Apoptosis, p53, and tumor cell sensitivity to anticancer agents.

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

ACTION OF X-RAYS ON MAMMALIAN CELLS

1956 • 1,660 citations

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

1997 • 1,568 citations

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1995 • 1,500 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

An Information-Intensive Approach to the Molecular Pharmacology of Cancer

1997 • 1,177 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1998 • 906 citations

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1992 • 766 citations

EXPERIMENTAL EVALUATION OF POTENTIAL ANTICANCER AGENTS. XIII. ON THE CRITERIA AND KINETICS ASSOCIATED WITH "CURABILITY" OF EXPERIMENTAL LEUKEMIA.

1964 • 763 citations

Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

1996 • 746 citations

Mediation of c-Myc-Induced Apoptosis by p53

1994 • 741 citations

E1A signaling to p53 involves the p19^ARFtumor suppressor

1998 • 614 citations

Radiation-induced apoptosis: Relevance to radiotherapy

1995 • 504 citations

The basic science of oncology

1987 • 425 citations

How Cancer Arises

1996 • 419 citations

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development.

1994 • 406 citations

Cell-cycle arrest versus cell death in cancer therapy

1997 • 394 citations

Experimental evaluation of potential anticancer agents VIII. Effects of certain nitrosoureas on intracerebral L1210 leukemia.

1963 • 369 citations

APOPTOSIS AND DISEASE: Regulation and Clinical Relevance of Programmed Cell Death

1997 • 361 citations

Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage.

1993 • 334 citations

Cell cycle arrests and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity.

1994 • 333 citations

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.

1994 • 290 citations

Transgenic mice with p53-responsive lacZ: p53activity varies dramatically during normal development and determines radiation and drug sensitivity invivo

1997 • 270 citations

p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines.

1993 • 229 citations

atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity

1997 • 227 citations

DNA damage and p53-mediated cell cycle arrest: A reevaluation

1996 • 216 citations

Apoptosis in small intestinal epithelia from p53-null mice: evidence for a delayed, p53-indepdendent G2/M-associated cell death after γ-irradiation

1997 • 211 citations

Dual modes of death induced by etoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival.

1996 • 206 citations

Proliferation Kinetics of X-irradiated Mouse L Cells Studied with Time-lapse Photography. II

1969 • 182 citations

To pop or not to pop: p53 as a critical modulator of tumour responsiveness to therapy in vivo?

1995 • 168 citations

Cells lacking CIP1/WAF1 genes exhibit preferential sensitivity to cisplatin and nitrogen mustard

1997 • 153 citations

bcl-2 over-expression delays radiation-induced apoptosis without affecting the clonogenic survival of human prostate cancer cells

1997 • 153 citations

What is an apoptotic index measuring? A commentary

1996 • 145 citations

BCL-2 expression delays drug-induced apoptosis but does not increase clonogenic survival after drug treatment in HeLa cells.

1995 • 144 citations

p53-dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cells

1998 • 143 citations

Loss of Matrix Adhesion Triggers Rapid Transformation-Selective Apoptosis in Fibroblasts

1997 • 135 citations

Loss of p21Waf1/Cip1 sensitizes tumors to radiation by an apoptosis-independent mechanism.

1997 • 118 citations

Adenovirus-based transfer of wild-type p53 gene increases ovarian tumor radiosensitivity.

1996 • 115 citations

Cell cycle synchrony unmasks the influence of p53 function on radiosensitivity of human glioblastoma cells.

1996 • 105 citations

Explaining differences in sensitivity to killing by ionizing radiation between human lymphoid cell lines.

1998 • 101 citations

Mutations in the p53 gene in radiation-sensitive and -resistant human squamous carcinoma cells.

1992 • 98 citations

Concomitant p53 gene mutation and increased radiosensitivity in rat lung embryo epithelial cells during neoplastic development.

1994 • 96 citations

Carcinoma cell lines become sensitive to DNA-damaging agents by the expression of the adenovirus E1A gene.

1996 • 95 citations

Abrogation of p53 function by transfection of HPV16 E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation.

1995 • 94 citations

Selective sensitivity to radiation of cerebral glioblastomas harboring p53 mutations.

1998 • 93 citations

The clinical significance of p53 aberrations in human tumours

1995 • 93 citations

Systems for Identifying New Drugs Are Often Faulty

1997 • 90 citations

Direct evidence that apoptosis enhances tumor responses to fractionated radiotherapy.

1998 • 87 citations

Mutant p53 increases radioresistance in rat embryo fibroblasts simultaneously transfected with HPV16-E7 and/or activated H-ras.

1994 • 83 citations

Prognostic value of P53 gene mutations in a large series of node-negative breast cancer patients.

1998 • 81 citations

p53 modulation of anchorage independent growth and experimental metastasis.

1996 • 80 citations

Relationship between p53 status and radiosensitivity in human tumour cell lines

1996 • 77 citations

Human papillomavirus E6 and E7 oncoproteins alter cell cycle progression but not radiosensitivity of carcinoma cells treated with low-dose-rate radiation

1997 • 73 citations

Increasing the susceptibility of the rat 208F fibroblast cell line to radiation-induced apoptosis does not alter its clonogenic survival dose-response

1995 • 68 citations

p53 mutations associated with increased sensitivity to ionizing radiation in human head and neck cancer cell lines

1996 • 66 citations

Apoptosis in tumorigenesis and cancer therapy

1997 • 64 citations

Tumour cure rate and cell survival of a transplantable rat Rhabdomyosarcoma following X-irradiation

1968 • 62 citations

Abrogation of P53 function by transfection of HPV16 E6 gene does not enhance resistance of human tumour cells to ionizing radiation

1996 • 58 citations

Relationship between radiation response and p53 status in human bladder cancer cells

1997 • 55 citations

p53 status affects the rate of the onset but not the overall extent of doxorubicin-induced cell death in rat-1 fibroblasts constitutively expressing c-Myc.

1997 • 54 citations

Apoptosis induced by X-irradiation of rec-myc cells is postmitotic and not predicted by the time after irradiation or behavior of sister cells.

1996 • 53 citations

p53 deficiency sensitizes clonogenic cells to irradiation in the large but not the small intestine.

1997 • 50 citations

Transfection of Rat Embryo Cells with Mutant p53 Increases the Intrinsic Radiation Resistance

1994 • 50 citations

Cure, regression and cell survival: a comparison of common radiobiological endpoints using an in vitro tumour model

1975 • 50 citations

Radiation-induced apoptosis: effects of cell age and dose fractionation.

1995 • 47 citations

NCI's anticancer drug screening program may not be selecting for clinically active compounds.

1997 • 46 citations

Radiation induced G1-block and p53 status in six human cell lines

1995 • 46 citations

Radioresistant MTp53-expressing rat embryo cell transformants exhibit increased DNA-dsb rejoining during exposure to ionizing radiation

1998 • 45 citations

Overexpression of p53 Protein Does Not Predict Local-Regional Control or Survival in Patients With Early-Stage Squamous Cell Carcinoma of the Glottic Larynx Treated With Radiotherapy

1998 • 45 citations

Cytogenetic damage and the radiation-induced G1-phase checkpoint.

1996 • 45 citations

Characterization of radiation-induced apoptosis in rodent cell lines.

1997 • 39 citations

P53 deficiency produces fewer regenerating spermatogenic tubules after irradiation

1996 • 34 citations

The Prognostic Significance of P53 Expression for Survival and Local Control in Rectal Carcinoma Treated with Surgery and Postoperative Radiotherapy

1998 • 31 citations

Transfected mutant p53 gene increases X‐ray‐induced cell killing and mutation in human fibroblasts immortalized with 4‐nitroquinoline 1‐oxide but does not induce neoplastic transformation of the cells

1995 • 27 citations

Lack of a correlation between p53 protein expression and radiation response in human tumor primary cultures

1995 • 23 citations

Effect of p53 overexpression on radiation sensitivity of human colon cancer cells

1997 • 19 citations

Anin Vitro¹²⁵IUdR-release Assay for Measuring the Kinetics of Cell Death

1991 • 13 citations