A mitochondrial bottleneck hypothesis of Alzheimer's disease

Sequence and organization of the human mitochondrial genome

1981 • 9,348 citations

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid

1992 • 1,453 citations

Uber eine eigenartige Erkrankung der Hirnrinde

1907 • 1,332 citations

DISEASES OF THE MITOCHONDRIAL DNA

1992 • 1,294 citations

Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?

1992 • 1,268 citations

Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

1991 • 1,191 citations

A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease

1991 • 1,121 citations

Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14

1992 • 941 citations

Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms.

1981 • 760 citations

Do defecs in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?

1993 • 583 citations

Mitochondrial DNA sequence variation in human evolution and disease.

1994 • 526 citations

Apolipoprotein E ε4 allele is associated with deposition of amyloid β-protein following head injury

1995 • 488 citations

Electron transport chain defects in Alzheimer's disease brain

1994 • 483 citations

Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14

1992 • 458 citations

Mitochondrial DNA Variants Observed in Alzheimer Disease and Parkinson Disease Patients

1993 • 449 citations

Expression of β amyloid protein precursor mRNAs: Recognition of a novel alternatively spliced form and quantitation in alzheimer's disease using PCR

1990 • 426 citations

Relationship of Lung Function to Severity of Osteoporosis in Women

1990 • 401 citations

Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24.3

1992 • 332 citations

Behavioral and anatomical deficits in mice homozygous for a modified ?-amyloid precursor protein gene

1994 • 307 citations

Localization of Amyloid β Protein Messenger RNA in Brains from Patients with Alzheimer's Disease

1987 • 297 citations

Role of the β‐amyloid protein in Alzheimer's disease

1995 • 258 citations

Brain dysfunction in mild to moderate hypoxia

1981 • 252 citations

Apolipoprotein E and alzheimer's disease: Ethnic variation in genotypic risks

1995 • 247 citations

Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells.

1992 • 215 citations

Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex

1991 • 206 citations

Reduced platelet cytochrome c oxidase activity in Alzheimer's disease

1994 • 199 citations

Mitochondrial function in brain tissue in primary degenerative dementia

1987 • 177 citations

The role of oxidative abnormalities in the pathophysiology of Alzheimer's disease.

1991 • 159 citations

Optic atrophy in Leber hereditary optic neuroretinopathy is probably determined by an X-chromosomal gene closely linked to DXS7.

1991 • 123 citations

Altered metabolic properties of cultured skin fibroblasts in Alzheimer's disease

1987 • 121 citations

Abnormality of the α‐ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease

1994 • 99 citations

Abnormalities of Energy Metabolism in Alzheimer's Disease Studied with PETa

1991 • 89 citations

An ‘anatomical cascade hypothesis’ for Alzheimer's disease

1992 • 77 citations

Cytochrome Oxidase Inhibition: A Novel Animal Model of Alzheimer's Disease

1992 • 74 citations

Widespread neuroanatomical damage and learning deficits following chronic alcohol consumption or vitamin-B1 (thiamine) deficiency in rats

1983 • 72 citations

Evidence that the APOE locus influences rate of disease progression in late onset familial Alzheimer's Disease but is not causative

1995 • 68 citations

Clinical Genetics and Genetic Counseling in Alzheimer Disease

1991 • 65 citations

Über präsenile Verblödungen

1932 • 60 citations

Mitochondria and Leber's Hereditary Optic Neuropathy

1990 • 60 citations

Molecular genetics of Alzheimer disease amyloid.

1991 • 56 citations

Regionally selective alterations in enzymatic activities and metabolic fluxes during thiamin deficiency

1989 • 34 citations

Genetic heterogeneity of gene defects responsible for familial Alzheimer disease

1993 • 32 citations

Neurodegeneration, Alzheimer's disease, and beta-amyloid toxicity

1994 • 26 citations

Clinical genetics and genetic counseling in Alzheimer's disease

1992 • 8 citations