Heterologous transmembrane signaling by a human insulin receptor-v-ros hybrid in Chinese hamster ovary cells.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Studies on transformation of Escherichia coli with plasmids

1983 • 11,179 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine.

1982 • 441 citations

Changes in protein phosphorylation in Rous sarcoma virus-transformed chicken embryo cells.

1981 • 440 citations

The Molecular Mechanism of Insulin Action

1985 • 424 citations

Acute insulin action requires insulin receptor kinase activity: introduction of an inhibitory monoclonal antibody into mammalian cells blocks the rapid effects of insulin.

1987 • 221 citations

Nucleotide sequence of avian sarcoma virus UR2 and comparison of its transforming gene with other members of the tyrosine protein kinase oncogene family

1985 • 167 citations

Changes in Protein Phosphorylation in Rous Sarcoma Virus-Transformed Chicken Embryo Cells

1981 • 158 citations

Insulin action is blocked by a monoclonal antibody that inhibits the insulin receptor kinase.

1986 • 142 citations

Cellular Sequences Related to Three New onc Genes of Avian Sarcoma Virus ( fps, yes , and ros ) and Their Expression in Normal and Transformed Cells

1982 • 131 citations

Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action.

1982 • 122 citations

Avian sarcoma virus UR2 encodes a transforming protein which is associated with a unique protein kinase activity

1982 • 109 citations

Proto-oncogene c-ros codes for a molecule with structural features common to those of growth factor receptors and displays tissue specific and developmentally regulated expression.

1986 • 100 citations

Mapping surface structures of the human insulin receptor with monoclonal antibodies: localization of main immunogenic regions to the receptor kinase domain

1986 • 81 citations

Some biological properties of two new avian sarcoma viruses

1981 • 61 citations

Genetic structure and transforming sequence of avian sarcoma virus UR2

1982 • 55 citations

Proto-Oncogene c-ros Codes for a Molecule with Structural Features Common to Those of Growth Factor Receptors and Displays Tissue-Specific and Developmentally Regulated Expression

1986 • 34 citations

Insulin receptors on chinese hamster ovary (CHO) cells: Altered insulin binding to glycosylation mutants

1984 • 27 citations

Linking functional domains of the human insulin receptor with the bacterial aspartate receptor.

1986 • 25 citations