T cell epitope: Friend or Foe? Immunogenicity of biologics in context☆

The Danger Model: A Renewed Sense of Self

2002 • 4,107 citations

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

2007 • 1,886 citations

Natural versus adaptive regulatory T cells

2003 • 1,363 citations

Pure Red-Cell Aplasia and Antierythropoietin Antibodies in Patients Treated with Recombinant Erythropoietin

2002 • 1,221 citations

Multiple sclerosis: a complicated picture of autoimmunity

2007 • 985 citations

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

2007 • 887 citations

Pegylation

2001 • 876 citations

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

2007 • 846 citations

More than one reason to rethink the use of peptides in vaccine design

2007 • 785 citations

B cell depletion as a novel treatment for systemic lupus erythematosus: A phase I/II dose‐escalation trial of rituximab

2004 • 768 citations

Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells

1989 • 706 citations

Rituximab Anti-CD20 Monoclonal Antibody Therapy in Non-Hodgkin’s Lymphoma: Safety and Efficacy of Re-Treatment

2000 • 695 citations

Epigenetic control of T-helper-cell differentiation

2009 • 658 citations

Several Common HLA-DR Types Share Largely Overlapping Peptide Binding Repertoires

1998 • 647 citations

Pivotal Study of Iodine I 131 Tositumomab for Chemotherapy-Refractory Low-Grade or Transformed Low-Grade B-Cell Non-Hodgkin’s Lymphomas

2001 • 599 citations

Immunogenicity of engineered antibodies

2005 • 587 citations

Clinical response to adalimumab: relationship to anti-adalimumab antibodies and serum adalimumab concentrations in rheumatoid arthritis

2007 • 536 citations

Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors

2007 • 518 citations

Immunogenicity of protein therapeutics

2007 • 502 citations

Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

2008 • 501 citations

Rituximab treatment in patients with primary Sjögren's syndrome: An open‐label phase II study

2005 • 486 citations

Low avidity recognition of self-antigen by T cells permits escape from central tolerance

1995 • 415 citations

CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked–like syndrome, and defective IL-10 expression from CD4 lymphocytes

2006 • 408 citations

Impact of Negative Selection on the T Cell Repertoire Reactive to a Self-Peptide

2000 • 377 citations

Extended Rituximab (anti-CD20 monoclonal antibody) therapy for relapsed or refractory low-grade or follicular non-Hodgkin's lymphoma

1999 • 369 citations

Formation of antibodies against infliximab and adalimumab strongly correlates with functional drug levels and clinical responses in rheumatoid arthritis

2008 • 367 citations

Immune epitope database analysis resource (IEDB-AR)

2008 • 350 citations

Self-representation in the thymus: an extended view

2004 • 339 citations

Humanised monoclonal antibody therapy for rheumatoid arthritis

1992 • 316 citations

Recommendations on risk-based strategies for detection and characterization of antibodies against biotechnology products

2008 • 313 citations

Immunodominant CD4+ T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection

1997 • 306 citations

Antibodies and B Cell Memory in Viral Immunity

2007 • 272 citations

DC activated via dectin‐1 convert Treg into IL‐17 producers

2008 • 262 citations

Immune Responses to Therapeutic Proteins in Humans - Clinical Significance, Assessment and Prediction

2002 • 253 citations

Autoimmune mechanisms in type 1 diabetes

2008 • 251 citations

Adjuvanted H5N1 vaccine induces early CD4⁺T cell response that predicts long-term persistence of protective antibody levels

2009 • 248 citations

Identification of immunodominant T cell epitopes of the hepatitis B virus nucleocapsid antigen.

1991 • 230 citations

The Kinetic Stability of MHC Class II:Peptide Complexes Is a Key Parameter that Dictates Immunodominance

2005 • 221 citations

Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind aBorrelia burgdorferipeptide

2006 • 202 citations

Reducing risk, improving outcomes: Bioengineering less immunogenic protein therapeutics

2009 • 188 citations

Comprehensive Analysis of Human Immunodeficiency Virus Type 1-Specific CD4 Responses Reveals Marked Immunodominance ofgagandnefand the Presence of Broadly Recognized Peptides

2004 • 182 citations

Computational methods for prediction of T-cell epitopes—a framework for modelling, testing, and applications

2004 • 170 citations

Immuno‐informatics: Mining genomes for vaccine components

2002 • 167 citations

Immunomics: discovering new targets for vaccines and therapeutics

2006 • 151 citations

High-affinity binding of an influenza hemagglutinin-derived peptide to purified HLA-DR.

1990 • 148 citations

Clinical validation of the “in silico” prediction of immunogenicity of a human recombinant therapeutic protein

2007 • 135 citations

Recognition of hepatitis B surface antigen by human T lymphocytes. Proliferative and cytotoxic responses to a major antigenic determinant defined by synthetic peptides.

1988 • 107 citations

Use of site-directed mutagenesis to enhance the epitope-shielding effect of covalent modification of proteins with polyethylene glycol.

1991 • 104 citations

Campath‐1h, a humanized monoclonal antibody, in refractory rheumatoid arthritis

1995 • 103 citations

An Interactive Web Site Providing Major Histocompatibility Ligand Predictions: Application to HIV Research

1997 • 101 citations

Prediction of immunogenicity for therapeutic proteins: state of the art.

2007 • 95 citations

Long-term human coronavirus-myelin cross-reactive T-cell clones derived from multiple sclerosis patients

2007 • 93 citations

A Positive Feedback Loop of IL-21 Signaling Provoked by Homeostatic CD4+CD25− T Cell Expansion Is Essential for the Development of Arthritis in Autoimmune K/BxN Mice

2009 • 92 citations

Targeting the development and effector functions of TH17 cells

2007 • 90 citations

Preparation of a non-immunogenic arginase by the covalent attachment of polyethylene glycol

1979 • 90 citations

Clinical link between MHC class II haplotype and interferon-beta (IFN-β) immunogenicity

2005 • 86 citations

Nonresponse to hepatitis B vaccines and the kinetics of anti-HBs production

1996 • 83 citations

Identification and removal of a promiscuous CD4+ T cell epitope from the C1 domain of factor VIII

2005 • 83 citations

The genetic basis of autoantibody production

2005 • 81 citations

Analyzing Mycobacterium tuberculosis proteomes for candidate vaccine epitopes

2004 • 81 citations

Treatment of therapy-refractory B-lineage acute lymphoblastic leukemia with an apoptosis-inducing CD19-directed tyrosine kinase inhibitor.

1999 • 80 citations

High-affinity T helper epitope induces complementary helper and APC polarization, increased CTL, and protection against viral infection

2001 • 80 citations

The autoimmune pathogenesis of rheumatoid arthritis: Role of autoreactive T cells and new immunotherapies

2001 • 79 citations

High-affinity T helper epitope induces complementary helper and APC polarization, increased CTL, and protection against viral infection

2001 • 77 citations

Diversity of Francisella tularensis Schu4 antigens recognized by T lymphocytes after natural infections in humans: Identification of candidate epitopes for inclusion in a rationally designed tularemia vaccine

2007 • 77 citations

Safety and biodistribution of 99mTechnetium-labeled anti-CD44v6 monoclonal antibody BIWA 1 in head and neck cancer patients.

2000 • 73 citations

De-immunization of therapeutic proteins by T-cell epitope modification.

2005 • 73 citations

Recombinant Staphylokinase Variants With Altered Immunoreactivity

1997 • 69 citations

SAP Is Required for Th Cell Function and for Immunity to Influenza

2006 • 67 citations

Development of a Maturing T-Cell-Mediated Immune Response in Patients with Idiopathic Parkinson’s Disease Receiving r-metHuGDNF Via Continuous Intraputaminal Infusion

2007 • 66 citations

Recombinant Staphylokinase Variants With Altered Immunoreactivity

1996 • 64 citations

Naive and memory B cells in T-cell-dependent and T-independent responses

2001 • 63 citations

The expanding realm of heterologous immunity: friend or foe?

2006 • 62 citations

Rescue of the autoimmune scurfy mouse by partial bone marrow transplantation or by injection with T-enriched splenocytes

2003 • 60 citations

An HLA-Directed Molecular and Bioinformatics Approach Identifies New HLA-A11 HIV-1 Subtype E Cytotoxic T Lymphocyte Epitopes in HIV-1-Infected Thais

2001 • 54 citations

HLA-A2-Restricted CD8⁺-Cytotoxic-T-Cell Responses to Novel Epitopes inMycobacterium tuberculosisSuperoxide Dismutase, Alanine Dehydrogenase, and Glutamine Synthetase

2004 • 51 citations

Comparative analysis of six European influenza vaccines

1996 • 50 citations

Some Factor VIII (FVIII) Inhibitors Recognise a FVIII Epitope(s) that Is Present only on FVIII-vWF Complexes

1999 • 50 citations

Human leukocyte antigens influence the immune response to a pre-S/S hepatitis B vaccine

1999 • 48 citations

Thyrotropin Receptor Epitopes and Their Relation to Histocompatibility Leukocyte Antigen-DR Molecules in Graves’ Disease

2006 • 45 citations

A call to cellular & humoral arms: Enlisting cognate T cell help to develop broad-spectrum vaccines against influenza A

2008 • 45 citations

A Single Helper T Cell Clone Is Sufficient to Commit Polyclonal Naive B Cells to Produce Pathogenic IgG in Experimental Pemphigus Vulgaris

2009 • 43 citations

Prediction of HIV Peptide Epitopes by a Novel Algorithm

1996 • 41 citations

Balance of Th1 and Th17 effector and peripheral regulatory T cells

2009 • 40 citations

Confirmation of Immunogenic Consensus Sequence HIV-1 T-cell Epitopes in Bamako, Mali and Providence, Rhode Island

2006 • 36 citations

A review of Campath in autoimmune disease: Biologic therapy in the gray zone between immunosuppression and immunoablation

2005 • 36 citations

Decision making during the conception and career of CD4+ T cells

2009 • 26 citations

Identification of an epitope for T-cells correlated with antibody response to hepatitis B surface antigen in vaccinated humans

1996 • 17 citations

Modelling the immunogenicity of therapeutic proteins using T cell epitope mapping.

2003 • 16 citations

DETECTION OF IGA ANTI-OKT3 ANTIBODIES IN OKT3-TREATED TRANSPLANT RECIPIENTS1

1996 • 15 citations

Resuscitating Adaptive Tregs with Combination Therapies?

2008 • 6 citations

Immunome-derived Epitope-driven Vaccines (ID-EDV) Protect against Viral or Bacterial Challenge in Humanized Mice

2009 • 3 citations