HIV Infection of Naturally Occurring and Genetically Reprogrammed Human Regulatory T-cells

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

2017 • 4,003 citations

HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time

1996 • 3,496 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

2001 • 1,831 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.

1996 • 1,335 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific

2000 • 1,282 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood

2001 • 1,168 citations

Donor-type CD4+CD25+ Regulatory T Cells Suppress Lethal Acute Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation

2002 • 1,117 citations

The infusion of ex vivo activated and expanded CD4+CD25+ immune regulatory cells inhibits graft-versus-host disease lethality

2002 • 1,061 citations

Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function

2001 • 1,008 citations

Pillars Article: Control of Regulatory T Cell Development by the Transcription Factor Foxp3. Science 2003. 299: 1057-1061.

2017 • 986 citations

JM2, encoding a fork head–related protein, is mutated in X-linked autoimmunity–allergic disregulation syndrome

2000 • 909 citations

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

1998 • 893 citations

Unique Chemotactic Response Profile and Specific Expression of Chemokine Receptors Ccr4 and Ccr8 by Cd4+Cd25+ Regulatory T Cells

2001 • 888 citations

Multifactorial Nature of Human Immunodeficiency Virus Disease: Implications for Therapy

1993 • 803 citations

IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo

2001 • 799 citations

Functionally Distinct Subsets of CD1d-restricted Natural Killer T Cells Revealed by CD1d Tetramer Staining

2002 • 758 citations

Human Immunodeficiency Virus Type 1 Spinoculation Enhances Infection through Virus Binding

2000 • 662 citations

Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells

2001 • 615 citations

Infectious Tolerance

2002 • 614 citations

Cd4+Cd25+ Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade

2001 • 580 citations

Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis

2003 • 574 citations

Distinct Functional Lineages of Human Vα24 Natural Killer T Cells

2002 • 567 citations

CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10

2001 • 564 citations

A history of prostate cancer treatment

2002 • 563 citations

CD4+CD25+ T Cells Regulate Virus-specific Primary and Memory CD8+ T Cell Responses

2003 • 531 citations

Human CD4+CD25+ thymocytes and peripheral T cells have immune suppressive activityin vitro

2001 • 498 citations

Angiogenic and HIV-Inhibitory Functions of KSHV-Encoded Chemokines

1997 • 479 citations

Human anergic/suppressive CD4+CD25+ T cells: a highly differentiated and apoptosis-prone population

2001 • 460 citations

CD4+ T-cell depletion in HIV infection: Are we closer to understanding the cause?

2002 • 458 citations

CD4 ⁺ CD25 ⁺ T regulatory cells control anti-islet CD8 ⁺ T cells through TGF-β–TGF-β receptor interactions in type 1 diabetes

2003 • 439 citations

Human CD4⁺CD25⁺Regulatory T Cells Control T-Cell Responses to Human Immunodeficiency Virus and Cytomegalovirus Antigens

2004 • 436 citations

Cytokine Signals Are Sufficient for HIV-1 Infection of Resting Human T Lymphocytes

1999 • 428 citations

T cell depletion in HIV-1 infection: how CD4+ T cells go out of stock

2000 • 392 citations

Rapid Turnover of T Lymphocytes in SIV-Infected Rhesus Macaques

1998 • 375 citations

Increased Turnover of T Lymphocytes in HIV-1 Infection and Its Reduction by Antiretroviral Therapy

2001 • 366 citations

Memory and flexibility of cytokine gene expression as separable properties of human TH1 and TH2 lymphocytes

2002 • 353 citations

Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease

2002 • 332 citations

Pancreatic Lymph Node-Derived CD4+CD25+ Treg Cells

2002 • 312 citations

Simultaneous measurement of six cytokines in a single sample of human tears using microparticle-based flow cytometry: allergics vs. non-allergics

2001 • 287 citations

Foxp3 and Natural Regulatory T Cells

2003 • 278 citations

Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells

2002 • 246 citations

CD25+CD4+ T cells contribute to the control of memory CD8+ T cells

2002 • 241 citations

CD4+ regulatory T cells in autoimmunity and allergy

2002 • 236 citations

CD1d-restricted Human Natural Killer T Cells Are Highly Susceptible to Human Immunodeficiency Virus 1 Infection

2002 • 217 citations

Regulatory CD4+CD25+ T Cells Restrict Memory CD8+ T Cell Responses

2002 • 209 citations

The scurfy mouse mutant has previously unrecognized hematological abnormalities and resembles Wiskott-Aldrich syndrome.

1990 • 195 citations

IPEX is a unique X-linked syndrome characterized by immune dysfunction, polyendocrinopathy, enteropathy, and a variety of autoimmune phenomena

2001 • 192 citations

Tracking the Immunoregulatory Mechanisms Active During Allograft Tolerance

2002 • 180 citations

Regulatory T cells in spontaneous autoimmune encephalomyelitis

2001 • 162 citations

Regulatory CD4 T Cells Control the Size of the Peripheral Activated/Memory CD4 T Cell Compartment

2000 • 153 citations

CD4 ⁺ CD25 ⁺ Regulatory Cells from Human Peripheral Blood Express Very High Levels of CD25 Ex Vivo

2003 • 138 citations

Genetic Reprogramming of Primary Human T Cells Reveals Functional Plasticity in Th Cell Differentiation

2003 • 112 citations

Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN

2002 • 99 citations

Identification and Simian Immunodeficiency Virus Infection of CD1d-Restricted Macaque Natural Killer T Cells

2003 • 50 citations

Depletion of CD4+ T Cells during Immunization with Nonviable Listeria monocytogenes Causes Enhanced CD8+ T Cell-Mediated Protection against Listeriosis

2004 • 26 citations

T Cell Signaling Mechanisms that Regulate HIV-1 Infection

2001 • 5 citations

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