CD4+CD25+FOXP3+ regulatory T cells in nonhuman primates

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

Mechanisms of suppression by suppressor T cells

2005 • 1,023 citations

Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

2004 • 805 citations

Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo

2001 • 658 citations

Cutting Edge: Direct Suppression of B Cells by CD4+CD25+ Regulatory T Cells

2005 • 578 citations

Messenger RNA forFOXP3in the Urine of Renal-Allograft Recipients

2005 • 536 citations

Immunocompetent T-Cells with a Memory-Like Phenotype are the Dominant Cell Type Following Antibody-Mediated T-Cell Depletion

2005 • 459 citations

Isolation and functional characterization of regulatory CD25^brightCD4⁺ T cells from the target organ of patients with rheumatoid arthritis

2003 • 452 citations

RESULTS FROM A HUMAN RENAL ALLOGRAFT TOLERANCE TRIAL EVALUATING THE HUMANIZED CD52-SPECIFIC MONOCLONAL ANTIBODY ALEMTUZUMAB (CAMPATH-1H)

2003 • 432 citations

Homeostatic proliferation is a barrier to transplantation tolerance

2003 • 403 citations

Campath-1H Induction Plus Rapamycin Monotherapy for Renal Transplantation: Results of a Pilot Study

2003 • 379 citations

CD25− T Cells Generate CD25+Foxp3+ Regulatory T Cells by Peripheral Expansion

2004 • 373 citations

Persistence of naive CD45RA+ regulatory T cells in adult life

2005 • 267 citations

Expansion of Functional Endogenous Antigen-Specific CD4+CD25+ Regulatory T Cells from Nonobese Diabetic Mice

2005 • 254 citations

Premature Induction of an Immunosuppressive Regulatory T Cell Response during Acute Simian Immunodeficiency Virus Infection

2006 • 241 citations

Regulatory CD25+ T Cells in Human Kidney Transplant Recipients

2003 • 232 citations

FN18-CRM9 IMMUNOTOXIN PROMOTES TOLERANCE IN PRIMATE RENAL ALLOGRAFTS1

1997 • 212 citations

CD4+CD25+ Tregs and NKT cells: regulators regulating regulators

2006 • 206 citations

In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation

2005 • 182 citations

Emerging possibilities in the development and function of regulatory T cells

2006 • 161 citations

Indoleamine 2,3 dioxygenase and regulation of T cell immunity

2005 • 149 citations

Campath-1H in renal transplantation: The University of Wisconsin experience

2004 • 148 citations

Accelerated Memory Cell Homeostasis during T Cell Depletion and Approaches to Overcome It

2006 • 139 citations

CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy

2005 • 134 citations

DURABLE DONOR-SPECIFIC T AND B CELL TOLERANCE IN RHESUS MACAQUES INDUCED WITH PERITRANSPLANTATION ANTI-CD3 IMMUNOTOXIN AND DEOXYSPERGUALIN

2000 • 79 citations

CD4+CD25+ Regulatory T Cells Inhibit the Maturation but Not the Initiation of an Autoantibody Response

2005 • 78 citations

CD4+CD25+ Regulatory T Cells Do Not Significantly Contribute to Direct Pathway Hyporesponsiveness in Stable Renal Transplant Patients

2003 • 77 citations

Antibody Induction Therapy in Renal Transplant Patients Receiving Calcineurin-Inhibitor Immunosuppressive Regimens

2005 • 74 citations

Metastable Tolerance to Rhesus Monkey Renal Transplants Is Correlated with Allograft TGF-β1+CD4+ T Regulatory Cell Infiltrates

2004 • 74 citations

Durable Donor-Specific T and B Cell Tolerance in Rhesus Macaques Induced with Peritransplantation Anti-CD3 Immunotoxin and Deoxyspergualin: Absence of Chronic Allograft Nephropathy

2006 • 65 citations

Dendritic Cells and CD4+CD25+ T Regulatory Cells: Crosstalk Between Two Professionals in Immunity versus Tolerance

2006 • 65 citations

SPLIT TOLERANCE INDUCED BY IMMUNOTOXIN IN A RHESUS KIDNEY ALLOGRAFT MODEL1

1997 • 53 citations

CD25+Foxp3+ Regulatory T Cells Facilitate CD4+ T Cell Clonal Anergy Induction during the Recovery from Lymphopenia

2006 • 33 citations

Treatment with immunotoxin

2001 • 32 citations

Prope tolerance with induction using Campath 1H and low-dose cyclosporin monotherapy in 31 cadaveric renal allograft recipients.

2000 • 29 citations

Engineered CD3 antibodies for immunosuppression

2003 • 18 citations

RETRACTED: Tolerance induced by anti-CD3 immunotoxin plus 15-deoxyspergualin associates with donor-specific indirect pathway unresponsiveness

2003 • 10 citations

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