Relationship between radiation response and p53 status in human bladder cancer cells

The American Journal of Human Genetics

1950 • 5,048 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

Identification of p53 Gene Mutations in Bladder Cancers and Urine Samples

1991 • 891 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes.

1988 • 781 citations

High levels of p53 protein in UV-irradiated normal human skin.

1993 • 689 citations

p53 mutations increase resistance to ionizing radiation.

1993 • 573 citations

An immunochemical analysis of the human nuclear phosphoprotein p53

1992 • 533 citations

p53 nuclear protein accumulation correlates with mutations in the p53 gene, tumor grade, and stage in bladder cancer.

1993 • 464 citations

Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles.

1991 • 440 citations

Rapid and quantitative preparation of cytoplasmic RNA from small numbers of cells

1988 • 406 citations

Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage.

1995 • 365 citations

Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage.

1993 • 334 citations

Cell cycle arrests and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity.

1994 • 333 citations

Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines.

1993 • 309 citations

Monoclonal antibody analysis of p53 expression in normal and transformed cells

1986 • 285 citations

The effects of storage of blood and isolated DNA on the integrity of DNA

1987 • 275 citations

Frequent association of p53 gene mutation in Invasive bladder cancer

1992 • 265 citations

p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation.

1994 • 264 citations

Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.

1994 • 231 citations

p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines.

1993 • 229 citations

The p53-dependent gamma-ray response of GADD45.

1994 • 225 citations

Recent Advances in Radiation Oncology

1995 • 130 citations

Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1.

1992 • 126 citations

Concomitant p53 gene mutation and increased radiosensitivity in rat lung embryo epithelial cells during neoplastic development.

1994 • 96 citations

Detection of p53 in primary lung tumors and nonsmall cell lung carcinoma cell lines.

1991 • 78 citations

Dosage‐dependent dominance over wild‐type p53 of a mutant p53 isolated from nasopharyngeal carcinoma ¹

1993 • 54 citations

Progression toward tumor cell phenotype is enhanced by overexpression of a mutant p53 tumor-suppressor gene isolated from nasopharyngeal carcinoma.

1993 • 54 citations

Establishment and characterization of a new human bladder cancer cell line showing features of squamous and glandular differentiation

1988 • 52 citations

Sensitivity of single-strand conformation polymorphism (SSCP) analysis in detecting p53 point mutations in tumors with mixed cell populations.

1993 • 38 citations

Wild-type mouse p53 down-regulates transcription from different virus enhancer/promoters.

1993 • 36 citations

Class I restricted CTL recognition of a soluble protein delivered by liposomes containing lipophilic polylysines

1992 • 36 citations

A radiobiological comparison of human tumor soft‐agar clonogenic assays

1986 • 31 citations

Characterization of cell lines derived from a multiply aneuploid human bladder transitional‐cell carcinoma, UCRU‐BL‐13

1989 • 30 citations

Transfected mutant p53 gene increases X‐ray‐induced cell killing and mutation in human fibroblasts immortalized with 4‐nitroquinoline 1‐oxide but does not induce neoplastic transformation of the cells

1995 • 27 citations

Simian virus 40 can overcome the antiproliferative effect of wild-type p53 in the absence of stable large T antigen-p53 binding

1991 • 25 citations

Characterization of a New Human Bladder Cancer Cell Line, Ucru-BL-28

1993 • 16 citations

Studies of X-irradiated bladder cancer cell lines showing differences in p53 status: absence of a p53-dependent cell cycle checkpoint pathway.

1996 • 6 citations