Cytochrome P-450 catalysis: radical intermediates and dehydrogenation reactions

Cytochrome P-450: Structure, Mechanism, and Biochemistry

1986 • 2,703 citations

Cytochrome P-450—Catalyzed Formation of Δ ⁴ -VPA, a Toxic Metabolite of Valproic Acid

1987 • 248 citations

Timing of the radical recombination step in cytochrome P-450 catalysis with ring-strained probes

1987 • 160 citations

Cytochrome P-450-catalyzed desaturation of valproic acid in vitro. Species differences, induction effects, and mechanistic studies.

1988 • 126 citations

Oxidation of Cycloalkylamines by Cytochrome P-450

1989 • 87 citations

N-hydroxyacetaminophen: A microsomal metabolite of N-hydroxyphenacetin but apparently not of acetaminophen

1979 • 83 citations

Dehydrogenation: A previously unreported pathway of lindane metabolism in mammals

1975 • 80 citations

Intermediates in the epoxidation of alkenes by cytochrome P-450 models. 2. Use of the trans-2,trans-3-diphenylcyclopropyl substituent in a search for radical intermediates

1988 • 70 citations

An unusual metabolite of testosterone. 17 beta-Hydroxy-4,6-androstadiene-3-one.

1986 • 70 citations

Labeled 1,N⁶-ethenoadenosine and 3,N⁴-ethenocytidine in hepatic RNA of mice given [ethyl-1,2-³H or ethyl-1-¹⁴C] ethyl carbamate (urethan)

1982 • 61 citations

Mechanism of oxidation of pi bonds by cytochrome P-450. Electronic requirements of the transition state in the turnover of phenylacetylenes.

1987 • 58 citations

Radical cations as precursors in the metabolic formation of quinones from benzo[a]pyrene and 6-fluorobenzo[a]pyrene

1988 • 52 citations

Evidence for a cytochrome P-450-catalyzed allylic rearrangement with double-bond topomerization

1988 • 46 citations

Mechanism of androstenedione formation from testosterone and epitestosterone catalyzed by purified cytochrome P-450b.

1988 • 46 citations

4-Alkyl radical extrusion in the cytochrome P-450-catalyzed oxidation of 4-alkyl-1,4-dihydropyridines

1988 • 41 citations

Cytochrome P-450-mediated oxidation of substrates by electron-transfer; Role of oxygen radicals and of 1- and 2-electron oxidation of paracetamol

1988 • 40 citations

A theoretical study on the metabolic activation of paracetamol by cytochrome P-450: indications for a uniform oxidation mechanism

1989 • 38 citations

Calibration of the bicyclo[2.1.0]pent-2-yl radical ring opening and an oxygen rebound rate constant for cytochrome P-450

1989 • 37 citations

Two species of cytochrome P-450 involved in ergosterol biosynthesis of yeast

1983 • 37 citations

Electron spin resonance studies of monoamine oxidase B. First direct evidence for a substrate radical intermediate

1989 • 27 citations

Alkylation of protein and DNA in mice treated with urethane

1988 • 26 citations

A dramatic solvent and stereoelectronic effect in a biomimetic oxidation: 9,10-dialkylanthracenes

1987 • 23 citations

Source of oxygen in cytochrome P-450 catalyzed carbinolamine formation

1982 • 21 citations

Isolation of 19,20-dehydroprostaglandins E1 and E2 in human seminal fluid and further studies on 18,19-dehydroprostaglandins E1 and E2

1987 • 9 citations

Tracazolate metabolites in rat tissue.

1985 • 2 citations