Lack of a correlation between p53 protein expression and radiation response in human tumor primary cultures

Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).

1984 • 3,268 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

p53 function and dysfunction

1992 • 1,918 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

1992 • 757 citations

Creative blocks: cell-cycle checkpoints and feedback controls

1992 • 686 citations

Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion.

1992 • 587 citations

X-ray induced DNA double strand break production and repair in mammalian cells as measured by neutral filter elution

1979 • 577 citations

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

1993 • 565 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

p53 nuclear protein accumulation correlates with mutations in the p53 gene, tumor grade, and stage in bladder cancer.

1993 • 464 citations

MDM2 gene amplification in metastatic osteosarcoma.

1993 • 340 citations

Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage.

1993 • 334 citations

An in vitro colony assay for human tumours grown in immune-suppressed mice and treated in vivo with cytotoxic agents

1978 • 296 citations

p53 as an Independent Prognostic Marker in Lymph Node-Negative Breast Cancer Patients

1993 • 243 citations

p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines.

1993 • 229 citations

Synergistic effect of the v-myc oncogene with H-ras on radioresistance.

1990 • 174 citations

Expression of mutant p53 in melanoma.

1991 • 170 citations

Mutant p53 proteins bind hsp 72/73 cellular heat shock-related proteins in SV40-transformed monkey cells.

1987 • 162 citations

The raf Oncogene Is Associated with a Radiation-Resistant Human Laryngeal Cancer

1987 • 150 citations

The role of the H-ras oncogene in radiation resistance and metastasis

1990 • 145 citations

Purification of complexes of nuclear oncogene p53 with rat and Escherichia coli heat shock proteins: in vitro dissociation of hsc70 and dnaK from murine p53 by ATP.

1988 • 106 citations

High Incidence of p53 Gene Mutation in Human Ovarian Cancer and Its Association with Nuclear Accumulation of p53 Protein and Tumor DNA Aneuploidy

1992 • 101 citations

Mutations in the p53 gene in radiation-sensitive and -resistant human squamous carcinoma cells.

1992 • 98 citations

Delayed Initiation of DNA Synthesis in Irradiated Human Diploid Cells

1968 • 90 citations

Expression of p53 protein in cutaneous melanoma

1992 • 64 citations

Radiation Response of the Cells of a Human Malignant Melanoma Xenograft. Effect of Hypoxic Cell Radiosensitizers

1981 • 57 citations

Prediction of the Radiation Sensitivity of Human Squamous Cell Carcinoma Cells Using DNA Filter Elution

1990 • 48 citations

DNA Double-strand Break Repair and Radiation Response in Human Tumour Primary Cultures

1994 • 34 citations

The effect of X irradiation on the progression of mouse 10T1/2 cells released from density-inhibited cultures.

1984 • 31 citations

The Efficiency of DNA Strand-Break Repair in Two Fibrosarcoma Tumors and in Normal Tissues of Mice Irradiated in Vivo with X Rays

1984 • 29 citations

The Effect of X Irradiation on the Progression of Mouse 10T 1/2 Cells Released from Density-Inhibited Cultures

1984 • 20 citations

P53 AND CATHEPSIN-D ARE INDEPENDENT OF ESTABLISHED PROGNOSTIC FACTORS IN BREAST-CANCER

1992 • 11 citations

RELIABILITY OF A PRIMARY CULTURE SYSTEM TO TEST CYTOTOXIC DRUG ACTIVITY IN HUMAN-MALIGNANT MELANOMA

1992 • 5 citations

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