Epidermal growth factor stimulates the synthesis of its own receptor in a human breast cancer cell line.

Silver staining of proteins in polyacrylamide gels

1981 • 3,565 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.

1976 • 1,293 citations

Epidermal Growth Factor and a New Derivative

1972 • 1,225 citations

Molecular cloning of gene sequences regulated by platelet-derived growth factor

1983 • 989 citations

A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles.

1982 • 788 citations

Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells

1978 • 647 citations

Functional role for c-myc in mitogenic response to platelet-derived growth factor

1984 • 578 citations

Expression of the c- fos Gene and of an fos -Related Gene Is Stimulated by Platelet-Derived Growth Factor

1984 • 445 citations

Human epidermal growth factor and the proliferation of human fibroblasts

1976 • 403 citations

Amplification and Enhanced Expression of the Epidermal Growth Factor Receptor Gene in A431 Human Carcinoma Cells

1984 • 400 citations

Regulation of epidermal growth factor receptor by estrogen.

1985 • 379 citations

MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF

1985 • 332 citations

Molecular mechanism of mitogen action: Processing of receptor induced by epidermal growth factor

1978 • 271 citations

Stimulation and inhibition of growth by EGF in different A431 cell clones is accompanied by the rapid induction of c-fos and c-myc proto-oncogenes.

1985 • 257 citations

Transforming growth factor-β controls receptor levels for epidermal growth factor in NRK fibroblasts

1984 • 232 citations

Epidermal growth factor and thyrotropin-releasing hormone act similarly on a clonal pituitary cell strain. Modulation of hormone production and inhibition of cell proliferation

1980 • 226 citations

Epidermal growth factor rapidly stimulates prolactin gene transcription

1982 • 208 citations

Reduction of epidermal growth factor receptor affinity by heterologous ligands: Evidence for a mechanism involving the breakdown of phosphoinositides and the activation of protein kinase C

1984 • 197 citations

Epidermal growth factor and expression of specific genes: effects on cultured rat pituitary cells are dissociable from the mitogenic response.

1980 • 191 citations

Synthesis, turnover, and down-regulation of epidermal growth factor receptors in human A431 epidermoid carcinoma cells and skin fibroblasts.

1982 • 185 citations

Control of a Cell Surface Major Glycoprotein by Epidermal Growth Factor

1977 • 136 citations

Biphasic effects of type beta transforming growth factor on epidermal growth factor receptors in NRK fibroblasts. Functional consequences for epidermal growth factor-stimulated mitosis.

1985 • 132 citations

Vasopressin inhibition of epidermal growth factor binding to cultured mouse cells.

1981 • 130 citations

EPIDERMAL GROWTH FACTOR STIMULATES SECRETION OF HUMAN CHORIONIC GONADOTROPIN BY CULTURED HUMAN CHORIOCARCINOMA CELLS

1978 • 126 citations

EGF receptor affinity is regulated by intracellular calcium and protein kinase C

1985 • 114 citations

Internalization and processing of the EGF receptor in the induction of DNA synthesis in cultured fibroblasts: The endocytic activation hypothesis

1979 • 100 citations

Characterization of the metabolic turnover of epidermal growth factor receptor protein in A‐431 cells

1984 • 94 citations

Inhibition of epidermal growth factor binding to mouse cultured cells by fibroblast-derived growth factor. Evidence for an indirect mechanism.

1982 • 90 citations

Regulation of epidermal growth factor receptor levels by thyroid hormone.

1984 • 79 citations

Genetic analysis of hyperproduction of epidermal growth factor receptors in human epidermoid carcinoma A431 cells

1984 • 77 citations

Aspects of the Metabolism of the Epidermal Growth Factor Receptor in A431 Human Epidermoid Carcinoma Cells

1984 • 62 citations

Diacylglycerol treatment rapidly decreases the affinity of the epidermal growth factor receptors of Swiss 3T3 cells

1985 • 49 citations

Inability of anti-epidermal growth factor receptor monoclonal antibody to block “autocrine” growth stimulation in transforming growth factor-secreting melanoma cells.

1984 • 44 citations

Vitamin K3 (menadione) and related quinones, like tumor-promoting phorbol esters, alter the affinity of epidermal growth factor for its membrane receptors.

1980 • 44 citations

Action of epidermal growth factor and retinoids on anchorage-dependent and -independent growth of nontransformed rat kidney cells.

1983 • 43 citations

Biosynthesis of the Epidermal Growth Factor Receptor in Cultured Human Cells*

1985 • 36 citations

Regulation of high- and low-affinity epidermal growth factor receptors by glucocorticoids

1984 • 33 citations

Aspects of the metabolism of the epidermal growth factor receptor in A431 human epidermoid carcinoma cells.

1984 • 33 citations