Reductive beta-scission of the hydroperoxides of fatty acids and xenobiotics: role of alcohol-inducible cytochrome P-450.

Oxygen Activation by Cytochrome P-4501

1980 • 1,013 citations

The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci

1989 • 609 citations

Resolution of the Cytochrome P-450-containing ω-Hydroxylation System of Liver Microsomes into Three Components

1969 • 573 citations

Purification and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanol-treated rabbits.

1982 • 537 citations

Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1)

1989 • 527 citations

ADP-activated lipid peroxidation coupled to the TPNH oxidase system of microsomes

1963 • 512 citations

Studies on hydroperoxide-dependent substrate hydroxylation by purified liver microsomal cytochrome P-450

1976 • 339 citations

An Oxidized Derivative of Phosphatidylcholine is a Substrate for the Platelet-Activating Factor Acetylhydrolase from Human Plasma

1989 • 234 citations

Metabolism of nitrosamines by purified rabbit liver cytochrome P-450 isozymes.

1985 • 221 citations

Immunochemical evidence for induction of the alcohol-oxidizing cytochrome P-450 of rabbit liver microsomes by diverse agents: ethanol, imidazole, trichloroethylene, acetone, pyrazole, and isoniazid.

1985 • 215 citations

An anaerobic reaction between lipoxygenase, linoleic acid and its hydroperoxides

1971 • 197 citations

Microsomal-catalyzed hydroperoxide-dependent C-oxidation of amines

1973 • 193 citations

Identification of Traumatin, a Wound Hormone, as 12-Oxo-trans-10-dodecenoic Acid

1979 • 185 citations

Properties of NADPH-cytochrome P-450 reductase purified from rabbit liver microsomes

1979 • 181 citations

Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450

1974 • 173 citations

Epidemiology of alcohol and cancer.

1979 • 158 citations

Enhancement of dimethylnitrosamine metabolism and activation to a mutagen following chronic ethanol consumption.

1981 • 156 citations

Alcohol and the Liver: 1984 Update

1984 • 153 citations

[10] Two forms of liver microsomal cytochrome P-450, P-450lm2 and P-450lm4 (rabbit liver)

1978 • 151 citations

Comparison of six rabbit liver cytochrome P-450 isozymes in formation of a reactive metabolite of acetaminophen

1983 • 146 citations

P ‐450 Cytochromes: Structure and Function

1987 • 145 citations

Benzene metabolism by ethanol-, acetone-, and benzene-inducible cytochrome P-450 (IIE1) in rat and rabbit liver microsomes.

1988 • 121 citations

Microsomal lipid peroxidation: The role of NADPH — Cytochrome P450 reductase and cytochrome P450

1990 • 103 citations

On the Fatty Acid and Hydrocarbon Hydroxylation in Rat Liver Microsomes

1968 • 94 citations

Ethanol Oxidation and Toxicity: Role of Alcohol P‐450 Oxygenase

1986 • 90 citations

Ethanol induction of acetaminophen toxicity and metabolism

1980 • 66 citations

Hydroperoxide-supported cytochrome P-450-linked fatty acid hydroxylation in liver microsomes

1975 • 65 citations

Concomitant alcohol and drug abuse enhancing acetaminophen toxicity. Report of a case.

1978 • 57 citations

A short-chain aldehyde is a major lipoxygenase product in arachidonic acid-stimulated porcine leukocytes.

1986 • 55 citations

[2] Hydrocarbon exhalation

1981 • 52 citations

Enhanced metabolism of volatile hydrocarbons in rat liver following food deprivation, restricted carbohydrate intake, and administration of ethanol, phenobarbital, polychlorinated biphenyl and 3-methylcholanthrene: a comparative study

1985 • 49 citations

Hydrocarbon formation in the reductive cleavage of hydroperoxides by cytochrome P-450.

1987 • 44 citations

Role of isosafrole as complexing agent and inducer of P-450LM4 in rabbit liver microsomes

1982 • 13 citations