Reactions and significance of cytochrome P-450 enzymes

The molecular biology of cytochrome P450s.

1988 • 1,294 citations

Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme

1989 • 1,244 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, and Recommended Nomenclature

1991 • 1,092 citations

Enzymatic Basis of Detoxication

1980 • 717 citations

Role of Hemoprotein P-450 in Fatty Acid ω-Hydroxylation in a Soluble Enzyme System from Liver Microsomes

1968 • 625 citations

The Role of Glutathione and Glutathione Transferases in Chemical Cardnogenesi

1990 • 466 citations

Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy.

1988 • 465 citations

Genetic and Molecular Aspects of 2,3,7,8-Tetra-Chlorodibenzo-P-Dioxin Action

1990 • 446 citations

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue

1989 • 382 citations

Uncoupling of the cytochrome P-450cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: possible role of the hydroxy amino acid in oxygen activation.

1989 • 364 citations

How Do Enzymes Work?

1988 • 359 citations

Regio- and stereoselective metabolism of two C19 steroids by five highly purified and reconstituted rat hepatic cytochrome P-450 isozymes.

1983 • 339 citations

On the stoichiometry of the oxidase and monooxygenase reactions catalyzed by liver microsomal cytochrome P-450. Products of oxygen reduction.

1984 • 324 citations

Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells.

1988 • 302 citations

Oxidation of quinidine by human liver cytochrome P-450.

1986 • 296 citations

On the mechanism of prostacyclin and thromboxane A2 biosynthesis

1989 • 287 citations

Nature's chemicals and synthetic chemicals: comparative toxicology.

1990 • 275 citations

Control of the catalytic activity of prosthetic heme by the structure of hemoproteins

1987 • 260 citations

Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates.

1982 • 251 citations

Enzymatic Oxidation of Xenobiotic Chemical

1990 • 250 citations

The Roles of Putidaredoxin and P450cam in Methylene Hydroxylation

1972 • 223 citations

Mechanisms of cytochrome P‐450 catalysis

1990 • 223 citations

Autooxidation and hydroxylation reactions of oxygenated cytochrome P-450cam.

1976 • 215 citations

Crystal structures of cytochrome P-450CAM complexed with camphane, thiocamphor, and adamantane: factors controlling P-450 substrate hydroxylation

1991 • 212 citations

Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation (cytochrome P-450 dbl/bufI)

1988 • 210 citations

Oxidase and Oxygenase Function of the Microsomal Cytochrome P450 Monooxygenase System

1982 • 195 citations

The structural basis for substrate-induced changes in redox potential and spin equilibrium in cytochrome P-450CAM

1989 • 181 citations

Oxidation-reduction properties of rat liver cytochromes P-450 and NADPH-cytochrome P-450 reductase related to catalysis in reconstituted systems

1983 • 177 citations

Chemical model systems for drug‐metabolizing cytochrome‐P‐450‐dependent monooxygenases

1989 • 173 citations

Isolation of preferentially expressed genes in the kidneys of hypertensive rats.

1991 • 170 citations

Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy-induced hypertension.

1990 • 169 citations

Polymorphisms of Oxidation at Carbon Centers of Drugs and Their Clinical Significance

1979 • 163 citations

Enantioselective oxidations of sulfides catalyzed by chloroperoxidase

1990 • 154 citations

Cytochrome P-450-dependent oxygenation of arachidonic acid to hydroxyicosatetraenoic acids.

1982 • 147 citations

Endogenous epoxyeicosatrienoyl-phospholipids. A novel class of cellular glycerolipids containing epoxidized arachidonate moieties.

1991 • 145 citations

Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase.

1990 • 143 citations

Cytochrome P-450cam binding surface defined by site-directed mutagenesis and electrostatic modeling

1990 • 139 citations

Probing the role of lysines and arginines in the catalytic function of cytochrome P450d by site-directed mutagenesis. Interaction with NADPH-cytochrome P450 reductase

1991 • 137 citations

Structure-mechanism relationships in hemoproteins. Oxygenations catalyzed by chloroperoxidase and horseradish peroxidase.

1987 • 128 citations

Isolation and characterization of natural allene oxides: unstable intermediates in the metabolism of lipid hydroperoxides.

1988 • 125 citations

Oxidation of substituted N,N-dimethylanilines by cytochrome P-450: estimation of the effective oxidation-reduction potential of cytochrome P-450

1989 • 121 citations

Cloning of the gene encoding a catalytically self-sufficient cytochrome P-450 fatty acid monooxygenase induced by barbiturates in Bacillus megaterium and its functional expression and regulation in heterologous (Escherichia coli) and homologous (Bacillus megaterium) hosts.

1987 • 115 citations

Cytochrome P-450-dependent oxidation of arachidonic acid to 16-, 17-, and 18-hydroxyeicosatetraenoic acids.

1990 • 96 citations

Hydrogen-deuterium exchange during propylene epoxidation by cytochrome P-450

1986 • 92 citations

Radiometric analysis of biological oxidations in man: sex differences in estradiol metabolism.

1980 • 91 citations

Regulation of Steroid Hydroxylase Gene Expression Is Multifactorial in Nature

1989 • 90 citations

Oxidation of Cycloalkylamines by Cytochrome P-450

1989 • 87 citations

Studies on the mechanism of action of mammalian hepatic azoreductase—II

1967 • 87 citations

On the mechanism of action of cytochrome P-450. Oxidation and reduction of the ferrous dioxygen complex of liver microsomal cytochrome P-450 by cytochrome b5.

1984 • 86 citations

Cytochrome P-450 catalysis: radical intermediates and dehydrogenation reactions

1989 • 85 citations

Transformation of thebaine to oripavine, codeine, and morphine by rat liver, kidney, and brain microsomes.

1988 • 83 citations

Reductive oxygenation of carbon tetrachloride: Trichloromethylperoxyl radical as a possible intermediate in the conversion of carbon tetrachloride to electrophilic chlorine

1983 • 82 citations

Covalent bonding of the prosthetic heme to protein: a potential mechanism for the suicide inactivation or activation of hemoproteins

1989 • 79 citations

Aromatase inhibition and its pharmacologic implications

1985 • 76 citations

Cytochrome P-450-catalyzed hydroxylation and carboxylic acid ester cleavage of Hantzsch pyridine esters.

1988 • 75 citations

Protein components of a cytochrome P-450 linalool 8-methyl hydroxylase.

1990 • 63 citations

Kinetics of iron(III) porphyrin catalyzed epoxidations

1985 • 63 citations

On the Mechanism of Action of Cytochrome P-450

1989 • 58 citations

Alteration of high and low spin equilibrium by a single mutation of amino acid 209 in mouse cytochromes P450

1991 • 57 citations

Properties of the oxygenated form of liver microsomal cytochrome P-450.

1983 • 56 citations

Cytochrome P450: molecular architecture, mechanism, and prospects for rational inhibitor design.

1988 • 55 citations

Endogenous Substrates for Udp-Glucuronosyl-Transferases

1988 • 50 citations

Deuterium isotope effects on toluene metabolism. Product release as a rate-limiting step in cytochrome P-450 catalysis

1989 • 48 citations

Reductive beta-scission of the hydroperoxides of fatty acids and xenobiotics: role of alcohol-inducible cytochrome P-450.

1990 • 47 citations

Flavin-catalyzed reductive dioxygen activation with N-methyldihydronicotinamide

1986 • 46 citations

Evidence for the involvement of cytochrome P-450 in reduction of benzo(a)pyrene 4,5-oxide by rat liver microsomes

1976 • 45 citations

Spectra of chloroperoxidase Compounds II and III

1985 • 45 citations

Covalent binding to apoprotein is a major fate of heme in a variety of reactions in which cytochrome P-450 is destroyed

1986 • 45 citations

25-Hydroxyvitamin D3-1 alpha-hydroxylase in porcine hepatic tissue: subcellular localization to both mitochondria and microsomes.

1990 • 37 citations

Enzymatic monooxygenation of halogen atoms: cytochrome P-450 catalyzed oxidation of iodobenzene by iodosobenzene

1980 • 36 citations

Isolation and characterization of an altered cytochrome P-450 from a yeast mutant defective in lanosterol 14 alpha-demethylation.

1987 • 34 citations

Formation of prostaglandin A analogues via an allene oxide.

1990 • 29 citations

On the nature of the cytochrome P450scc “ultimate oxidant”: Characterization of a productive radical intermediate

1990 • 25 citations

Hepatic mitochondrial cytochrome P-450 system. Identification and characterization of a precursor form of mitochondrial cytochrome P-450 induced by 3-methylcholanthrene.

1988 • 24 citations

Unique role of oxygen in regulation of hepatic monooxygenation and glucuronidation.

1990 • 17 citations

Bioregulation of Binding and Dynamics: The Cytochrome P-450CAM Model

1985 • 9 citations