Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation (cytochrome P-450 dbl/bufI)
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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
1951 • 319,299 citations
Statistical methods
1967 • 19,533 citations
POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN
1977 • 1,196 citations
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism
1988 • 717 citations
A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.
1980 • 544 citations
Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man
1984 • 368 citations
High-performance liquid chromatographic assays for bufuralol 1′-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver
1987 • 262 citations
Genetically Determined Variability in Acetylation and Oxidation Therapeutic Implications
1985 • 197 citations
Competitive inhibition of sparteine oxidation in human liver by β-adrenoceptor antagonists and other cardiovascular drugs
1984 • 185 citations
Hepatic monooxygenase activities in subjects with a genetic defect in drug oxidation
1983 • 123 citations
Single-dose quinidine treatment inhibits metoprolol oxidation in extensive metabolizers
1986 • 113 citations
Debrisoquine/sparteine-type polymorphism of drug oxidation. Purification and characterization of two functionally different human liver cytochrome P-450 isozymes involved in impaired hydroxylation of the prototype substrate bufuralol.
1986 • 112 citations
Evidence for an enzymatic defect in the 4‐hydroxylation of debrisoquine by human liver.
1981 • 93 citations
Inhibition of desmethylimipramine 2-hydroxylation by drugs in human liver microsomes
1985 • 91 citations
Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism) — Increased michaelis constant (km) and loss of stereoselectivity of bufuralol 1′-hydroxylation in poor metabolizers
1984 • 66 citations
Enzymatic basis of the debrisoquine/sparteine-type genetic polymorphism of drug oxidation
1987 • 63 citations
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