Mechanisms of calcium channel modulation by β-adrenergic agents and dihydropyridine calcium agonists

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists

1984 • 1,292 citations

Calcium channel modulation by neurotransmitters, enzymes and drugs

1983 • 1,267 citations

The role of protein phosphorylation in neural and hormonal control of cellular activity

1982 • 1,116 citations

Novel dihydropyridines with positive inotropic action through activation of Ca2+ channels

1983 • 1,010 citations

Sodium and calcium channels in bovine chromaffin cells

1982 • 983 citations

Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state.

1984 • 834 citations

The variance of sodium current fluctuations at the node of Ranvier

1980 • 772 citations

Calcium Channels in Excitable Cell Membranes

1983 • 725 citations

Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology.

1985 • 715 citations

Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists.

1984 • 553 citations

The dependence of slow inward current in Purkinje fibres on the extracellular calcium‐concentration

1967 • 544 citations

Inactivation of calcium channels in mammalian heart cells: joint dependence on membrane potential and intracellular calcium.

1985 • 477 citations

The regulation of the calcium conductance of cardiac muscle by adrenaline.

1977 • 475 citations

Calcium and Cardiac Excitation-Contraction Coupling

1979 • 425 citations

Localization of beta adrenergic receptors, and effects of noradrenaline and cyclic nucleotides on action potentials, ionic currents and tension in mammalian cardiac muscle

1974 • 422 citations

Injection of subunits of cyclic AMP-dependent protein kinase into cardiac myocytes modulates Ca2+ current

1982 • 421 citations

Properties of Two Inward Membrane Currents in the Heart

1979 • 409 citations

β-Adrenergic modulation of calcium channels in frog ventricular heart cells

1984 • 387 citations

Cyclic AMP Mediates the Effects of Adrenaline on Cardiac Purkinje Fibres

1972 • 346 citations

Properties of single calcium channels in cardiac cell culture

1982 • 342 citations

Dihydropyridine derivatives prolong the open state of Ca channels in cultured cardiac cells.

1984 • 323 citations

Ca2+ channel modulation by 8-bromocyclic AMP in cultured heart cells

1983 • 304 citations

ADH ACTION: EVIDENCE FOR A MEMBRANE SHUTTLE MECHANISM*

1981 • 291 citations

Cyclic AMP and contractile activity in heart.

1977 • 291 citations

Inactivation of calcium channel current in the calf cardiac Purkinje fiber. Evidence for voltage- and calcium-mediated mechanisms.

1984 • 272 citations

A metabolic control mechanism for calcium ion influx that may protect the ventricular myocardial cell

1976 • 270 citations

Effects of adrenaline on membrane inward currents during the cardiac action potential

1969 • 267 citations

The agonist effect of dihydropyridines on Ca channels

1984 • 264 citations

Elementary currents through Ca2+ channels in Guinea pig myocytes

1983 • 220 citations

?-Adrenergic increase in the calcium conductance of cardiac myocytes studied with the patch clamp

1984 • 210 citations

Cyclic AMP and contractile activity in heart.

1977 • 195 citations

Adrenaline-like Effects of Intracellular Iontophoresis of Cyclic AMP in Cardiac Purkinje Fibres

1973 • 168 citations

Isoproterenol-induced phosphorylation of a 15-kilodalton sarcolemmal protein in intact myocardium.

1985 • 159 citations

Disturbances in neurogenic control of the circulation

1981 • 155 citations

Inotropic drugs and their mechanisms of action

1984 • 151 citations

Injection of catalytic subunit of cAMP-dependent protein kinase into isolated cardiac myocytes

1983 • 149 citations

Calcium-mediated inactivation of the calcium conductance in cesium-loaded frog heart cells.

1984 • 148 citations

Kinetics of binding of membrane-active drugs to receptor sites. Diffusion-limited rates for a membrane bilayer approach of 1,4-dihydropyridine calcium channel antagonists to their active site.

1985 • 147 citations

A dihydropyridine (Bay k 8644) that enhances calcium currents in guinea pig and calf myocardial cells. A new type of positive inotropic agent.

1985 • 137 citations

Time course of the increase in the myocardial slow inward current after a photochemically generated concentration jump of intracellular cAMP.

1983 • 132 citations

Calcium Channels in Planar Lipid Bilayers: Insights into Mechanisms of Ion Permeation and Gating

1986 • 131 citations

Cyclic adenosine monophosphate effects on the myocardium: A man who blows hot and cold with one breath

1983 • 124 citations

Modulation of gated ion channels as a mode of transmitter action

1983 • 115 citations

The conductance of sodium channels under conditions of reduced current at the node of Ranvier.

1980 • 86 citations

Single channel Ca2+ currents inHelix pomatia neurons

1981 • 77 citations

Analysis of catecholamine effects in single atrial trabeculae of the frog heart

1977 • 65 citations

Prolongation of calcium channel open time by the dihydropyridine derivative BAY K 8644 in cardiac myocytes.

1984 • 58 citations

Vasopressin increases water permeability by inducing pores

1980 • 52 citations

New Insights into Cell and Membrane Transport Processes

1986 • 45 citations

Nitrendipine and isoproterenol induce phosphorylation of a 42,000 dalton protein that co-migrates with the affinity labeled calcium channel regulatory subunit

1984 • 41 citations

Calcium Channels: Mechanisms of -Adrenergic Modulation and Ion Permeation

1983 • 40 citations

Isolation of cardiac membrane proteolipids by high pressure liquid chromatography. A comparison of reticular and sarcolemmal proteolipids, phospholamban and calciductin

1983 • 30 citations

Shifts between Modes of Calcium Channel Gating as a Basis for Pharmacological Modulation of Calcium Influx in Cardiac, Neuronal, and Smooth-Muscle-Derived Cells

1986 • 16 citations

Two potentially arrhythmogenic mechanisms of adrenaline action in cardiac muscle

1984 • 14 citations

Stimulation of Ca-dependent action potentials in mammalian ventricular myocardium by a novel dihydropyridine.

1984 • 11 citations

β-Adrenoceptor agonist accelerates recovery from inactivation of calcium-dependent action potentials

1985 • 11 citations

Frequency and Time Domain Analysis of Epithelial Transport Regulation

1986 • 6 citations

Control of conductance in cardiac membrane permeability.

1973 • 5 citations

Ca current inactivation is slowed in dialyzed snail neurons by the substitution of atp-gamma-s for internal atp

1985 • 3 citations