Effect of p53 overexpression on radiation sensitivity of human colon cancer cells

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Cell Cycle Control and Cancer

1994 • 2,575 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

1991 • 1,301 citations

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

1995 • 865 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

A p53-Dependent Mouse Spindle Checkpoint

1995 • 668 citations

Variations in Several Responses of HeLa Cells to X-Irradiation during the Division Cycle

1963 • 592 citations

Cyclic X-Ray Responses in Mammalian Cellsin Vitro¹

2012 • 505 citations

p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.

1994 • 410 citations

Cyclic X-Ray Responses in Mammalian Cells in Vitro

1968 • 403 citations

Mean Inactivation Dose: A Useful Concept for Intercomparison of Human Cell Survival Curves

2012 • 361 citations

Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage.

1993 • 334 citations

Mean Inactivation Dose: A Useful Concept for Intercomparison of Human Cell Survival Curves

1984 • 294 citations

Identification of a sister gene to P-glycoprotein.

1995 • 236 citations

p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines.

1993 • 229 citations

Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein.

1991 • 142 citations

Cell cycle synchrony unmasks the influence of p53 function on radiosensitivity of human glioblastoma cells.

1996 • 105 citations

Mutations in the p53 gene in radiation-sensitive and -resistant human squamous carcinoma cells.

1992 • 98 citations

Use of wild‐type p53 to achieve complete treatment sensitization of tumor cells expressing endogenous mutant p53

1995 • 97 citations

Abrogation of p53 function by transfection of HPV16 E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation.

1995 • 94 citations

p53 mutations associated with increased sensitivity to ionizing radiation in human head and neck cancer cell lines

1996 • 66 citations

Abrogation of P53 function by transfection of HPV16 E6 gene does not enhance resistance of human tumour cells to ionizing radiation

1996 • 58 citations

Thermal denaturation of DNA for immunochemical staining of incorporated bromodeoxyuridine (BrdUrd): Critical factors that affect the amount of fluorescence and the shape of BrdUrd/DNA histogram

1989 • 54 citations

Expression of wild-type p53 stimulates an increase in both Bax and Bcl-xL protein content in HT29 cells.

1996 • 48 citations

The potential superiority of bromodeoxyuridine to iododeoxyuridine as a radiation sensitizer in the treatment of colorectal cancer.

1992 • 47 citations

Sensitivities of NIH/3T3-derived clonal cell lines to ionizing radiation: significance for gene transfer studies.

1989 • 37 citations

Bcl-2 protects murine erythroleukemia cells from p53-dependent and -independent radiation-induced cell death

1995 • 33 citations

Use of fluorescence in situ hybridization (fish) to study chromosomal damage induced by radiation and bromodeoxyuridine in human colon cancer cells

1994 • 8 citations