Probing the role of lysines and arginines in the catalytic function of cytochrome P450d by site-directed mutagenesis. Interaction with NADPH-cytochrome P450 reductase

The 2.6-A crystal structure of Pseudomonas putida cytochrome P-450.

1985 • 815 citations

On the membrane topology of vertebrate cytochrome P-450 proteins.

1988 • 362 citations

Hepatic microsomal cytochrome P-450 from rats treated with isosafrole. Purification and characterization of four enzymic forms.

1980 • 286 citations

Temperature dependence of cytochrome P-450 reduction. A model for NADPH-cytochrome P-450 reductase:cytochrome P-450 interaction.

1976 • 241 citations

Interactions of cytochrome P-450, NADPH-cytochrome P-450 reductase, phospholipid, and substrate in the reconstituted liver microsomal enzyme system.

1980 • 224 citations

A missense mutation at Ile172----Asn or Arg356----Trp causes steroid 21-hydroxylase deficiency.

1990 • 152 citations

Cytochrome P-450cam binding surface defined by site-directed mutagenesis and electrostatic modeling

1990 • 139 citations

Putidaredoxin competitively inhibits cytochrome b5-cytochrome P-450cam association: a proposed molecular model for a cytochrome P-450cam electron-transfer complex

1989 • 131 citations

Purified liver microsomal cytochrome P-450. Electron-accepting properties and oxidation-reduction potential.

1975 • 120 citations

Site-directed mutageneses of rat liver cytochrome P-450d: catalytic activities toward benzphetamine and 7-ethoxycoumarin

1989 • 101 citations

Single turnover kinetics of the reaction between oxycytochrome P-450cam and reduced putidaredoxin.

1988 • 100 citations

Site-directed mutageneses of rat liver cytochrome P-450d: axial ligand and heme incorporation

1988 • 83 citations

Kinetics of reduction of cytochrome P-450LM4 in a reconstituted liver microsomal enzyme system.

1979 • 77 citations

Selective chemical modification of a functionally linked lysine in cytochrome P-450 LM2

1984 • 74 citations

Fluorescein Isothiocyanate Specifically Modifies Lysine 338 of Cytochrome P-450scc and Inhibits Adrenodoxin Binding

1989 • 73 citations

Interaction of liver microsomal cytochrome P-450 and NADPH-cytochrome P-450 reductase in the presence and absence of lipid.

1984 • 70 citations

Cytochrome P-450 LM2 Reduction

1989 • 64 citations

Inhibition of electron transfer from adrenodoxin to cytochrome P-450scc by chemical modification with pyridoxal 5'-phosphate: identification of adrenodoxin-binding site of cytochrome P-450scc

1989 • 50 citations

Interaction between cytochrome P-450 (P-450C21) and NADPH-cytochrome P-450 reductase from adrenocortical microsomes in a reconstituted system.

1984 • 48 citations

Mutations at the distal and proximal sites of cytochrome P-450d changed regio-specificity of acetanilide hydroxylations

1989 • 42 citations

Adrenodoxin reductase . adrenodoxin complex. Rapid formation and breakdown of the complex and a slow conformational change in the flavoprotein.

1980 • 40 citations

The effect of NADPH concentration on the reduction of cytochrome P-450 LM2.

1988 • 31 citations

Protein-protein and lipid-protein interactions in a reconstituted cytochrome P-450 dependent microsomal monooxygenase

1987 • 26 citations

Expression of cytochrome P-450_dbySaccharomyces cerevisiae

1986 • 25 citations

Detergents as probes of reconstituted rat liver cytochrome P-450 function

1987 • 19 citations

Zwitterionic detergent mediated interaction of purified cytochrome P-450LM4 from 5,6-benzoflavone-treated rabbits with NADPH-cytochrome P-450 reductase

1987 • 11 citations

Electron spin resonance studies of wild-type and mutant cytochromes P-450d: effects of mutations at proximal, aromatic and distal sites on g values

1990 • 11 citations

Chemical modification of microsomal cytochrome P450: role of lysyl residues in hydroxylation activity

1983 • 9 citations