Mitochondrial toxins in models of neurodegenerative diseases. I: in vivo brain hydroxyl radical production during sytemic MPTP treatment or following microdialysis infusion of methylpyridinium or azide ions

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Mitochondrial Complex I Deficiency in Parkinson's Disease

1990 • 2,147 citations

MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE

1989 • 1,717 citations

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

1985 • 1,253 citations

Abnormalities of the electron transport chain in idiopathic parkinson's disease

1989 • 1,067 citations

Anatomic and Disease Specificity of NADH CoQ₁ Reductase (Complex I) Deficiency in Parkinson's Disease

1990 • 676 citations

Origin and functional consequences of the complex I defect in Parkinson's disease

1996 • 629 citations

Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity.

1996 • 626 citations

Cytochrome oxidase deficiency in Alzheimer's disease

1990 • 581 citations

Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists

1991 • 554 citations

Brain Cytochrome Oxidase in Alzheimer's Disease

1992 • 526 citations

Effect of Peroxynitrite on the Mitochondrial Respiratory Chain: Differential Susceptibility of Neurones and Astrocytes in Primary Culture

1995 • 493 citations

Electron transport chain defects in Alzheimer's disease brain

1994 • 483 citations

Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

1992 • 457 citations

Low platelet mitochondrial complex I and complex II/III activity in early untreated parkinson's disease

1995 • 430 citations

Inhibition of neuronal nitric oxide synthase prevents MPTP–induced parkinsonism in baboons

1996 • 422 citations

Inhibition of Neuronal Nitric Oxide Synthase by 7‐Nitroindazole Protects Against MPTP‐Induced Neurotoxicity in Mice

1995 • 416 citations

Nitric Oxide‐Mediated Inhibition of the Mitochondrial Respiratory Chain in Cultured Astrocytes

1994 • 407 citations

Expression of heme oxygenase‐1 in the senescent and alzheimer‐diseased brain

1995 • 352 citations

Platelet mitochondria function in Parkinson's disease

1992 • 350 citations

Mitochondrial oxidative phosphorylation defects in parkinson's disease

1991 • 334 citations

1-Methyl-4-phenylpyridinium (MPP+) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles

1990 • 323 citations

MPTP mechanisms of neurotoxicity and their implications for Parkinson's disease

1991 • 302 citations

IV. MPTP, MPP+ and mitochondrial function

1987 • 249 citations

Respiratory chain abnormalities in skeletal muscle from patients with Parkinson's disease

1991 • 224 citations

Reduced platelet cytochrome c oxidase activity in Alzheimer's disease

1994 • 199 citations

Energy-driven uptake of N-methyl-4-phenylpyridine by brain mitochondria mediates the neurotoxicity of MPTP

1986 • 179 citations

Role of mitochondria in the etiology and pathogenesis of Parkinson's disease

1995 • 172 citations

Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium

1993 • 171 citations

Selective retention of MPP+ within the monoaminergic systems of the primate brain following MPTP administration: An in vivo autoradiographic study

1991 • 171 citations

Altered Calcium Homeostasis in Cells Transformed by Mitochondria from Individuals with Parkinson's Disease

1997 • 151 citations

Prevention of the Nigrostriatal Toxicity of 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine by Inhibitors of 3,4‐Dihydroxyphenylethylamine Transport

1986 • 135 citations

Mitochondria1 respiratory chain activity in skeletal muscle from patients with Parkinson's disease

1993 • 127 citations

In vivo trapping of hydroxyl free radicals in the striatum utilizing intracranial microdialysis perfusion of salicylate: effects of MPTP, MPDP+, and MPP+

1992 • 106 citations

Blockade of 1-methyl-4-phenylpyridinium ion (MPP+) nigral toxicity in the rat by prior decortication or MK-801 treatment: A stereological estimate of neuronal loss

1993 • 103 citations

Dopamine transporter mutants selectively enhance MPP⁺ transport

1993 • 100 citations

Functional Alterations in Alzheimerʼs Disease

1993 • 88 citations

Inhibition of mitochondrial respiration by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mouse brain in vivo

1988 • 87 citations

Impaired oxidative decarboxylation of pyruvate in fibroblasts from patients with Parkinson's disease

1994 • 83 citations

Cytochrome Oxidase Inhibition: A Novel Animal Model of Alzheimer's Disease

1992 • 74 citations

The non-competitive NMDA-receptor antagonist MK-801 prevents the massive release of glutamate and aspartate from rat striatum induced by 1-methyl-4-phenylpyridinium (MPP+)

1990 • 74 citations

Generation of reactive oxygen species during the monoamine oxidase-catalyzed oxidation of the neurotoxicant, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1993 • 70 citations

Do NMDA receptor antagonists protect against MPTP-toxicity? Biochemical and immunocytochemical analyses in black mice

1992 • 68 citations

Spin Trapping of Azidyl and Hydroxyl Radicals in Azide-Inhibited Rat Brain Submitochondrial Particles

1994 • 64 citations

Reduction of MPP+-induced hydroxyl radical formation and nigrostriatal MPTP toxicity by inhibiting nitric oxide synthase

1994 • 62 citations

Synergy between chronic corticosterone and sodium azide treatments in producing a spatial learning deficit and inhibiting cytochrome oxidase activity.

1996 • 53 citations

Partial protective effect of MK-801 on MPTP-induced reduction of striatal dopamine in mice

1992 • 44 citations