Cytochrome P450: molecular architecture, mechanism, and prospects for rational inhibitor design.

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

High-resolution crystal structure of cytochrome P450cam

1987 • 1,396 citations

Oxygen Activation by Cytochrome P-4501

1980 • 1,013 citations

Pigments of rat liver microsomes

1958 • 634 citations

Crystal structure of substrate-free Pseudomonas putida cytochrome P-450

1986 • 545 citations

Studies on pig liver microsomes. I. Enzymic and pigment composition of different microsomal fractions

1958 • 433 citations

Structure of beef liver catalase

1981 • 426 citations

Pigments of rat liver microsomes

2002 • 416 citations

EFFECT OF DRUGS ON THE FORMATION OF SMOOTH ENDOPLASMIC RETICULUM AND DRUG‐METABOLIZING ENZYMES

1965 • 381 citations

Calculation of the Relative Change in Binding Free Energy of a Protein-Inhibitor Complex

1987 • 317 citations

Genetic Mechanisms Controlling the Induction of Polysubstrate Monooxygenase (P-450) Activities

1981 • 296 citations

THE LIGHT REVERSIBLE CARBON MONOXIDE INHIBITION OF THE STEROID C21-HYDROXYLASE SYSTEM OF THE ADRENAL CORTEX.

1963 • 189 citations

Stereochemistry and deuterium isotope effects in camphor hydroxylation by the cytochrome P450cam monooxygenase system

1982 • 189 citations

Magnetic circular dichroism studies. 43. Oxidized cytochrome P-450. Magnetic circular dichroism evidence for thiolate ligation in the substrate-bound form. Implications for the catalytic mechanism

1976 • 183 citations

Electron paramagnetic resonance detectable states of cytochrome P-450cam

1980 • 175 citations

Camphor binding of Pseudomonas putida cytochrome P-450. Kinetics and thermodynamics of the reaction

1972 • 146 citations

Structural Characteristics of Cytochrome P-450. Possible Location of the Heme-Binding Cysteine in Determined Amino-Acid Sequences

1983 • 146 citations

Dihydrofolate reductase. The stereochemistry of inhibitor selectivity.

1985 • 139 citations

The cytochrome P-450 active site. Regiospecificity of prosthetic heme alkylation by olefins and acetylenes.

1983 • 138 citations

Evidence for a homolytic mechanism of peroxide oxygen–oxygen bond cleavage during substrate hydroxylation by cytochrome P-450.

1980 • 124 citations

Studies on the Specificity and Site of Action of α-Cyclopropyl-α-[p-methoxyphenyl]-5-pyrimidine Methyl Alcohol (Ancymidol), a Plant Growth Regulator

1978 • 120 citations

Inhibitors of Adrenal Steroid Biosynthesis

1970 • 105 citations

Cytochrome c peroxidase compound ES is identical with horseradish peroxidase compound I in iron-ligand distances

1986 • 84 citations

Amino acid sequence of the Pseudomonas putida cytochrome P-450. II. Cyanogen bromide peptides, acid cleavage peptides, and the complete sequence.

1982 • 78 citations

Interaction of metopyrone with adrenal mitochondrial cytochrome P-450. Mechanism for the inhibition of adrenal steroid 11.beta.-hydroxylation

1969 • 49 citations

Competing modes of peroxyacid flux through cytochrome P-450.

1983 • 32 citations

Thromboxane synthase as a cytochrome P450 enzyme.

1983 • 19 citations