Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats.

Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.

1967 • 10,659 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Substrate-inducible Microsomal Aryl Hydroxylase in Mammalian Cell Culture

1968 • 1,691 citations

Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties.

1985 • 1,081 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

Purification, induction, and distribution of placental glutathione transferase: a new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis.

1985 • 501 citations

Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

1979 • 478 citations

Methods in Membrane Biology

1978 • 417 citations

[27] Glutathione S-transferases (rat and human)

1981 • 410 citations

Purification of P-glycoprotein from plasma membrane vesicles of Chinese hamster ovary cell mutants with reduced colchicine permeability.

1979 • 368 citations

Cellular biochemistry of the stepwise development of cancer with chemicals: G. H. A. Clowes memorial lecture.

1984 • 363 citations

Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells

1984 • 340 citations

Amplification and Expression of Genes Associated with Multidrug Resistance in Mammalian Cells

1986 • 293 citations

Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line.

1986 • 253 citations

Induction of resistant hepatocytes as a new principle for a possible short-term in vivo test for carcinogens.

1980 • 243 citations

Human Dioxin-Inducible Cytochrome P ₁ -450: Complementary DNA and Amino Acid Sequence

1985 • 233 citations

Changes in molecular forms of rat hepatic glutathione S-transferase during chemical hepatocarcinogenesis.

1984 • 222 citations

Cloning and the nucleotide sequence of rat glutathione S-transferase P cDNA

1985 • 215 citations

The resistance of putative premalignant liver cell populations, hyperplastic nodules, to the acute cytotoxic effects of some hepatocarcinogens.

1976 • 188 citations

Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.

1985 • 176 citations

Alteration of plasma membrane glycopeptides and gangliosides of Chinese hamster cells accompanying development of resistance to daunorubicin and vincristine.

1983 • 146 citations

A methotrexate-resistant human breast cancer cell line with multiple defects, including diminished formation of methotrexate polyglutamates.

1984 • 145 citations

Hepatocellular adaptation and injury. Structural and biochemical changes following dieldrin and methyl butter yellow.

1969 • 122 citations

Increased synthesis of a low molecular weight protein in vincristine-resistant cells

1981 • 121 citations

A relative deficiency of cytochrome P-450 and aryl hydrocarbon [benzo(a)pyrene] hydroxylase in hyperplastic nodules induced by 2-acetylaminofluorene in rat liver.

1976 • 118 citations

[24] Genetic differences in microsomal electron transport: The Ah Locus

1978 • 99 citations

[20] 4-Nitrophenol UDPglucuronyltransferase (rat liver)

1981 • 94 citations

Vinca alkaloid-resistant phenotype in cultured human leukemic lymphoblasts.

1983 • 91 citations

Human glutathione S-transferases. Characterization of the anionic forms from lung and placenta

1984 • 90 citations

[24] Aryl sulfotransferases

1981 • 80 citations

Characterization of drug-metabolizing systems in hyperplastic nodules from the livers of rats receiving 2-acetylaminofluorene in their diet

1983 • 79 citations

Dihydrofolate reductase gene amplification and possible rearrangement in estrogen-responsive methotrexate-resistant human breast cancer cells.

1982 • 75 citations

Development of resistance to cytotoxicity during aflatoxin carcinogenesis

1977 • 68 citations

Overexpression and Amplification of Five Genes in a Multidrug-Resistant Chinese Hamster Ovary Cell Line

1986 • 68 citations

Glutathione peroxidase, glutathione S-transferase and glutathione reductase activities in normal and neoplastic human breast tissue

1985 • 66 citations

Increased uridine diphosphate-glucuronyltransferase activity in preneoplastic liver nodules and Morris hepatomas.

1982 • 65 citations

In vitro measurement of carcinogen‐resistant liver cells during hepatocarcinogenesis

1978 • 56 citations

The activity of the peroxide-metabolizing system in human colon carcinoma

1980 • 46 citations

Cytochrome P-450 in hyperplastic liver nodules during hepatocarcinogenesis with N-2-fluorenylacetamide in rats.

1976 • 40 citations

Irreversible binding of etoposide (VP-16-213) to deoxyribonucleic acid and proteins

1984 • 35 citations

Microsomal interactions and inhibition of lipid peroxidation by etoposide (VP-16, 213): Implications for mode of action

1985 • 35 citations

Sulfotransferase and deacetylase in normal and tumor-bearing liver of CD rats: autoradiographical studies with N-hydroxy-2-acetylamino-fluorene and N-hydroxy-4-acetylaminobiphenyl in vitro andin vivo

1982 • 19 citations

Biotransformations of daunorubicin aglycones by rat liver microsomes.

1984 • 16 citations

Phenobarbital stimulation of cytochrome P-450 and aminopyrine N-demethylase in hyperplastic liver nodules during LD-ethionine carcinogenesis

1978 • 16 citations