Radiation induced G1-block and p53 status in six human cell lines

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1994 • 1,669 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Flow cytometric measurement of total DNA content and incorporated bromodeoxyuridine.

1983 • 978 citations

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

1984 • 874 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

1993 • 799 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents.

1993 • 770 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents.

1989 • 698 citations

p53 mutations increase resistance to ionizing radiation.

1993 • 573 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

An immunochemical analysis of the human nuclear phosphoprotein p53

1992 • 533 citations

Growth regulation of a cellular tumour antigen, p53, in nontransformed cells

1984 • 524 citations

Induction of cellular p53 activity by DNA-damaging agents and growth arrest.

1993 • 440 citations

A comparison of the biological activities of wild‐type and mutant p53

1993 • 423 citations

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.

1990 • 353 citations

Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage.

1993 • 334 citations

Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines.

1993 • 309 citations

The Nude Mouse in Experimental and Clinical Research

1979 • 306 citations

Microinjection of monoclonal antibody to protein p53 inhibits serum-induced DNA synthesis in 3T3 cells.

1982 • 279 citations

Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells.

1993 • 253 citations

Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression.

1991 • 251 citations

p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines.

1993 • 229 citations

Temperature‐Gradient gel electrophoresis of nucleic acids: Analysis of conformational transitions, sequence variations, and protein‐nucleic acid interactions

1989 • 219 citations

Role of the p53 protein in cell proliferation as studied by microinjection of monoclonal antibodies.

1984 • 216 citations

The Nude mouse in experimental and clinical research

1978 • 205 citations

SV40-53K antigen: A possible role for 53K in normal cells

1981 • 187 citations

Involvement of wild-type p53 in pre-B-cell differentiation in vitro.

1991 • 168 citations

p53 interacts with p34cdc2 in mammalian cells: implications for cell cycle control and oncogenesis.

1990 • 156 citations

Oncogenes in Radioresistant, Noncancerous Skin Fibroblasts from a Cancer-Prone Family

1987 • 111 citations

Tumor Radiosensitivity Prediction by the Cytokinesis-Block Micronucleus Assay

1991 • 109 citations

Guanine nucleotide biosynthesis is regulated by the cellular p53 concentration.

1991 • 99 citations

Wild type human p53 is antiproliferative in SV40-transformed hamster cells.

1990 • 97 citations

Expression of the p53 protein during the cell cycle of human peripheral blood lymphocytes

1985 • 96 citations

Concomitant p53 gene mutation and increased radiosensitivity in rat lung embryo epithelial cells during neoplastic development.

1994 • 96 citations

Micronuclei in Human Lymphocytes Irradiated in Vitro or in Vivo

1991 • 93 citations

Effects of X-irradiation on cell-cycle progression, induction of chromosomal aberrations and cell killing in ataxia telangiectasia (AT) fibroblasts

1985 • 92 citations

Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells.

1988 • 77 citations

Radiosensitivity and Growth Parametersin Vitroof Three Human Melanoma Cell Strains

1978 • 73 citations

TRANSMISSION OF IN-VITRO RADIORESISTANCE IN A CANCER-PRONE FAMILY

1981 • 62 citations

Growth-dependent expression of human Mr 53,000 tumor antigen messenger RNA in normal and neoplastic cells.

1986 • 50 citations

Co-operation between the p53 protein tumor antigen and platelet-poor plasma in the induction of cellular DNA synthesis

1986 • 49 citations

Lymphocyte stimulation: concanavalin A induces the expression of a 53K protein

1980 • 34 citations

Cell union and protein synthesis in conjugation of Blepharisma

1976 • 31 citations

The effect of X irradiation on the progression of mouse 10T1/2 cells released from density-inhibited cultures.

1984 • 31 citations

Induction of Quiescent S-phase Cells by Irradiation and/or Hyperthermia. I. Time and Dose Dependence

1993 • 24 citations

The Effect of X Irradiation on the Progression of Mouse 10T 1/2 Cells Released from Density-Inhibited Cultures

1984 • 20 citations

Importance of Thermotolerance for Radiothermotherapy as Assessed Using Two Human Melanoma Cell Lines

1988 • 7 citations