Nitric Oxide Synthase Inhibition and Cerebrovascular Regulation

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Localization of nitric oxide synthase indicating a neural role for nitric oxide

1990 • 2,996 citations

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1992 • 2,725 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

1989 • 1,850 citations

Handbook of Physiology—The Cardiovascular System

1985 • 1,128 citations

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1993 • 1,024 citations

Nitric Oxide: First in a New Class of Neurotransmitters

1992 • 1,001 citations

Measurement of nitric oxide in biological models

1993 • 925 citations

Cerebral Blood Flow and Metabolism

1994 • 779 citations

The 1991 Ulf von Euler Lecture:The <scp>l</scp>‐arginine: nitric oxide pathway

1992 • 654 citations

The NO hypothesis: possible effects of a short-lived, rapidly diffusible signal in the development and function of the nervous system.

1990 • 653 citations

Nitric Oxide Measured by a Porphyrinic Micro Sensor in Rat Brain after Transient Middle Cerebral Artery Occlusion

1993 • 632 citations

Synthesis of nitric oxide in CNS glial cells

1993 • 627 citations

NG-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists.

1993 • 521 citations

Mammalian Nitric Oxide Synthases

1992 • 514 citations

Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse

1991 • 509 citations

Regulation of the cerebral microcirculation during neural activity: is nitric oxide the missing link?

1993 • 474 citations

The double-edged role of nitric oxide in brain function and superoxide-mediated injury.

1991 • 471 citations

Identification of arginine as a precursor of endothelium-derived relaxing factor.

1988 • 407 citations

Possible Origins and Distribution of Immunoreactive Nitric Oxide Synthase-Containing Nerve Fibers in Cerebral Arteries

1993 • 382 citations

Nitric oxide synthase: Irreversible inhibition by L-N -Nitroarginine in brain and

1991 • 368 citations

Nitric oxide mediates vasodilatation in response to activation of N-methyl-D-aspartate receptors in brain.

1993 • 339 citations

Nitric oxide production during focal cerebral ischemia in rats.

1993 • 272 citations

Autoregulation of Cerebral Blood Flow

1997 • 268 citations

Brain Extracellular pH: The Main Factor Controlling Cerebral Blood Flow

1968 • 263 citations

Does nitric oxide mediate the increases in cerebral blood flow elicited by hypercapnia?

1992 • 260 citations

Regional distribution of EDRF/NO-synthesizing enzyme(s) in rat brain

1990 • 252 citations

Inhibition of Nitric Oxide Synthesis Increases Focal Ischemic Infarction in Rat

1992 • 239 citations

The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemia

1992 • 237 citations

Pressure-induced myogenic activation of cat cerebral arteries is dependent on intact endothelium.

1987 • 229 citations

Role of nitric oxide in the coupling of cerebral blood flow to neuronal activation in rats

1993 • 223 citations

Stimulation of the nucleus basalis of Meynert increases acetylcholine release in the cerebral cortex in rats

1989 • 208 citations

Nitric Oxide Donors Increase Blood Flow and Reduce Brain Damage in Focal Ischemia: Evidence That Nitric Oxide is Beneficial in the Early Stages of Cerebral Ischemia

1994 • 206 citations

Role of endothelium-derived relaxing factor in cerebral circulation: large arteries vs. microcirculation

1991 • 199 citations

Nitric oxide synthase-containing neural processes on large cerebral arteries and cerebral microvessels

1993 • 196 citations

Endothelial cells metabolize NG -monomethyl-L-arginine to L-citrulline and subsequently to L-arginine

1990 • 185 citations

Possible role of nitric oxide in transmitting information from vasodilator nerve to cerebroarterial muscle

1990 • 180 citations

The non specificity of specific nitric oxide synthase inhibitors

1992 • 176 citations

Endothelium-dependent contraction to stretch in canine basilar arteries

1987 • 175 citations

Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell <scp>l</scp>‐arginine transporter

1992 • 172 citations

Inhibition of nitric oxide synthesis induces a significant reduction in local cerebral blood flow in the rat

1991 • 169 citations

Nitric Oxide Synthesis and Regional Cerebral Blood Flow Responses to Hypercapnia and Hypoxia in the Rat

1993 • 153 citations

Nitric oxide synthesis couples cerebral blood flow and metabolism

1992 • 152 citations

Role of nitric oxide in neurally induced cerebroarterial relaxation.

1991 • 151 citations

Nitroprusside improves blood flow and reduces brain damage after focal ischemia

1993 • 145 citations

Blockade of nitric oxide formation by mitigates ischemic brain edema and subsequent cerebral infarction in rats

1992 • 142 citations

Effects of Endothelium-Derived Nitric Oxide on Cerebral Circulation during Normoxia and Hypoxia in the Rat

1992 • 140 citations

Role of adenosine in regulation of cerebral blood flow: effects of theophylline during normoxia and hypoxia

1987 • 139 citations

Neuroprotective effects of NG-nitro-L-arginine in focal stroke in the 7-day old rat

1992 • 133 citations

Electrical stimulation of cerebellar fastigial nucleus increases cerebral cortical blood flow without change in local metabolism: Evidence for an intrinsic system in brain for primary vasodilation

1983 • 130 citations

Effect of NO synthase inhibition on NMDA- and ischaemia-induced hippocampal lesions

1992 • 129 citations

Effects of NG‐nitro‐L‐arginine and L‐arginine on regional cerebral blood flow in the cat.

1992 • 126 citations

Spontaneous Flow Oscillations in the Cerebral Cortex during Acute Changes in Mean Arterial Pressure

1992 • 126 citations

Role of Nitric Oxide in the Regulation of Cerebral Blood Flow

1996 • 123 citations

Evidence that L-arginine possesses proconvulsant effects mediated through nitric oxide

1991 • 122 citations

Cerebral vasodilation during hypercapnia. Role of glibenclamide-sensitive potassium channels and nitric oxide.

1994 • 122 citations

Endothelium-dependent L-Arg- and L-NMMA-sensitive mechanisms regulate tone of brain microvessels

1990 • 121 citations

<scp>l</scp>‐Arginine dilates rat pial arterioles by nitric oxide‐dependent mechanisms and increases blood flow during focal cerebral ischaemia

1992 • 120 citations

Inhibition of nitric oxide synthesis does not reduce infarct volume in a rat model of focal cerebral ischaemia

1992 • 119 citations

Independent blockade of cerebral vasodilation from acetylcholine and nitric oxide

1988 • 119 citations

Nitric oxide-dependent and -independent components of cerebrovasodilation elicited by hypercapnia

1994 • 116 citations

H2O2 and endothelium-dependent cerebral arteriolar dilation. Implications for the identity of endothelium-derived relaxing factor generated by acetylcholine.

1990 • 113 citations

The effect of nitric oxide synthase inhibition on infarct volume after reversible focal cerebral ischemia in conscious rats.

1993 • 112 citations

Importance of Nitric Oxide Synthase Inhibition to the Attenuated Vascular Responses Induced by Topical L-Nitroarginine during Vibrissal Stimulation

1994 • 110 citations

Cerebral blood flow and metabolism

1994 • 107 citations

Nitric oxide (NO) is involved in increased cerebral cortical blood flow following stimulation of the nucleus basalis of Meynert in anesthetized rats

1992 • 102 citations

Competitive inhibition of nitric oxide synthase prevents the cortical hyperemia associated with peripheral nerve stimulation.

1992 • 100 citations

Nitric Oxide Mediates the Neurogenic Vasodilation of Bovine Cerebral Arteries

1991 • 88 citations

Endothelium-Dependent Responses of Cerebral Arterioles to Adenosine 5&amp;rsquo;-Diphosphate

1992 • 87 citations

Rhythmic contractions of isolated small arteries from rat: influence of the endothelium

1993 • 85 citations

Vasomotion of basilar arteries in vivo

1990 • 82 citations

Inhibition of Nitric Oxide Synthesis: Effects on Cerebral Blood Flow and Glucose Utilisation in the Rat

1993 • 82 citations

enhances neuronal death following transient forebrain ischemia in gerbils

1992 • 81 citations

Regulation of the cerebral circulation by endothelium

1992 • 79 citations

Role of nitric oxide synthase-containing vascular nerves in cerebrovasodilation elicited from cerebellum

1993 • 78 citations

Pharmacology of cerebral ischemia

1992 • 78 citations

Inhibition of nitric oxide synthesis impairs autoregulation of local cerebral blood flow in the rat

1993 • 77 citations

Low Dose L-NAME Reduces Infarct Volume in the Rat MCAO/Reperfusion Model

1993 • 76 citations

Hypercapnia and stimulation of the substantia innominata increase rat frontal cortical blood flow by different cholinergic mechanisms

1991 • 75 citations

Major Role of Nitric Oxide in the Mediation of Regional CO2 Responsiveness of the Cerebral and Spinal Cord Vessels of the Cat

1994 • 74 citations

Nitric Oxidergic Neurogenic Vasodilation in the Porcine Basilar Artery

1991 • 71 citations

Nitric oxide does not act as a mediator coupling cerebral blood flow to neural activity following somatosensory stimuli in rats

1993 • 69 citations

Endothelium-derived relaxing factor in brain blood vessels is not nitric oxide.

1992 • 69 citations

Nitric oxide synthase is critical in mediating basal forebrain regulation of cortical cerebral circulation

1992 • 68 citations

Development and Remodeling of Cerebral Blood Vessels and Their Flow in Postnatal Mice Observed with in vivo Videomicroscopy

1992 • 67 citations

Blockade of Nitric Oxide Synthesis in Rats Strongly Attenuates the CBF Response to Extracellular Acidosis

1993 • 67 citations

NG-monomethyl-l-arginine causes nitric oxide synthesis in isolated arterial rings: Trouble in paradise

1992 • 66 citations

EPR spin-trapping study of nitric oxide formation during bilateral carotid occlusion in the rat

1993 • 66 citations

Inhibition of Nitric Oxide Synthase Attenuates the Cerebral Blood Flow Response to Stimulation of Postganglionic Parasympathetic Nerves in the Rat

1993 • 66 citations

Indomethacin Abolishes Cerebral Blood Flow Increase in Response to Acetazolamide-Induced Extracellular Acidosis: A Mechanism for its Effect on Hypercapnia?

1993 • 65 citations

Is autoregulation of cerebral blood flow in rats influenced by nitro‐<scp>l</scp>‐arginine, a blocker of the synthesis of nitric oxide?

1992 • 65 citations

Halothane Vasodilation and Nitric Oxide in Rat Pial Vessels

1993 • 63 citations

Nitric oxide participates in the cerebrovasodilation elicited from cerebellar fastigial nucleus

1992 • 63 citations

Examination of the role of nitric oxide for the hypercapnic rise of cerebral blood flow in rats

1994 • 62 citations

Flow-induced relaxation of the rabbit middle cerebral artery is composed of both endothelium-dependent and -independent components.

1993 • 61 citations

Effects of Nitric Oxide Synthase Inhibition on Cerebral Blood Flow following Bilateral Carotid Artery Occlusion and Recirculation in the Rat

1993 • 59 citations

Cerebrovascular NADPH diaphorase-containing nerve fibers in the rat

1993 • 59 citations

Nitric Oxide Synthase Blockade Enhances Vasomotion in the Cerebral Microcirculation of Anesthetized Rats

1993 • 55 citations

N??-Nitro-L-Arginine Methyl Ester Prevents Cerebral Hyperemia by Inhaled Anesthetics in Dogs

1993 • 54 citations

A brief hypoperfusion precedes spreading depression if nitric oxide synthesis is inhibited

1993 • 52 citations

Nitric oxide contributes to dilatation of cerebral arterioles during seizures

1993 • 52 citations

NOS neurones lie near branchings of cortical arteriolae

1993 • 52 citations

Effects in cats of inhibition of nitric oxide synthesis on cerebral vasodilation and endothelium-derived relaxing factor from acetylcholine.

1992 • 47 citations

Role of local neurons in cerebrocortical vasodilation elicited from cerebellum

1987 • 47 citations

Mono-L-arginine-containing compounds dilate piglet pial arterioles via an endothelium-derived relaxing factor-like substance.

1990 • 45 citations

Nitro-L-arginine attenuates hypercapnic cerebrovasodilation without affecting cerebral metabolism

1994 • 44 citations

Hypoxia, alpha 2-adrenergic, and nitric oxide-dependent interactions on canine cerebral blood flow

1994 • 41 citations

Nitric Oxide and Prostanoids Contribute to Isoflurane-induced Cerebral Hyperemia in Pigs

1994 • 41 citations

N omega-nitro-L-arginine influences cerebral metabolism in awake sheep

1992 • 31 citations

Methylene blue inhibits hypoxic cerebral vasodilation in awake sheep

1992 • 27 citations

Nitric oxide synthase inhibition attenuates hypoglycemic cerebral hyperemia in piglets

1994 • 25 citations

Interaction of non-arginine compounds with the endothelium-derived relaxing factor inhibitor, NG-monomethyl L-arginine.

1992 • 24 citations

Effects of methylene blue on hypoxic cerebral vasodilatation in the rabbit.

1990 • 24 citations

Monkey cerebral arterial relaxation caused by hypercapnic acidosis and hypertonic bicarbonate

1993 • 22 citations

L-arginine suffusion restores response to acetylcholine in brain arterioles with damaged endothelium

1992 • 16 citations

Therapeutic Potential of L-Arginine, a Precursor of Nitric Oxide, in Focal Cerebral Ischemia

1994 • 9 citations

NITRIC OXIDE SYNTHASE INHIBITORS DECREASE CEREBRAL BLOOD FLOW BUT DO NOT AFFECT PRESSURE AUTOREGULATION IN RATS

1992 • 5 citations