DNA damage and p53-mediated cell cycle arrest: A reevaluation

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

1989 • 3,036 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Cell Cycle Control and Cancer

1994 • 2,575 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

1995 • 1,193 citations

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

1994 • 1,165 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

1995 • 865 citations

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit

1993 • 778 citations

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

1996 • 654 citations

p53 modulation of TFIIH–associated nucleotide excision repair activity

1995 • 555 citations

Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.

1995 • 491 citations

p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.

1994 • 410 citations

Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage.

1995 • 365 citations

Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance.

1995 • 351 citations

p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.

1994 • 347 citations

Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage.

1993 • 334 citations

Cell cycle arrests and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity.

1994 • 333 citations

Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines.

1993 • 309 citations

Evidence for a second cell cycle block at G2/M by p53.

1995 • 306 citations

p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines.

1993 • 229 citations

A C-terminal alpha-helix plus basic region motif is the major structural determinant of p53 tetramerization.

1992 • 193 citations

p53 involvement in control of G2 exit of the cell cycle: role in DNA damage-induced apoptosis.

1995 • 147 citations

Absence of Radiation-induced G1 Arrest in Two Closely Related Human Lymphoblast Cell Lines That Differ in p53 Status

1995 • 136 citations

Cell cycle synchrony unmasks the influence of p53 function on radiosensitivity of human glioblastoma cells.

1996 • 105 citations

Relationships between G1 arrest and stability of the p53 and p21Cip1/Waf1 proteins following gamma-irradiation of human lymphoma cells.

1995 • 104 citations

Relationship between radiation-induced G1 phase arrest and p53 function in human tumor cells.

1995 • 87 citations

Loss of oncogenic ras expression does not correlate with loss of tumorigenicity in human cells.

1996 • 78 citations

Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines.

1995 • 58 citations

Evidence that wild‐type TP53, and not genes on either chromosome 1 or 11, controls the tumorigenic phenotype of the human fibrosarcoma HT1080

1994 • 35 citations

The basic carboxy-terminal domain of human p53 is dispensable for both transcriptional regulation and inhibition of tumor cell growth.

1995 • 22 citations