Two insulin-like growth factor I messenger RNAs are expressed in human liver.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

Rapid and Sensitive Protein Similarity Searches

1985 • 4,091 citations

Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis

1983 • 2,609 citations

Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.

1983 • 2,456 citations

Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange.

1977 • 2,408 citations

Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing

1983 • 2,298 citations

Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products

1982 • 2,114 citations

Efficient isolation of genes by using antibody probes.

1983 • 2,065 citations

Rapid similarity searches of nucleic acid and protein data banks.

1983 • 1,577 citations

The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin.

1978 • 1,530 citations

Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action.

1984 • 1,171 citations

Primary structure of human insulin‐like growth factor II

1978 • 776 citations

Insulin-like growth factor I stimulates growth in hypophysectomized rats

1982 • 605 citations

Evidence that somatomedin is synthesized by multiple tissues in the fetus

1980 • 434 citations

THE PATHWAY OF EUKARYOTIC mRNA FORMATION

1983 • 429 citations

Sequence of cDNA encoding human insulin-like growth factor I precursor

1983 • 401 citations

Induction of Immunoreactive Somatomedin C in Human Serum by Growth Hormone: Dose-Response Relationships and Effect on Chromatographic Profiles*

1980 • 356 citations

Hormonal Control of Immunoreactive Somatomedin Production by Cultured Human Fibroblasts

1981 • 323 citations

Intricate combinatorial patterns of exon splicing generate multiple regulated troponin T isoforms from a single gene

1985 • 314 citations

Purification and primary structure of a polypeptide with multiplication-stimulating activity from rat liver cell cultures. Homology with human insulin-like growth factor II.

1981 • 298 citations

1 Biological and immunological properties of insulin-like growth factors (IGF) I and II

1984 • 279 citations

Human chromosomal mapping of genes for insulin-like growth factors I and II and epidermal growth factor

1984 • 267 citations

Localization of insulin-like growth factor genes to human chromosomes 11 and 12

1984 • 180 citations

A New Method for Purifying Lambda DNA From Phage Lysates

1985 • 178 citations

Isolation of the human insulin-like growth factor I gene using a single synthetic DNA probe.

1984 • 177 citations

Characterization of the structural gene and putative 5′-regulatory sequences for human proopiomelanocortin

1982 • 164 citations

[26] A sensitive and rapid method for recombinant phage screening

1979 • 150 citations

Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression.

1985 • 140 citations

Variables controlling somatomedin production by cultured human fibroblasts

1983 • 129 citations

Measurement of Insulin-Like Growth Factor II by a Specific Radioreceptor Assay in Serum of Normal Individuals, Patients with Abnormal Growth Hormone Secretion, and Patients with Tumor-Associated Hypoglycemia*

1981 • 123 citations

Comparison of α-tropomyosin sequences from smooth and striated muscle

1985 • 114 citations

Biosynthesis of polyprotein precursors to regulatory peptides

1982 • 91 citations

Isolation and Partial Sequence Analysis of Rat Basic Somatomedin*

1982 • 87 citations

Apple II Computer Software for DNA and Protein Sequence Data

1983 • 73 citations

Somatomedin carrier proteins

1984 • 58 citations

Partial characterization of a mitogenic factor with somatomedin-like activity produced by culture WI-38 human fibroblasts

1981 • 42 citations

Extraction of Somatomedin Activity from Rat Liver*

1982 • 33 citations

Divergence of Binding Sites, in Vitro Action, and Secretory Regulation of the Somatomedin Peptides, IGF-I and IGF-II

1982 • 29 citations