bcl-2 over-expression delays radiation-induced apoptosis without affecting the clonogenic survival of human prostate cancer cells

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome Translocation

1984 • 1,761 citations

Cancer statistics, 1995

1995 • 1,434 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer.

1992 • 1,063 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy

1993 • 738 citations

Detection of the apoptosis-suppressing oncoprotein bc1-2 in hormone-refractory human prostate cancers.

1993 • 597 citations

Overexpression of bcl-2 protects prostate cancer cells from apoptosis in vitro and confers resistance to androgen depletion in vivo.

1995 • 537 citations

Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene

1993 • 495 citations

bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs.

1992 • 487 citations

Cell cycle arrests and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity.

1994 • 333 citations

Basic fibroblast growth factor protects endothelial cells against radiation-induced programmed cell death in vitro and in vivo.

1994 • 333 citations

Expression of the vascular endothelial growth factor (VEGF) receptor gene, KDR, in hematopoietic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing radiation.

1995 • 311 citations

Constitutive expression of human Bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis.

1993 • 275 citations

bcl-2 protein inhibits etoposide-induced apoptosis through its effects on events subsequent to topoisomerase II-induced DNA strand breaks and their repair.

1993 • 218 citations

Expression of bcl-2 protein predicts efficacy of adjuvant treatments in operable node-positive breast cancer.

1995 • 203 citations

Cell proliferation, DNA repair, and p53 function are not required for programmed death of prostatic glandular cells induced by androgen ablation.

1993 • 201 citations

Paradoxical inhibition of solid tumor cell growth by bcl2.

1994 • 190 citations

Neoadjuvant hormonal therapy improves the therapeutic ratio in patients with bulky prostatic cancer treated with three-dimensional conformal radiation therapy

1994 • 173 citations

BCL-2 expression delays drug-induced apoptosis but does not increase clonogenic survival after drug treatment in HeLa cells.

1995 • 144 citations

Expression of bcl-2 and the progression of human and rodent prostatic cancers.

1996 • 139 citations

Suppression of Bcl-2 messenger RNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor alpha, and ceramide.

1995 • 137 citations

Development of apoptosis in irradiated murine tumors as a function of time and dose.

1993 • 117 citations

Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3.

1995 • 115 citations

Relationship between radiation-induced G1 phase arrest and p53 function in human tumor cells.

1995 • 87 citations

Development of Apoptosis in Irradiated Murine Tumors as a Function of Time and Dose

1993 • 80 citations

Combined Antitumor Effect of Suramin Plus Irradiation in Human Prostate Cancer Cells: The Role of Apoptosis

1993 • 49 citations

Radiation-induced Apoptosis: Its Role in a MADCaT (Mitosis-opoptosis-differentiation-calcium Toxicity) Scheme of Cytotoxicity Mechanisms

1992 • 48 citations

Radiation-induced apoptosis: effects of cell age and dose fractionation.

1995 • 47 citations

Induction of apoptosis in androgen‐independent human prostate cancer cells undergoing thymineless death

1994 • 38 citations

Apoptosis: therapeutic significance in the treatment of androgen-dependent and androgen-independent prostate cancer

1994 • 35 citations

Bcl-2 protects murine erythroleukemia cells from p53-dependent and -independent radiation-induced cell death

1995 • 33 citations

Radiation-induced apoptosis of Ewing's sarcoma cells: DNA fragmentation and proteolysis of poly(ADP-ribose) polymerase.

1995 • 28 citations

Partial growth suppression of human prostate cancer cells by the Krev‐1 suppressor gene

1994 • 16 citations

Repair processes in the treatment and induction of cancer with radiation

1990 • 13 citations