Regulation of cardiac ion channels by catecholamines, acetylcholine and second messenger systems

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo

1952 • 2,384 citations

INTRACELLULAR CALCIUM HOMEOSTASIS

1987 • 2,183 citations

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

Primary structure of the receptor for calcium channel blockers from skeletal muscle

1987 • 1,359 citations

Multiple Calcium Channels and Neuronal Function

1987 • 1,336 citations

The heart and cardiovascular system

1986 • 1,333 citations

Pirenzepine distinguishes between different subclasses of muscarinic receptors

1980 • 1,299 citations

Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure.

1986 • 1,297 citations

Electrophysiology of the Heart.

1960 • 1,295 citations

Calcium channel modulation by neurotransmitters, enzymes and drugs

1983 • 1,267 citations

How is the level of free arachidonic acid controlled in mammalian cells?

1982 • 1,193 citations

The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

1987 • 1,186 citations

Structure and Function of Voltage-Sensitive Ion Channels

1988 • 1,171 citations

Biochemical Properties of Hormone-Sensitive Adenylate Cyclase

1980 • 1,016 citations

Intracellular phospholipases A

1980 • 989 citations

Sodium and calcium channels in bovine chromaffin cells

1982 • 983 citations

G Proteins: A Family of Signal Transducers

1986 • 975 citations

Time and calcium dependence of activation and inactivation of calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell.

1985 • 904 citations

GTP-binding proteins couple cardiac muscarinic receptors to a K channel

1985 • 868 citations

Cell membrane receptors for drugs and hormones: A multidisciplinary approach

1979 • 850 citations

Über humorale übertragbarkeit der Herznervenwirkung

1921 • 817 citations

Roles of G protein subunits in transmembrane signalling

1988 • 794 citations

Physiology of the heart

1977 • 769 citations

A novel type of cardiac calcium channel in ventricular cells

1985 • 745 citations

Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein.

1981 • 735 citations

A basis for distinguishing two types of purinergic receptor

1978 • 725 citations

RECEPTORS AND PHOSPHOINOSITIDE-GENERATED SECOND MESSENGERS

1985 • 722 citations

Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology.

1985 • 715 citations

Inward current channels activated by intracellular Ca in cultured cardiac cells

1981 • 687 citations

Studies on the Mechanism of Hormone Action

1972 • 682 citations

Beta-adrenergic receptors: biochemical mechanisms of physiological regulation

1984 • 672 citations

The binding of agonists to brain muscarinic receptors.

1978 • 656 citations

Cyclic GMP Metabolism and Involvement in Biological Regulation

1977 • 629 citations

Inactivation of Ca channels

1984 • 616 citations

Forskolin: its biological and chemical properties.

1986 • 566 citations

How does adrenaline accelerate the heart?

1979 • 563 citations

Adenyl Cyclase

1962 • 555 citations

A G Protein Directly Regulates Mammalian Cardiac Calcium Channels

1987 • 551 citations

The dependence of slow inward current in Purkinje fibres on the extracellular calcium‐concentration

1967 • 544 citations

Uncoupling of cardiac muscarinic and β-adrenergic receptors from ion channels by a guanine nucleotide analogue

1985 • 527 citations

On the mechanism of activation of muscarinic K+ channels by adenosine in isolated atrial cells: involvement of GTP-binding proteins

1986 • 510 citations

Purified ryanodine receptor from skeletal muscle sarcoplasmic reticulum is the Ca2+-permeable pore of the calcium release channel.

1987 • 503 citations

Mechanisms of calcium channel modulation by β-adrenergic agents and dihydropyridine calcium agonists

1986 • 493 citations

The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres

1968 • 488 citations

ADENYLATE CYCLASE-COUPLED BETA-ADRENERGIC RECEPTORS: Structure and Mechanisms of Activation and Desensitization

1983 • 486 citations

α1Adrenoceptor subtypes linked to different mechanisms for increasing intracellular Ca2+ in smooth muscle

1987 • 482 citations

Molecular Properties of the Muscarinic Acetylcholine Receptor

1987 • 478 citations

Inactivation of calcium channels in mammalian heart cells: joint dependence on membrane potential and intracellular calcium.

1985 • 477 citations

Über humorale Übertragbarkeit der Herznervenwirkung

1924 • 473 citations

Acetylcholine activation of single muscarinic K+ channels in isolated pacemaker cells of the mammalian heart

1983 • 471 citations

Purification of the calcium antagonist receptor of the voltage-sensitive calcium channel from skeletal muscle transverse tubules

1984 • 469 citations

CALCIUM‐INDUCED RELEASE OF CALCIUM FROM THE SARCOPLASMIC RETICULUM OF SKINNED CELLS FROM ADULT HUMAN, DOG, CAT, RABBIT, RAT, AND FROG HEARTS AND FROM FETAL AND NEW‐BORN RAT VENTRICLES*

1978 • 469 citations

Properties of the hyperpolarizing‐activated current (if) in cells isolated from the rabbit sino‐atrial node.

1986 • 468 citations

Subunit structure of dihydropyridine-sensitive calcium channels from skeletal muscle.

1987 • 468 citations

Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres

1969 • 462 citations

Elevation of Guanosine 3′,5′-Cyclic Phosphate in Rat Heart after Perfusion with Acetylcholine

1970 • 455 citations

Regulation of Calcium Release Is Gated by Calcium Current, Not Gating Charge, in Cardiac Myocytes

1989 • 451 citations

Simulated calcium current can both cause calcium loading in and trigger calcium release from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell.

1985 • 445 citations

Direct Activation of Mammalian Atrial Muscarinic Potassium Channels by GTP Regulatory Protein G _k

1987 • 441 citations

G-protein βγ-subunits activate the cardiac muscarinic K+-channel via phospholipase A2

1989 • 438 citations

Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells

1984 • 436 citations

Phosphorylation of a 22,000-dalton component of the cardiac sarcoplasmic reticulum by adenosine 3':5'-monophosphate-dependent protein kinase.

1975 • 431 citations

The surprising heart: a review of recent progress in cardiac electrophysiology.

1984 • 429 citations

Compartments of cyclic AMP and protein kinase in mammalian cardiomyocytes.

1983 • 428 citations

Localization of beta adrenergic receptors, and effects of noradrenaline and cyclic nucleotides on action potentials, ionic currents and tension in mammalian cardiac muscle

1974 • 422 citations

Injection of subunits of cyclic AMP-dependent protein kinase into cardiac myocytes modulates Ca2+ current

1982 • 421 citations

Simultaneous determination of beta-1 and beta-2-adrenergic receptors in tissues containing both receptor subtypes.

1979 • 418 citations

An enzymatic mechanism for calcium current inactivation in dialysed Helix neurones.

1986 • 409 citations

Purified dihydropyridine-binding site from skeletal muscle t-tubules is a functional calcium channel

1986 • 405 citations

Inositol 1,4,5-trisphosphate activates a channel from smooth muscle sarcoplasmic reticulum

1988 • 399 citations

The generation of electric currents in cardiac fibers by Na/Ca exchange

1979 • 399 citations

An M2 Muscarinic Receptor Subtype Coupled to Both Adenylyl Cyclase and Phosphoinositide Turnover

1987 • 398 citations

On the mechanism of ?-adrenergic regulation of the Ca channel in the guinea-pig heart

1985 • 396 citations

Voltage-activated calcium channels that must be phosphorylated to respond to membrane depolarization.

1987 • 393 citations

Regenerative Calcium Release within Muscle Cells

1970 • 393 citations

β-Adrenergic modulation of calcium channels in frog ventricular heart cells

1984 • 387 citations

(�)[125Iodo]cyanopindolol, a new ligand for ?-adrenoceptors: Identification and quantitation of subclasses of ?-adrenoceptors in guinea pig

1981 • 387 citations

Calcium channels: Molecular pharmacology, structure and regulation

1988 • 382 citations

Adenosine 3′:5′-Monophosphate-dependent Protein Kinase-catalyzed Phosphorylation Reaction and Its Relationship to Calcium Transport in Cardiac Sarcoplasmic Reticulum

1974 • 382 citations

Separation of vesicles of cardiac sarcolemma from vesicles of cardiac sarcoplasmic reticulum. Comparative biochemical analysis of component activities.

1979 • 381 citations

[3H]nitrendipine receptors in skeletal muscle.

1983 • 381 citations

Parasympathetic control of the heart

1984 • 375 citations

Binding profile of a novel cardioselective muscarine receptor antagonist, AF-DX 116, to membranes of peripheral tissues and brain in the rat

1986 • 373 citations

Fluctuations in the microsecond time range of the current through single acetylcholine receptor ion channels

1981 • 366 citations

VAGAL AND SYMPATHETIC EFFECTS ON THE PACEMAKER FIBERS IN THE SINUS VENOSUS OF THE HEART

1956 • 359 citations

The parasympathetic neuroeffector junction of the heart.

1985 • 359 citations

The Role of Cyclic-AMP-Dependent Protein Kinase in the Regulation of Glycogen Metabolism in Mammalian Skeletal Muscle

1978 • 352 citations

The effect of troponin I phosphorylation on the Ca2+-binding properties of the Ca2+-regulatory site of bovine cardiac troponin.

1982 • 351 citations

beta-Adrenergic stimulation of phospholamban phosphorylation and Ca2+-ATPase activity in guinea pig ventricles.

1983 • 348 citations

Cyclic AMP Mediates the Effects of Adrenaline on Cardiac Purkinje Fibres

1972 • 346 citations

Compartmentalization of adenosine 3':5'-monophosphate and adenosine 3':5'-monophosphate-dependent protein kinase in heart tissue.

1977 • 345 citations

Maximal Oxygen Uptake

1971 • 345 citations

A study of the ion selectivity and the kinetic properties of the calcium dependent slow inward current in mammalian cardiac muscle.

1977 • 344 citations

Voltage‐clamp investigations of membrane currents underlying pace‐maker activity in rabbit sino‐atrial node.

1980 • 340 citations

Opposite effects of cyclic GMP and cyclic AMP on Ca2+ current in single heart cells

1986 • 338 citations

Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart.

1987 • 334 citations

Early outward current in rat single ventricular cells.

1984 • 332 citations

Kinetics of smooth and skeletal muscle activation by laser pulse photolysis of caged inositol 1,4,5-trisphosphate

1987 • 331 citations

Modification by islet-activating protein of receptor-mediated regulation of cyclic AMP accumulation in isolated rat heart cells.

1981 • 326 citations

Dihydropyridine derivatives prolong the open state of Ca channels in cultured cardiac cells.

1984 • 323 citations

Multiple effects of calcium antagonists on plateau currents in cardiac Purkinje fibers.

1975 • 320 citations

Phosphoinositides and receptor mechanisms

1987 • 320 citations

The α Subunit of the GTP Binding Protein G _k Opens Atrial Potassium Channels

1987 • 317 citations

Purification and characterization of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from bovine tissues.

1982 • 317 citations

Regulation of a Heart Potassium Channel by Protein Kinase A and C

1988 • 317 citations

Cardiac muscarinic cholinergic receptors. Biochemical identification and characterization.

1978 • 314 citations

The G protein-gated atrial K+ channel is stimulated by three distinct GIα-subunits

1988 • 306 citations

Adrenaline and the plateau phase of the cardiac action potential

1969 • 306 citations

Biologic regulation through opposing influences of cyclic GMP and cyclic AMP: the Yin Yang hypothesis.

1975 • 305 citations

Ca2+ channel modulation by 8-bromocyclic AMP in cultured heart cells

1983 • 304 citations

Structural changes in glycogen phosphorylase induced by phosphorylation

1988 • 302 citations

The relation between membrane potential, membrane currents and activation of contraction in ventricular myocardial fibres

1970 • 302 citations

Arachidonic acid metabolites as intracellular modulators of the G protein-gated cardiac K+ channel

1989 • 299 citations

The Mechanism of the Action of Caffeine on Sarcoplasmic Reticulum

1968 • 298 citations

Alpha 1-adrenergic and muscarinic cholinergic stimulation of phosphoinositide hydrolysis in adult rat cardiomyocytes.

1985 • 298 citations

A unique regulatory profile and regional distribution of [3H]pirenzepine binding in the rat provide evidence for distinct M1 and M2 muscarinic receptor subtypes

1983 • 298 citations

Inward current activated during hyperpolarization in the rabbit sinoatrial node cell

1980 • 297 citations

The effect of epinephrine on adenosine 3', 5'-phosphate levels in the isolated perfused rat heart.

1965 • 297 citations

Cyclic AMP and contractile activity in heart.

1977 • 291 citations

Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization

1985 • 284 citations

On the mechanism of muscarinic inhibition of the cardiac Ca current

1986 • 283 citations

Cyclic Nucleotide-dependent Protein Kinases

1972 • 282 citations

Muscarinic Modulation of Cardiac Rate at Low Acetylcholine Concentrations

1989 • 277 citations

Message Transmission: Receptor Controlled Adenylate Cyclase System

1984 • 275 citations

The stimulatory G protein of adenylyl cyclase, Gs, also stimulates dihydropyridine-sensitive Ca2+ channels. Evidence for direct regulation independent of phosphorylation by cAMP-dependent protein kinase or stimulation by a dihydropyridine agonist.

1988 • 273 citations

Inactivation of calcium channel current in the calf cardiac Purkinje fiber. Evidence for voltage- and calcium-mediated mechanisms.

1984 • 272 citations

A metabolic control mechanism for calcium ion influx that may protect the ventricular myocardial cell

1976 • 270 citations

Effect of Forskolin on Voltage-Gated K ⁺ Channels Is Independent of Adenylate Cyclase Activation

1988 • 269 citations

Effects of adrenaline on membrane inward currents during the cardiac action potential

1969 • 267 citations

Effects of protein kinase C activators on cardiac Ca2+ channels

1988 • 264 citations

Nervous Control of Cardiovascular Function

1985 • 263 citations

Influence of Caffeine and other Methylxanthines on Mechanical Properties of Isolated Mammalian Heart Muscle: EVIDENCE FOR A DUAL MECHANISM OF ACTION

1972 • 262 citations

Characterization of single pacemaker channels in cardiac sino-atrial node cells

1986 • 262 citations

Differentiation of cardiac chronotropic and inotropic effects of ?-adrenoceptor agonists

1977 • 260 citations

Changes in membrane currents in bullfrog atrium produced by acetylcholine.

1976 • 259 citations

Inositol 1,4,5-trisphosphate induces calcium release from sarcoplasmic reticulum of skeletal muscle

1985 • 258 citations

Direct G protein gating of ion channels

1988 • 258 citations

Phosphorylation of phospholamban by calcium-activated, phospholipid-dependent protein kinase. Stimulation of cardiac sarcoplasmic reticulum calcium uptake.

1984 • 255 citations

Modulation of Ca current during the phosphorylation cycle in the guinea pig heart

1986 • 254 citations

Autonomic Regulation of a Chloride Current in Heart

1989 • 254 citations

Phosphorylation of the calcium antagonist receptor of the voltage-sensitive calcium channel by cAMP-dependent protein kinase.

1985 • 253 citations

Multiple molecular forms of cyclic nucleotide phosphodiesterase in cardiac and smooth muscle and in platelets

1986 • 249 citations

Effects of a protein phosphatase inhibitor, okadaic acid, on membrane currents of isolated guinea-pig cardiac myocytes

1988 • 249 citations

A New Generation of Phosphodiesterase Inhibitors: Multiple Molecular Forms of Phosphodiesterase and the Potential for Drug Selectivity

1985 • 248 citations

Zum Mechanismus der Membranwirkung des Acetylcholin an der Herzmuskelfaser

1958 • 247 citations

Differentiated blockade of the chronotropic effects of various adrenergic stimuli in the cat heart

1972 • 246 citations

Phorbol ester increases calcium current and simulates the effects of angiotensin II on cultured neonatal rat heart myocytes.

1988 • 245 citations

The pharmacological specificity of beta-1 and beta-2 adrenergic receptors in rat heart and lung in vitro.

1979 • 243 citations

Voltage clamp experiments on frog atrial heart muscle fibres with the sucrose gap technique

1968 • 241 citations

Stimulation of forskolin of intact S49 lymphoma cells involves the nucleotide regulatory protein of adenylate cyclase.

1982 • 240 citations

?Run-down? of the Ca current during long whole-cell recordings in guinea pig heart cells: role of phosphorylation and intracellular calcium

1988 • 239 citations

Selective activation of particulate cAMP-dependent protein kinase by isoproterenol and prostaglandin E1.

1980 • 237 citations

Guanine nucleotides modulate muscarinic receptor binding in the heart

1979 • 236 citations

Molecular Properties of Dihydropyridine-Sensitive Calcium Channels from Skeletal Muscle

1988 • 234 citations

Cellular mechanism of release of atrial natriuretic factor

1984 • 233 citations

Mechanisms for inhibition of the catalytic activity of adenylate cyclase by the guanine nucleotide-binding proteins serving as the substrate of islet-activating protein, pertussis toxin.

1986 • 233 citations

Is potassium conductance of cardiac Purkinje fibres controlled by [Ca2+]i?

1975 • 233 citations

Synaptic excitation and inhibition resulting from direct action of acetylcholine on two types of chemoreceptors on individual amphibian parasympathetic neurones

1977 • 233 citations

Inositol trisphosphate enhances calcium release in skinned cardiac and skeletal muscle

1986 • 232 citations

Structural characterization of the 1,4-dihydropyridine receptor of the voltage-dependent Ca2+ channel from rabbit skeletal muscle. Evidence for two distinct high molecular weight subunits.

1987 • 231 citations

Two types of transient outward currents in adult human atrial cells

1987 • 231 citations

Phosphorylation of troponin I and phospholamban during catecholamine stimulation of rabbit heart

1982 • 230 citations

Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: a receptor for new cardiotonic drugs.

1986 • 230 citations

Interaction between cyclic adenosine monophosphate and cyclic gunaosine monophosphate in guinea pig ventricular myocardium.

1975 • 228 citations

Single channel recordings of K+ currents in squid axons

1980 • 226 citations

The role of phosphoinositiees in signal transduction

1986 • 225 citations

Muscarinic cholinergic receptor modulation of beta-adrenergic receptor affinity for catecholamines.

1978 • 224 citations

Inward membrane currents in mammalian myocardium

1972 • 223 citations

Existence of two transient outward currents in sheep cardiac Purkinje fibers

1982 • 223 citations

Cyclic GMP-dependent protein kinase phosphorylates phospholamban in isolated sarcoplasmic reticulum from cardiac and smooth muscle

1988 • 223 citations

Quantitative resolution of beta-adrenergic receptor subtypes by selective ligand binding: application of a computerized model fitting technique.

1979 • 220 citations

The cardiac hyperpolarizing-activated current, if. origins and developments

1985 • 220 citations

Excitation-Contraction Coupling of Isolated Cardiac Fibers with Disrupted or Closed Sarcolemmas: CALCIUM-DEPENDENT CYCLIC AND TONIC CONTRACTIONS

1972 • 219 citations

Agonists differentiate muscarinic receptors that inhibit cyclic AMP formation from those that stimulate phosphoinositide metabolism.

1984 • 219 citations

On the mechanism of the negative inotropic effect of acetylcholine

1976 • 218 citations

Effects of Intracellular Free Magnesium on Calcium Current in Isolated Cardiac Myocytes

1988 • 218 citations

Coexistence of Guanylate Cyclase and Atrial Natriuretic Factor Receptor in a 180-kD Protein

1987 • 218 citations

Pirenzepine distinguishes between muscarinic receptor-mediated phosphoinositide breakdown and inhibition of adenylate cyclase.

1985 • 217 citations

Mechanism of action of acetylcholine on calcium current in single cells from frog ventricle.

1986 • 214 citations

Effects of Epinephrine on the Pacemaker Potassium Current of Cardiac Purkinje Fibers

1974 • 213 citations

Alpha 1-adrenergic agonists selectively suppress voltage-dependent K+ current in rat ventricular myocytes.

1988 • 213 citations

Adrenaline: Mechanism of Action on the Pacemaker Potential in Cardiac Purkinje Fibers

1968 • 213 citations

Cholinergic Innervation of the Canine and Human Ventricular Conducting System

1974 • 212 citations

?-Adrenergic increase in the calcium conductance of cardiac myocytes studied with the patch clamp

1984 • 210 citations

Alpha 1-adrenoceptor-mediated phosphoinositide breakdown and inotropic response in rat left ventricular papillary muscles.

1988 • 210 citations

Effects of sodium nitroprusside, nitroglycerin, and sodium azide on levels of cyclic nucleotides and mechanical activity of various tissues.

1977 • 209 citations

Magnesium ions in cardiac function

1989 • 209 citations

The heterogeneity of protein kinase C in various rat tissues

1988 • 208 citations

Relaxing effects of catecholamines on mammalian heart

1972 • 205 citations

Mechanism of muscarinic receptor-induced K+ channel activation as revealed by hydrolysis-resistant GTP analogues.

1988 • 205 citations

Modulation by intracellular Ca2+ of the hyperpolarization‐activated inward current in rabbit single sino‐atrial node cells.

1989 • 202 citations

Cardiac Cellular Potentials: Effect of Vagal Stimulation and Acetylcholine

1953 • 202 citations

On the negative inotropic effect in the cat's auricle

1953 • 202 citations

Protein Phosphorylation Catalyzed by Cyclic AMP-Dependent and Cyclic GMP-Dependent Protein Kinases

1980 • 201 citations

Relaxation of the ACh-induced potassium current in the rabbit sinoatrial node cell

1978 • 200 citations

A nucleotide regulatory site for somatostatin inhibition of adenylate cyclase in S49 lymphoma cells

1983 • 200 citations

Cyclic guanosine 3',5'‐monophosphate regulates the calcium current in single cells from frog ventricle.

1987 • 199 citations

Molecular properties of dihydropyridine-sensitive calcium channels in skeletal muscle.

1988 • 196 citations

Cyclic AMP and contractile activity in heart.

1977 • 195 citations

Protein kinase C in transmembrane signalling

1990 • 194 citations

Studies on the phosphorylation of the inhibitory subunit of troponin during modification of contraction in perfused rat heart

1976 • 192 citations

Rapid ionic modifications during the aequorin-detected calcium transient in a skinned canine cardiac Purkinje cell.

1985 • 192 citations

Characterization and photoaffinity labeling of receptor sites for the Ca2+ channel inhibitors d-cis-diltiazem, (+/-)-bepridil, desmethoxyverapamil, and (+)-PN 200-110 in skeletal muscle transverse tubule membranes.

1986 • 190 citations

A diacylglycerol analogue reduces neuronal calcium currents independently of protein kinase C activation

1989 • 190 citations

Phosphorylation of the inhibitory subunit of troponin and its effect on the calcium dependence of cardiac myofibril adenosine triphosphatase

1976 • 188 citations

Electrophysiology of the sinoatrial node.

1982 • 187 citations

Sodium-Calcium Exchange in the Heart

1982 • 186 citations

Identification of cardiac beta-adrenergic receptors by (minus) [3H]alprenolol binding.

1975 • 185 citations

Sensory transduction in bacterial chemotaxis involves phosphotransfer between CHE proteins

1988 • 181 citations

Characterization of a novel cGMP binding protein from rat lung.

1980 • 179 citations

Muscarinic control of the hyperpolarization‐activated current (if) in rabbit sino‐atrial node myocytes.

1988 • 178 citations

Human cardiac beta-adrenergic receptors: Subtype heterogeneity delineated by direct radioligand binding

1983 • 178 citations

GTP-dependent inhibition of cardiac adenylate cyclase by muscarinic cholinergic agonists

1979 • 178 citations

Regulation of adenylate cyclase of human platelet membranes by forskolin.

1982 • 178 citations

Muscarinic acetylcholine receptors in developing chick heart

1977 • 177 citations

Calcium‐sensitive and insensitive transient outward current in rabbit ventricular myocytes.

1989 • 176 citations

Control of action potential duration by calcium ions in cardiac Purkinje fibers.

1976 • 173 citations

Release of Ca2+ from a non-mitochondrial store site in peritoneal macrophages treated with saponin by inositol 1,4,5-trisphosphate

1984 • 171 citations

Ionic currents in single isolated bullfrog atrial cells.

1983 • 170 citations

Cyclic adenosine 3′,5′-monophosphate-dependent protein kinase stimulation of calcium uptake by canine cardiac microsomes

1972 • 170 citations

Adrenaline-like Effects of Intracellular Iontophoresis of Cyclic AMP in Cardiac Purkinje Fibres

1973 • 168 citations

Calcium current‐dependent and voltage‐dependent inactivation of calcium channels in Helix aspersa

1981 • 167 citations

A transient outward current in isolated cells from the crista terminalis of rabbit heart.

1985 • 166 citations

Cyclic nucleotides and cardiac function.

1979 • 166 citations

Inhibition of the hyperpolarization‐activated current (if) induced by acetylcholine in rabbit sino‐atrial node myocytes.

1988 • 166 citations

Neuronal and cellular oscillators

1989 • 165 citations

Pertussis toxin attenuates atrial natriuretic factor-mediated inhibition of adenylate cyclase. Involvement of inhibitory guanine nucleotide regulatory protein.

1987 • 165 citations

Intracellular phospholipases A

1980 • 165 citations

Calcium conductance and tension in mammalian ventricular muscle

1975 • 164 citations

The effect of intracellular cyclic nucleotides and calcium on the action potential and acetylcholine response of isolated cardiac cells

1982 • 164 citations

Voltage dependence of intracellular [Ca2+]i transients in guinea pig ventricular myocytes.

1987 • 164 citations

Modulation by intracellular ATP and cyclic AMP of the slow inward current in isolated single ventricular cells of the guinea‐pig.

1983 • 164 citations

The 1,4-dihydropyridine receptor associated with the skeletal muscle voltage-dependent Ca2+ channel. Purification and subunit composition.

1985 • 163 citations

Slow inward current and its role mediating the chronotropic effect of epinephrine in the rabbit sinoatrfal node

1980 • 163 citations

A novel mechanism for the inhibition of adenylate cyclase via inhibitory GTP-binding proteins. Calmodulin-dependent inhibition of the cyclase catalyst by the beta gamma-subunits of GTP-binding proteins.

1987 • 161 citations

The relationship between muscarinic receptor occupancy and adenylate cyclase inhibition in the rabbit myocardium.

1985 • 161 citations

Identification and characterization of the dihydropyridine-binding subunit of the skeletal muscle dihydropyridine receptor.

1987 • 161 citations

Regulation of Hormone Receptors and Adenylyl Cyclases by Guanine Nucleotide Binding N Proteins

1985 • 159 citations

Reconstitution of the voltage-sensitive calcium channel purified from skeletal muscle transverse tubules

1986 • 157 citations

Adenosine 3', 5'-Monophosphate-Dependent Membrane Phosphorylation

1974 • 156 citations

Differential distribution of beta-1 and beta-2 adrenergic receptors in cat and guinea-pig heart.

1980 • 156 citations

Phosphorylation of purified cardiac muscle C-protein by purified cAMP-dependent and endogenous Ca2+-calmodulin-dependent protein kinases.

1984 • 155 citations

Inotropic effect of cyclic AMP in calf ventricular muscle studied by a cut end method.

1976 • 155 citations

The positive dynamic current and its inactivation properties in cardiac Purkinje fibres

1973 • 155 citations

Modulation of Acetylcholine Receptor Desensitization by Forskolin Is Independent of cAMP

1988 • 154 citations

Correlation between contraction and phosphorylation of the inhibitory subunit of troponin in perfused rat heart

1975 • 151 citations

Control of cardiac contractility at the cellular level

1983 • 151 citations

On the presence and distribution of ?-adrenoceptors in the heart of various mammalian species

1978 • 151 citations

Identification of a novel 1,4-dihydropyridine- and phenylalkylamine-binding polypeptide in calcium channel preparations.

1987 • 150 citations

Injection of catalytic subunit of cAMP-dependent protein kinase into isolated cardiac myocytes

1983 • 149 citations

The phosphorylation of troponin I from cardiac muscle

1975 • 148 citations

Cyclic GMP regulates the Ca-channel current in guinea pig ventricular myocytes

1989 • 148 citations

Calcium-mediated inactivation of the calcium conductance in cesium-loaded frog heart cells.

1984 • 148 citations

Phosphorylation of cardiac troponin by cyclic adenosine 3':5'-monophosphate-dependent protein kinase.

1977 • 148 citations

The rate of calcium uptake into sarcoplasmic reticulum of cardiac muscle and skeletal muscle. Effects of cyclic amp-dependent protein kinase and phosphorylase b kinase

1976 • 147 citations

Regulation of the L-type calcium channel

1987 • 147 citations

Cardiac Purkinje fibres

1977 • 145 citations

Influence of chloride, potassium, and tetraethylammonium on the early outward current of sheep cardiac Purkinje fibers.

1979 • 145 citations

The ionic basis of concentration‐related effects of noradrenaline on the action potential of calf cardiac purkinje fibres.

1982 • 144 citations

Rapid photochemical inactivation of Ca2+-antagonists shows that Ca2+ entry directly activates contraction in frog heart

1983 • 143 citations

Regulation of the cardiac calcium channel by protein phosphatases

1987 • 143 citations

Fast-deactivating calcium channels in chick sensory neurons.

1988 • 142 citations

Mechanisms controlling cardiac autonomic function and their relation to arrhythmogenesis

1986 • 142 citations

Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel.

1988 • 141 citations

Excitation—contraction coupling in frog ventricle: evidence from voltage clamp studies

1971 • 139 citations

Purification of the dihydropyridine receptor of the voltage-dependent Ca2+ channel from skeletal muscle transverse tubules using (+) [3H]PN 200-110

1984 • 139 citations

Intracellular Ca2+ and protein kinase C modulate K+ current in guinea pig heart cells

1987 • 139 citations

Comparison of [3H]pirenzepine and [3H]quinuclidinylbenzilate binding to muscarinic cholinergic receptors in rat brain.

1984 • 137 citations

Observations on adrenergic innervation of dog heart

1965 • 137 citations

Effects of noradrenaline and isoprenaline, in combination with α‐ and β‐receptor blocking substances, on the action potential of cardiac Purkinje fibres

1973 • 136 citations

Positive inotropic effects of phenylephrine in the isolated rabbit papillary muscle mediated both by ?-and ?-adrenoceptors

1974 • 135 citations

Identification and properties of cyclic nucleotide phosphodiesterases

1982 • 135 citations

Phosphorylation of cardiac troponin by guanosine 3‘:5‘-monophosphate-dependent protein kinase.

1978 • 134 citations

Epinephrine enhances Ca2+ current-regulated Ca2+ release and Ca2+ reuptake in rat ventricular myocytes.

1988 • 132 citations

Does the ?pacemaker current? generate the diastolic depolarization in the rabbit SA node cells?

1983 • 132 citations

THE POTASSIUM CURRENT UNDERLYING DELAYED RECTIFICATION IN CAT VENTRICULAR MUSCLE

1978 • 132 citations

Production of Membrane Potential Changes in the Frog's Heart by Inhibitory Nerve Impulses

1955 • 132 citations

Pharmacology and inotropic potential of forskolin in the human heart.

1984 • 131 citations

Calcium Channels in Planar Lipid Bilayers: Insights into Mechanisms of Ion Permeation and Gating

1986 • 131 citations

Cardiovascular effects of atrial extracts in anesthetized rats

1984 • 130 citations

The time course of the effects of ?-and ?-adrenoceptor stimulation by isoprenaline and methoxamine on the contractile force and cAMP level of the isolated rabbit papillary muscle

1975 • 130 citations

Inositol phosphate production following α₁‐adrenergic, muscarinic or electrical stimulation in isolated rat heart

1986 • 129 citations

Effects of adrenergic amines on electrophysiological properties and automaticity of neonatal and adult canine Purkinje fibers: evidence for alpha- and beta-adrenergic actions.

1977 • 128 citations

Regulation of cardiac contractile proteins. Correlations between physiology and biochemistry.

1984 • 128 citations

Cyclic Adenosine 3′,5′-Monophosphate-stimulated Protein Kinase and a Substrate Associated with Cardiac Sarcoplasmic Reticulum

1973 • 128 citations

Beta-adrenergic receptors and their mode of coupling to adenylate cyclase

1986 • 126 citations

Effects of α‐adrenoceptor stimulation with phenylephrine in the presence of propranolol on force of contraction, slow inward current and cyclic AMP content in the bovine heart

1984 • 125 citations

Modification of calcium requirement for activation of cardiac myofibrillar ATPase by cyclic AMP dependent phosphorylation

1979 • 125 citations

Mechanisms of slow postsynaptic potentials

1981 • 124 citations

Does cyclic GMP mediate the negative inotropic effect of acetylcholine in the heart?

1977 • 123 citations

Inositol trisphosphate does not release Ca²⁺ from permeabilized cardiac myocytes and sarcoplasmic reticulum

1985 • 123 citations

Acetylcholine activation of K+ channels in cell-free membrane of atrial cells

1986 • 122 citations

Alpha1-adrenergic receptors in guinea pig myocardium: Identification by binding of a new radioligand, (3H)-prazosin

1979 • 122 citations

Existence and functional role of alpha1-adrenoceptors in the mammalian heart

1985 • 121 citations

Biochemical and ultrastructural characterization of the 1,4-dihydropyridine receptor from rabbit skeletal muscle. Evidence for a 52,000 Da subunit.

1988 • 120 citations

Phosphorylation of phospholamban in intact myocardium. Role of Ca2+-calmodulin-dependent mechanisms.

1985 • 120 citations

Phosphorylation and dephosphorylation of dihydropyridine-sensitive voltage-dependent Ca2+ channel in skeletal muscle membranes by cAMP- and Ca2+-dependent processes.

1986 • 120 citations

Function of myocardial α-adrenoceptors

1990 • 119 citations

Functional compartmentation of cyclic AMP and protein kinase in heart.

1981 • 118 citations

Acquisition by innervated cardiac myocytes of a pertussis toxin-specific regulatory protein linked to the alpha 1-receptor

1985 • 118 citations

Adenosine receptors in frog sinus venosus: slow inhibitory potentials produced by adenine compounds and acetylcholine.

1979 • 118 citations

The 165‐KDa peptide of the purified skeletal muscle dihydropyridine receptor contains the known regulatory sites of the calcium channel

1987 • 117 citations

Action of the cardiac alpha 1-adrenergic receptor. Activation of cyclic AMP degradation.

1985 • 117 citations

Single cardiac Purkinje cells: general electrophysiology and voltage‐clamp analysis of the pace‐maker current.

1984 • 117 citations

Role of the contractile proteins and sarcoplasmic reticulum in the response of the heart to catecholamines: an historical review.

1979 • 116 citations

Kinetics of Cyclic Adenosine Monophosphate Changes in Rat Heart following Epinephrine Administration

1965 • 116 citations

Effects of Beta- and Alpha-Adrenoceptor Activators and Adrenergic Transmitter Releasing Agents on the Mechanical Activity of the Heart

1980 • 116 citations

On the mechanism underlying the action of D-600 on slow inward current and tension in mammalian myocardium.

1977 • 116 citations

Multiple conductance states of the purified calcium release channel complex from skeletal sarcoplasmic reticulum

1989 • 115 citations

Solubilization of the calcium antagonist receptor from rat brain.

1983 • 115 citations

Atrial natriuretic peptide secretion: Synergistic effect of phorbol ester and A23187

1985 • 115 citations

Photoaffinity labelling of the phenylalkylamine receptor of the skeletal muscle transverse‐tubule calcium channel

1987 • 114 citations

Guanine nucleotide regulation of a mammalian myocardial muscarinic receptor system. Evidence for homo- and heterotropic cooperativity in ligand binding analyzed by computer-assisted curve fitting.

1985 • 113 citations

Membrane currents underlying delayed rectification and pace‐maker activity in frog atrial muscle

1969 • 113 citations

Cardiac calcium channels in planar lipid bilayers. L-type channels and calcium-permeable channels open at negative membrane potentials.

1988 • 113 citations

Calcium sensitivity of the contractile system and phosphorylation of troponin in hyperpermeable cardiac cells.

1980 • 112 citations

Purified skeletal muscle 1,4-dihydropyridine receptor forms phosphorylation-dependent oligomeric calcium channels in planar bilayers.

1988 • 112 citations

Pharmacology of the bipyridines: amrinone and milrinone.

1986 • 112 citations

Phosphorylation of a myofibrillar protein of M_r 150 000 in perfused rat heart, and the tentative identification of this as C‐protein

1980 • 111 citations

Cardiac Purkinje fibres

1977 • 111 citations

Phosphorylation of cardiac sarcolemma proteins by the calcium-activated phospholipid-dependent protein kinase.

1984 • 111 citations

Relaxation of Isolated Ventricular Cardiomyocytes by a Voltage-Dependent Process

1988 • 108 citations

Regulation of Phosphorylase Activation in Skeletal Muscle in Vivo

1971 • 108 citations

Studies on Receptor-mediated Activation of Adenylyl Cyclases

1974 • 107 citations

Dihydropyridine and phenylalkylamine receptors associated with cardiac and skeletal muscle calcium channels are structurally different.

1988 • 107 citations

Purification of a functional receptor for calcium‐channel blockers from rabbit skeletal‐muscle microsomes

1986 • 107 citations

Agonists Bay-K8644 and CGP-28392 open calcium channels reconstituted from skeletal muscle transverse tubules

1985 • 106 citations

Muscarinic cholinergic inhibition of beta-adrenergic stimulation of phospholamban phosphorylation and Ca2+ transport in guinea pig ventricles.

1985 • 106 citations

Catheter ablation for treatment of tachyarrhythmias: present role and potential promise.

1986 • 105 citations

Membrane currents and their modification by acetylcholine in isolated single atrial cells of the guinea‐pig.

1985 • 105 citations

Synaptic delay in the heart: an ionophoretic study.

1978 • 105 citations

Synthesis and biochemical studies of various 8-substituted derivatives of guanosine cyclic-3',5' phosphate, inosine cyclic-3',5' phosphate, and xanthosine cyclic-3',5' phosphate

1973 • 105 citations

Neural Regulation of the Heart.

1977 • 104 citations

The Na/K Pump of Cardiac Cells

1984 • 104 citations

Membrane currents in the rabbit atrioventricular node cell

1982 • 104 citations

Effects of cholinergic and adrenergic agonists on phosphorylation of a 165,000-dalton myofibrillar protein in intact cardiac muscle.

1982 • 104 citations

In vivo regulation of muscarinic acetylcholine receptor number and function in embryonic chick heart.

1981 • 103 citations

Phosphorylation of the purified receptor for calcium channel blockers by cAMP kinase and protein kinase C

1987 • 103 citations

Inactivation and Block of Calcium Channels by Photo-Released Ca ²⁺ in Dorsal Root Ganglion Neurons

1988 • 102 citations

Control of calcium transport in the myocardium by the cyclic AMP-Protein kinase system.

1975 • 102 citations

Slow inward current and contraction of sheep cardiac Purkinje fibers.

1975 • 101 citations

Voltage clamp of bull‐frog cardiac pace‐maker cells: a quantitative analysis of potassium currents.

1985 • 101 citations

Pacemaker shift in the sino-atrial node during vagal stimulation

1968 • 100 citations

Oscillation of Cyclic Adenosine Monophosphate Concentration during the Myocardial Contraction Cycle

1973 • 100 citations

Characterization of [3H](+/-)carazolol binding to beta-adrenergic receptors. Application to study of beta-adrenergic receptor subtypes in canine ventricular myocardium and lung.

1981 • 100 citations

Stimulation of cardiac alpha receptors increases Na/K pump current and decreases gK via a pertussis toxin-sensitive pathway

1988 • 99 citations

Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, Gi.

1988 • 99 citations

Modulation of the delayed rectifier potassium current in frog cardiomyocytes by beta‐adrenergic agonists and magnesium.

1989 • 98 citations

Purification of the putative calcium channel from skeletal muscle with the aid of [3H]-nimodipine binding

1983 • 98 citations

Inactivation, reactivation and pacing dependence of calcium current in frog cardiocytes: correlation with current density.

1988 • 97 citations

Alpha-adrenergic stimulation of sarcolemmal protein phosphorylation and slow responses in intact myocardium.

1986 • 97 citations

Role of Ca2+ channel in development of tension in heart muscle

1987 • 97 citations

Immunochemical analysis of subunit structures of 1,4-dihydropyridine receptors associated with voltage-dependent calcium channels in skeletal, cardiac, and smooth muscles

1986 • 96 citations

Transient outward current carried by potassium and sodium in quiescent atrioventricular node cells of rabbits.

1985 • 96 citations

Attenuation of muscarinic cholinergic inhibition by islet-activating protein in the heart

1985 • 95 citations

Die Wirkung von Adrenalin auf Purkinje-Fasern von S�ugetierherzen

1958 • 95 citations

Identification of an endogenous protein kinase C activity and its intrinsic 15-kilodalton substrate in purified canine cardiac sarcolemmal vesicles.

1985 • 95 citations

Effects of the beta 2‐adrenoceptor antagonist ICI 118,551 on exercise tachycardia and isoprenaline‐induced beta‐adrenoceptor responses in man.

1985 • 94 citations

Characterization and autoradiographic localization of β‐adrenoceptor subtypes in human cardiac tissues

1987 • 94 citations

Photoaffinity labelling and phosphorylation of a 165 kilodalton peptide associated with dihydropyridine and phenylalkylamine-sensitive calcium channels

1987 • 94 citations

The putative M1 muscarinic receptor does not regulate phosphoinositide hydrolysis. Studies with pirenzepine and McN-A343 in chick heart and astrocytoma cells.

1985 • 92 citations

The action of acetylcholine on background conductance in frog atrial trabeculae.

1978 • 91 citations

Adrenoceptor‐mediated changes of excitation and contraction in ventricular heart muscle from guinea‐pigs and rabbits.

1988 • 91 citations

Voltage clamp and tracer flux data: effects of a restricted extra-cellular space

1979 • 90 citations

Photoaffinity labelling of Ca²⁺ channels with [³H]azidopine

1984 • 90 citations

Acetylcholine inhibits activation of the cardiac hyperpolarizing-activated current,i f

1987 • 89 citations

Distribution of muscarinic acetylcholine receptors and presynaptic nerve terminals in amphibian heart.

1980 • 88 citations

Removal of Ca current inactivation in dialysed guinea-pig atrial cardioballs by Ca chelators

1985 • 88 citations

On the Difference Between the Heart's Output and Its Contractile State

1971 • 87 citations

Adrenergic modulation of the transient outward current in isolated canine Purkinje cells.

1988 • 87 citations

Cyclic Adenosine Monophosphate and Cardiac Contractility

1973 • 87 citations

Effects of magnesium on inactivation of the voltage-gated calcium current in cardiac myocytes.

1989 • 86 citations

Alpha-adrenoceptor-mediated restoration of calcium-dependent potential in the partially depolarized rabbit papillary muscle

1978 • 86 citations

Calcium and Cell Physiology.

1986 • 86 citations

Specificity of Cyclic GMP Activation of a Multi-substrate Cyclic Nucleotide Phosphodiesterase from Rat Liver

2005 • 86 citations

Kinetics and magnitude of the time-dependent potassium current in the rabbit sinoatrial node

1979 • 86 citations

A Monoclonal Antibody to the α Subunit of G _k Blocks Muscarinic Activation of Atrial K ⁺ Channels

1988 • 85 citations

Activation of adenylate cyclase and inhibition of glucose transport in rat adipocytes by forskolin analogues: structural determinants for distinct sites of action.

1988 • 85 citations

Binding of iodinated beta adrenergic antagonists to proteins derived from rat heart.

1976 • 85 citations

Muscarinic stimulation of phosphatidylinositol metabolism in atria.

1983 • 85 citations

A possible physiological role of the Ca-dependent protease calpain and its inhibitor calpastatin on the Ca current in guinea pig myocytes

1988 • 85 citations

The effect of brief vagal stimulation on the isolated rabbit sinus node.

1979 • 84 citations

The ionic currents underlying pacemaker activity in rabbit sino-atrial node: experimental results and computer simulations

1984 • 83 citations

LY195115: a potent, selective inhibitor of cyclic nucleotide phosphodiesterase located in the sarcoplasmic reticulum.

1986 • 83 citations

Cyclic changes in levels of cyclic AMP and cyclic GMP in frog myocardium during the cardiac cycle

1973 • 82 citations

Substrate proteins for calmodulin-sensitive and phospholipid-sensitive Ca2+-dependent protein kinases in heart, and inhibition of their phosphorylation by palmitoylcarnitine.

1981 • 82 citations

Atrial natriuretic factor regulates the calcium current in frog isolated cardiac cells.

1988 • 81 citations

Zur Membranwirkung des Adrenalins an der Herzmuskelfaser

1960 • 81 citations

Opening of dihydropyridine calcium channels in skeletal muscle membranes by inositol trisphosphate

1988 • 80 citations

Effects of several phosphodiesterase-inhibitors on guinea-pig myocardium

1978 • 80 citations

On the kinetics of the potassium channel activated by acetylcholine in the S-A node of the rabbit heart

1980 • 79 citations

Dissociation of changes in apparent myofibrillar Ca2+ sensitivity and twitch relaxation induced by adrenergic and cholinergic stimulation in isolated ferret cardiac muscle.

1988 • 79 citations

Ontogenesis of physiological responsiveness and guanine nucleotide sensitivity of cardiac muscarinic receptors during chick embryonic development

1984 • 79 citations

Effects of acetylcholine and parasympathetic nerve stimulation on membrane potential in quiescent guinea‐pig atria.

1978 • 79 citations

Norepinephrine and potassium fluxes in cardiac Purkinje fibers

1971 • 78 citations

Distribution of cholinesterase within the sinus node and AV node of the human heart

1966 • 78 citations

The epinephrine‐induced activation of the cardiac slow Ca²⁺ channel is mediated by the cAMP‐dependent phosphorylation of calciductin, a 23 000 M_r sarcolemmal protein

1981 • 78 citations

Characterization of the pace‐maker current kinetics in calf Purkinje fibres.

1984 • 77 citations

Phosphorylation of contractile proteins in relation to muscle function.

1980 • 77 citations

The bovine cardiac receptor for calcium channel blockers is a 195‐kDa protein

1988 • 77 citations

Effect of acetylcholine on membrane currents in guinea‐pig papillary muscle.

1980 • 77 citations

Are increases in cyclic GMP levels responsible for the negative inotropic effects of acetylcholine in the heart?

1977 • 77 citations

Positive inotropic effects of methoxamine: evidence for alpha-adrenergic receptors in ventricular myocardium

1975 • 77 citations

Direct analysis of beta-adrenergic receptor subtypes on intact adult ventricular myocytes of the rat.

1985 • 76 citations

Catecholamines and the sodium pump in excitable cells

1981 • 76 citations

Purified calcium channels have three allosterically coupled drug receptors

1986 • 75 citations

The cyclic AMP-dependent modulation of cardiac sarcolemmal slow calcium channels

1982 • 75 citations

Function of muscarinic and nicotinic acetylcholine receptors

1976 • 75 citations

Certain Slow Synaptic Responses: Their Properties and Possible Underlying Mechanisms

1980 • 75 citations

β-Adrenoceptor agonists increase membrane K+ conductance in cardiac Purkinje fibres

1983 • 75 citations

Effects of phosphorylated and unphosphorylated C-protein on cardiac actomyosin ATPase

1985 • 74 citations

The negative inotropic effect of acetylcholine on ferret ventricular myocardium.

1988 • 74 citations

REGIONAL DISTRIBUTION OF CATECHOLAMINES IN THE HEARTS OF VARIOUS SPECIES*

1969 • 74 citations

On the mechanism of isoprenaline‐ and forskolin‐induced depolarization of single guinea‐pig ventricular myocytes.

1988 • 74 citations

Inositol (1,4,5)-trisphosphate activates a calcium channel in isolated sarcoplasmic reticulum membranes

1988 • 73 citations

Coexistence of β1 and β2-Adrenoceptors in the Rabbit Heart

1982 • 73 citations

Potassium conductance of the squid giant axon. Single-channel studies.

1988 • 73 citations

Studies on Receptor-mediated Activation of Adenylyl Cyclases

1974 • 73 citations

Identification and characterization of both the cytosolic and particulate forms of cyclic GMP-stimulated cyclic AMP phosphodiesterase from rat liver

1986 • 73 citations

Purification and characterization of the dihydropyridine-sensitive voltage-dependent calcium channel from cardiac tissue.

1987 • 72 citations

Muscarinic receptor regulation of cardiac adenylate cyclase activity*

1987 • 72 citations

Inositol triphosphate-induced Ca2+ release from human platelet membranes

1985 • 71 citations

The role of cyclic adenosine 3', 5'-monophosphate and calcium in the regulation of contractility and glycogen phosphorylase activity in guinea pig papillary muscle.

1976 • 71 citations

Activation of Muscarinic Potassium Currents by ATPγS in Atrial Cells

1988 • 71 citations

Modulation of Ca2+ control of dog and rabbit cardiac myofibrils by Mg2+. Comparison with rabbit skeletal myofibrils.

1976 • 71 citations

Adrenergic modulation of the delayed rectifier potassium channel in calf cardiac Purkinje fibers

1986 • 71 citations

Pertussis toxin treatment blocks hyperpolarization by muscarinic agonists in chick atrium.

1985 • 71 citations

The ?2-adrenoceptor antagonist CGP 20712 A unmasks ?2-adrenoceptors activated by (?)-adrenaline in rat sinoatrial node

1986 • 71 citations

Alpha-subunit of Gs directly activates cardiac calcium channels in lipid bilayers

1988 • 70 citations

Occurrence of an Inhibitory Guanine Nucleotide‐Binding Regulatory Component of the Adenylate Cyclase System in cyc⁻ Variants of S49 Lymphoma Cells

1983 • 69 citations

Heterogeneity of conductance states in calcium channels of skeletal muscle

1988 • 69 citations

Desensitization of the acetylcholine‐induced increase of potassium conductance in rabbit cardiac Purkinje fibres.

1986 • 69 citations

Delineation of the distribution of beta-adrenergic receptor subtypes in canine myocardium.

1988 • 69 citations

Qualitative Differences between β‐Adrenergic and α‐Adrenergic Inotropic Effects in Rat Heart Muscle

1978 • 69 citations

Effect of Vagal Stimulation on the Sinus Venosus of the Frog's Heart

1955 • 69 citations

Biochemical Mechanisms for the Inotropic Effect of the Cardiotonic Drug Milrinone

1987 • 69 citations

Effect of phorbol esters on contractile state and calcium flux in cultured chick heart cells

1987 • 69 citations

Modulation of intracellular Na+ activity and cardiac force by norepinephrine and Ca2+

1983 • 69 citations

Determination of the molecular size of the nitrendipine-sensitive Ca2+ channel by radiation inactivation

1983 • 69 citations

The role of cyclic GMP in the regulation of cyclic AMP hydrolysis

1975 • 69 citations

Cardiac Pacemaker Oscillation and Its Modulation by Autonomic Transmitters

1979 • 68 citations

Phosphorylation of C-protein in intact amphibian cardiac muscle. Correlation between 32P incorporation and twitch relaxation.

1984 • 68 citations

Function of myocardial α-adrenoceptors

1982 • 68 citations

Na channel kinetics during the spontaneous heart beat in embryonic chick ventricle cells

1987 • 68 citations

Catecholamines modulate the delayed rectifying potassium current (IK) in guinea pig ventricular myocytes

1987 • 67 citations

Mode of Action of Chronotropic Agents in Cardiac Purkinje Fibers

1974 • 67 citations

Dual mechanism for inhibition of calcium-dependent action potentials by acetylcholine in avian ventricular muscle. Relationship to cyclic AMP.

1980 • 67 citations

Islet activating protein inhibits physiological responses evoked by cardiac muscarinic acetylcholine receptors. Role of guanosine triphosphate binding proteins in regulation of potassium permeability

1985 • 66 citations

Are there α-adrenoceptors in the mammalian heart?

1979 • 66 citations

Cyclic AMP stimulation of membrane phosphorylation and Ca2+-activated, Mg2+-dependent ATPase in cardiac sarcoplasmic reticulum

1977 • 66 citations

Forskolin's effect on transient K current in nudibranch neurons is not reproduced by cAMP

1987 • 66 citations

A photoisomerizable muscarinic antagonist. Studies of binding and of conductance relaxations in frog heart.

1982 • 65 citations

Analysis of catecholamine effects in single atrial trabeculae of the frog heart

1977 • 65 citations

THE EFFECT OF VAGUS INHIBITION ON THE OUTPUT OF POTASSIUM FROM THE HEART

1908 • 63 citations

On the ionic mechanism underlying adrenergic-cholinergic antagonism in ventricular muscle.

1982 • 63 citations

Monoclonal antibodies that coimmunoprecipitate the 1,4-dihydropyridine and phenylalkylamine receptors and reveal the calcium channel structure

1987 • 63 citations

Modification of L‐type calcium current by intracellularly applied trypsin in guinea‐pig ventricular myocytes.

1988 • 63 citations

Transient outward current and rate dependence of action potential duration in rabbit cardiac ventricular muscle

1983 • 63 citations

Increase in IP3 precedes α-adrenoceptor-induced increase in force of contraction in cardiac muscle

1987 • 62 citations

Effects of forskolin on contractile responses and protein phosphorylation in the isolated perfused rat heart

1987 • 62 citations

The α Subunit of the GTP Binding Protein Activates Muscarinic Potassium Channels of the Atrium

1988 • 62 citations

?-Adrenergic modulation in the heart

1988 • 62 citations

Voltage dependence of inositol 1,4,5-trisphosphate-induced Ca2+ release in peeled skeletal muscle fibers.

1988 • 61 citations

Calcium- and voltage-activated plateau currents of cardiac Purkinje fibers.

1987 • 61 citations

Characterization of the acetylcholine‐induced potassium current in rabbit cardiac Purkinje fibres.

1986 • 61 citations

Cyclic AMP inhibits contractility of detergent treated glycerol extracted cardiac muscle

1981 • 61 citations

alpha-Adrenergic reduction of cyclic adenosine monophosphate concentrations in rat myocardium.

1977 • 61 citations

Epinephrine and the pacemaking mechanisms at plateau potentials in sheep cardiac Purkinje fibers

1979 • 60 citations

Subclasses of cyclic AMP phosphodiesterase in cardiac muscle

1987 • 60 citations

Structure of C protein purified from cardiac muscle.

1985 • 60 citations

Intracellular injection of cyclic GMP depresses cardiac slow action potentials.

1985 • 59 citations

Calcium channel activity in a purified dihydropyridine-receptor preparation of skeletal muscle

1987 • 59 citations

Muscarinic receptor-mediated increase of intracellular Na+-ion activity and force of contraction

1985 • 59 citations

Induction of slow action potentials by microiontophoresis of cyclic AMP into heart cells

1981 • 58 citations

A time- and voltage-dependent K+ current in single cardiac cells from bullfrog atrium.

1986 • 58 citations

Autonomic Control of Cardiac C-AMP

1971 • 58 citations

Actions of atrial natriuretic peptide (ANP) on cyclic nucleotide concentrations and phosphatidylinositol turnover in ventricular myocytes

1987 • 58 citations

Effect of forskolin and acetylcholine on calcium current in single isolated cardiac myocytes.

1987 • 58 citations

8-Bromo-guanosine-3′,5′-monophosphate mimics the effect of acetylcholine on slow response action potential and contractile force in mammalian atrial myocardium

1978 • 57 citations

Identification of the pace‐maker current in frog atrium.

1976 • 57 citations

Molecular mechanisms involved in α-adrenergic responses

1982 • 57 citations

Phosphorylation of the 165-kDa dihydropyridine/phenylalkylamine receptor from skeletal muscle by protein kinase C.

1988 • 57 citations

The time course of the muscarinic response to ionophoretic acetylcholine application to the S-A node of the rabbit heart

1981 • 56 citations

Strontium, nifedipine and 4‐aminopyridine modify the time course of the action potential in cells from rat ventricular muscle

1984 • 56 citations

Subcellular distribution of high-affinity type IV cyclic AMP phosphodiesterase activity in rabbit ventricular myocardium: relations to the effects of cardiotonic drugs.

1988 • 55 citations

Multiple phosphorylation sites in the 165-Kilodalton peptide associated with dihydropyridine-sensitive calcium channels

1988 • 55 citations

Tissue extract recovers cardiac calcium channels from ‘run-down’

1988 • 55 citations

Pertussis toxin-insensitive phosphoinositide hydrolysis, membrane depolarization, and positive inotropic effect of carbachol in chick atria.

1987 • 55 citations

Role of phosphodiesterase in regulation of calcium current in isolated cardiac myocytes.

1988 • 55 citations

Delayed rectification in the calf cardiac Purkinje fiber. Evidence for multiple state kinetics

1985 • 55 citations

Dihydropyridine-sensitive calcium channels in cardiac and skeletal muscle membranes: studies with antibodies against the .alpha. subunits

1987 • 55 citations

Forskolin effects on the voltage-gated K+ conductance of human T cells

1988 • 55 citations

Changes by acetylcholine of membrane currents in rabbit cardiac Purkinje fibres.

1986 • 54 citations

Relationship between cyclic AMP metabolism and inotropic response of perfused rat hearts to phenylephrine and other adrenergic amines.

1975 • 54 citations

Interactive effects of isoprenaline, forskolin and acetylcholine on Ca2+ current in frog ventricular myocytes.

1989 • 54 citations

Differences in muscarinic receptor reserve for inhibition of adenylate cyclase and stimulation of phosphoinositide hydrolysis in chick heart cells.

1986 • 54 citations

Differential inhibition of cardiac cyclic nucleotide phosphodiesterase isozymes by cardiotonic drugs.

1986 • 53 citations

Characterization of beta-1 and beta-2 adrenoceptors in guinea pig atrium: functional and receptor binding studies.

1987 • 53 citations

Adenylate cyclase inhibition and GTPase stimulation by somatostatin in S49 lymphoma cyc⁻ variants are prevented by islet‐activating protein

1983 • 53 citations

Electrophysiologic correlates of the inotropic effects of Isoproterenol in canine myocardium

1975 • 53 citations

Tissue-specific regulation of GTP-binding protein and muscarinic acetylcholine receptor levels during cardiac development

1987 • 52 citations

-adrenoceptor density and relative number of -adrenoceptor subtypes in biopsies from human right atrial, left ventricular, and right ventricular myocard

1985 • 52 citations

Catecholamine effects on intracellular sodium activity and tension in dog heart

1982 • 51 citations

Effects of phenylephrine on calcium current and contractility of feline ventricular myocytes

1988 • 51 citations

The questionable role of cyclic guanosine 3′ : 5′-monophosphate in heart

1979 • 51 citations

Gating of delayed rectification in acutely isolated canine cardiac Purkinje myocytes. Evidence for a single voltage-gated conductance

1985 • 50 citations

Cholinergic and adrenergic receptors on mouse cardiocytes in vitro

1977 • 50 citations

CHARACTERIZATION OF ADRENOCEPTORS MEDIATING POSITIVE INOTROPIC RESPONSES IN THE VENTRICULAR MYOCARDIUM OF THE DOG

1978 • 50 citations

Effects of acetylcholine on electrophysiological properties of rabbit cardiac Purkinje fibers.

1983 • 49 citations

Antagonism of forskolin effects by adenosine in isolated hearts and ventricular myocytes

1986 • 49 citations

Forskolin prolongs action potential duration and blocks potassium current in embryonic chick sensory neurons

1985 • 49 citations

Na+-Ca2+ exchange contributes to increase of cytosolic Ca2+ concentration during depolarization in heart muscle

1986 • 49 citations

Cyclic nucleotide regulation of the contractile proteins in mammalian cardiac muscle.

1980 • 48 citations

An isoprenaline activated sodium-dependent inward current in ventricular myocytes

1987 • 48 citations

Forskolin-induced block of delayed rectifying K+ channels in pancreatic?-cells is not mediated by cAMP

1988 • 48 citations

Inositol 1,4,5-trisphosphate is not effective in releasing calcium from skeletal sarcoplasmic reticulum microsomes

1985 • 48 citations

Cardiac α adrenoceptors

1980 • 48 citations

Incorporation of calcium channels from cardiac sarcolemmal membrane vesicles into planar lipid bilayers.

1986 • 48 citations

Alpha-adrenergic receptors on rat ventricular myocytes: characteristics and linkage to cAMP metabolism

1986 • 48 citations

The inotropic actions of adrenaline on frog ventricular muscle: relaxing versus potentiating effects

1981 • 47 citations

Stimulation by phenylephrine of adrenergic alpha- and beta-receptors in the isolated perfused rabbit heart

1974 • 47 citations

Muscarinic receptors mediate negative and positive inotropic effects in mammalian ventricular myocardium: differentiation by agonists

1987 • 47 citations

Injection of guanosine 5'-cyclic monophosphate into heart cells blocks calcium slow channels

1985 • 47 citations

Heterogeneity of calcium channels from a purified dihydropyridine receptor preparation

1987 • 47 citations

Inositol trisphosphate stimulates calcium release from peeled skeletal muscle fibers

1987 • 46 citations

Differences between α‐Adrenergic and β‐Adrenergic Inotropic Effects in Rat Heart Papillary Muscles

1982 • 46 citations

Agonist binding to multiple muscarinic receptors.

1984 • 46 citations

α‐ADRENOCEPTORS CAN MEDIATE CHRONOTROPIC RESPONSES IN THE RAT HEART

1981 • 46 citations

Lack of relationship between myocardial cyclic AMP concentrations and inotropic effects of sympathomimetic amines

1971 • 45 citations

Comparison of effects of acetylcholine on calcium and potassium currents in frog atrium and ventricle.

1987 • 45 citations

Purification and partial characterization of membrane-associated type II (cGMP-activatable) cyclic nucleotide phosphodiesterase from rabbit brain

1988 • 45 citations

The calcium channel antagonists receptor from rabbit skeletal muscle

1987 • 45 citations

The effect of adrenaline on the K and Na fluxes in the frog's atrium

1965 • 44 citations

Regulation of cardiac cyclic GMP-dependent protein kinase

1981 • 44 citations

Cardiac Muscle: the Regulation of Excitation and Contraction

1986 • 44 citations

Effects on guanine nucleotide and sulfhydryl reagent on subpopulations of muscarinic acetylcholine receptors in mammalian hearts: Possible evidence for interconversion of super-high and low affinity agonist binding sites

1984 • 44 citations

Adrenergic control of cardiac pacemaker currents

1975 • 44 citations

Phosphorylation of bovine cardiac C-protein by protein kinase C

1985 • 43 citations

Effect of acetylcholine on time-independent currents in sheep cardiac Purkinje fibers

1980 • 43 citations

Muscarinic antagonism of the effects of phosphodiesterase inhibitor (methylisobutylxanthine) in embryonic chick ventricle.

1980 • 43 citations

Phosphorylation of cardiac native tropomyosin and troponin: Inhibitory effect of actomyosin and possible presence of endogenous myofibrillar-located cyclic-AMP-dependent protein kinase

1973 • 42 citations

Autoradiographic localization of beta-1 and beta-2 adrenoceptors in guinea pig atrium and regions of the conducting system.

1987 • 42 citations

Interaction of acetylcholine and epinephrine on heart cyclic AMP-dependent protein kinase

1978 • 42 citations

Forskolin-induced change of the size of adenylate cyclase.

1985 • 42 citations

A time-dependent and voltage-sensitive K+ current in single cells from frog atrium.

1986 • 41 citations

Adrenaline, noradrenaline and potassium fluxes in rabbit auricles

1961 • 41 citations

Agonist-induced changes in the modulation of K+ permeability and beating rate by muscarinic agonists in cultured heart cells.

1982 • 41 citations

Effect of alpha adrenergic agonists and blockers on Purkinje fiber transmembrane potentials and automaticity in the dog.

1984 • 41 citations

Acetylcholine increases resting membrane potassium conductance in atrial but not in ventricular muscle during muscarinic inhibition of Ca++-dependent action potentials in chick heart.

1983 • 41 citations

Evidence for a carbachol stimulated phosphatidylinositol effect in heart

1982 • 41 citations

Regulation of myocardial and vascular alpha-adrenergic receptor affinity. Effects of guanine nucleotides, cations, estrogen, and catecholamine depletion.

1984 • 41 citations

Interaction of a radiolabeled agonist with cardiac muscarinic cholinergic receptors.

1983 • 41 citations

A quantitative analysis of the acetylcholine-activated potassium current in single cells from frog atrium

1987 • 40 citations

Non‐stationary fluctuations of the potassium conductance at the node of ranvier of the frog.

1984 • 40 citations

Noradrenaline hyperpolarizes cells of the canine coronary sinus by increasing their permeability to potassium ions.

1983 • 40 citations

Influence of Ca++-channel blocking agents on calcium transients and tension development in isolated mammalian heart muscle.

1983 • 40 citations

Relationship between the level of cAMP and the contractile force under stimulation of ?- and ?-adrenoceptors by phenylephrine in the isolated rabbit papillary muscle

1976 • 40 citations

Evidence that cyclic GMP may regulate cyclic AMP metabolism in the isolated frog ventricle

1981 • 40 citations

Modulation of calcium channel function by phosphorylation in guinea pig ventricular cells and phospholipid bilayer membranes.

1987 • 40 citations

Characterization of the adrenoceptors mediating the positive ino- and chronotropic effect of phenylephrine on isolated atria from guinea pigs and rabbits by means of adrenolytic drugs

1974 • 40 citations

5′-Guanylimidodiphosphate stimulation of slow Ca2+ current in myocardial cells

1978 • 40 citations

Cholinergic antagonism of beta-adrenergic stimulation of cardiac membrane protein phosphorylation in situ.

1983 • 39 citations

Effect of rate‐dependent changes in the transient outward current on the action potential in sheep Purkinje fibres.

1981 • 39 citations

The regulation of cardiac α1-adrenergic receptors by guanine nucleotides and by muscarinic cholinergic agonists

1980 • 39 citations

Negative inotropic effect of cyclic GMP in cardiac fiber fragments

1976 • 39 citations

?-Adrenergic receptors in guinea-pig myocardial tissue

1976 • 38 citations

Photoaffinity labelling of the cardiac calcium channel. (−)-[3H]azidopine labels a 165 kDa polypeptide, and evidence against a [3H]-1,4-dihydropyridine-isothiocyanate being a calcium-channel-specific affinity ligand

1987 • 38 citations

[On the membrane effect of adrenalin on the myocardial fiber].

1960 • 38 citations

Sidedness of reconstituted calcium channels from muscle transverse tubules as determined by D600 and D890 blockade

1986 • 38 citations

STIMULANT ACTION OF METHOXAMINE IN THE ISOLATED ATRIA OF NORMAL AND 6-PROPYL-2-THIOURACIL-FED RATS

1973 • 38 citations

Stimulation of muscarinic receptors raises free intracellular Ca2+ concentration in rat ventricular myocytes.

1988 • 38 citations

Voltage-Activated K Channels in Embryonic Chick Heart

1984 • 37 citations

Threshold effects of acetylcholine on primary pacemaker cells of the rabbit sino-atrial node

1985 • 37 citations

Dissociation of cyclic GMP from the negative inotropic action of carbachol in guinea pig atria.

1977 • 37 citations

Cardiac calcium channels and their control by neurotransmitters and drugs

1985 • 36 citations

Structural basis of muscarinic acetylcholine receptor subtype diversity.

1988 • 36 citations

α‐SYMPATHOMIMETIC AMINES AND CALCIUM‐MEDIATED ACTION POTENTIALS IN GUINEA‐PIG VENTRICULAR MUSCLE

1980 • 36 citations

Die Wirkung von Adrenalin auf das Ruhepotential von Myokardfasern des Vorhofs

1956 • 36 citations

Multiple effects of putative ?-adrenoceptor agonists on the electrical and mechanical activity of guinea-pig papillary muscle

1981 • 36 citations

Evidence that phosphoinositide response is mediated by α1-adrenoceptor stimulation, but not linked with excitation-contraction coupling in cardiac muscle

1986 • 36 citations

Inhibitory effects of catecholamines in canine cardiac Purkinje fibers

1976 • 36 citations

Changes in Sino-atrial Node Transmembrane Potentials on Vagal Stimulation of the Isolated Rabbit Atrium

1965 • 36 citations

Functional β₁ ‐ and β₂‐adrenoceptors in the human myocardium

1985 • 36 citations

A transient outward current related to calcium release and development of tension in elephant seal atrial fibres.

1984 • 35 citations

Inhibition of cardiac slow action potentials by 8-bromo-cyclic GMP occurs independent of changes in cyclic AMP levels

1988 • 35 citations

Cardiac β2-adrenoceptor in the frog

1978 • 35 citations

Alpha-subunit of Gk activates atrial K+ channels of chick, rat, and guinea pig

1988 • 35 citations

Effects of Ach on slow inward current and tension components of the bullfrog atrium

1977 • 35 citations

Effects of acetylcholine on calcium-dependent electrical and mechanical responses in the guinea-pig papillary muscle partially depolarized by potassium

1977 • 35 citations

Effects of the cyclic GMP lowering agent LY83583 on the interaction of carbachol with forskolin in rabbit isolated cardiac preparations.

1986 • 35 citations

Inotropic responses of the frog ventricle to dibutyryl cyclic AMP and 8-bromo cyclic GMP and related changes in endogenous cyclic nucleotide levels

1981 • 34 citations

Delayed rectifier K+ current in embryonic chick heart ventricle

1988 • 34 citations

Role of a pertussis toxin-sensitive protein in the modulation of canine Purkinje fiber automaticity.

1988 • 34 citations

A novel cyclic GMP-lowering agent, LY83583, blocks carbachol-indiiced cyclic GMP elevation in rabbit atrial strips without blocking the negative inotropic effects of carbachol

1985 • 34 citations

Mechanisms of muscarinic modulation of protein phosphorylation in intact ventricles.

1984 • 34 citations

Acetylcholine-Induced K+ Current in Amphibian Atrial Cells

1984 • 34 citations

[7] Purification and assay of cAMP, cGMP, and cyclic nucleotide analogs in cells treated with cyclic nucleotide analogs

1988 • 34 citations

Electrophysiological Effects of Cyclic GMP on Canine Cardiac Purkinje Fibers

1985 • 34 citations

Beta 2-adrenergic receptors contribute to catecholamine-stimulated shortening of action potential duration in dog atrial muscle.

1985 • 34 citations

Membrane current following activity in canine cardiac Purkinje fibers.

1984 • 33 citations

Effect of Epinephrine on the Metabolism of the Inositol Phosphatides in Rat Heart in vivo

1966 • 33 citations

Positive inotropic effect of acetylcholine in canine cardiac Purkinje fibers

1985 • 33 citations

Myocardial actions of milrinone: characterization of its mechanism of action.

1986 • 33 citations

Inhibition of hormonally regulated adenylate cyclase by the beta gamma subunit of transducin.

1985 • 33 citations

THE ROLE OF THE POSITIVE DYNAMIC CURRENT ON THE ACTION POTENTIAL OF CARDIAC PURKINJE FIBERS

1975 • 32 citations

Muscarinic receptors and responses in intact embryonic chick atrial and ventricular heart cells

1984 • 32 citations

[8] cAMP export and its regulation by prostaglandin A1

1988 • 31 citations

Delayed rectification in the cardiac Purkinje fiber is not activated by intracellular calcium

1984 • 31 citations

α-adrenergic receptors and pacemaker current in cardiac Purkinje fibres

1976 • 30 citations

Lack of detectable change in cyclic AMP during the cardiac inotropic response to isoproterenol immobilized on glass beads.

1975 • 30 citations

Selective inhibition of cyclic AMP phosphodiesterase from various human tissues by milrinone, a potent cardiac bipyridine

1988 • 30 citations

Forskolin stabilizes a functionally coupled state between activated guanine nucleotide-binding stimulatory regulatory protein, Ns, and catalytic protein of adenylate cyclase system in rat erythrocytes

1986 • 30 citations

Agonist interactions with cardiac muscarinic receptors. Effects of Mg2+, guanine nucleotides, and monovalent cations.

1985 • 30 citations

The dependence of twitch relaxation on sodium ions and on internal Ca2+ stores in voltage clamped frog atrial fibres

1979 • 30 citations

The electrogenic Na-Ca exchange and the cardiac electrical activity. I--Simulation on Purkinje fibre action potential.

1981 • 29 citations

Muscarinic acetylcholine receptor function in chick heart cells cultured in serum-free medium

1988 • 29 citations

β-Adrenergic Regulation of Contractility and Protein Phosphorylation in Spontaneously Beating Isolated Rat Myocardial Cells1

1987 • 28 citations

Effects of derivatives of cyclic AMP and cyclic GMP on contraction force of cat papillary muscles

1976 • 28 citations

Effects of acetylcholine on potassium movements in the guinea-pig sinus node.

1977 • 28 citations

The effect of isoproterenol on the metabolism of phosphatidylinositol by rat heart in vitro

1975 • 28 citations

Phosphorylation of guinea pig cardiac natural actomyosin and its effect on ATPase activity

1976 • 28 citations

Cardiac and hemodynamic responses to synthetic atrial natriuretic factor in rats

1987 • 28 citations

Phosphorylation of a bovine cardiac actin complex

1979 • 28 citations

Muscarinic regulation of phosphatidylinositol turnover and cyclic nucleotide metabolism in the heart.

1984 • 28 citations

Muscarinic-receptor stimulation enhances polyphosphoinositide breakdown in guinea-pig ileum smooth muscle

1984 • 28 citations

Regional and subcellular distribution of β- and α-adrenergic receptors in the myocardium of different species

1979 • 27 citations

Antibodies reveal the cytolocalization and subunit structure of the 1,4-dihydropyridine component of the neuronal Ca2+ channel

1986 • 27 citations

Zum Mechanismus der negativ inotropen Acetylcholin-Wirkung auf das isolierte Froschmyokard

1968 • 27 citations

Effect of ?- and ?-sympathomimetic agonists on calcium-dependent slow action potential and force of contraction in the rabbit papillary muscle

1982 • 27 citations

Influence of isoproterenol and methylisobutylxanthine on the contractile and cyclic nucleotide effects of methacholine in isolated rat atria.

1980 • 27 citations

Stimulation of phosphoinositide hydrolysis and inhibition of cyclic AMP formation by muscarinic agonists in developing chick heart

1985 • 26 citations

Identification of alpha 1-adrenergic receptors in cultured rat myocardial cells with a new iodinated alpha 1-adrenergic antagonist, [125I]IBE 2254.

1982 • 26 citations

DIFFERENTIAL RESPONSES TO CARBACHOL, SODIUM NITRO‐PRUSSIDE AND 8‐BROMO‐GUANOSINE 3‘,5’‐MONOPHOSPHATE OF CANINE ATRIAL AND VENTRICULAR MUSCLE

1981 • 25 citations

Cholinergic attenuation of the electrophysiological effects of forskolin.

1986 • 25 citations

5'-Guanylylimidodiphosphate-activated adenylate cyclase of cardiac sarcolemma displays higher affinity for magnesium ions.

1977 • 25 citations

Block by Cs of K currenti K1 and of carbachol induced K currenti Cch in frog atrium

1983 • 25 citations

Influence of acetycholine on the positive inotropic effect evoked by ?- or ?-adrenoceptor stimulation in the rabbit heart

1982 • 25 citations

Effects of Cs on acetylcholine induced current

1981 • 25 citations

Phosphorylation of the inhibitory subunit of troponin in perfused hearts of mice deficient in phosphorylase kinase. Evidence for the phosphorylation of troponin by adenosine 3′:5′-phosphate-dependent protein kinase in vivo

1977 • 25 citations

PHYSIOLOGICAL APPRAISAL OF THE ACTIONS OF CATECHOLAMINES ON MYOCARDIAL CONTRACTIONS

1967 • 24 citations

Mechanism of the positive inotropic effect of milrinone in cultured embryonic chick ventricular cells*

1987 • 24 citations

Differential inotropic and chronotropic effects of various protein kinase C activators on isolated guinea pig atria

1987 • 24 citations

Methylxanthines modulate adenosine release from slices of cerebral cortex

1981 • 24 citations

Effects of calcium overload on relaxation in cultured heart cells

1981 • 24 citations

Forskolin, a new positive inotropic agent, and its influence on myocardial electrogenic cation movements.

1984 • 23 citations

Indications for the existence of two types of cardiac β-adrenergic receptors

1975 • 23 citations

Beta adrenergic receptor subtypes in the atria: evidence for close coupling of beta-1 and beta-2 adrenergic receptors to adenylate cyclase.

1986 • 22 citations

Photoaffinity labeling of alpha 1-adrenergic receptors of rat heart.

1986 • 22 citations

Guanine nucleotides and alpha1 adrenergic receptors in the heart

1983 • 22 citations

Sarcolemmal phospholamban is phosphorylated in isolated rat hearts perfused with isoprenaline

1983 • 22 citations

Evidence against a role of a pertussis toxin-sensitive guanine nucleotide-binding protein in the alpha1-adrenoceptor-mediated positive inotropic effect in the heart

1987 • 22 citations

On the cellular mechanism of the inotropic action of acetylcholine on isolated rabbit and dog atria

1973 • 22 citations

Component of whole cell Ca current due to electrogenic Na-Ca-exchange in cardiac myocytes

1987 • 22 citations

Carbachol inhibits electrophysiological effects of cyclic AMP in ventricular myocytes

1986 • 21 citations

Optical measurement of voltage-dependent Ca2+ influx in frog heart.

1985 • 20 citations

Photochemically produced intracellular concentration jumps of cAMP mimic the effects of catecholamines on excitation-contraction coupling in frog atrial fibers

1985 • 20 citations

Voltage clamp and tracer flux data: effects of a restricted extracellular space

1979 • 20 citations

POSITIVE CHRONOTROPIC RESPONSES PRODUCED BY α‐ADRENORECEPTORS IN THE PITHED RAT

1982 • 20 citations

Failure of dibutyryl and 8-bromo-cyclic gmp to mimic the antagonistic action of carbachol on the positive inotropic effects of sympathomimetic amines in the canine isolated ventricular myocardium

1979 • 19 citations

Separation of current induced by potassium accumulation from acetylcholine-induced relaxation current in the rabbit S-A node

1980 • 19 citations

[On the mechanism of the negative inotropic acetylcholine effect on the isolated frog myocardium].

1968 • 19 citations

Acetylcholine and the mammalian 'slow inward' current : a computer investigation

1987 • 19 citations

Are acetylcholine‐induced increases in 42K efflux mediated by intracellular cyclic GMP in turtle cardiac pace‐maker tissue?

1981 • 19 citations

Autonomic transmitter actions on cardiac pacemaker tissue: a brief review.

1981 • 18 citations

K channel kinetics during the spontaneous heart beat in embryonic chick ventricle cells

1988 • 18 citations

Crystallization of Arginase from Normal and Cirrhotic Human Liver

1965 • 18 citations

Voltage-dependent effects of isoproterenol on cytosolic Ca concentration in rat heart

1987 • 18 citations

A comparison of muscarinic acetylcholine receptors coupled to phosphatidylinositol turnover and to adenylate cyclase in guinea-pig atria and ventricles

1987 • 18 citations

Involvement of cyclic nucleotides in the beating response of rat heart cells in culture

1976 • 18 citations

A kinetic model for the muscarinic action of acetylcholine

1979 • 18 citations

Neurotransmitter and cyclic nucleotide modulation of frog cardiac contractility

1978 • 17 citations

[18] Preparation and characterization of adenylate cyclase from heart and skeletal muscle

1974 • 17 citations

Does the calcium current modulate the contraction of the accompanying beat? A study of E-C coupling in mammalian ventricular muscle using cobalt ions.

1981 • 17 citations

Cyclic GMP-dependent phosphorylation of an endogenous protein from rat heart

1981 • 16 citations

Expression of single calcium channels in Xenopus oocytes after injection of mRNA from rat heart

1987 • 16 citations

'Wrong' subunit regulates cardiac potassium channels

1987 • 15 citations

Phosphorylation of a Kidney Preparation of Na,K-ATPase by the Catalytic Subunit of cAMP-Dependent Protein Kinase

1983 • 15 citations

Properties of detergent-dispersed myocardial adenylate cyclase

1978 • 15 citations

The effect of acetylcholine, ischemia, and anoxia on rat heart purine cyclic nucleotides and contractility.

1981 • 14 citations

Pertussis toxin-insensitive mechanism for carbachol-induced depolarization and positive inotropic effect in heart muscle.

1988 • 14 citations

Two potentially arrhythmogenic mechanisms of adrenaline action in cardiac muscle

1984 • 14 citations

Inotropic and electrophysiological effects of 8-substituted cyclic AMP analogues on guinea-pig papillary muscle

1987 • 14 citations

Ca-dependent outward currents in bullfrog myocardium.

1983 • 13 citations

Do catecholamines directly modulate the delayed plateau potassium current in frog atrium?

1985 • 13 citations

Joint voltage- and calcium dependent inactivation of Ca channels in frog atrial myocardium.

1986 • 13 citations

Stimulation by phenylephrine of myocardial alpha-adrenoceptors in the left ventricle of the cat

1975 • 13 citations

Thrombin stimulates Ca-channel currents in isolated frog ventricular cells

1988 • 13 citations

Analysis of the negative inotropic effect of acetylcholine on frog atrial fibres.

1981 • 12 citations

Differences in the properties of muscarinic cholinergic receptors in the developing chick myocardium.

1985 • 12 citations

The interaction of carbachol and forskolin in rabbit papillary muscles

1984 • 12 citations

An effect of noradrenaline on resting potential and Na activity in sheep cardiac Purkinje fibres

1986 • 12 citations

.BETA.-Actions of catecholamines on the K-related currents of the bullfrog atrial muscle.

1984 • 11 citations

Effects of norepinephine, calcium, and rate of discharge on 42K movements in canine cardiac Purkinje fibers.

1978 • 11 citations

Depolarizing effects of catecholamines in quiescent sheep cardiac Purkinje fibers

1986 • 11 citations

[62] Isolation and comparison of bovine heart cGMP-inhibited and cGMP-stimulated phosphodiesterases

1988 • 11 citations

Protein kinase C in transmembrane signaling.

1988 • 11 citations

Nonstationary fluctuation analysis of the delayed rectifier K channel in cardiac Purkinje fibers. Actions of norepinephrine on single-channel current

1989 • 11 citations

β-Adrenoceptor agonist accelerates recovery from inactivation of calcium-dependent action potentials

1985 • 11 citations

Phosphorylation of the myofibrillar proteins and the regulation of contractile activity in muscle

1983 • 10 citations

Mechanisms of β-Adrenergic and Cholinergic Control of Ca and K Currents in the Heart

1986 • 10 citations

[22] Using immunocolloidal gold electron microscopy to investigate cAMP-dependent protein kinase cellular compartmentalization

1988 • 10 citations

Interaction between alpha and beta adrenergic receptors and cholinergic receptors in isolated perfused rat heart: effects on cAMP-protein kinase and phosphorylase.

1980 • 10 citations

Electrophysiological responses of cardiac muscle to isoproterenol covalently linked to glass beads.

1977 • 10 citations

Inhibition of forskolin activated adenylate cyclase in hamster adipocyte membranes with prostaglandin E1 and clonidine.

1982 • 9 citations

Electrophysiological and pharmacological study of the inotropic effects of adrenaline, dopamine and tryptamine on frog atrial fibres

1982 • 9 citations

Oscillations of cAMP with the cardiac cycle

1983 • 9 citations

Mode of action of theophylline on sodium efflux in barnacle muscle fibers

1978 • 9 citations

Distribution of muscarinic acetylcholine receptors in amphibian cardiac muscle

1979 • 9 citations

Effect of acetylcholine on glycogen phosphorylase activity and cyclic nucleotide content in isolated perfused rat hearts.

1976 • 8 citations

Effect of forskolin on action potential, slow inward current and tension of frog atrial fibers.

1985 • 8 citations

Forskolin, a New Positive Inotropic Agent, and Its Influence on Myocardial Electrogenic Cation Movements

1984 • 7 citations

Purification and partial characterization of membrane-associated type II (cGMP-activatable) cyclic nucleotide phosphodiesterase from rabbit brain

1988 • 7 citations

Activation of lipolysis and cyclic AMP accumulation in rabbit adipocytes by isoproterenol in the presence of forskolin or pertussis toxin

1984 • 7 citations

Enzymatic Cleavage of the <italic>O</italic><sup>2′</sup>-Butyryl Ester Bond of <italic>N</italic><sup>6</sup>, <italic>O</italic><sup>2′</sup> Dibutyryl Cyclic AMP and Its Possible Involvement in the Action of Cyclic AMP Derivatives <italic>In Vivo</italic>

1979 • 7 citations

Inactivation and Modulation of Cardiac Ca Channels

1986 • 7 citations

The action of muscarinic agonists and antagonists on frog atrial fibers. Electrophysiological studies.

1982 • 6 citations

Neural regulation of cyclic AMP, cyclic AMP-dependent protein kinase, and phosphorylase in bullfrog ventricular myocardium.

1982 • 6 citations

Inhibition by Ba of background current and of its modifications by carbachol in frog atrium

1983 • 6 citations

Stimulant Action of Methoxamine in the Isolated Atria of Normal and 6-Propyl-2-Thiouracil-Fed Rats

1973 • 5 citations

Regional Distribution of Choline Acetyltransferase Activity and Multiple Affinity forms of the Muscarinic Receptor in Heart

1983 • 5 citations

Protein Phosphorylation

2003 • 4 citations

[23] Direct cytochemical localization of the free catalytic subunit of cAMP-dependent protein kinase

1988 • 2 citations

Development and Regulation of Cardiac Muscarinic Acetylcholine Receptor Number, Function and Gyanyl Nucleotide Sensitivity

1983 • 2 citations

Deleted Work

1955 • 0 citations