Aromatase inhibition and its pharmacologic implications

The Involvement of Human Placental Microsomal Cytochrome P-450 in Aromatization

1974 • 587 citations

Suicide substrates: mechanism-based enzyme inactivators

1982 • 443 citations

Plasma Precursors of Estrogen. II. Correlation of the Extent of Conversion of Plasma Androstenedione to Estrone with Age¹

1974 • 436 citations

In Situ Estrogen Production via the Estrone Sulfatase Pathway in Breast Tumors: Relative Importance versus the Aromatase Pathway*

1984 • 403 citations

Aromatization of Androgens by Muscle and Adipose Tissue in Vivo*

1978 • 392 citations

RAPID INDUCTION OF MAMMARY CARCINOMA IN THE RAT AND THE INFLUENCE OF HORMONES ON THE TUMORS

1959 • 376 citations

The Effect of an Aromatase Inhibitor, 4-Hydroxy-4-Androstene- 3,17-Dione, On Estrogen-Dependent Processes in Reproduction and Breast Cancer¹¹

1977 • 369 citations

Aminoglutethimide Inhibits Extraglandular Estrogen Production in Postmenopausal Women with Breast Carcinoma*

1978 • 345 citations

Studies on the Mechanism of Estrogen Biosynthesis. VIII. The Development of Inhibitors of the Enzyme System in Human Placenta1

1973 • 301 citations

An epidemiological investigation of cancer of the endometrium

1966 • 259 citations

Plasma Precursors of Estrogen. I. Extent of Conversion of Plasma Δ⁴-Androstenedione to Estrone in Normal Males and Nonpregnant Normal, Castrate and Adrenalectomized Females

1967 • 257 citations

4-HYDROXYANDROSTENEDIONE IN TREATMENT OF POSTMENOPAUSAL PATIENTS WITH ADVANCED BREAST CANCER

1984 • 235 citations

Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo

1981 • 215 citations

A Randomized Trial Comparing Surgical Adrenalectomy with Aminoglutethimide plus Hydrocortisone in Women with Advanced Breast Cancer

1981 • 204 citations

Metabolic clearance and blood production rates of estrogens in postmenopausal women

1971 • 169 citations

Stereoselective Inhibition of Aromatase by Enantiomers of Aminoglutethimide*

1979 • 149 citations

Aromatization of androgens by human breast cancer

1979 • 144 citations

Substrate-induced inactivation of aromatase by allenic and acetylenic steroids

1981 • 141 citations

Steroid hormones and endometrial cancer.

1978 • 137 citations

10 beta-propynyl-substituted steroids. Mechanism-based enzyme-activated irreversible inhibitors of estrogen biosynthesis.

1981 • 127 citations

The conversion of androstenedione to estrone, estradiol, and testosterone in breast tissue

1980 • 123 citations

Suicide enzyme inhibitors as potential drugs

1981 • 119 citations

ŒSTRADIOL SYNTHESIS BY A HUMAN BREAST CARCINOMA

1974 • 119 citations

Mechanism of estrogenbiosynthesis. III. Stereochemistry of aromatization of C19 and C18 steroids

1968 • 116 citations

Studies on the mechanism of estrogen biosynthesis in the rat ovary–I

1976 • 113 citations

Synthesis and biochemical evaluation of inhibitors of estrogen biosynthesis

1978 • 112 citations

ENZYME-GENERATED INTERMEDIATES DERIVED FROM 4-ANDR0STENE-3,6,17-TRI0NE AND 1,4,6-ANDR0STATRIENE-3,17-DI0NE CAUSE A TIME-DEPENDENT DECREASE IN HUMAN PLACENTAL AROMATASE ACTIVITY

1981 • 104 citations

Inhibition of Peripheral Aromatization by Aromatase Inhibitors, 4-Hydroxy- and 4-Acetoxy-Androstene-3,17 Dione*

1980 • 99 citations

Estrogen sulfatase and estrogen sulfotransferase in human primary mammary carcinoma

1983 • 99 citations

Aromatase inhibitors. Synthesis and biological activity of androstenedione derivatives

1985 • 96 citations

Novel Approaches to Cancer Chemotherapy

1984 • 93 citations

Mechanism of estrogen biosynthesis. VI. The stereochemistry of hydrogen elimination at C-2 during aromatization

1969 • 88 citations

Biochemical and Endocrine Properties of a Mechanism-Based Inhibitor of Aromatase

1984 • 78 citations

Estrogen synthesis and estradiol binding by human mammary tumors.

1978 • 78 citations

Aromatase inhibitors—iv. Regression of hormone-dependent, mammary tumors in the rat with 4-acetoxy-4-androstene-3,17-dione

1979 • 70 citations

Active-site-directed inactivation of aromatase from human placental microsomes by brominated androgen derivatives

1976 • 67 citations

Effect of the antiestrogen C1628 on the growth of rat mammary tumors.

1974 • 65 citations

Effects of aromatase inhibitors, aminoglutethimide, and 4-hydroxyandrostenedione on cyclic rats and rats with 7,12-dimethylbenz(a)anthracene-induced mammary tumors.

1985 • 65 citations

Hormonal therapy in cancer of the breast.XIX. Effect of oral administration of Δ1-testololactone on clinical course and hormonal excretion

1962 • 58 citations

Stereoselective Inhibition of Cholesterol Side Chain Cleavage by Enantiomers of Aminoglutethimide¹²

1977 • 54 citations

Androgen and Estrogen Metabolism in Male Rhesus Monkeys*

1979 • 52 citations

Aromatase inhibitors and their use in controlling oestrogen-dependent processes

1979 • 52 citations

Inhibition studies on the aromatization of androst-4-ene-3,17-dione by human placental microsomal preparations

1972 • 50 citations

The Mechanism of Estrogen Biosynthesis

1962 • 49 citations

Aminoglutethimide as an aromatase inhibitor in the treatment of cancer

1984 • 42 citations

Effect of an aromatase inhibitor, 1,4,6-androstatriene-3,17-dione, on 7,12-dimethylbenz[a]anthracene-induced mammary tumors in the rat and its mechanism of action in vivo

1982 • 40 citations

Compensatory Increase in TSH Secretion without Effect on Prolactin Secretion in Patients Treated with Aminoglutethimide

1977 • 40 citations

Aromatase inhibitors, their pharmacology and application

1983 • 39 citations

Stereochemistry of estrogen biosynthesis

1969 • 35 citations

Aromatase Inhibitors Prevent Granulosa Cell Differentiation: An Obligatory Role for Estrogens in Luteinizing Hormone Receptor Expression

1985 • 34 citations

Metabolism of the aromatase inhibitor 4-hydroxy-4-androstene-3,17-dione by male rhesus monkeys

1981 • 30 citations

Role of fsh and oestradiol-17β in the development of meiotic competence in rat oocytes

1983 • 25 citations

SUPPRESSION OF RESIDUAL OESTROGEN PRODUCTION WITH AMINOGLUTETHIMIDE IN WOMEN FOLLOWING SURGICAL HYPOPHYSECTOMY OR ADRENALECTOMY

1984 • 25 citations

Comparison of Luteolytic Potencies of Aminoglutethimide Enantiomers in the Rabbit and Rat*

1978 • 17 citations

Effects of testosterone, estradiol, aromatase inhibitor, gonadotropin and prolactin on the response of mouse testes to acute gonadotropin stimulation

1983 • 16 citations

Effect of an Aromatase Inhibitor (4-Acetoxy-4-androstene-3,17-dione) on the Stimulatory Action of Luteinizing Hormone on Estradiol-17β Synthesis by Rat Preovulatory Follicles in vitro1

1981 • 6 citations

Deleted Work

1955 • 0 citations