T regulatory cells: an overview and intervention techniques to modulate allergy outcome

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

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The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

‘Actively Acquired Tolerance’ of Foreign Cells

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An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

2005 • 1,189 citations

Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells

2005 • 1,090 citations

Mechanisms of suppression by suppressor T cells

2005 • 1,023 citations

Pillars Article: Control of Regulatory T Cell Development by the Transcription Factor Foxp3. Science 2003. 299: 1057-1061.

2017 • 986 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

2005 • 955 citations

Cell interactions in the induction of tolerance: the role of thymic lymphocytes.

1970 • 920 citations

Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells

2001 • 856 citations

Selective Stimulation of T Cell Subsets with Antibody-Cytokine Immune Complexes

2006 • 843 citations

Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease

2004 • 730 citations

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

2003 • 674 citations

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

2005 • 591 citations

Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients

2005 • 583 citations

The role of T lymphocytes in the pathogenesis of asthma

2003 • 572 citations

IL‐35 is a novel cytokine with therapeutic effects against collagen‐induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells

2007 • 562 citations

Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice

1969 • 554 citations

Cutting Edge: Estrogen Drives Expansion of the CD4+CD25+ Regulatory T Cell Compartment

2004 • 510 citations

Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent

2005 • 507 citations

Large-scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells

2004 • 505 citations

Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma

2004 • 497 citations

In vivo switch to IL-10–secreting T regulatory cells in high dose allergen exposure

2008 • 464 citations

CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function

2005 • 397 citations

Regulation of the T cell response

2006 • 394 citations

Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells

2005 • 378 citations

CD4+CD25+ Regulatory T Cells Suppress Mast Cell Degranulation and Allergic Responses through OX40-OX40L Interaction

2008 • 377 citations

Human CD4+ T Cells Express TLR5 and Its Ligand Flagellin Enhances the Suppressive Capacity and Expression of FOXP3 in CD4+CD25+ T Regulatory Cells

2005 • 368 citations

T regulatory cells in allergy: Novel concepts in the pathogenesis, prevention, and treatment of allergic diseases

2005 • 349 citations

Induction of regulatory T cells by physiological level estrogen

2007 • 335 citations

Grass pollen immunotherapy induces Foxp3-expressing CD4+CD25+ cells in the nasal mucosa

2008 • 325 citations

Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling

2006 • 318 citations

Sequential development of interleukin 2–dependent effector and regulatory T cells in response to endogenous systemic antigen

2005 • 296 citations

In vitro–expanded human CD4+CD25+ T-regulatory cells can markedly inhibit allogeneic dendritic cell–stimulated MLR cultures

2004 • 281 citations

Absence of T-regulatory cell expression and function in atopic dermatitis skin

2005 • 266 citations

Dendritic cells expand antigen‐specific Foxp3⁺CD25⁺CD4⁺ regulatory T cells including suppressors of alloreactivity

2006 • 261 citations

Role of regulatory T cells in human diseases

2005 • 261 citations

New targets for drug development in asthma

2008 • 236 citations

Natural regulatory T cells and self-tolerance

2005 • 234 citations

Glucocorticoid amplifies IL‐2‐dependent expansion of functional FoxP3⁺CD4⁺CD25⁺ T regulatory cells in vivo and enhances their capacity to suppress EAE

2006 • 218 citations

Thymic regulatory T cells

2005 • 181 citations

Thymic development and peripheral homeostasis of regulatory T cells

2007 • 160 citations

Function of the IL-2R for Thymic and Peripheral CD4+CD25+ Foxp3+ T Regulatory Cells

2007 • 156 citations

Toll‐like receptors and immune regulation: their direct and indirect modulation on regulatory CD4⁺ CD25⁺ T cells

2007 • 152 citations

Regulatory T cells in human disease and their potential for therapeutic manipulation

2006 • 134 citations

Endogenous interleukin‐10 suppresses allergen‐induced airway inflammation and nonspecific airway responsiveness

2000 • 132 citations

An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2

2007 • 121 citations

Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR/GITR‐L interaction, IL‐10 and TGF‐β

2008 • 108 citations

Suppression of Murine Allergic Airway Disease by IL-2:Anti-IL-2 Monoclonal Antibody-Induced Regulatory T Cells

2008 • 108 citations

Regulatory T-lymphocytes in asthma

2005 • 102 citations

Interleukin-10–Secreting “Regulatory” T Cells Induced by Glucocorticoids and β₂-Agonists

2005 • 98 citations

IL-10-producing type 1 regulatory T cells and allergy.

2007 • 96 citations

Fluticasone propionate increases CD4+CD25+ T regulatory cell suppression of allergen-stimulated CD4+CD25− T cells by an IL-10–dependent mechanism

2004 • 88 citations

Regular Tai Chi Chuan exercise improves T cell helper function of patients with type 2 diabetes mellitus with an increase in T-bet transcription factor and IL-12 production

2008 • 84 citations

Immunologic Principles of Allergic Disease

2007 • 80 citations

Sublingual Immunotherapy

2008 • 78 citations

Pulmonary chemokines and their receptors differentiate children with asthma and chronic cough

2005 • 73 citations

Anti-Inflammatory Effects of FTY720 against Viral-Induced Immunopathology: Role of Drug-Induced Conversion of T Cells to Become Foxp3+ Regulators

2008 • 71 citations

Regulatory T cells in health and disease

2007 • 69 citations

Selective Availability of IL-2 Is a Major Determinant Controlling the Production of CD4+CD25+Foxp3+ T Regulatory Cells

2006 • 56 citations

Myeloid Dendritic Cells of Patients With Chronic HCV Infection Induce Proliferation of Regulatory T Lymphocytes

2008 • 55 citations

Measles Virus Infection in Adults Induces Production of IL-10 and Is Associated with Increased CD4+CD25+ Regulatory T Cells

2008 • 52 citations

CD4⁺CD25⁺ regulatory T cells: I. Phenotype and physiology

2004 • 49 citations

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Inhibits Experimental Autoimmune Thyroiditis by the Expansion of CD4+CD25+ Regulatory T Cells

2008 • 48 citations

Impact of Mycobacterium vaccae immunization on lung histopathology in a murine model of chronic asthma

2003 • 44 citations

Rapamycin Enhances the Number of Alloantigen-Induced Human CD103+CD8+ Regulatory T Cells In Vitro

2007 • 31 citations

IL-15-IgG2b fusion protein accelerates and enhances a Th2 but not a Th1 immune responsein vivo, while IL-2-IgG2b fusion protein inhibits both

1998 • 25 citations

Treatment with Mycobacterium vaccae ameliorates airway histopathology in a murine model of asthma

2008 • 6 citations