Effects of Beta- and Alpha-Adrenoceptor Activators and Adrenergic Transmitter Releasing Agents on the Mechanical Activity of the Heart

A STUDY OF THE ADRENOTROPIC RECEPTORS

1948 • 2,856 citations

Differentiation of Receptor Systems activated by Sympathomimetic Amines

1967 • 2,054 citations

Specific Pharmacology of Calcium in Myocardium, Cardiac Pacemakers, and Vascular Smooth Muscle

1977 • 1,745 citations

Regulation of noradrenaline release by presynaptic receptor systems

1977 • 1,482 citations

Cell Communication, Calcium Ion, and Cyclic Adenosine Monophosphate

1970 • 1,097 citations

Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiace and skeletal muscles.

1978 • 1,086 citations

Some Aspects of the Biological Role of Adenosine 3',5'-monophosphate (Cyclic AMP)

1968 • 976 citations

A further Contribution regarding the influence of the different Constituents of the Blood on the Contraction of the Heart

1883 • 941 citations

Physiology of the heart

1977 • 769 citations

Force-velocity relations in mammalian heart muscle

1962 • 709 citations

The Relationship between Caffeine Contracture of Intact Muscle and the Effect of Caffeine on Reticulum

1968 • 683 citations

ADENYL CYCLASE AS AN ADRENERGIC RECEPTOR*

1967 • 682 citations

Cyclic GMP Metabolism and Involvement in Biological Regulation

1977 • 629 citations

Thyroid hormone regulation of beta-adrenergic receptor number.

1977 • 591 citations

The role of cyclic-3',5'-AMP in responses to catecholamines and other hormones.

1966 • 573 citations

THE INFLUENCE OF THE INTERVAL BETWEEN BEATS ON MYOCARDIAL CONTRACTILITY.

1963 • 569 citations

Adenyl Cyclase

1962 • 555 citations

The dependence of slow inward current in Purkinje fibres on the extracellular calcium‐concentration

1967 • 544 citations

Divalent cations as charge carriers in excitable membranes

1973 • 516 citations

PHARMACOLOGY OF A NEW ADRENERGIC BETA-RECEPTOR-BLOCKING COMPOUND (NETHALIDE)

1962 • 508 citations

A NEW ADRENERGIC

1964 • 485 citations

The regulation of the calcium conductance of cardiac muscle by adrenaline.

1977 • 475 citations

Frontiers in Catecholamine Research

1976 • 451 citations

Handbook of Physiology Section 7: Endocrinology

1976 • 448 citations

The action of adrenalin

1905 • 430 citations

Calcium release from the sarcoplasmic reticulum.

1977 • 428 citations

Localization of beta adrenergic receptors, and effects of noradrenaline and cyclic nucleotides on action potentials, ionic currents and tension in mammalian cardiac muscle

1974 • 422 citations

Supersensitivity and subsensitivity to sympathomimetic amines.

1963 • 412 citations

Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart

1976 • 388 citations

Mechanisms of Contraction of the Normal and Failing Heart.

1976 • 367 citations

Contractile proteins of the heart.

1970 • 365 citations

The Physiological Effects of Extracts of the Suprarenal Capsules

1895 • 356 citations

Excitation-Contraction Coupling

1976 • 355 citations

Derivatives of cyclic 3′,5′-adenosine monophosphate

1962 • 354 citations

Brief Reviews Exchange of Calcium Ions in the Mammalian Myocardium

1974 • 350 citations

Cyclic AMP Mediates the Effects of Adrenaline on Cardiac Purkinje Fibres

1972 • 346 citations

Diminished inotropic response of aged myocardium to catecholamines.

1975 • 336 citations

Adrenaline and the plateau phase of the cardiac action potential

1969 • 306 citations

THE ULTRASTRUCTURE OF THE CAT MYOCARDIUM

1969 • 306 citations

Biologic regulation through opposing influences of cyclic GMP and cyclic AMP: the Yin Yang hypothesis.

1975 • 305 citations

Excitation-contraction coupling in heart muscle: Membrane control of development of tension

1973 • 304 citations

The relation between membrane potential, membrane currents and activation of contraction in ventricular myocardial fibres

1970 • 302 citations

The subcellular basis for the mechanism of inotropic action of cardiac glycosides.

1971 • 299 citations

The effect of epinephrine on adenosine 3', 5'-phosphate levels in the isolated perfused rat heart.

1965 • 297 citations

THE CONTOUR OF THE VENTRICULAR VOLUME CURVES UNDER DIFFERENT CONDITIONS

1922 • 293 citations

Alpha sympathomimetic inhibition of adrenergic and cholinergic transmission in the rabbit heart

1972 • 293 citations

Cyclic AMP and contractile activity in heart.

1977 • 291 citations

Implications of muscle mechanics in the heart.

1962 • 276 citations

A metabolic control mechanism for calcium ion influx that may protect the ventricular myocardial cell

1976 • 270 citations

Effects of adrenaline on membrane inward currents during the cardiac action potential

1969 • 267 citations

Effects of acidosis and ischemia on contractility and intracellular pH of rat heart.

1977 • 263 citations

Influence of Caffeine and other Methylxanthines on Mechanical Properties of Isolated Mammalian Heart Muscle: EVIDENCE FOR A DUAL MECHANISM OF ACTION

1972 • 262 citations

Calcium-Dependent Action Potentials Produced by Catecholamines in Guinea Pig Atrial Muscle Fibers Depolarized by Potassium

1970 • 253 citations

EFFECTS OF CAFFEINE ON MAMMALIAN ATRIAL MUSCLE, AND ITS INTERACTION WITH ADENOSINE AND CALCIUM.

1965 • 242 citations

Receptor Binding Studies in Adrenergic Pharmacology

1978 • 240 citations

Heart: Excitation-Contraction Coupling

1973 • 234 citations

Cyclic adenosine monophosphate, CA++, and membranes.

1968 • 228 citations

Interaction between cyclic adenosine monophosphate and cyclic gunaosine monophosphate in guinea pig ventricular myocardium.

1975 • 228 citations

Adrenergic blockade of the mammalian heart by a dichloro analogue of isoproterenol.

1958 • 218 citations

Hormonal control of protein phosphorylation.

1977 • 213 citations

Relaxing effects of catecholamines on mammalian heart

1972 • 205 citations

Effects of derivatives of adenosine 3′,5′-phosphate on liver slices and intact animals

1967 • 203 citations

Mechanism of Action of Epinephrine and Glucagon on the Canine Heart: EVIDENCE FOR INCREASE IN SARCOTUBULAR CALCIUM STORES MEDIATED BY CYCLIC 3',5'-AMP

1969 • 199 citations

THE ULTRASTRUCTURE OF FROG VENTRICULAR CARDIAC MUSCLE AND ITS RELATIONSHIP TO MECHANISMS OF EXCITATION-CONTRACTION COUPLING

1968 • 198 citations

Thyroxine and propylthiouracil effects in vivo on alpha and beta adrenergic receptors in rat heart

1977 • 196 citations

Studies on the phosphorylation of the inhibitory subunit of troponin during modification of contraction in perfused rat heart

1976 • 192 citations

Structures of physiological interest in the frog heart ventricle

1972 • 190 citations

Relation between mechanics of contraction and relaxation in mammalian cardiac muscle

1969 • 189 citations

Studies of the contractility of mammalian myocardium at low rates of stimulation.

1976 • 182 citations

The receptors for epinephrine and norepinephrine (adrenergic receptors).

1959 • 180 citations

Mechanisms of Contraction of the Normal and Failing Heart

1967 • 174 citations

Cyclic Adenosine Monophosphate Modulation of Slow Calcium Influx Channels in Guinea Pig Hearts

1974 • 173 citations

Slow Ca2+ and Na+ responses induced by isoproterenol and methylxanthines in isolated perfused guinea pig hearts exposed to elevated K+

1975 • 172 citations

PHYSICAL FACTORS IN THE ANALYSIS OF THE ACTIONS OF DRUGS ON MYOCARDIAL CONTRACTILITY.

1963 • 171 citations

Cyclic adenosine 3′,5′-monophosphate-dependent protein kinase stimulation of calcium uptake by canine cardiac microsomes

1972 • 170 citations

Receptor binding studies in adrenergic pharmacology

1979 • 169 citations

Adrenaline-like Effects of Intracellular Iontophoresis of Cyclic AMP in Cardiac Purkinje Fibres

1973 • 168 citations

Calcium Current Channels Induced by Catecholamines in Chick Embryonic Hearts Whose Fast Sodium Channels are Blocked by Tetrodotoxin or Elevated Potassium

1972 • 165 citations

Effect of pH on ionic exchange and function in rat and rabbit myocardium

1975 • 165 citations

The effect of substances releasing intracellular calcium ions on sodium‐dependent calcium efflux from guinea‐pig auricles.

1975 • 163 citations

Nature of the Inotropic Action of Angiotensin on Ventricular Myocardium

1965 • 159 citations

The contractile state of rabbit papillary muscle in relation to stimulation frequency.

1976 • 159 citations

THE EFFECTS OF VARIOUS DRUGS ON CALCIUM EXCHANGE IN THE ISOLATED GUINEA-PIG LEFT AURICLE.

1964 • 157 citations

Adenosine 3', 5'-Monophosphate-Dependent Membrane Phosphorylation

1974 • 156 citations

Inotropic effect of cyclic AMP in calf ventricular muscle studied by a cut end method.

1976 • 155 citations

Correlation between contraction and phosphorylation of the inhibitory subunit of troponin in perfused rat heart

1975 • 151 citations

On the presence and distribution of ?-adrenoceptors in the heart of various mammalian species

1978 • 151 citations

Andrenergic receptive mechanism of canine ileum.

1959 • 150 citations

Phosphorylation of cardiac troponin by cyclic adenosine 3':5'-monophosphate-dependent protein kinase.

1977 • 148 citations

Calcium Movements and Excitation–Contraction Coupling in Cardiac Cells

1972 • 147 citations

Myocardial alpha adrenergic receptors and their role in the production of a positive inotropic effect by sympathomimetic agents.

1968 • 146 citations

Sensitivity to H, Li and Mg ions of the slow inward sodium current in frog atrial fibres

1975 • 143 citations

Some Properties of Fragmented Frog Sarcoplasmic Reticulum with Particular Reference to Its Response to Caffeine*

1970 • 143 citations

Calcium exchange in cardiac muscle: A basic mechanism of drug action

1967 • 141 citations

The potentiation of cardiac inotropic responses to norepinephrine by theophylline.

1963 • 139 citations

Effects of noradrenaline and isoprenaline, in combination with α‐ and β‐receptor blocking substances, on the action potential of cardiac Purkinje fibres

1973 • 136 citations

Positive inotropic effects of phenylephrine in the isolated rabbit papillary muscle mediated both by ?-and ?-adrenoceptors

1974 • 135 citations

Phosphorylation of cardiac troponin by guanosine 3‘:5‘-monophosphate-dependent protein kinase.

1978 • 134 citations

Positive Inotropic Effects of Dibutyryl Cyclic Adenosine 3',5'-Monophosphate

1970 • 133 citations

Regulatory role of membrane systems in heart function

1977 • 133 citations

The effect of methylxanthines and local anesthetics on fragmented sarcoplasmic reticulum.

1969 • 131 citations

MECHANISMS INVOLVED IN THE RELEASE OF NORADRENALINE FROM SYMPATHETIC NERVES

1973 • 131 citations

The contractile state of the heart as expressed by force-velocity relations

1969 • 130 citations

The time course of the effects of ?-and ?-adrenoceptor stimulation by isoprenaline and methoxamine on the contractile force and cAMP level of the isolated rabbit papillary muscle

1975 • 130 citations

THYROID HORMONE‐DEPENDENT INTERCONVERSION OF MYOCARDIAL α‐ AND β‐ADRENOCEPTORS IN THE RAT

1977 • 129 citations

Cyclic Adenosine 3′,5′-Monophosphate-stimulated Protein Kinase and a Substrate Associated with Cardiac Sarcoplasmic Reticulum

1973 • 128 citations

Die Restitution der Erregungsfortleitung und Kontraktionskraft des K+-gelähmten Frosch- und Säugetiermyokards durch Adrenalin

1961 • 119 citations

Potentiation of the effects of isoprenaline and noradrenaline by hydrocortisone in cat heart muscle

1972 • 117 citations

Kinetics of Cyclic Adenosine Monophosphate Changes in Rat Heart following Epinephrine Administration

1965 • 116 citations

Effects of thyroid state on adrenoceptor properties

1974 • 115 citations

Frequency-dependence of the positive inotropic effect of methoxamine and naphazoline mediated by ?-adrenoceptors in the isolated rabbit papillary muscle

1975 • 114 citations

Active State in Heart Muscle

1967 • 114 citations

Relaxing and inotropic effects of cyclic AMP on skinned cardiac cells

1975 • 113 citations

New Aspects of Storage and Release Mechanisms of Catecholamines

1970 • 111 citations

Demonstration in human atrial preparations of ?-adrenoceptors mediating positive inotropic effects

1978 • 108 citations

Studies on Receptor-mediated Activation of Adenylyl Cyclases

1974 • 107 citations

Evidence favouring the Existence of a Single Adrenergic Receptor

1968 • 107 citations

�ber die Wirkung von Adrenalin auf den cellul�ren Ca-Umsatz des Meerschweinchenvorhofs

1965 • 106 citations

β-Adrenergic receptors in rat heart: Effects of thyroidectomy

1977 • 103 citations

Control of calcium transport in the myocardium by the cyclic AMP-Protein kinase system.

1975 • 102 citations

Influence of low extracellular pH upon the Ca inward current and isometric contractile force in mammalian ventricular myocardium

1976 • 102 citations

The role of potassium and calcium ions in the effect of epinephrine on cardiac cyclic adenosine 3',5'-monophosphate, phosphorylase kinase, and phosphorylase.

1968 • 102 citations

Cardiac histamine receptors: differences between left and right atria and right ventricle.

1977 • 102 citations

Effects of Catecholamines on Metabolism

1972 • 100 citations

Determinants of active state in heart muscle: force, velocity, instantaneous muscle length, time.

1965 • 99 citations

Strom-Spannungsbeziehungen von Purkinje-Fasern bei verschiedenen extracellul�ren Calcium-Konzentrationen und unter Adrenalineinwirkung

1966 • 99 citations

Comparative ultrastructure of cardiac cell membrane specializations. A review

1970 • 98 citations

A positive inotropic effect of phenylephrine mediated through adrenergic receptors

1967 • 97 citations

Alpha-adrenergic receptors in rat myocardium. Identification by binding of [3H]dihydroergocryptine.

1978 • 95 citations

The Adrenergic Receptor

1966 • 94 citations

Classification of Sympathomimetic Amines

1972 • 92 citations

Effect of Epinephrine on Phosphorylase b Kinase in Perfused Rat Hearts

1966 • 91 citations

Blockade of myocardial slow inward current at low pH

1977 • 90 citations

STUDIES ON THE POSITIVE INOTROPIC EFFECT OF PHENYLEPHRINE: A COMPARISON WITH ISOPRENALINE

1975 • 90 citations

Activation of skinned cardiac cells. Subcellular effects of cardioactive drugs.

1973 • 88 citations

Cyclic Adenosine Monophosphate and Cardiac Contractility

1973 • 87 citations

Interactions between sympathomimetic amines and blocking agents on the rat ventricle strip.

1966 • 87 citations

Cyclic AMP and cyclic GMP may play opposing roles in influencing force of contraction in mammalian myocardium

1976 • 86 citations

Alpha-adrenoceptor-mediated restoration of calcium-dependent potential in the partially depolarized rabbit papillary muscle

1978 • 86 citations

Calcium-mediated action potentials in mammalian myocardium

1973 • 85 citations

Chemical pharmacology of the synapse

1976 • 84 citations

Temperature‐induced interconversion of alpha‐and beta‐adrenoceptors in the frog heart.

1976 • 83 citations

INTERACTIONS OF SYMPATHOMIMETIC DRUGS, PROPRANOLOL AND PHENTOLAMINE, ON ATRIAL REFRACTORY PERIOD AND CONTRACTILITY

1967 • 82 citations

Inotropic stimuli and systolic transmembrane calcium flow in depolarized guinea-pig atria.

1974 • 82 citations

Cardiac Actions of Methoxamine

1961 • 81 citations

Factors influencing myocardial contractility

1969 • 80 citations

Effects of several phosphodiesterase-inhibitors on guinea-pig myocardium

1978 • 80 citations

ACTIONS OF AUTONOMIC DRUGS ON PHOSPHORYLASE ACTIVITY AND FUNCTION.

1965 • 80 citations

Contractile Effects of a Calcium Ionophore

1973 • 80 citations

Electrical Phenomena in the Heart

1977 • 78 citations

Positive inotropic effects of methoxamine: evidence for alpha-adrenergic receptors in ventricular myocardium

1975 • 77 citations

Kinetics of radiocaffeine uptake and release in frog sartorius.

1962 • 77 citations

Effects of epinephrine on cardiac cyclic 3',5'-AMP, phosphorylase kinase, and phosphorylase.

1968 • 76 citations

Adenyl Cyclase and Cyclic AMP

1971 • 76 citations

Protein kinase-catalyzed membrane phosphorylation and its possible relationship to the role of calcium in the adrenergic regulation of cardiac contraction

1978 • 75 citations

The effects of adrenaline and theophylline on action potential and contraction of mammalian ventricular muscle under “rested-state” and “steady-state” stimulation

1977 • 74 citations

Adrenergic receptors in heart muscle: relations among factors influencing the sensitivity of the cat papillary muscle to catecholamines.

1970 • 74 citations

Synthesis and biological activity of some 2' derivatives of adenosine 3',5'-cyclic phosphate

1973 • 73 citations

The Action of Acetylcholine and Epinephrine on the Cellular Membrane Potentials and Contractility of Rat Atrium

1956 • 73 citations

Studies on Receptor-mediated Activation of Adenylyl Cyclases

1974 • 73 citations

Phospholamban: a regulatory protein of the cardiac sarcoplasmic reticulum.

1975 • 72 citations

Identification and regulation of alpha- and beta-adrenergic receptors.

1978 • 71 citations

The role of cyclic adenosine 3', 5'-monophosphate and calcium in the regulation of contractility and glycogen phosphorylase activity in guinea pig papillary muscle.

1976 • 71 citations

Cardiostimulatory effects of cyclic 3?,5?-adenosine monophosphate and its acylated derivatives

1970 • 71 citations

Cardiac muscle mechanics in the evaluation of myocardial contractility and pump function: Problems, concepts, and directions

1973 • 70 citations

Qualitative Differences between β‐Adrenergic and α‐Adrenergic Inotropic Effects in Rat Heart Muscle

1978 • 69 citations

Temperature modulation of α‐ and β‐adrenoceptors in the isolated frog heart

1970 • 68 citations

The β-adrenergic receptor

1976 • 68 citations

EFFECT OF HYPOTHYROID STATUS ON MYOCARDIAL RESPONSES TO SYMPATHOMIMETIC DRUGS

1971 • 68 citations

The Chemorelease of Norepinephrine from Mouse Hearts. Structure-Activity Relationships. I. Sympathomimetic and Related Amines

1966 • 68 citations

Direct effects of the monovalent cation ionophores monensin and nigericin on myocardium.

1977 • 68 citations

Effect of catecholamines, histamine and oxyfedrine on isotonic contraction and cyclic AMP in the guinea-pig heart

1973 • 67 citations

Propranolol-insensitive effects of epinephrine on action potential repolarization in electrically driven atria of the guinea pig.

1971 • 67 citations

Effects of theophylline on myocardial mechanics

1972 • 67 citations

Analysis of catecholamine effects in single atrial trabeculae of the frog heart

1977 • 65 citations

Paradoxical Effects of Epinephrine on Excitation-Contraction Coupling in Cardiac Muscle

1966 • 64 citations

Regulation of Cardiac Contraction

1972 • 63 citations

Ventricular distensibility and pressure-volume curve during sympathetic stimulation

1963 • 62 citations

Catecholamine receptors

2006 • 62 citations

Influence of caffeine on force development and force-frequency relations in cat and rat heart muscle

1974 • 62 citations

alpha-Adrenergic reduction of cyclic adenosine monophosphate concentrations in rat myocardium.

1977 • 61 citations

The effects of drugs on calcium uptake and calcium release by mitochondria and sarcoplasmic reticulum of frog skeletal muscle

1974 • 60 citations

The mammalian myocardium

1974 • 59 citations

Inhibition of sarcotubular calcium transport by caffeine: Species and temperature dependence

1969 • 59 citations

Drugs and the Mechanical Properties of Heart Muscle

1968 • 59 citations

α-Adrenoceptors in the ventricular myocardium: clonidine, naphazoline and methoxamine as partial α-agonists exerting a competitive dualism in action to phenylephrine

1976 • 58 citations

Mechanism of the histamine-induced positive inotropic action in cardiac muscle

1976 • 57 citations

Investigation into the positive inotropic effect of clondine in isolated hearts

1974 • 56 citations

Cyclic AMP and calcium uptake of the sarcoplasmic reticulum in relation to increased rate of relaxation under the influence of catecholamines

1970 • 56 citations

Effect of caffeine on cardiac contractile activity and radiocalcium movement

1963 • 56 citations

[Current-tension relations of Purkinje fibers in different extracellular concentrations of calcium and under the influence of adrenaline].

1966 • 56 citations

Inotrope Effekte von ATP und Adrenalin am hypodynamen Froschmyokard nach elektro-mechanischer Entkoppelung durch Ca++-Entzug

1960 • 55 citations

Restoration by histamine of the calcium-dependent electrical and mechanical response in the guinea-pig papillary muscle partially depolarized by potassium

1976 • 55 citations

α-ADRENOCEPTORS MEDIATING POSITIVE INOTROPIC EFFECTS ON THE VENTRICULAR MYOCARDIUM: SOME ASPECTS OF STRUCTURE-ACTIVITY RELATIONSHIP OF SYMPATHOMIMETIC AMINES

1976 • 55 citations

Stimulatory effects of DB-c-AMP and adrenaline on myocardial contraction and 45Ca exchange. Experiments at reduced calcium concentration and low frequencies of stimulation

1973 • 54 citations

Relationship between cyclic AMP metabolism and inotropic response of perfused rat hearts to phenylephrine and other adrenergic amines.

1975 • 54 citations

Nervous control of the heart

1965 • 53 citations

Electrophysiologic correlates of the inotropic effects of Isoproterenol in canine myocardium

1975 • 53 citations

Enzymatic Deacylation of Mono- and Dibutyryl Derivatives of Cyclic Adenosine 3′, 5′-Monophosphate by Extracts of Rat Tissues

1972 • 52 citations

Transformation of Adrenergic Receptors in the Myocardium

1973 • 52 citations

Characterization of α‐adrenoceptors in the myocardium

1973 • 52 citations

Mode of action of the calcium ionophores X-537A and A23187 on cardiac contractility

1974 • 52 citations

Some Effects of Caffeine and Quinidine on Sarcoplasmic Reticulum of Skeletal and Cardiac Muscle

1973 • 51 citations

BLOCKADE OF SOME CARDIAC ACTIONS OF ADRENALINE BY DICHLOROISOPROTERENOL

1960 • 51 citations

An evaluation of adrenergic blockade of the mammalian heart.

1961 • 50 citations

Cyclic 3′,5′-Nucleotides: Mechanisms of Action.

1979 • 50 citations

The action of imidazole on the effects of methyl-xanthines and catecholamines on cardiac contraction and phosphorylase activity.

1967 • 50 citations

High Potassium and Low Sodium Contractures in Sheep Cardiac Muscle

1971 • 49 citations

Studies of fetal mouse hearts in organ culture: influence of prolonged exposure to triiodothyronine on cardiac responsiveness to isoproterenol, glucagon, theophylline, acetylcholine and dibutyryl cyclic 3',5'-adenosine monophosphate.

1974 • 49 citations

Dissociation of the increased formation of cardiac adenosine 3',5'-monophosphate from the positive inotropic effect of norepinephrine.

1969 • 48 citations

Structural and Functional Characterization of Dog Heart Microsomes

1969 • 48 citations

Influence of temperature on the positive inotropic effects mediated by α- and β-adrenoceptors in the isolated rabbit papillary muscle

1975 • 48 citations

Control of cardiac sarcolemmal adenylate cyclase and sodium, potassium-activated adenosinetriphosphatase activities.

1975 • 48 citations

Evidence for adrenergic alpha receptor depressant activity in the heart

1968 • 48 citations

Blockade of responses of isolated myocardium to epinephrine.

1961 • 47 citations

Caffeine effects upon contraction and calcium exchange in rabbit myocardium

1971 • 47 citations

Stimulation by phenylephrine of adrenergic alpha- and beta-receptors in the isolated perfused rabbit heart

1974 • 47 citations

The positive inotropic effect of phenylephrine in the presence of propranolol. Increase in time to peak force and in relaxation time without increase in c-AMP

1978 • 47 citations

Analysis of the adrenergic receptors of pacemaker and myocardial cells

1972 • 47 citations

Adenyl Cyclase and the Differentiation of β-Adrenoreceptors

1972 • 46 citations

Effectiveness of theophylline to increase cyclic AMP levels and force of contraction in electrically paced guinea-pig auricles. Comparison with isoprenaline, calcium and ouabain

1977 • 46 citations

Receptors and acceptors: a necessary distinction in hormone binding studies.

1974 • 46 citations

MODIFICATION BY RESERPINE OF THE RESPONSE OF THE ATRIAL PACEMAKER TO SYMPATHOMIMETIC AMINES.

1963 • 46 citations

Lack of relationship between myocardial cyclic AMP concentrations and inotropic effects of sympathomimetic amines

1971 • 45 citations

Lack of correlation between the positive inotropic effect evoked by α-adrenoceptor stimulation and the levels of cyclic AMP and/or cyclic GMP in the isolated ventricle strip of the rabbit

1978 • 44 citations

Effects of adrenergic agonists and antagonists on adenylate cyclase activity of dog heart and liver.

1972 • 44 citations

Possible role of cyclic AMP in the relaxation process of mammalian heart: Effects of dibutyryl cyclic AMP and theophylline on potassium contractures in cat papillary muscles

1976 • 43 citations

Papaverine blockade of an inward slow Ca2+ current in guinea pig heart

1975 • 43 citations

Specific inhibition by burimamide of histamine effects on myocardial contraction and cyclic AMP

1973 • 43 citations

The nature of the antagonism by methoxamine of the chronotropic and inotropic effects of catecholamines

1964 • 43 citations

Influence of temperature on the sensitivity of the ?-receptors and the contractility of guinea-pig atrium

1972 • 42 citations

Heart β-Adrenoceptors

1978 • 42 citations

Interaction of acetylcholine and epinephrine on heart cyclic AMP-dependent protein kinase

1978 • 42 citations

Kinetic studies of epinephrine effects in the perfused rat heart.

1966 • 42 citations

Influence of cyclization and acyl substitution on the inotropic effects of adenine nucleotides

1973 • 42 citations

Quantitative relations between cyclic AMP and contraction as affected by stimulators of adenylate cyclase and inhibitors of phosphodiesterase.

1975 • 41 citations

EFFECTS OF SYMPATHETIC INNERVATION AND TEMPERATURE ON THE PROPERTIES OF RAT HEART ADRENOCEPTORS

1977 • 41 citations

EVIDENCE FOR THE EXISTENCE OF ALPHA ADRENERGIC RECEPTOR IN ISOLATED RAT ATRIA

1972 • 41 citations

Mechanical activity of mammalian heart muscle: variable onset, species differences, and the effect of caffeine

1975 • 41 citations

Dissociations between changes in myocardial cyclic adenosine monophosphate and contractility.

1975 • 40 citations

Effect of isoproterenol on relation between maximal rate of contraction and maximal rate of relaxation

1977 • 40 citations

Characterization of the adrenoceptors mediating the positive ino- and chronotropic effect of phenylephrine on isolated atria from guinea pigs and rabbits by means of adrenolytic drugs

1974 • 40 citations

Effect of Phenylephrine on Cardiac Contractility and Adenyl Cyclase Activity

1971 • 40 citations

Membrane phosphorylation and calcium transport in cardiac and skeletal muscle membranes

1976 • 40 citations

Frequency dependence of the α-adrenoceptor-mediated positive inotropic effect in guinea pig heart

1976 • 40 citations

Der Einflu� der Natriumionen auf die Beziehung zwischen Frequenz und Kraft der Kontraktion des isolierten Meerschweinchenmyokards

1966 • 40 citations

Relationship between the level of cAMP and the contractile force under stimulation of ?- and ?-adrenoceptors by phenylephrine in the isolated rabbit papillary muscle

1976 • 40 citations

Differences in the inotropic cardiac effects of noradrenaline and dihydro-ouabain

1972 • 39 citations

?-Adrenergic receptors in guinea-pig myocardial tissue

1976 • 38 citations

STIMULANT ACTION OF METHOXAMINE IN THE ISOLATED ATRIA OF NORMAL AND 6-PROPYL-2-THIOURACIL-FED RATS

1973 • 38 citations

The calcium accumulating activity of subcellular fractions isolated from rat and guinea pig heart muscle

1975 • 38 citations

Alpha adrenergic involvement in heart metabolism: effects on adenosine cyclic 3',5'-monophosphate, adenosine cyclic 3',5'-monophosphate-dependent protein kinase, guanosine cyclic 3',5'-monophosphate, and glucose transport.

1977 • 38 citations

Adrenoceptors

1978 • 38 citations

Aged Sediments

1973 • 37 citations

The positive inotropic effect of cyclic AMP.

1972 • 37 citations

Effects of intracellularly applied cyclic 3',5'-adenosine monophosphate and dibutyryl cyclic 3',5'-adenosine monophosphate on the electrical activity of sinoatrial nodal cells of the rabbit.

1974 • 36 citations

The Mechanics of Myocardial Contraction

1966 • 36 citations

Effect of noradrenaline on an early and a late component of the myocardial contraction

1978 • 36 citations

Cyclic Adenosine 3′:5′-Monophosphate-dependent Protein Kinase

1973 • 36 citations

Studies on β-adrenoceptors mediating changes in mechanical events and adenosine 3′,5′-monophosphate levels. Rat atria

1978 • 36 citations

Cardiac stimulant substances

1967 • 36 citations

Involvement of cAMP-dependent protein kinase in the regulation of heart contractile force

1977 • 36 citations

Hormonal regulation of myocardial adenosine 3′,5′-monophosphate

1969 • 36 citations

Glucagon: effect on adenosine 3', 5'-monophosphate in the rat heart

1968 • 35 citations

Studies on the cardiodynamic actions of drugs. II. The mechanism of cardiac stimulation by epinephrin

1927 • 35 citations

Inotropic and Metabolic Effects of Dibutyryl Cyclic Adenosine 3‘, 5’‐Monophosphate in the Perfused Rat Heart

1971 • 35 citations

Inotropic and chronotropic effects of dibutyryl cyclic AMP.

1972 • 35 citations

Dibutyryl cyclic AMP and adrenaline increase contractile force and 45Ca uptake in mammalian cardiac muscle

1973 • 35 citations

Die Beziehung von Calcium und Natrium zur inotropen Glykosidwirkung

1963 • 35 citations

Effects of Cyclic Amp and Dibutyryl Cyclic Amp on the Heart and Coronary Circulation

1974 • 35 citations

The effect of adrenaline on the tension developed in contractures and twitches of the ventricle of the frog

1968 • 34 citations

Hydroxylated chlorpromazine metabolites: positive inotropic action and the release of catecholamines.

1977 • 33 citations

EFFECTS OF CAFFEINE ON THE MEMBRANE POTENTIALS, MEMBRANE CURRENTS AND CONTRACTILITY OF THE BULLFROG ATRIUM

1974 • 32 citations

Reserpine-induced depletion of the norepinephrine stores: is it a reliable criterion for the classification of the mechanism of action of sympathomimetic amines?

1974 • 32 citations

The role of cyclic AMP in the modulation of cardiac contractility.

1974 • 32 citations

Positive Inotropic Effect without Cyclic AMP Elevation after α–Adrenergic Stimulation of Perfused Hearts from Hypothyroid Rats

1976 • 32 citations

Contracture and Catecholamines in Mammalian Myocardium

1969 • 31 citations

Influence of phenylephrine on transmembrane potentials and effective refractory period of single purkinje fibres of sheep heart

1971 • 31 citations

Membrane physiology of nerve and muscle fibres.

1976 • 30 citations

Lack of detectable change in cyclic AMP during the cardiac inotropic response to isoproterenol immobilized on glass beads.

1975 • 30 citations

Discussion of evidence regarding induced changes in adrenoceptors.

1977 • 30 citations

Positive inotropy induced by ouabain, by increased frequency, by X537A (RO2-2985), by calcium and by isoproterenol: The lack of correlation with phosphorylation of TnI

1977 • 30 citations

Comparison of the mechanisms underlying the positive inotropic actions of dopamine, adrenaline and isoprenaline on the isolated rabbit papillary muscle

1977 • 30 citations

Drugs and Heart Muscle

1972 • 29 citations

The dependence on contraction frequency of the positive inotropic effect of dihydro-ouabain

1977 • 29 citations

Second Symposium on Catecholamines.

1966 • 28 citations

Effects of derivatives of cyclic AMP and cyclic GMP on contraction force of cat papillary muscles

1976 • 28 citations

Interchange of adenyl and guanyl cyclases as an explanation for transformation of β- to α-adrenergic responses in the rat atrium

1975 • 28 citations

Adrenoceptors in cardiac ventricular muscle and changes in duration of action potential caused by noradrenaline and isoprenaline

1975 • 28 citations

Respiratory acid-base changes and myocardial contractility: Interaction between calcium and hydrogen ions

1976 • 28 citations

Temperature immutability of adenyl cyclase-coupled β adrenergic recptors

1974 • 27 citations

Die positiv inotrope Adrenalinwirkung auf den Meerschweinchen-Papillarmuskel bei Variation der �u�eren Calcium- und Natriumkonzentration

1965 • 27 citations

Dual Effects of a New Coronary Vasodilator, Diltiazem, on the Contractile Force of the Blood-Perfused Papillary Muscle Of The Dog

1975 • 27 citations

Effects of caffeine and isoprenaline on mammalian ventricular muscle

1973 • 26 citations

Effects of papaverine on isolated rabbit papillary muscle

1975 • 26 citations

Effects of isoprenaline and phenylephrine on energy‐rich phosphate compounds and glucose‐6‐phosphate in smooth and cardiac muscle

1971 • 26 citations

Norepinephrine- and isoproterenol- induced changes in cardiac contractility and cyclic adenosine 3':5' -monophosphate levels during early development of the embryonic chick.

1977 • 26 citations

Oppositional effects of acetylcholine and isoproterenol on isometric tension and cyclic nucleotide concentrations in rabbit atria.

1975 • 26 citations

Cardiovascular Beta Adrenergic Responses

1970 • 26 citations

Effect of Changes in Initial Tension, Initial Volume and Epinephrine on Ventricular Relaxation Process

1952 • 26 citations

The effects of glycogen on phosphorylase b interactions with 5′‐AMP and phosphate

1977 • 25 citations

The effects of isoprenaline and tyramine on the 45calcium uptake, the total calcium content and the contraction force of isolated guinea-pig atria in dependence on different extracellular hydrogen ion concentrations

1972 • 25 citations

Restoration effects of histamine on action potential in potassium-depolarized guinea-pig papillary muscle.

1973 • 25 citations

PHYSIOLOGICAL APPRAISAL OF THE ACTIONS OF CATECHOLAMINES ON MYOCARDIAL CONTRACTIONS

1967 • 24 citations

On the Augmentor (Accelerator) Nerves of the Heart of Cold‐blooded Animals

1884 • 24 citations

The role of cyclic 3′5′-AMP in the cardiac response to adrenaline

1970 • 24 citations

Activation of Phosphorylase by Cyclic AMP without Augmentation of Contractility in the Perfused Guinea Pig Heart

1971 • 24 citations

Biochemical and mechanical effects of phenylephrine on the heart

1976 • 24 citations

Studies on the cardiodynamic actions of drugs. I. The application of optical methods of pressure registration in the study of cardiac stimulants and depressants

1927 • 24 citations

Possible effects of hydrogen ions in ischemic myocardium.

1976 • 24 citations

Changes in mechanical events and adenosine 3',5'-monophosphate levels induced by enantiomers of isoproterenol in isolated rat atria and uteri.

1975 • 23 citations

Studies on the positive inotropic effect of dopamine in the guinea-pig heart

1977 • 23 citations

Untersuchungen über die Innervation des Herzens

1863 • 23 citations

Immunoglobulin Structure

1972 • 23 citations

�ber die Wirkung verschiedener sympathomimetischer Amine auf Kontraktionskraft und 45Ca-Aufnahme isolierter Meerschweinchenvorh�fe

1967 • 23 citations

�ber die Wirkung von Dibutyryl-3?,5?-AMP am isolierten Herzen

1968 • 23 citations

EFFECTS OF CAFFEINE ON TENSION DEVELOPMENT IN DOG PAPILLARY MUSCLE UNDER VOLTAGE CLAMP

1973 • 23 citations

Influence of respiratory and metabolic acidosis on epinephrine-inotropic effect in isolated guinea pig atria

1974 • 22 citations

Ca-action potentials and contractions of heart muscle in Na-free solutions. Influence of caffeine.

1972 • 22 citations

Ambiguous effect of caffeine upon the transmembrane Ca current in mammalian ventricular myocardium

1974 • 22 citations

DISSOCIATION OF CARDIAC INOTROPIC AND ADENYLATE CYCLASE ACTIVATING ADRENOCEPTORS

1974 • 22 citations

Cardiac physiology for the clinician

1976 • 22 citations

Phenylephrine-induced increases in cardiac contractility, cyclic adenosine monophosphate and phosphorylase a.

1973 • 22 citations

NO EVIDENCE FOR INVOLVEMENT OF DOPAMINERGIC RECEPTORS IN THE POSITIVE INOTROPIC ACTION OF DOPAMINE ON THE ISOLATED RABBIT PAPILLARY MUSCLE

1978 • 22 citations

�ber den Einflu� von Mangan-Ionen auf die positiv inotrope Wirkung von Adrenalin, Theophyllin und Digitoxigenin an isolierten Meerschweinchenvorh�fen

1969 • 22 citations

Lack of evidence for a temperature-mediated change of adrenoceptor type in the rat heart

1978 • 21 citations

Influence of papaverine and isoprenaline on contractility and cyclic AMP level of left guinea-pig atria at different rates of beat

1977 • 21 citations

�ber den Mechanismus der positiv inotropen Wirkung von Theophyllin am Warmbl�terherzen

1971 • 21 citations

Adenosine 3‘, 5’‐cyclic Monophosphate in Perfused Rat Hearts Exposed to Isoprenaline and Dopamine

1976 • 21 citations

Block of Conduction in Partially Depolarized Cardiac Purkinje Fibres induced by an α-Adrenergic Agent

1971 • 21 citations

Effects of AMP and cyclic AMP on the mechanical and electrical activity of isolated mammalian atria

1972 • 21 citations

MECHANISM OF CARDIAC ACTIVITIES SYMPATHOMIMETIC AMINES ON ISOLATED AURICLES OF RABBITS.

1964 • 20 citations

Cardiac adrenoceptors at low temperature: what is the experimental evidence for the adrenoceptor interconversion hypothesis?

1977 • 20 citations

Contractile and biochemical responses of cardiac and skeletal muscle to isoproterenol covalently linked to glass beads.

1977 • 20 citations

Relaxation of heart muscle by catecholamines and by dibutyryl cyclic adenosine 3?,5?-monophosphate

1977 • 20 citations

Influence of glyceryl trinitrate on force of contraction and action potential of guinea-pig myocardium

1975 • 20 citations

The Effect of Noradrenaline and Tyramine on Cardiac Contractility, Cyclic AMP, and Phosphorylase a in Normal and Hyperthyroid Rats

1974 • 20 citations

Effects of Norepinephrine on Tissues of the Frog Heart Atrium poisoned by Tetrodotoxin

1967 • 20 citations

EFFECTS OF ACETYLSTROPHANTHIDIN, LEVARTERENOL AND CARBACHOL ON THE INTERVAL—STRENGTH RELATIONSHIP OF HEART MUSCLE

1964 • 19 citations

Die spezifische Beschleunigung des Erschlaffungsprozesses durch sympathische �bertr�gerstoffe und die Hemmung dieses Effektes durch ?-Receptoren-Blockade

1968 • 19 citations

Cardiac histamine receptors and cyclic AMP

1976 • 19 citations

Blockade of the cardiac action of phenylephrine by bretylium or cocaine.

1970 • 19 citations

Cyclic AMP regulation of active calcium transport across membranes of sarcoplasmic reticulum: role of the 22,000-dalton protein phospholamban.

1978 • 19 citations

CARDIAC ADRENOCEPTORS AT LOW TEMPERATURE AND THE ADRENOCEPTOR INTERCONVERSION HYPOTHESIS

1977 • 19 citations

Sensitivity changes of adrenergic ?-receptors induced by alterations of the metabolic state of isolated organs

1972 • 19 citations

Lack of Interaction between Norepinephrine or Histamine and Theophylline on Cardiac Cyclic AMP

1974 • 19 citations

Comparison of the inotropic response to glucagon, ouabain and noradrenaline

1970 • 19 citations

Effect of DB-c-AMP on mechanical characteristics of ventricular and atrial preparations of several mammalian species

1974 • 19 citations

Medium Energy Inelastic Hadron Scattering and Nuclear Structure

1976 • 18 citations

Temperature dependence of phenoxybenzamine effects and the adrenoceptor transformation hypothesis

1975 • 18 citations

The role of cyclic AMP in the inotropic response to isoprenaline and glucagon.

1972 • 18 citations

EFFECT OF TEMPERATURE ON CAFFEINE-INDUCED CALCIUM RELEASE FROM ISOLATED RETICULUM IN FROG SKELETAL MUSCLE

1970 • 18 citations

The influence of the extracellular potassium concentration on the glycoside effects upon contractile force and action potential duration of the guinea-pig papillary muscle

1966 • 18 citations

Uptake and catabolism of N6, 2'-O-dibutyryl cyclic AMP by the perfused heart

1974 • 18 citations

Calcium binding to cardiac troponin and the effect of cyclic AMP‐dependent protein kinase

1977 • 18 citations

THEOPHYLLINE AND PHENYLEPHRINE EFFECTS ON CARDIAC RELAXATION

1977 • 17 citations

Accumulation of cAMP and positive inotropic effect evoked by isoproterenol under the graded inhibition of phosphodiesterase by papaverine in the isolated rabbit papillary muscle

1975 • 17 citations

THE INFLUENCE OF "HEART STIMULANTS" ON THE CONTRACTION OF ISOLATED MAMMALIAN CARDIAC MUSCLE

1944 • 17 citations

�ber die positiv inotrope Wirkung von Dibutyryl-3?,5?-AMP an isolierten Rattenvorh�fen

1972 • 17 citations

Differences in contracture development of ventricular and atrial preparations of mammalian cardiac muscle

1969 • 16 citations

Effect of epinephrine on stress relaxation and distensibility of the isolated cat heart

1965 • 16 citations

Combinations of alpha and beta adrenergic blockers in isolated guinea-pig atria.

1969 • 16 citations

Catecholamines

1972 • 16 citations

Blockade of biochemical and physiological responses of cardiac muscle to norepinephrine by N-tert.-butylmethoxamine (butoxamine).

1972 • 15 citations

The effect of variations of pH upon the activation of phosphorylase by epinephrine in perfused contracting heart, liver slices and skeletal muscle.

1967 • 15 citations

The heart‐ventricular function

1968 • 15 citations

Contraction and Relaxation in the Myocardium

1977 • 15 citations

Effect of papaverine on the frequency—force relationship in guinea-pig left atria

1977 • 15 citations

�ber den Mechanismus der positiv inotropen Wirkung von Theophyllin am Warmbl�terherzen

1971 • 15 citations

The adrenergic receptors of the coronary circulation in the isolated dog heart.

1969 • 15 citations

INTERACTIONS OF PHENYLEPHRINE AND THEOPHYLLINE IN CONTRACTILITY AND EXCITABILITY OF ISOLATED RABBIT LEFT ATRIA

1973 • 14 citations

Drugs and Properties of Heart Muscle

1965 • 14 citations

A comparison of the effectiveness of adrenergic blocking drugs in inhibiting the cardiac actions of sympathomimetic amines.

1957 • 14 citations

Interaction of four methylxanthine compounds and norepinephrine on cardiac phosphorylase activation and cardiac contractility.

1973 • 14 citations

Effects of verapamil on myocardial contractility, cardiac adenosine 3,'5'-monophosphate and heart phosphorylase.

1975 • 14 citations

The Myocardial Cell

1966 • 14 citations

The inotropic action of noradrenaline on rested-state contractions of guinea-pig cardiac ventricular muscle

1978 • 14 citations

RELATIONSHIP BETWEEN THEOPHYLLINE UPTAKE AND INOTROPIC EFFECT IN THE GUINEA‐PIG HEART

1974 • 14 citations

The effect of temperature on cardiac adrenoceptors.

1977 • 14 citations

�ber den Zusammenhang der Wirkungen von Adrenalin, einem ?-Adrenolyticum und Chinidin auf Kontraktionskraft und Calcium-Umsatz des Meerschweinchenvorhofs

1966 • 14 citations

Electrical and mechanical activity of mammalian heart muscle fibres treated with papaverine

1977 • 14 citations

Effect of respiratory acidosis on heart and circulation in cats, pigs, dogs and rabbits

1972 • 13 citations

The effect of theophylline on amine-induced cardiac cyclic AMP and cardiac contractile force

1977 • 13 citations

The effect of extracellular calcium on actions of noradrenaline, �-blockers and quinidine in isolated guinea-pig auricles

1967 • 13 citations

The effect of calcium on cardiac phosphorylase activation, contractile force and cyclic AMP in euthyroid and hyperthyroid rat hearts

1976 • 13 citations

Stimulation by phenylephrine of myocardial alpha-adrenoceptors in the left ventricle of the cat

1975 • 13 citations

Cardiac adenylate cyclase activity in relation to beta-adrenergic responses

1975 • 13 citations

The role of cyclic AMP in temperature-dependent changes of contractile force and sensitivity to isoprenaline and papaverine in guinea-pig atria

1978 • 13 citations

Interconversion of myocardial adrenoceptors: Its relationship to adenylate cyclase activation

1976 • 12 citations

Effects of chlorpromazine, d,1-propranolol, and d-propranolol in the isolated rat heart: Modification of the response to isoprenaline and glucagon

1971 • 12 citations

Effect of glycerol on atrial contractions and ultrastructure.

1969 • 12 citations

Temperature, phenoxybenzamine and adrenoceptor transformation

1976 • 12 citations

Phenylephrine effects on cardiac contractility adenyl cyclase, and phosphorylase.

1972 • 12 citations

Cyclic AMP and the positive inotropic effect of norepinephrine and phenylephrine

1977 • 11 citations

Adenosine cyclic 3',5'-monophosphate concentrations during the positive inotropic response of cat cardiac muscle to polymeric immobilized isoproterenol.

1978 • 11 citations

Iontophoretic application of autonomic mediators and cyclic nucleotides in the sinus node cells

1977 • 11 citations

Effect of papaverine on cyclic AMP, calcium uptake and force of contraction in isolated guinea-pig auricles.

1977 • 11 citations

Oscillatorische Kontraktionen des Herzmuskels unter der Einwirkung von Adrenalin

1963 • 11 citations

THE DEVELOPMENT OF TENSION IN CARDIAC MUSCLE

1964 • 11 citations

�ber die Beziehung zwischen Membranpotential und Kontraktion am Herzen unter dem Einflu� von Adrenalin

1968 • 10 citations

The nature of the positive inotropic response of the isolated frog heart to theophylline and to iminazole

1972 • 10 citations

Functional antagonism between calcium-antagonists and noradrenaline on isolated guinea-pig atria

1975 • 10 citations

The effects of temperature on responses of the isolated perfused heart of the guinea pig to catecholamines: A separation of the rate and force responses

1972 • 10 citations

A postsynaptic effect of tyramine in ventricular muscle

1972 • 10 citations

Role of adenylate cyclase-cyclic AMP in cardiac actions of adrenergic amines.

1973 • 10 citations

?Supramaximal? enhancement of the inotropic effect of noradrenaline by tyramine

1972 • 10 citations

Interaction of phentolamine and noradrenaline on myocardial contractility and adenyl cyclase activity

1974 • 10 citations

Electrophysiological responses of cardiac muscle to isoproterenol covalently linked to glass beads.

1977 • 10 citations

Über den Ca-Umsatz des Meerschweinchenvorhofs unter der Einwirkung von Adrenalin

1964 • 10 citations

[OSCILLATORY CONTRACTION PHENOMENA OF THE MYOCARDIUM UNDER THE INFLUENCE OF ADRENALIN].

1965 • 10 citations

Effect of Varying K+ Concentrations on Phosphorylase Activity, Lipolysis, and cAMP Levels in Perfused Rat Heart

1972 • 9 citations

Cardiac adenylate cyclase—II

1975 • 9 citations

Electrical responses of cardiac muscle in Na-free high-Ca solution

1972 • 9 citations

Catecholamines: Introduction

1973 • 9 citations

Positive Inotropic and Chronotropic Effects of 8-Substituted Derivatives of 3', 5'-Cyclic Amp

1975 • 9 citations

Alpha- and beta-adrenergic receptor stimulation in cultures of beating rat heart cells and its effect on automaticity and cyclic AMP levels.

1977 • 9 citations

Zur Wirkung positiv inotroper Substanzen auf die Kontraktion und Relaxation isolierter Herzpräparate

1973 • 8 citations

Zur Frage einer therapeutischen Steigerung der Kontraktilit�t bei Abk�hlung des Herzens

1970 • 8 citations

Stimulation of myocardial contractility by a new cyclic nucleotide analog, 8-(benzylthio)-N6-n-butyladenosine cyclic 3',5'-phosphate (SQ 80122).

1976 • 8 citations

Effect of theophylline on calcium exchangeability in ventricular myocardium

1976 • 8 citations

Possible sites of temperature-dependent changes in sensitivity of the positive inotropic and chronotropic responses to sympathomimetic amines by comparisons of the temperature optima for a range of agonists.

1978 • 8 citations

Proceedings: Beta-and-or alpha-adrenoceptors in the ventricular muscle of the rabbit?

1974 • 8 citations

Cyclic AMP in Cardiovascular Pharmacology

1975 • 8 citations

Divergent influences of Ca2+ on the action of several cardiotonic steroids in isolated heart muscle preparations

1974 • 8 citations

EFFECTS OF BETA ADRENERGIC STIMULATION AND BLOCKADE ON MYOCARDIAL MECHANICS

1970 • 8 citations

Potentiation of the inotropic effects of norepinephrine and dibutyryl cyclic AMP by theophylline

1971 • 8 citations

Blockad of the positive inotropic action of norepinephrine by cardiac glycosides in the dog during hypothermia.

1962 • 8 citations

On the presence of myocardial alpha-adrenoceptors in the atrium of the guinea pig.

1977 • 8 citations

Influence of temperature and frequency on the positive inotropic action of phenylephrine in the isolated rabbit papillary muscle.

1977 • 8 citations

DISSOCIATION OF THEOPHYLLINE UPTAKE AND INOTROPIC EFFECT IN MYOCARDIAL TISSUE: INFLUENCE OF TEMPERATURE, pH AND CALCIUM

1975 • 7 citations

Calcium-dependent depolarizations and contractions in ventricular myocardial fibers: effects of adrenaline and cardiac glycosides.

1975 • 7 citations

Adrenaline, DB-c-AMP and myocardial 45Ca exchange. Comparative studies in rat and guinea-pig auricles

1973 • 7 citations

Dependence of the cardiac uptake of digitalis glucosides on the extracellular calcium concentration in guinea pig isolated hearts

1975 • 7 citations

The relationship between adenosine 3',5'-monophosphate levels and systolic transmembrane calcium flux.

1975 • 7 citations

Influence of Dibenamine and Piperidino‐Methyl‐Benzodioxane (933 F) upon the Effect of 1‐Adrennline rind 1‐Noradrenaline on the Isolated Rat Heart

1952 • 7 citations

Influence of some inhibitors and ions on the positive inotropic action of epinephrine, tyramine and calcium.

1968 • 7 citations

Release of noradrenaline proposed as a mechanism for the positive inotropic action of dipyridamole

1976 • 7 citations

New adrenergic blocking drugs : their pharmacological, biochemical and clinical actions

1967 • 7 citations

Stimulation of rat and cat heart adenylate cyclase by triiodothyronine in the presence of 5'-guanylylimidodiphosphate.

1976 • 7 citations

Effects of the antibiotic ionophore X-537A on contractility and ionic exchange in rabbit ventricular myocardium.

1977 • 6 citations

Caffeine and KCl contracture in cat myocardium

1976 • 6 citations

Epinephrine, cyclic AMP, calcium, and myocardial contractility.

1976 • 6 citations

Quantitative Untersuchungen am Meerschweinchenvorhof �ber die Abh�ngigkeit der Digitoxigenin wirkung von der extracellul�ren Calciumkonzentration

1963 • 6 citations

Über den Einfluß der extracellulären Wasserstoffionenkonzentration auf die Wirkung kreislaufaktiver Pharmaka

1971 • 6 citations

Der Einfluss von Adrenalin auf das Verhalten des zellulären Kalziums während der K-Depolarisation des Herzmuskels von Meerschweinchen

1968 • 6 citations

A comparative description of inotropic agents in vitro.

1973 • 6 citations

Differentiation of inotropic mechanisms by experiments on cardiac contracture

1974 • 6 citations

Evidence for a dibutyryl-c-AMP increased 45Ca release from cardiac muscle.

1975 • 5 citations

Influence of thyroid state on the specific binding of noradrenaline to a cardiac particulate fraction and on catecholamine-sensitive cardiac adenylate cyclase activity.

1976 • 5 citations

Differential effects of clonidine on guinea-pig atrial and papillary muscles.

1972 • 5 citations

Temperature, phenoxybenzamine and adrenoceptor transformation (reply)

1976 • 5 citations

Influence of ouabain on the positive inotropic responses to norepinephrine in isolated guinea-pig and dog heart preparations at 37 degrees and 27 degrees.

1967 • 5 citations

Response of isolated human ventricular myocardium to cyclic AMP and its dibutyryl derivative

1974 • 5 citations

Die indirekt sympathicomimetische Wirkung von Heptaminol auf den Herzmuskel

1970 • 5 citations

Positive inotropic but no relaxant effects of phenylephrine in cat papillary muscle.

1978 • 5 citations

The response of Ca-mediated action potentials and contractile activity in mammalian ventricular myocardium towards alkalosis

1976 • 5 citations

Untersuchungen �ber Wechselwirkungen zwischen Digitoxigenin, Noradrenalin und Calcium unter Hypothermiebedingungen an isolierten Pr�paraten aus S�ugetierherzen

1968 • 5 citations

Dibenamine Blockade as a Method of Distinguishing Between Inotropic Actions of Epinephrine and Digitalis.

1951 • 5 citations

Failure of reserpinization to decrease the positive inotropic effect of dibutyryl cyclic AMP.

1973 • 4 citations

The positive inotroopic and chronotropic actions of some amino acids and their effects in mobilizing noradrenaline

1976 • 4 citations

Anatomic types of subpulmonary stenosis in D-transposition of the great arteries by echo and angiography

1978 • 4 citations

Transmitter release and adrenergic mechanical responses in the heart: Effect of papaverine and imidazole

1977 • 4 citations

The Positive Inotropic Effect of Phenylephrine in Bovine Cardiac Muscle

1978 • 3 citations

Effect of phosphodiesterase inhibitors and dBcAMP on the inotropic and relaxing actions of histamine in cardiac muscle

1977 • 3 citations

The opposed influences ofβ-adrenergic stimulation and adenosine on the frequency-force relationship of isolated left atria of guinea-pigs

1977 • 3 citations

Contraction and Relaxation of Heart Muscle as Influenced by cAMP, Isoproterenol, Glucagon, Ouabain, and Calcium

1977 • 3 citations

Effects of D 600 and papaverine on the inotropic response to isoprenaline on left guinea-pig atria under the graded influence of changes of frequency and temperature.

1977 • 2 citations

The effect of temperature upon the positive inotropic and chronotropic responses of isolated cardiac preparations to isoprenaline and its modification by experimental variables.

1976 • 2 citations

Effects of inotropic agents on contraction and relaxation of papillary muscle

1975 • 2 citations

Inotropic effects of derivatives of cyclic AMP on the blood-perfused papillary muscle of the dog

1975 • 2 citations

Enhancement of the cardiac phosphorylase activating effect of dibutyryl cyclic AMP by thyroid hormone.

1977 • 1 citations

Cardiodepressive and noradrenaline-antagonistic effects of the organic calcium-antagonist D 600 in the spontaneously beating guinea-pig atrium.

1977 • 1 citations