin receptor kinase activity: introduction of an inhibitory monoclonal antibody into mammalian cells blocks the rapid effects of insulin.

1987 • 221 citations

Insulin as a Potent, Specific Growth Factor in a Rat Hepatoma Cell Line

1981 • 221 citations

The Type II Insulin-Like Growth Factor (IGF) Receptor Has Low Affinity for IGF-I Analogs: Pleiotypic Actions of IGFs on Myoblasts Are Apparently Mediated by the Type I Receptor*

1987 • 204 citations

Ontogenesis of somatomedin and insulin receptors in the human fetus.

1983 • 197 citations

Distinct biologically active receptors for insulin, insulin-like growth factor I, and insulin-like growth factor II in cultured skeletal muscle cells.

1985 • 187 citations

Two types of receptor for insulin-like growth factors in mammalian brain.

1985 • 163 citations

Evidence from Monoclonal Antibody Studies that Insulin Stimulates Deoxyribonucleic Acid Synthesis through the Type I Somatomedin Receptor*

1985 • 160 citations

Preferential enhancement of myoblast differentiation by insulin‐like growth factors (IGF I and IGF II) in primary cultures of chicken embryonic cells

1983 • 159 citations

The high affinity insulin receptor mediates growth stimulation in rat hepatoma cells.

1982 • 152 citations

The type II insulin-like growth factor receptor does not mediate increased DNA synthesis in H-35 hepatoma cells.

1984 • 145 citations

Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action.

1982 • 122 citations

Characterization of insulin-like growth factor I-stimulated tyrosine kinase activity associated with the beta-subunit of type I insulin-like growth factor receptors of rat liver cells.

1985 • 119 citations

The type I insulin-like growth factor receptor mediates the rapid effects of multiplication-stimulating activity on membrane transport systems in rat soleus muscle.

1984 • 104 citations

Modulation of binding and bioactivity of insulin by anti-insulin antibody: relation to possible role of receptor self-aggregation in hormone action.

1979 • 99 citations

Effect of an anti-insulin-like growth factor I receptor antibody on insulin-like growth factor II stimulation of DNA synthesis in human fibroblasts

1986 • 98 citations

Insulin and insulinlike growth factor receptors and responses in cultured human muscle cells

1986 • 81 citations

Interaction of Insulin-Like Growth Factors with a Nonfusing Mouse Muscle Cell Line: Binding, Action, and Receptor Down-Regulation*

1984 • 79 citations

Purification of an insulin-like growth factor II receptor from rat chondrosarcoma cells.

1983 • 78 citations

Interaction of the Monoclonal AntibodiesαlR-1 andαIR-3 with Insulin and Somatomedin-C Receptors

1986 • 78 citations

Dual regulation of glycogen metabolism by insulin and insulin-like growth factors in human hepatoma cells (HEP-G2). Analysis with an anti-receptor monoclonal antibody.

1984 • 73 citations

Purification of the type II insulin-like growth factor receptor from rat placenta.

1983 • 71 citations

The insulin-like growth factor II receptor is phosphorylated by a tyrosine kinase in adipocyte plasma membranes.

1986 • 65 citations

Structure of the insulin-like growth factor receptor in chicken embryo fibroblasts.

1982 • 60 citations

Inhibition of intracellular proteolysis in muscle cultures by multiplication-stimulating activity. Comparison of effects of multiplication-stimulating activity and insulin on proteolysis, protein synthesis, amino acid uptake, and sugar transport.

1984 • 45 citations

Mediation of Insulin-Like Growth Factor Actions by the Insulin Receptor in H-35 Rat Hepatoma Cells*

1987 • 44 citations

INTERACTIONS OF A MONOCLONAL ANTIBODY TO THE INSULIN RECEPTOR WITH RECEPTORS FOR INSULIN-LIKE GROWTH FACTORS

1983 • 42 citations

Characterization of monoclonal antibodies to the IGF-I receptor that inhibit IGF-I binding to human cells

1985 • 41 citations

Differential Biological Activities between Mono- and Bivalent Fragments of Anti-Prolactin Receptor Antibodies

1984 • 35 citations

Induction of tyrosine aminotransferase and amino acid transport in rat hepatoma cells by insulin and the insulin-like growth factor, multiplication-stimulating activity

1980 • 28 citations

The Pathophysiology of Insulin Receptors: A Model for Peptide Hormone Action*

1980 • 5 citations