p53-dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cells

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

1995 • 1,193 citations

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

1994 • 1,165 citations

Cisplatin

1984 • 942 citations

Testicular Germ-Cell Cancer

1997 • 895 citations

Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.

1997 • 872 citations

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1994 • 671 citations

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

1996 • 654 citations

Cellular responses to cisplatin. The roles of DNA-binding proteins and DNA repair.

1994 • 646 citations

Cisplatin and DNA repair in cancer chemotherapy

1995 • 506 citations

Post-translational regulation of the 54K cellular tumor antigen in normal and transformed cells.

1981 • 491 citations

Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.

1995 • 491 citations

Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene.

1994 • 465 citations

Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

1994 • 450 citations

Activation of programmed cell death by anticancer agents: cisplatin as a model system.

1990 • 408 citations

Cell-cycle arrest versus cell death in cancer therapy

1997 • 394 citations

Association between cisplatin resistance and mutation of p53 gene and reduced bax expression in ovarian carcinoma cell systems.

1996 • 382 citations

Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53.

1983 • 313 citations

Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents.

1996 • 298 citations

Negative feedback regulation of wild-type p53 biosynthesis.

1995 • 281 citations

A comparative study of p53 gene mutations, protein accumulation, and response to cisplatin-based chemotherapy in advanced ovarian carcinoma.

1996 • 277 citations

Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos

1987 • 261 citations

Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax:Bcl-2 ratio.

1996 • 257 citations

Influence of cis-diamminedichloroplatinum(II) on DNA synthesis and cell cycle progression in excision repair proficient and deficient Chinese hamster ovary cells.

1988 • 226 citations

Microsatellite instability, apoptosis, and loss of p53 function in drug-resistant tumor cells.

1996 • 218 citations

A functionally inactive p53 protein interatocarcinoma cells is activated by either DNA damage or cellular differentiation

1996 • 209 citations

Cancer therapy and p53

1995 • 194 citations

Post-Translational Regulation of the 54K Cellular Tumor Antigen in Normal and Transformed Cells

1981 • 177 citations

p53-independent apoptosis induced by paclitaxel through an indirect mechanism

1997 • 173 citations

The role of cell cycle progression in cisplatin-induced apoptosis in Chinese hamster ovary cells.

1994 • 145 citations

The role of apoptosis in cell killing by cisplatin: a flow cytometric study

1994 • 141 citations

Translational regulation of human p53 gene expression.

1996 • 139 citations

p53 Protein alterations in human testicular cancer including pre‐invasive intratubular germ‐cell neoplasia

1991 • 133 citations

Mutant p53 protein overexpression is associated with poor outcome in patients with well or moderately differentiated ovarian carcinoma

1995 • 128 citations

Two Distinct Mechanisms Regulate the Levels of a Cellular Tumor Antigen, p53

1983 • 104 citations

The amino acid sequence of murine p53 determined from a c-DNA clone

1984 • 104 citations

Lack of correlation between cisplatin-induced apoptosis,p53 status and expression of Bcl-2 family proteins in testicular germ cell tumour cell lines

1997 • 102 citations

Cisplatin resistance in human cancers

1991 • 96 citations

The p53 and mdm‐2 genes in human testicular germ‐cell tumors

1995 • 94 citations

Identification of p53 genetic suppressor elements which confer resistance to cisplatin

1997 • 81 citations

Differential sensitivity to the induction of apoptosis by cisplatin in proliferating and quiescent immature rat thymocytes is independent of the levels of drug accumulation and DNA adduct formation.

1994 • 72 citations

DDP-induced cytotoxicity is not influenced by p53 in nine human ovarian cancer cell lines with different p53 status

1997 • 65 citations

A p53-independent pathway for induction of p21waf1cip1 and concomitant G1 arrest in UV-irradiated human skin fibroblasts.

1997 • 63 citations

p53 and translational control

1996 • 55 citations

Mutations of the p53 gene are not detectable in human testicular tumors.

1994 • 40 citations

Drug resistance: The clinical problem

1989 • 31 citations

p53 Gene Mutations in Chinese Human Testicular Seminoma

1993 • 29 citations

Characterization of protein kinase CK2 protein subunits and p53 in F9 teratocarcinoma cells in the absence and presence of cisplatin.

1994 • 1 citations