A 22-kd protein (sorcin/V19) encoded by an amplified gene in multidrug-resistant cells, is homologous to the calcium-binding light chain of calpain.

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

A rapid alkaline extraction procedure for screening recombinant plasmid DNA

1979 • 15,511 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

[2] New M13 vectors for cloning

1983 • 5,402 citations

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1978 • 4,566 citations

Rapid and Sensitive Protein Similarity Searches

1985 • 4,091 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids

1977 • 3,019 citations

3′ Non-coding region sequences in eukaryotic messenger RNA

1976 • 3,001 citations

Phosphorylation-Dephosphorylation of Enzymes

1979 • 2,205 citations

Transcription termination and 3′ processing: the end is in site!

1985 • 1,482 citations

Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

1983 • 1,001 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

1970 • 752 citations

Active outward transport of daunomycin in resistant ehrlich ascites tumor cells

1973 • 729 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1982 • 667 citations

Human Multidrug-Resistant Cell Lines: Increased mdr 1 Expression Can Precede Gene Amplification

1986 • 604 citations

Point mutations close to the AUG initiator codon affect the efficiency of translation of rat preproinsulin in vivo

1984 • 520 citations

Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

1979 • 478 citations

Detection of P-glycoprotein in ovarian cancer: a molecular marker associated with multidrug resistance.

1985 • 410 citations

Genetic and biochemical characterization of multidrug resistance

1985 • 405 citations

Reversal of Adriamycin Resistance by Verapamil in Human Ovarian Cancer

1984 • 398 citations

Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells

1984 • 340 citations

Evolutionary origin of a calcium-dependent protease by fusion of genes for a thiol protease and a calcium-binding protein?

1984 • 337 citations

Structure of vitamin D-dependent calcium-binding protein from bovine intestine

1981 • 309 citations

Sequence determinants of cytosolic N-terminal protein processing

1986 • 304 citations

Amplification and Expression of Genes Associated with Multidrug Resistance in Mammalian Cells

1986 • 293 citations

Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line.

1986 • 253 citations

Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells.

1986 • 226 citations

Multidrug (pleiotropic) resistance in doxorubicin-selected variants of the human sarcoma cell line MES-SA.

1985 • 210 citations

Daunorubicin-resistant Chinese hamster ovary cells expressing multidrug resistance and a cell-surface P-glycoprotein.

1983 • 201 citations

DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression.

1982 • 201 citations

Multidrug-resistance phenotype in Chinese hamster ovary cells.

1983 • 194 citations

Chicken calmodulin genes. A species comparison of cDNA sequences and isolation of a genomic clone.

1983 • 187 citations

Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by tamoxifen and other triparanol analogues.

1984 • 182 citations

Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.

1985 • 176 citations

Transport and binding of daunorubicin, adriamycin, and rubidazone in ehrlich ascites tumour cells

1977 • 169 citations

A phosphoglycoprotein associated with taxol resistance in J774.2 cells.

1985 • 158 citations

The structure of the B subunit of calcineurin

1984 • 156 citations

Anthracycline resistance in P388 murine leukemia and its circumvention by calcium antagonists.

1985 • 149 citations

Alteration of plasma membrane glycopeptides and gangliosides of Chinese hamster cells accompanying development of resistance to daunorubicin and vincristine.

1983 • 146 citations

Enhancement of vincristine- and adriamycin-induced cytotoxicity by verapamil in P388 leukemia and its sublines resistant to vincristine and adriamycin

1982 • 132 citations

Increased synthesis of a low molecular weight protein in vincristine-resistant cells

1981 • 121 citations

Synthetic peptides corresponding to the site phosphorylated in 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as substrates of cyclic nucleotide-dependent protein kinases.

1986 • 116 citations

Reversal of acquired resistance to vinca alkaloids and anthracycline antibiotics.

1983 • 116 citations

Drug resistance in Chinese hamster lung and mouse tumor cells.

1983 • 105 citations

Gene amplification-associated cytogenetic aberrations and protein changes in vincristine-resistant Chinese hamster, mouse, and human cells.

1985 • 100 citations

Markedly altered membrane transport and intracellular binding of vincristine in multidrug‐resistant Chinese hamster cells selected for resistance to vinca alkaloids

1986 • 94 citations

Vinca alkaloid-resistant phenotype in cultured human leukemic lymphoblasts.

1983 • 91 citations

A putative Ca2+-binding protein: structure of the light subunit of porcine calpain elucidated by molecular cloning and protein sequence analysis.

1985 • 91 citations

Restoration of doxorubicin responsiveness in doxorubicin-resistant P388 murine leukaemia cells

1984 • 86 citations

Alterations in cell surface membranes in chinese hamster lung cells resistant to adriamycin

1982 • 84 citations

Stabilization of the long central helix of troponin C by intrahelical salt bridges between charged amino acid side chains.

1985 • 80 citations

Active efflux common to vincristine and daunorubicin in vincristine-resistant P388 leukemia

1981 • 77 citations

Differential Effects of Polyadenylation Regions on Gene Expression in Mammalian Cells

1986 • 75 citations

Primary sequence analysis and folding behavior of EF hands in relation to the mechanism of action of troponin C and calmodulin

1983 • 75 citations

Mode of action of calcium antagonists which alter anthracycline resistance

1984 • 69 citations

Overexpression and Amplification of Five Genes in a Multidrug-Resistant Chinese Hamster Ovary Cell Line

1986 • 68 citations

Plasma membrane proteins and glycoproteins from chinese hamster cells sensitive and resistant to actinomycin D

1978 • 66 citations

Nucleotide sequence of a cDNA coding for the small subunit of human calcium-dependent protease.

1986 • 63 citations

Cellular pharmacology of vinca alkaloid resistance and its circumvention

1984 • 61 citations

Identification of a novel calcium‐binding protein (CP₂₂) in multidrug‐resistant murine and hamster cells

1986 • 53 citations

Co-amplification of double minute chromosomes, multiple drug resistance, and cell surface P-glycoprotein in DNA-mediated transformants of mouse cells.

1984 • 52 citations

Calcium Channel Blocker Enhancement of Anticancer Drug Cytotoxicity—A Review

1984 • 49 citations

DNA-Mediated Transfer of Multiple Drug Resistance and Plasma Membrane Glycoprotein Expression

1982 • 48 citations

Potentiation of antitumor agents by calcium channel blockers with special reference to cross-resistance patterns

1985 • 45 citations

Multidrug resistance

1984 • 42 citations

Pleiotropic drug resistance and gene amplification in a SEWA mouse tumor cell line

1985 • 37 citations

Enhancement of doxorubicin and vinblastine sensitivity in anthracycline-resistant P388 cells.

1983 • 27 citations

Cure of mice bearing P388 leukemia by vincristine in combination with a calcium channel blocker.

1985 • 23 citations

Gene amplification in Djungarian hamster cell lines possessing decreased plasma membrane permeability for colchicine and some other drugs

1985 • 23 citations

Co-Amplification of Double Minute Chromosomes, Multiple Drug Resistance, and Cell Surface P-Glycoprotein in DNA-Mediated Transformants of Mouse Cells

1984 • 21 citations

Interactions between calcium antagonists, calcium fluxes and anthracycline transport

1984 • 19 citations

Regular pattern of karyotypic alterations accompanying gene amplification in Djungarian hamster cells: study of colchicine, adriablastin, and methotrexate resistance

1985 • 16 citations

Gene amplification in multidrug‐resistant cells: Molecular and karyotypic events

1985 • 9 citations

Hyperproduction of a specific protein in cells resistant to colchicine and adriablastin

1983 • 6 citations

Cited By (0)

No citing papers found in database